Author results

2AKP
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HSP90 DELTA24-N210 MUTANT
分子名称:ATP-dependent molecular chaperone HSP82
著者Richter, K., Moser, S., Hagn, F., Friedrich, R., Hainzl, O., Heller, M., Schlee, S., Kessler, H., Reinstein, J., Buchner, J.
登録日2005-08-03
公開日2006-01-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献Intrinsic inhibition of the Hsp90 ATPase activity.
J.Biol.Chem., 281, 2006
3WHW
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MTH1 IN COMPLEX WITH RUTHENIUM-BASED INHIBITOR
分子名称:7,8-dihydro-8-oxoguanine triphosphatase, SULFATE ION, [4-amino-2-methyl-6-(pyridin-2-yl-kappaN)quinazolin-7-yl-kappaC~7~](carbonyl){1-[(2,6-dimethoxyphenoxy)carbonyl]cyclopenta-2,4-dien-1-yl}ruthenium
著者Streib, M., Kraeling, K., Richter, K., Steuber, H., Meggers, E.
登録日2013-09-03
公開日2014-02-12
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (2.701 Å)
主引用文献An Organometallic Inhibitor for the Human Repair Enzyme 7,8-Dihydro-8-oxoguanosine Triphosphatase.
Angew.Chem.Int.Ed.Engl., 53, 2014
2LLV
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SOLUTION STRUCTURE OF THE YEAST STI1 DP1 DOMAIN
分子名称:Heat shock protein STI1
著者Schmid, A.B., Lagleder, S., Graewert, M.A., Roehl, A., Hagn, F., Wandinger, S.K., Cox, M.B., Demmer, O., Richter, K., Groll, M., Kessler, H., Buchner, J.
登録日2011-11-17
公開日2012-01-25
最終更新日2012-04-04
実験手法SOLUTION NMR
主引用文献The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop.
Embo J., 31, 2012
2LLW
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SOLUTION STRUCTURE OF THE YEAST STI1 DP2 DOMAIN
分子名称:Heat shock protein STI1
著者Schmid, A.B., Lagleder, S., Graewert, M.A., Roehl, A., Hagn, F., Wandinger, S.K., Cox, M.B., Demmer, O., Richter, K., Groll, M., Kessler, H., Buchner, J.
登録日2011-11-17
公開日2012-01-25
最終更新日2012-04-04
実験手法SOLUTION NMR
主引用文献The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop.
Embo J., 31, 2012
3UPV
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TPR2B-DOMAIN:PHSP70-COMPLEX OF YEAST STI1
分子名称:Heat shock protein STI1, Heat shock protein SSA4
著者Schmid, A.B., Lagleder, S., Graewert, M.A., Roehl, A., Hagn, F., Wandinger, S.K., Cox, M.B., Demmer, O., Richter, K., Groll, M., Kessler, H.
登録日2011-11-18
公開日2012-01-25
最終更新日2012-04-04
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop.
Embo J., 31, 2012
3UQ3
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TPR2AB-DOMAIN:PHSP90-COMPLEX OF YEAST STI1
分子名称:Heat shock protein STI1, Heat shock protein
著者Schmid, A.B., Lagleder, S., Graewert, M.A., Roehl, A., Hagn, F., Wandinger, S.K., Cox, M.B., Demmer, O., Richter, K., Groll, M., Kessler, H., Buchner, J.
登録日2011-11-19
公開日2012-01-18
最終更新日2012-04-04
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The architecture of functional modules in the Hsp90 co-chaperone Sti1/Hop.
Embo J., 31, 2012
4JA7
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RAT PP5 CO-CRYSTALLIZED WITH P5SA-2
分子名称:Serine/threonine-protein phosphatase 5, MAGNESIUM ION
著者Haslbeck, V., Helmuth, M., Alte, F., Popowicz, G., Schmidt, W., Weiwad, M., Fischer, G., Gemmecker, G., Sattler, M., Striggow, F., Groll, M., Richter, K.
登録日2013-02-18
公開日2014-02-19
最終更新日2016-08-10
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism.
Biosci.Rep., 35, 2015
4JA9
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RAT PP5 APO
分子名称:Serine/threonine-protein phosphatase 5, MAGNESIUM ION
著者Haslbeck, V., Helmuth, M., Alte, F., Popowicz, G., Schmidt, W., Weiwad, M., Fischer, G., Gemmecker, G., Sattler, M., Striggow, F., Groll, M., Richter, K.
登録日2013-02-18
公開日2014-02-19
最終更新日2016-08-10
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism.
Biosci.Rep., 35, 2015
3C7X
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HEMOPEXIN-LIKE DOMAIN OF MATRIX METALLOPROTEINASE 14
分子名称:Matrix metalloproteinase-14, SODIUM ION, CHLORIDE ION
著者Tochowicz, A., Itoh, Y., Maskos, K., Bode, W., Goettig, P.
登録日2008-02-08
公開日2009-02-10
最終更新日2018-06-20
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The dimer interface of the membrane type 1 matrix metalloproteinase hemopexin domain: crystal structure and biological functions
J.Biol.Chem., 286, 2011
6FZN
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SMURFP-Y56R MUTANT IN COMPLEX WITH BILIVERDIN
分子名称:smURFP, 3-[5-[[(3~{R},4~{R})-3-ethenyl-4-methyl-5-oxidanylidene-3,4-dihydropyrrol-2-yl]methyl]-2-[[5-[(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-yl)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1~{H}-pyrrol-2-yl]methyl]-4-methyl-1~{H}-pyrrol-3-yl]propanoic acid
著者Janowski, R., Fuenzalida-Wernera, J.P., Mishra, K., Vetschera, P., Weidenfeld, I., Richter, K., Niessing, D., Ntziachristos, V., Stiel, A.C.
登録日2018-03-15
公開日2018-10-17
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of a biliverdin-bound phycobiliprotein: Interdependence of oligomerization and chromophorylation.
J. Struct. Biol., 204, 2018
6FZO
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SMURFP-Y56F MUTANT
分子名称:Smurfp, SULFATE ION, 1,2-ETHANEDIOL, ...
著者Janowski, R., Fuenzalida-Wernera, J.P., Mishra, K., Vetschera, P., Weidenfeld, I., Richter, K., Niessing, D., Ntziachristos, V., Stiel, A.C.
登録日2018-03-15
公開日2018-10-17
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of a biliverdin-bound phycobiliprotein: Interdependence of oligomerization and chromophorylation.
J. Struct. Biol., 204, 2018
5DL1
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CLPP FROM STAPHYLOCOCCUS AUREUS IN COMPLEX WITH AV145
分子名称:ATP-dependent Clp protease proteolytic subunit, 1-(propan-2-yl)-N-{[2-(thiophen-2-yl)-1,3-oxazol-4-yl]methyl}-1H-pyrazolo[3,4-b]pyridine-5-carboxamide
著者Vielberg, M.-T., Groll, M.
登録日2015-09-04
公開日2015-11-25
最終更新日2018-10-24
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Reversible Inhibitors Arrest ClpP in a Defined Conformational State that Can Be Revoked by ClpX Association.
Angew.Chem.Int.Ed.Engl., 54, 2015
1NU7
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STAPHYLOCOAGULASE-THROMBIN COMPLEX
分子名称:Thrombin light chain, Thrombin heavy chain, Staphylocoagulase, ...
著者Friedrich, R., Bode, W., Fuentes-Prior, P., Panizzi, P., Bock, P.E.
登録日2003-01-31
公開日2003-10-07
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation
NATURE, 425, 2003
1NU9
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STAPHYLOCOAGULASE-PRETHROMBIN-2 COMPLEX
分子名称:Thrombin light and heavy chains, Staphylocoagulase, N-(sulfanylacetyl)-D-phenylalanyl-N-[(2S,3S)-6-{[amino(iminio)methyl]amino}-1-chloro-2-hydroxyhexan-3-yl]-L-prolinamide, ...
著者Friedrich, R., Bode, W., Fuentes-Prior, P., Panizzi, P., Bock, P.E.
登録日2003-01-31
公開日2003-10-07
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Staphylocoagulase is a prototype for the mechanism of cofactor-induced zymogen activation
NATURE, 425, 2003
4UQF
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CRYSTAL STRUCTURE OF LISTERIA MONOCYTOGENES GTP CYCLOHYDROLASE I
分子名称:GTP CYCLOHYDROLASE 1
著者Schuessler, S., Perbandt, M., Fischer, M., Graewert, T.
登録日2014-06-23
公開日2015-07-01
最終更新日2018-03-07
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal Structure of Listeria GTP Cyclohydrolase I
To be Published
5LIR
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STRUCTURE OF THE SALTY SIGMA CROSS-REACTING PROTEIN 27A (SCRP-27A) FROM SALMONELLA TYPHIMURIUM
分子名称:Sigma cross-reacting protein 27A (SCRP-27A), DI(HYDROXYETHYL)ETHER
著者Schneider, S., Mandel, M., Sieber, S.A.
登録日2016-07-15
公開日2016-09-14
最終更新日2016-11-30
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Natural-Product-Inspired Aminoepoxybenzoquinones Kill Members of the Gram-Negative Pathogen Salmonella by Attenuating Cellular Stress Response.
Angew.Chem.Int.Ed.Engl., 55, 2016
6EK4
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PAXB FROM PHOTORHABDUS LUMINESCENS
分子名称:PaxB, SODIUM ION
著者Braeuning, B., Groll, M.
登録日2017-09-25
公開日2018-05-16
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure and mechanism of the two-component alpha-helical pore-forming toxin YaxAB.
Nat Commun, 9, 2018
6EK7
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YAXA FROM YERSINIA ENTEROCOLITICA
分子名称:YaxA, (4S)-2-METHYL-2,4-PENTANEDIOL
著者Braeuning, B., Groll, M.
登録日2017-09-25
公開日2018-05-16
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure and mechanism of the two-component alpha-helical pore-forming toxin YaxAB.
Nat Commun, 9, 2018
6EK8
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YAXB FROM YERSINIA ENTEROCOLITICA
分子名称:YaxB
著者Braeuning, B., Groll, M.
登録日2017-09-25
公開日2018-05-16
実験手法X-RAY DIFFRACTION (4 Å)
主引用文献Structure and mechanism of the two-component alpha-helical pore-forming toxin YaxAB.
Nat Commun, 9, 2018
6EL1
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YAXAB PORE COMPLEX
分子名称:YaxA, YaxB
著者Braeuning, B., Bertosin, E., Dietz, H., Groll, M.
登録日2017-09-27
公開日2018-05-16
実験手法ELECTRON MICROSCOPY (6.1 Å)
主引用文献Structure and mechanism of the two-component alpha-helical pore-forming toxin YaxAB.
Nat Commun, 9, 2018
6H23
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CRYSTAL STRUCTURE OF THE HCLPP Y118A MUTANT WITH AN ACTIVATING SMALL MOLECULE
分子名称:ATP-dependent Clp protease proteolytic subunit, mitochondrial, ~{N}-(1,3-benzodioxol-5-ylmethyl)-5-[(2-chloranyl-4-fluoranyl-phenyl)methyl]-1,3,4-oxadiazole-2-carboxamide, ...
著者Kick, L.M., Sieber, S.A., Schneider, S.
登録日2018-07-13
公開日2018-08-29
最終更新日2019-04-03
実験手法X-RAY DIFFRACTION (3.089 Å)
主引用文献Selective Activation of Human Caseinolytic Protease P (ClpP).
Angew. Chem. Int. Ed. Engl., 57, 2018