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5A6I
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BU of 5a6i by Molmil
V122I Transthyretin structure in complex with Tolcalpone
Descriptor: TRANSTHYRETIN, Tolcapone
Authors:Reverter, D, Gallego, P, Santana, R, Ventura, S.
Deposit date:2015-06-26
Release date:2016-02-24
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Repositioning Tolcapone as a Potent Inhibitor of Transthyretin Amyloidogenesis and its Associated Cellular Toxicity
Nat.Commun., 7, 2016
6RO9
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BU of 6ro9 by Molmil
Human spectrin SH3 domain D48G, E7V, K60V
Descriptor: Spectrin alpha, non-erythrocytic 1
Authors:Reverter, D, Navarro, S, Ventura, S.
Deposit date:2019-05-10
Release date:2020-06-03
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.814 Å)
Cite:Human spectrin SH3 domain D48G, E7V, K60V
To Be Published
1Z5S
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BU of 1z5s by Molmil
Crystal structure of a complex between UBC9, SUMO-1, RANGAP1 and NUP358/RANBP2
Descriptor: Ran GTPase-activating protein 1, Ran-binding protein 2, Ubiquitin-conjugating enzyme E2 I, ...
Authors:Reverter, D, Lima, C.D.
Deposit date:2005-03-19
Release date:2005-06-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex.
Nature, 435, 2005
1DTV
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BU of 1dtv by Molmil
NMR STRUCTURE OF THE LEECH CARBOXYPEPTIDASE INHIBITOR (LCI)
Descriptor: CARBOXYPEPTIDASE INHIBITOR
Authors:Reverter, D, Fernandez-Catalan, C, Bode, W, Holak, T.A, Aviles, F.X.
Deposit date:2000-01-13
Release date:2000-07-19
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex with human carboxypeptidase A2.
Nat.Struct.Biol., 7, 2000
1DTD
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BU of 1dtd by Molmil
CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE LEECH CARBOXYPEPTIDASE INHIBITOR AND THE HUMAN CARBOXYPEPTIDASE A2 (LCI-CPA2)
Descriptor: CARBOXYPEPTIDASE A2, GLUTAMIC ACID, METALLOCARBOXYPEPTIDASE INHIBITOR, ...
Authors:Reverter, D, Fernandez-Catalan, C, Bode, W, Holak, T.A, Aviles, F.X.
Deposit date:2000-01-12
Release date:2000-07-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex with human carboxypeptidase A2.
Nat.Struct.Biol., 7, 2000
7AL8
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BU of 7al8 by Molmil
Structure of ATSI with bovine trypsin
Descriptor: CALCIUM ION, Cationic trypsin, SULFATE ION, ...
Authors:Reverter, D, Covaleda, G.
Deposit date:2020-10-05
Release date:2021-10-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structure of ATSI with bovine trypsin
To Be Published
1TGZ
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BU of 1tgz by Molmil
Structure of human Senp2 in complex with SUMO-1
Descriptor: SULFATE ION, Sentrin-specific protease 2, Ubiquitin-like protein SMT3C
Authors:Reverter, D, Lima, C.D.
Deposit date:2004-05-31
Release date:2004-09-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex
Structure, 12, 2004
1TH0
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BU of 1th0 by Molmil
Structure of human Senp2
Descriptor: Sentrin-specific protease 2
Authors:Reverter, D, Lima, C.D.
Deposit date:2004-05-31
Release date:2004-09-14
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex
Structure, 12, 2004
1XT9
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BU of 1xt9 by Molmil
Crystal Structure of Den1 in complex with Nedd8
Descriptor: Neddylin, Sentrin-specific protease 8
Authors:Reverter, D, Wu, K, Erdene, T.G, Pan, Z.Q, Wilkinson, K.D, Lima, C.D.
Deposit date:2004-10-21
Release date:2004-12-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of a Complex between Nedd8 and the Ulp/Senp Protease Family Member Den1.
J.Mol.Biol., 345, 2005
2IO2
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BU of 2io2 by Molmil
Crystal structure of human Senp2 in complex with RanGAP1-SUMO-1
Descriptor: Ran GTPase-activating protein 1, Sentrin-specific protease 2, Small ubiquitin-related modifier 1
Authors:Reverter, D, Lima, C.D.
Deposit date:2006-10-09
Release date:2006-11-21
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates.
Nat.Struct.Mol.Biol., 13, 2006
2IO3
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BU of 2io3 by Molmil
Crystal structure of human Senp2 in complex with RanGAP1-SUMO-2
Descriptor: Ran GTPase-activating protein 1, Sentrin-specific protease 2, Small ubiquitin-related modifier 2
Authors:Reverter, D, Lima, C.D.
Deposit date:2006-10-09
Release date:2006-11-14
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates.
Nat.Struct.Mol.Biol., 13, 2006
2IO0
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BU of 2io0 by Molmil
Crystal structure of human Senp2 in complex with preSUMO-2
Descriptor: SULFATE ION, Sentrin-specific protease 2, Small ubiquitin-related modifier 2 precursor
Authors:Reverter, D, Lima, C.D.
Deposit date:2006-10-09
Release date:2006-11-14
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates.
Nat.Struct.Mol.Biol., 13, 2006
2IO1
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BU of 2io1 by Molmil
Crystal structure of human Senp2 in complex with preSUMO-3
Descriptor: Sentrin-specific protease 2, Small ubiquitin-related modifier 3 precursor
Authors:Reverter, D, Lima, C.D.
Deposit date:2006-10-09
Release date:2006-11-14
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates.
Nat.Struct.Mol.Biol., 13, 2006
6EOA
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BU of 6eoa by Molmil
Crystal Structure of HAL3 from Cryptococcus neoformans
Descriptor: FLAVIN MONONUCLEOTIDE, Phosphopantothenoylcysteine decarboxylase
Authors:Reverter, D, Zhang, C, Molero, C, Arino, J.
Deposit date:2017-10-09
Release date:2018-10-31
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Characterization of the atypical Ppz/Hal3 phosphatase system from the pathogenic fungus Cryptococcus neoformans.
Mol.Microbiol., 111, 2019
5O71
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BU of 5o71 by Molmil
Crystal structure of human USP25
Descriptor: Ubiquitin carboxyl-terminal hydrolase 25
Authors:Reverter, D, Liu, B.
Deposit date:2017-06-07
Release date:2018-06-20
Last modified:2019-04-17
Method:X-RAY DIFFRACTION (3.283 Å)
Cite:A quaternary tetramer assembly inhibits the deubiquitinating activity of USP25.
Nat Commun, 9, 2018
1UWY
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BU of 1uwy by Molmil
Crystal structure of human carboxypeptidase M
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CARBOXYPEPTIDASE M, ZINC ION
Authors:Maskos, K, Reverter, D, Bode, W.
Deposit date:2004-02-17
Release date:2004-04-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal Structure of Human Carboxypeptidase M, a Membrane-Bound Enzyme that Regulates Peptide Hormone Activity
J.Mol.Biol., 338, 2004
7R2E
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BU of 7r2e by Molmil
Structure of human Senp7 with SUMO2
Descriptor: Sentrin-specific protease 7, Small ubiquitin-related modifier 3, prop-2-en-1-amine
Authors:Reverter, D, Li, Y.
Deposit date:2022-02-04
Release date:2022-12-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structural Basis for the SUMO2 Isoform Specificity of SENP7.
J.Mol.Biol., 434, 2022
7P99
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BU of 7p99 by Molmil
Structure of human USPL1 in complex with SUMO2
Descriptor: SUMO-specific isopeptidase USPL1, Small ubiquitin-related modifier, ZINC ION
Authors:Reverter, D, Ying, L.
Deposit date:2021-07-26
Release date:2022-03-02
Last modified:2022-09-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for the SUMO protease activity of the atypical ubiquitin-specific protease USPL1.
Nat Commun, 13, 2022
4D7B
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BU of 4d7b by Molmil
Structure of human transthyretin in complex with Tolcapone
Descriptor: TRANSTHYRETIN, Tolcapone
Authors:Gallego, P, Sant'anna, R.O, Ventura, S, Reverter, D.
Deposit date:2014-11-21
Release date:2016-01-20
Last modified:2016-03-02
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Repositioning Tolcapone as a Potent Inhibitor of Transthyretin Amyloidogenesis and its Associated Cellular Toxicity
Nat.Commun., 7, 2016
1AYE
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BU of 1aye by Molmil
HUMAN PROCARBOXYPEPTIDASE A2
Descriptor: PROCARBOXYPEPTIDASE A2, ZINC ION
Authors:Garcia-Saez, I, Reverte, D, Vendrell, J, Aviles, F.X, Coll, M.
Deposit date:1997-11-03
Release date:1999-01-13
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The three-dimensional structure of human procarboxypeptidase A2. Deciphering the basis of the inhibition, activation and intrinsic activity of the zymogen.
EMBO J., 16, 1997
7ZQ7
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BU of 7zq7 by Molmil
Structure of RpF-1
Descriptor: Crotonase/enoyl-CoA hydratase family protein
Authors:Sanchez-Alba, L, Reverter, D, Conchillo, O, Yero, D, Daura, X, Gibert, I.
Deposit date:2022-04-29
Release date:2023-05-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure of RpF-1
To Be Published
4UEE
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BU of 4uee by Molmil
Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with the PHOSPHINIC INHIBITOR Acetyl-Leu-Ala-Y(PO2CH2)-homoPhe-OH
Descriptor: (2S)-2-{[(R)-{(1R)-1-[(N-acetyl-L-leucyl)amino]ethyl}(hydroxy)phosphoryl]methyl}-4-phenylbutanoic acid, CARBOXYPEPTIDASE A1, ZINC ION
Authors:Gallego, P, Covaleda, G, Costenaro, L, Devel, L, Dive, V, Aviles, F.X, Reverter, D.
Deposit date:2014-12-17
Release date:2016-01-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Crystal Structure of the Human Carboxypeptidase A1 in Complex with Phosphinic Inhibitors
To be Published
4UEZ
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BU of 4uez by Molmil
Crystal structure of the human CARBOXYPEPTIDASE A1 in complex with the PHOSPHINIC INHIBITOR Acetyl-Leu-Phe-Y(PO2CH2)-Phe-OH
Descriptor: (2S)-3-[(R)-{(1R)-1-[(N-acetyl-L-leucyl)amino]-2-phenylethyl}(hydroxy)phosphoryl]-2-benzylpropanoic acid, HUMAN CARBOXYPEPTIDASE A1, ZINC ION
Authors:Gallego, P, Covaleda, G, Costenaro, L, Devel, L, Dive, V, Aviles, F.X, Reverter, D.
Deposit date:2014-12-22
Release date:2016-01-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Crystal Structure of the Human Carboxypeptidase A1 in Complex with Phosphinic Inhibitors
To be Published
7QC5
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BU of 7qc5 by Molmil
Crystal structure of human wild type transthyretin in complex with (3,4-dihydroxy-5-nitrophenyl)-(3-fluoro-5-hydroxyphenyl)methanone compound
Descriptor: (3-fluoranyl-5-oxidanyl-phenyl)-[3-nitro-4,5-bis(oxidanyl)phenyl]methanone, Transthyretin
Authors:Varejao, N, Pinheiro, F, Pallares, I, Ventura, S, Reverter, D.
Deposit date:2021-11-22
Release date:2022-11-30
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Development of a Highly Potent Transthyretin Amyloidogenesis Inhibitor: Design, Synthesis, and Evaluation.
J.Med.Chem., 65, 2022
5AEK
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BU of 5aek by Molmil
Crystal structure of the human SENP2 C548S in complex with the human SUMO1 K48M F66W
Descriptor: SENTRIN-SPECIFIC PROTEASE 2, SMALL UBIQUITIN-RELATED MODIFIER 1
Authors:Gallego, P, Grana-Montes, R, Espargaro, A, Castillo, V, Torrent, J, Lange, R, Papaleo, E, Lindorff-Larsend, K, Ventura, S, Reverter, D.
Deposit date:2014-12-23
Release date:2016-01-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Stepping Back and Forward on Sumo Folding Evolution
To be Published

 

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