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1DTD
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE LEECH CARBOXYPEPTIDASE INHIBITOR AND THE HUMAN CARBOXYPEPTIDASE A2 (LCI-CPA2)
Descriptor:CARBOXYPEPTIDASE A2, METALLOCARBOXYPEPTIDASE INHIBITOR, ZINC ION, ...
Authors:Reverter, D., Fernandez-Catalan, C., Bode, W., Holak, T.A., Aviles, F.X.
Deposit date:2000-01-12
Release date:2000-07-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex with human carboxypeptidase A2.
Nat.Struct.Biol., 7, 2000
1DTV
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NMR STRUCTURE OF THE LEECH CARBOXYPEPTIDASE INHIBITOR (LCI)
Descriptor:CARBOXYPEPTIDASE INHIBITOR
Authors:Reverter, D., Fernandez-Catalan, C., Bode, W., Holak, T.A., Aviles, F.X.
Deposit date:2000-01-13
Release date:2000-07-19
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of a novel leech carboxypeptidase inhibitor determined free in solution and in complex with human carboxypeptidase A2.
Nat.Struct.Biol., 7, 2000
1TGZ
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STRUCTURE OF HUMAN SENP2 IN COMPLEX WITH SUMO-1
Descriptor:Sentrin-specific protease 2, Ubiquitin-like protein SMT3C, SULFATE ION
Authors:Reverter, D., Lima, C.D.
Deposit date:2004-05-31
Release date:2004-09-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex
Structure, 12, 2004
1TH0
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STRUCTURE OF HUMAN SENP2
Descriptor:Sentrin-specific protease 2
Authors:Reverter, D., Lima, C.D.
Deposit date:2004-05-31
Release date:2004-09-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex
Structure, 12, 2004
1XT9
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CRYSTAL STRUCTURE OF DEN1 IN COMPLEX WITH NEDD8
Descriptor:Sentrin-specific protease 8, Neddylin
Authors:Reverter, D., Wu, K., Erdene, T.G., Pan, Z.Q., Wilkinson, K.D., Lima, C.D.
Deposit date:2004-10-21
Release date:2004-12-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of a Complex between Nedd8 and the Ulp/Senp Protease Family Member Den1.
J.Mol.Biol., 345, 2005
1Z5S
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CRYSTAL STRUCTURE OF A COMPLEX BETWEEN UBC9, SUMO-1, RANGAP1 AND NUP358/RANBP2
Descriptor:Ubiquitin-conjugating enzyme E2 I, Ubiquitin-like protein SMT3C, Ran GTPase-activating protein 1, ...
Authors:Reverter, D., Lima, C.D.
Deposit date:2005-03-19
Release date:2005-06-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex.
Nature, 435, 2005
2IO0
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CRYSTAL STRUCTURE OF HUMAN SENP2 IN COMPLEX WITH PRESUMO-2
Descriptor:Sentrin-specific protease 2, Small ubiquitin-related modifier 2 precursor, SULFATE ION
Authors:Reverter, D., Lima, C.D.
Deposit date:2006-10-09
Release date:2006-11-14
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates.
Nat.Struct.Mol.Biol., 13, 2006
2IO1
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CRYSTAL STRUCTURE OF HUMAN SENP2 IN COMPLEX WITH PRESUMO-3
Descriptor:Sentrin-specific protease 2, Small ubiquitin-related modifier 3 precursor
Authors:Reverter, D., Lima, C.D.
Deposit date:2006-10-09
Release date:2006-11-14
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates.
Nat.Struct.Mol.Biol., 13, 2006
2IO2
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CRYSTAL STRUCTURE OF HUMAN SENP2 IN COMPLEX WITH RANGAP1-SUMO-1
Descriptor:Sentrin-specific protease 2, Small ubiquitin-related modifier 1, Ran GTPase-activating protein 1
Authors:Reverter, D., Lima, C.D.
Deposit date:2006-10-09
Release date:2006-11-21
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates.
Nat.Struct.Mol.Biol., 13, 2006
2IO3
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CRYSTAL STRUCTURE OF HUMAN SENP2 IN COMPLEX WITH RANGAP1-SUMO-2
Descriptor:Sentrin-specific protease 2, Small ubiquitin-related modifier 2, Ran GTPase-activating protein 1
Authors:Reverter, D., Lima, C.D.
Deposit date:2006-10-09
Release date:2006-11-14
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates.
Nat.Struct.Mol.Biol., 13, 2006
5A6I
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V122I TRANSTHYRETIN STRUCTURE IN COMPLEX WITH TOLCALPONE
Descriptor:TRANSTHYRETIN, Tolcapone
Authors:Reverter, D., Gallego, P., Santana, R., Ventura, S.
Deposit date:2015-06-26
Release date:2016-02-24
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Repositioning Tolcapone as a Potent Inhibitor of Transthyretin Amyloidogenesis and its Associated Cellular Toxicity
Nat.Commun., 7, 2016
5O71
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CRYSTAL STRUCTURE OF HUMAN USP25
Descriptor:Ubiquitin carboxyl-terminal hydrolase 25
Authors:Reverter, D., Liu, B.
Deposit date:2017-06-07
Release date:2018-06-20
Method:X-RAY DIFFRACTION (3.283 Å)
Cite:Crystal structure of human USP25
To Be Published
1UWY
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CRYSTAL STRUCTURE OF HUMAN CARBOXYPEPTIDASE M
Descriptor:CARBOXYPEPTIDASE M, N-ACETYL-D-GLUCOSAMINE, ZINC ION
Authors:Maskos, K., Reverter, D., Bode, W.
Deposit date:2004-02-17
Release date:2004-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal Structure of Human Carboxypeptidase M, a Membrane-Bound Enzyme that Regulates Peptide Hormone Activity
J.Mol.Biol., 338, 2004
4D7B
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STRUCTURE OF HUMAN TRANSTHYRETIN IN COMPLEX WITH TOLCAPONE
Descriptor:TRANSTHYRETIN, Tolcapone
Authors:Gallego, P., Sant'anna, R.O., Ventura, S., Reverter, D.
Deposit date:2014-11-21
Release date:2016-01-20
Last modified:2016-03-02
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Repositioning Tolcapone as a Potent Inhibitor of Transthyretin Amyloidogenesis and its Associated Cellular Toxicity
Nat.Commun., 7, 2016
6EOA
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CRYSTAL STRUCTURE OF HAL3 FROM CRYPTOCOCCUS NEOFORMANS
Descriptor:Phosphopantothenoylcysteine decarboxylase, FLAVIN MONONUCLEOTIDE
Authors:Reverter, D., Zhang, C., Molero, C., Arino, J.
Deposit date:2017-10-09
Release date:2018-10-31
Last modified:2018-12-26
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Characterization of the atypical Ppz/Hal3 phosphatase system from the pathogenic fungus Cryptococcus neoformans.
Mol. Microbiol., 2018
4BWR
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CRYSTAL STRUCTURE OF C5321: A PROTECTIVE ANTIGEN PRESENT IN UROPATHOGENIC ESCHERICHIA COLI STRAINS DISPLAYING AN SLR FOLD
Descriptor:PROTEIN CORRESPONDING TO LOCUS C5321 FROM CFT073 E.COLI STRAIN, MAGNESIUM ION, CHLORIDE ION, ...
Authors:Urosev, D., Ferrer-Navarro, M., Pastorello, I., Cartocci, E., Costenaro, L., Zhulenkovs, D., Marechal, J.-D., Leonchiks, A., Reverter, D., Serino, L., Soriani, M., Daura, X.
Deposit date:2013-07-04
Release date:2013-07-24
Last modified:2013-10-23
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Crystal Structure of C5321: A Protective Antigen Present in Uropathogenic Escherichia Coli Strains Displaying an Slr Fold.
Bmc Struct.Biol., 13, 2013
5OM9
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CRYSTAL STRUCTURE OF THE HUMAN CARBOXYPEPTIDASE A1 IN COMPLEX WITH A THIIRANE MECHANISM-BASED INHIBITOR
Descriptor:Carboxypeptidase A1, (2~{R})-4-methyl-2-[(1~{S})-1-sulfanylethyl]pentanoic acid, ZINC ION
Authors:Gallego, P., Granados, C., Fernandez, D., Pallares, I., Covaleda, G., Aviles, F.X., Vendrell, J., Reverter, D.
Deposit date:2017-07-28
Release date:2017-08-09
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of Mechanism-Based Inactivators for Human Pancreatic Carboxypeptidase A from a Focused Synthetic Library.
ACS Med Chem Lett, 8, 2017
5FO2
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STRUCTURE OF HUMAN TRANSTHYRETIN MUTANT A108I
Descriptor:TRANSTHYRETIN
Authors:Varejao, N., Santanna, R., Saraiva, M.J., Gallego, P., Ventura, S., Reverter, D.
Deposit date:2015-11-17
Release date:2016-11-30
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (1.449 Å)
Cite:Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation.
Sci Rep, 7, 2017
5FW6
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STRUCTURE OF HUMAN TRANSTHYRETIN MUTANT A108V
Descriptor:TRANSTHYRETIN
Authors:Gallego, P., Varejao, N., Santanna, R., Saraiva, M.J., Ventura, S., Reverter, D.
Deposit date:2016-02-12
Release date:2017-03-08
Last modified:2017-06-14
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation.
Sci Rep, 7, 2017
5G59
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STRUCTURE OF THE PYROCOCCUS FURIOSUS ESTERASE PF2001 WITH SPACE GROUP P3121
Descriptor:ESTERASE, MERCURY (II) ION
Authors:Varejao, N., Reverter, D.
Deposit date:2016-05-23
Release date:2017-06-21
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (1.613 Å)
Cite:Structural Mechanism for the Temperature-Dependent Activation of the Hyperthermophilic Pf2001 Esterase.
Structure, 26, 2018
5G5C
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STRUCTURE OF THE PYROCOCCUS FURIOSUS ESTERASE PF2001 WITH SPACE GROUP C2221
Descriptor:ESTERASE
Authors:Varejao, N., Reverter, D.
Deposit date:2016-05-23
Release date:2017-06-21
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Structural Mechanism for the Temperature-Dependent Activation of the Hyperthermophilic Pf2001 Esterase.
Structure, 26, 2018
5G5M
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STRUCTURE OF THE PYROCOCCUS FURIOSUS ESTERASE PF2001 WITH SPACE GROUP P21
Descriptor:ESTERASE, S-methyl hexanethioate
Authors:Varejao, N., Reverter, D.
Deposit date:2016-05-26
Release date:2017-06-21
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Structural Mechanism for the Temperature-Dependent Activation of the Hyperthermophilic Pf2001 Esterase.
Structure, 26, 2018
5LCN
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STRUCTURE OF THE PYROCOCCUS FURIOSUS ESTERASE PF2001 WITH SPACE GROUP P212121
Descriptor:Uncharacterized protein, PENTAETHYLENE GLYCOL
Authors:VAREJAO, N., REVERTER, D.
Deposit date:2016-06-22
Release date:2017-08-02
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Mechanism for the Temperature-Dependent Activation of the Hyperthermophilic Pf2001 Esterase.
Structure, 26, 2018
6I6Z
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CRYSTAL STRUCTURE OF THE HUMAN CARBOXYPEPTIDASE A1 IN COMPLEX WITH THE PHOSPHINIC INHIBITOR ACETYL-TYR-ALA-Y(PO2CH2)-HOMOPHE-OH
Descriptor:Carboxypeptidase A1, (2S)-2-{[(S)-{(1R)-1-[(N-acetyl-L-tyrosyl)amino]ethyl}(hydroxy)phosphoryl]methyl}-4-phenylbutanoic acid, ZINC ION
Authors:Gallego, P., Reverter, D.
Deposit date:2018-11-15
Release date:2018-12-12
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Synthesis and Structural/Functional Characterization of Selective M14 Metallocarboxypeptidase Inhibitors Based on Phosphinic Pseudopeptide Scaffold: Implications on the Design of Specific Optical Probes.
J. Med. Chem., 62, 2019
1JQG
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CRYSTAL STRUCTURE OF THE CARBOXYPEPTIDASE A FROM HELICOVERPA ARMIGERA
Descriptor:carboxypeptidase A, ZINC ION
Authors:Estebanez-Perpina, E., Bayes, A., Vendrell, J., Jongsma, M.A., Bown, D.P., Gatehouse, J.A., Huber, R., Bode, W., Aviles, F.X., Reverter, D.
Deposit date:2001-08-07
Release date:2002-08-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a novel mid-gut procarboxypeptidase from the cotton pest Helicoverpa armigera.
J.Mol.Biol., 313, 2001
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