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1D9K
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BU of 1d9k by Molmil
CRYSTAL STRUCTURE OF COMPLEX BETWEEN D10 TCR AND PMHC I-AK/CA
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CONALBUMIN PEPTIDE, ...
Authors:Reinherz, E.L, Tan, K, Tang, L, Kern, P, Liu, J.-H, Xiong, Y, Hussey, R.E, Smolyar, A, Hare, B, Zhang, R, Joachimiak, A, Chang, H.-C, Wagner, G, Wang, J.-H.
Deposit date:1999-10-28
Release date:1999-12-15
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The crystal structure of a T cell receptor in complex with peptide and MHC class II.
Science, 286, 1999
8FWF
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BU of 8fwf by Molmil
Crystal structure of Apo form Fab235
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ...
Authors:Tan, K, Kim, M, Reinherz, E.L.
Deposit date:2023-01-21
Release date:2023-10-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility.
Nat Commun, 14, 2023
8FZ2
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BU of 8fz2 by Molmil
Crystal structure of Fab460 in complex with MPER peptide
Descriptor: Fab460, H chain, L chain, ...
Authors:Tan, K, Kim, M, Reinherz, E.L.
Deposit date:2023-01-27
Release date:2023-10-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility.
Nat Commun, 14, 2023
8FYM
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BU of 8fym by Molmil
Crystal structure of Fab235 in complex with MPER peptide
Descriptor: ALA-SER-LEU-TRP-ASN-TRP-PHE-ASN-ILE-THR-ASN-TRP-LEU-TRP-TYR-ILE-LYS-LYS-LYS, CHLORIDE ION, Fab235, ...
Authors:Tan, K, Kim, M, Reinherz, E.L.
Deposit date:2023-01-26
Release date:2023-10-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility.
Nat Commun, 14, 2023
8FXJ
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BU of 8fxj by Molmil
Crystal structure of Fab460
Descriptor: ACETATE ION, CHLORIDE ION, Fab460, ...
Authors:Tan, K, Kim, M, Reinherz, E.L.
Deposit date:2023-01-24
Release date:2023-10-11
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility.
Nat Commun, 14, 2023
1BQH
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BU of 1bqh by Molmil
MURINE CD8AA ECTODOMAIN FRAGMENT IN COMPLEX WITH H-2KB/VSV8
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTEIN (BETA-2-MICROGLOBULIN ), PROTEIN (CD8A OR LYT2 OR LYT-2), ...
Authors:Wang, J.H, Reinherz, E.L, Kern, P.S, Chang, H.C.
Deposit date:1998-08-16
Release date:1998-08-19
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis of CD8 coreceptor function revealed by crystallographic analysis of a murine CD8alphaalpha ectodomain fragment in complex with H-2Kb.
Immunity, 9, 1998
1BWM
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BU of 1bwm by Molmil
A SINGLE-CHAIN T CELL RECEPTOR
Descriptor: PROTEIN (ALPHA-BETA T CELL RECEPTOR (TCR) (D10))
Authors:Hare, B.J, Wyss, D.F, Reinherz, E.L, Wagner, G.
Deposit date:1998-09-23
Release date:1999-07-22
Last modified:2023-12-27
Method:SOLUTION NMR
Cite:Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptor.
Nat.Struct.Biol., 6, 1999
7JI2
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BU of 7ji2 by Molmil
Crystal Structure of H2-Kb in complex with a OVA mutant peptide
Descriptor: Beta-2-microglobulin, GLYCEROL, H-2 class I histocompatibility antigen, ...
Authors:Li, X, Mallis, R.J, Mizsei, R, Tan, K, Reinherz, E.L, Wang, J.
Deposit date:2020-07-22
Release date:2020-12-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Pre-T cell receptors topologically sample self-ligands during thymocyte beta-selection.
Science, 371, 2021
2ATP
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BU of 2atp by Molmil
Crystal structure of a CD8ab heterodimer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, T-cell surface glycoprotein CD8 alpha chain, T-cell surface glycoprotein CD8 beta chain, ...
Authors:Chang, H.C, Tan, K, Ouyang, J, Parisini, E, Liu, J.H, Le, Y, Wang, X, Reinherz, E.L, Wang, J.H.
Deposit date:2005-08-25
Release date:2005-12-27
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and Mutational Analyses of a CD8alphabeta Heterodimer and Comparison with the CD8alphaalpha Homodimer.
Immunity, 23, 2005
6MF8
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BU of 6mf8 by Molmil
TCR alpha transmembrane domain
Descriptor: T-cell receptor alpha chain C region
Authors:Brazin, K.N, Reinherz, E.L.
Deposit date:2018-09-10
Release date:2018-12-12
Last modified:2019-12-18
Method:SOLUTION NMR
Cite:The T Cell Antigen Receptor alpha Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations.
Immunity, 49, 2018
1JBJ
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BU of 1jbj by Molmil
CD3 Epsilon and gamma Ectodomain Fragment Complex in Single-Chain Construct
Descriptor: CD3 Epsilon and gamma Ectodomain Fragment Complex
Authors:Sun, Z.-Y.J, Kim, K.S, Wagner, G, Reinherz, E.L.
Deposit date:2001-06-05
Release date:2001-12-05
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Mechanisms contributing to T cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3 epsilon gamma heterodimer.
Cell(Cambridge,Mass.), 105, 2001
2JXB
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BU of 2jxb by Molmil
Structure of CD3epsilon-Nck2 first SH3 domain complex
Descriptor: T-cell surface glycoprotein CD3 epsilon chain, Cytoplasmic protein NCK2
Authors:Takeuchi, K, Yang, H, Ng, E, Park, S, Sun, Z.J, Reinherz, E.L, Wagner, G.
Deposit date:2007-11-09
Release date:2008-09-23
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Structural and functional evidence that Nck interaction with CD3epsilon regulates T-cell receptor activity.
J.Mol.Biol., 380, 2008
1NFD
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BU of 1nfd by Molmil
AN ALPHA-BETA T CELL RECEPTOR (TCR) HETERODIMER IN COMPLEX WITH AN ANTI-TCR FAB FRAGMENT DERIVED FROM A MITOGENIC ANTIBODY
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, H57 FAB, N15 ALPHA-BETA T-CELL RECEPTOR
Authors:Wang, J.-H, Lim, K, Smolyar, A, Teng, M.-K, Sacchittini, J, Reinherz, E.L.
Deposit date:1997-08-04
Release date:1998-01-28
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Atomic structure of an alphabeta T cell receptor (TCR) heterodimer in complex with an anti-TCR fab fragment derived from a mitogenic antibody.
EMBO J., 17, 1998
1QA9
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BU of 1qa9 by Molmil
Structure of a Heterophilic Adhesion Complex Between the Human CD2 and CD58(LFA-3) Counter-Receptors
Descriptor: HUMAN CD2 PROTEIN, HUMAN CD58 PROTEIN
Authors:Wang, J.-H, Smolyar, A, Tan, K, Liu, J.-H, Kim, M, Sun, Z.J, Wagner, G, Reinherz, E.L.
Deposit date:1999-04-13
Release date:1999-04-29
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors.
Cell(Cambridge,Mass.), 97, 1999
6WL3
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BU of 6wl3 by Molmil
preTCRbeta-pMHC complex crystal structure
Descriptor: ARG-GLY-TYR-LEU-TYR-GLN-GLY-LEU, H-2 class I histocompatibility antigen, K-B alpha chain, ...
Authors:Li, X, Mallis, R.J, Mizsei, R, Tan, K, Reinherz, E.L, Wang, J.
Deposit date:2020-04-18
Release date:2020-12-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Pre-T cell receptors topologically sample self-ligands during thymocyte beta-selection.
Science, 371, 2021
6WL2
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BU of 6wl2 by Molmil
preTCRbeta-pMHC complex crystal structure
Descriptor: ARG-GLY-TYR-VAL-TYR-GLN-GLY-LEU, H-2 class I histocompatibility antigen, K-B alpha chain, ...
Authors:Li, X, Mallis, R.J, Mizsei, R, Tan, K, Reinherz, E.L, Wang, J.
Deposit date:2020-04-18
Release date:2020-12-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Pre-T cell receptors topologically sample self-ligands during thymocyte beta-selection.
Science, 371, 2021
6WL4
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BU of 6wl4 by Molmil
preTCRbeta-pMHC complex crystal structure
Descriptor: ARG-GLY-TYR-VAL-TYR-GLN-GLY-LEU, H-2 class I histocompatibility antigen, K-B alpha chain, ...
Authors:Li, X, Mallis, R.J, Mizsei, R, Tan, K, Reinherz, E.L, Wang, J.
Deposit date:2020-04-18
Release date:2020-12-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Pre-T cell receptors topologically sample self-ligands during thymocyte beta-selection.
Science, 371, 2021
1JL4
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BU of 1jl4 by Molmil
CRYSTAL STRUCTURE OF THE HUMAN CD4 N-TERMINAL TWO DOMAIN FRAGMENT COMPLEXED TO A CLASS II MHC MOLECULE
Descriptor: H-2 CLASS II HISTOCOMPATIBILITY ANTIGEN, A-K ALPHA CHAIN, A-K BETA CHAIN, ...
Authors:Wang, J.-H, Meijers, R, Reinherz, E.L.
Deposit date:2001-07-15
Release date:2001-09-19
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (4.3 Å)
Cite:Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule.
Proc.Natl.Acad.Sci.USA, 98, 2001
1L2Z
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BU of 1l2z by Molmil
CD2BP2-GYF domain in complex with proline-rich CD2 tail segment peptide
Descriptor: CD2 ANTIGEN (CYTOPLASMIC TAIL)-BINDING PROTEIN 2, T-CELL SURFACE ANTIGEN CD2
Authors:Freund, C, Kuhne, R, Yang, H, Park, S, Reinherz, E.L, Wagner, G.
Deposit date:2002-02-26
Release date:2002-11-20
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Dynamic interaction of CD2 with the GYF and the SH3 domain of compartmentalized effector molecules
Embo J., 21, 2002
2ME1
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BU of 2me1 by Molmil
HIV-1 gp41 clade B double alanine mutant Membrane Proximal External Region peptide in DPC micelle
Descriptor: Gp41
Authors:Sun, Z.J, Wagner, G, Reinherz, E.L, Kim, M, Song, L, Choi, J, Cheng, Y, Chowdhury, B, Bellot, G, Shih, W.
Deposit date:2013-09-20
Release date:2013-10-09
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Disruption of Helix-Capping Residues 671 and 674 Reveals a Role in HIV-1 Entry for a Specialized Hinge Segment of the Membrane Proximal External Region of gp41.
J.Mol.Biol., 426, 2014
2ME2
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BU of 2me2 by Molmil
HIV-1 gp41 clade C Membrane Proximal External Region peptide in DPC micelle
Descriptor: Envelope glycoprotein gp160
Authors:Sun, Z.J, Wagner, G, Reinherz, E.L, Kim, M, Song, L, Choi, J, Cheng, Y, Chowdhury, B, Bellot, G, Shih, W.
Deposit date:2013-09-20
Release date:2013-10-09
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Disruption of Helix-Capping Residues 671 and 674 Reveals a Role in HIV-1 Entry for a Specialized Hinge Segment of the Membrane Proximal External Region of gp41.
J.Mol.Biol., 426, 2014
2ME3
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BU of 2me3 by Molmil
HIV-1 gp41 clade C Membrane Proximal External Region peptide in DPC micelle
Descriptor: Envelope glycoprotein gp160
Authors:Sun, Z.J, Wagner, G, Reinherz, E.L, Kim, M, Song, L, Choi, J, Cheng, Y, Chowdhury, B, Bellot, G, Shih, W.
Deposit date:2013-09-20
Release date:2013-10-09
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Disruption of Helix-Capping Residues 671 and 674 Reveals a Role in HIV-1 Entry for a Specialized Hinge Segment of the Membrane Proximal External Region of gp41.
J.Mol.Biol., 426, 2014
2ME4
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BU of 2me4 by Molmil
HIV-1 gp41 clade C Membrane Proximal External Region peptide in DPC micelle
Descriptor: Envelope glycoprotein gp160
Authors:Sun, Z.J, Wagner, G, Reinherz, E.L, Kim, M, Song, L, Choi, J, Cheng, Y, Chowdhury, B, Bellot, G, Shih, W.
Deposit date:2013-09-20
Release date:2013-10-09
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Disruption of Helix-Capping Residues 671 and 674 Reveals a Role in HIV-1 Entry for a Specialized Hinge Segment of the Membrane Proximal External Region of gp41.
J.Mol.Biol., 426, 2014
2PV6
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BU of 2pv6 by Molmil
HIV-1 gp41 Membrane Proximal Ectodomain Region peptide in DPC micelle
Descriptor: Envelope glycoprotein
Authors:Sun, Z.-Y.J, Oh, K.J, Kim, M, Reinherz, E.L, Wagner, G.
Deposit date:2007-05-09
Release date:2008-03-18
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane
Immunity, 28, 2008
1WBY
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BU of 1wby by Molmil
CRYSTAL STRUCTURES OF MURINE MHC CLASS I H-2 Db AND Kb MOLECULES IN COMPLEX WITH CTL EPITOPES FROM INFLUENZA A VIRUS: IMPLICATIONS FOR TCR REPERTOIRE SELECTION AND IMMUNODOMINANCE
Descriptor: BETA-2MICROGLOBULIN, H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN, D-B ALPHA CHAIN, ...
Authors:Meijers, R, Lai, C, Yang, Y, Liu, J, Zhong, W, Wang, J, Reinherz, E.L.
Deposit date:2004-11-05
Release date:2005-01-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structures of Murine Mhc Class I H-2 D(B) and K(B) Molecules in Complex with Ctl Epitopes from Influenza a Virus: Implications for Tcr Repertoire Selection and Immunodominance
J.Mol.Biol., 345, 2005

 

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