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2XI5
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N-TERMINAL ENDONUCLEASE DOMAIN OF LA CROSSE VIRUS L-PROTEIN
Descriptor:RNA POLYMERASE L, MANGANESE (II) ION
Authors:Reguera, J., Weber, F., Cusack, S.
Deposit date:2010-06-28
Release date:2010-10-06
Last modified:2012-07-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Bunyaviridae RNA Polymerases (L-Protein) Have an N-Terminal, Influenza-Like Endonuclease Domain, Essential for Viral CAP-Dependent Transcription.
Plos Pathog., 6, 2010
2XI7
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N-TERMINAL ENDONUCLEASE DOMAIN OF LA CROSSE VIRUS L-PROTEIN
Descriptor:RNA POLYMERASE L, MANGANESE (II) ION, 2-4-DIOXO-4-PHENYLBUTANOIC ACID
Authors:Reguera, J., Weber, F., Cusack, S.
Deposit date:2010-06-28
Release date:2010-10-06
Last modified:2012-07-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Bunyaviridae RNA Polymerases (L-Protein) Have an N-Terminal, Influenza-Like Endonuclease Domain, Essential for Viral CAP-Dependent Transcription.
Plos Pathog., 6, 2010
4BGP
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CRYSTAL STRUCTURE OF LA CROSSE VIRUS NUCLEOPROTEIN
Descriptor:NUCLEOPROTEIN, GLYCEROL, SULFATE ION
Authors:Reguera, J., Malet, H., Weber, F., Cusack, S.
Deposit date:2013-03-28
Release date:2013-04-24
Last modified:2013-05-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis for Encapsidation of Genomic RNA by La Crosse Orthobunyavirus Nucleoprotein
Proc.Natl.Acad.Sci.USA, 110, 2013
4BHH
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CRYSTAL STRUCTURE OF TETRAMER OF LA CROSSE VIRUS NUCLEOPROTEIN IN COMPLEX WITH SSRNA
Descriptor:NUCLEOPROTEIN, POLY-URIDINE 45-MER
Authors:Reguera, J., Malet, H., Weber, F., Cusack, S.
Deposit date:2013-04-03
Release date:2013-04-24
Last modified:2013-05-15
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structural Basis for Encapsidation of Genomic RNA by La Crosse Orthobunyavirus Nucleoprotein.
Proc.Natl.Acad.Sci.USA, 110, 2013
4F2M
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CRYSTAL STRUCTURE OF A TGEV CORONAVIRUS SPIKE FRAGMENT IN COMPLEX WITH THE TGEV NEUTRALIZING MONOCLONAL ANTIBODY 1AF10
Descriptor:monoclonal antibody 1AF10, heavy chain, light chain, ...
Authors:Reguera, J., Santiago, C., Mudgal, G., Ordono, D., Enjuanes, L., Casasnovas, J.M.
Deposit date:2012-05-08
Release date:2012-08-22
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural bases of coronavirus attachment to host aminopeptidase N and its inhibition by neutralizing antibodies.
Plos Pathog., 8, 2012
5IZE
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HANTAAN VIRUS L PROTEIN CAP-SNATCHING ENDONUCLEASE
Descriptor:RNA-directed RNA polymerase L, MANGANESE (III) ION
Authors:Reguera, J., Cusack, S.
Deposit date:2016-03-25
Release date:2016-06-29
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases.
Plos Pathog., 12, 2016
5IZH
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LASSA VIRUS L PROTEIN CAP-SNATCHING ENDONUCLEASE. APO FORM
Descriptor:RNA-directed RNA polymerase L
Authors:Reguera, J., Cusack, S.
Deposit date:2016-03-25
Release date:2016-06-29
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases.
Plos Pathog., 12, 2016
5J1N
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LASSA VIRUS L PROTEIN CAP-SNATCHING ENDONUCLEASE. BOUND TO ONE MANGANESE ION
Descriptor:RNA-directed RNA polymerase L, MANGANESE (III) ION, (4S)-2-METHYL-2,4-PENTANEDIOL
Authors:Reguera, J., Cusack, S.
Deposit date:2016-03-29
Release date:2016-06-29
Method:X-RAY DIFFRACTION (1.09 Å)
Cite:Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases.
Plos Pathog., 12, 2016
5J1P
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LASSA VIRUS L PROTEIN CAP-SNATCHING ENDONUCLEASE. BOUND TO TWO MANGANESE IONS
Descriptor:RNA-directed RNA polymerase L, MANGANESE (III) ION
Authors:Reguera, J., Cusack, S.
Deposit date:2016-03-29
Release date:2016-06-29
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Comparative Structural and Functional Analysis of Bunyavirus and Arenavirus Cap-Snatching Endonucleases.
Plos Pathog., 12, 2016
4F5C
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CRYSTAL STRUCTURE OF THE SPIKE RECEPTOR BINDING DOMAIN OF A PORCINE RESPIRATORY CORONAVIRUS IN COMPLEX WITH THE PIG AMINOPEPTIDASE N ECTODOMAIN
Descriptor:Aminopeptidase N, PRCV spike protein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Santiago, C., Reguera, J., Gaurav, M., Ordono, D., Enjuanes, L., Casasnovas, J.M.
Deposit date:2012-05-13
Release date:2012-08-22
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural bases of coronavirus attachment to host aminopeptidase N and its inhibition by neutralizing antibodies.
Plos Pathog., 8, 2012
5AMQ
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STRUCTURE OF THE LA CROSSE BUNYAVIRUS POLYMERASE IN COMPLEX WITH THE 3' AND 5' VIRAL RNA
Descriptor:RNA POLYMERASE L, RNA
Authors:Reguera, J., Gerlach, P., Cusack, S.
Deposit date:2015-03-12
Release date:2015-06-03
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural Insights Into Bunyavirus Replication and its Regulation by the Vrna Promoter.
Cell, 161, 2015
5AMR
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STRUCTURE OF THE LA CROSSE BUNYAVIRUS POLYMERASE IN COMPLEX WITH THE 3' VIRAL RNA
Descriptor:RNA POLYMERASE L, RNA
Authors:Reguera, J., Gerlach, P., Cusack, S.
Deposit date:2015-03-12
Release date:2015-06-03
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.57 Å)
Cite:Structural Insights Into Bunyavirus Replication and its Regulation by the Vrna Promoter.
Cell(Cambridge,Mass.), 161, 2015
6QVV
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STRUCTURE AND FUNCTION OF PHENUIVIRIDAE CAP SNATCHING ENDONUCLEASES
Descriptor:RNA-dependent RNA polymerase, MANGANESE (III) ION, SULFATE ION, ...
Authors:Reguera, J., Jones, R., Bragagniolo, G., Lessoued, S., Mate, M.
Deposit date:2019-03-05
Release date:2019-09-25
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure and function of the Toscana virus cap-snatching endonuclease.
Nucleic Acids Res., 47, 2019
6QW0
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STRUCTURE AND FUNCTION OF TOSCANA VIRUS CAP SNATCHING ENDONUCLEASES
Descriptor:RNA-dependent RNA polymerase, MANGANESE (III) ION, SULFATE ION, ...
Authors:Reguera, J., Jones, R., Bragagniolo, G., Lessoued, S., Mate, M.
Deposit date:2019-03-05
Release date:2019-09-25
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure and function of the Toscana virus cap-snatching endonuclease.
Nucleic Acids Res., 47, 2019
6QW5
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STRUCTURE AND FUNCTION OF THE TOSCANA VIRUS CAP SNATCHING ENDONUCLEASE
Descriptor:RNA-dependent RNA polymerase, MANGANESE (II) ION, 2-4-DIOXO-4-PHENYLBUTANOIC ACID, ...
Authors:Reguera, J., Jones, R., Bragagniolo, G., Lessoued, S., Mate, M.
Deposit date:2019-03-05
Release date:2019-09-25
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (1.988 Å)
Cite:Structure and function of the Toscana virus cap-snatching endonuclease.
Nucleic Acids Res., 47, 2019
5LDS
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STRUCTURE OF THE PORCINE AMINOPEPTIDASE N ECTODOMAIN
Descriptor:Aminopeptidase N, beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-6)-[beta-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Santiago, C., Reguera, J., Mudgal, G., Casasnovas, J.M.
Deposit date:2016-06-27
Release date:2017-04-05
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Allosteric inhibition of aminopeptidase N functions related to tumor growth and virus infection.
Sci Rep, 7, 2017
5LG6
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STRUCTURE OF THE DEGLYCOSYLATED PORCINE AMINOPEPTIDASE N ECTODOMAIN
Descriptor:Aminopeptidase N, 2-acetamido-2-deoxy-beta-D-glucopyranose, ZINC ION
Authors:Santiago, C., Reguera, J., Mudgal, G., Casasnovas, J.M.
Deposit date:2016-07-06
Release date:2017-04-12
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Allosteric inhibition of aminopeptidase N functions related to tumor growth and virus infection.
Sci Rep, 7, 2017
5MUS
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STRUCTURE OF THE C-TERMINAL DOMAIN OF A REPTARENAVIRUS L PROTEIN
Descriptor:L protein, GLYCEROL, CHLORIDE ION
Authors:Rosenthal, M., Gogrefe, N., Reguera, J., Vogel, D., Rauschenberger, B., Cusack, S., Gunther, S., Reindl, S.
Deposit date:2017-01-14
Release date:2017-05-17
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (2.009 Å)
Cite:Structural insights into reptarenavirus cap-snatching machinery.
PLoS Pathog., 13, 2017
5MUY
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STRUCTURE OF A C-TERMINAL DOMAIN OF A REPTARENAVIRUS L PROTEIN WITH M7GTP
Descriptor:L protein, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE
Authors:Rosenthal, M., Gogrefe, N., Reguera, J., Vogel, D., Rauschenberger, B., Cusack, S., Gunther, S., Reindl, S.
Deposit date:2017-01-14
Release date:2017-05-17
Last modified:2017-05-24
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structural insights into reptarenavirus cap-snatching machinery.
PLoS Pathog., 13, 2017
5MUZ
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STRUCTURE OF A C-TERMINAL DOMAIN OF A REPTARENAVIRUS L PROTEIN
Descriptor:L protein
Authors:Rosenthal, M., Gogrefe, N., Reguera, J., Vogel, D., Rauschenberger, B., Cusack, S., Gunther, S., Reindl, S.
Deposit date:2017-01-14
Release date:2017-05-17
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.776 Å)
Cite:Structural insights into reptarenavirus cap-snatching machinery.
PLoS Pathog., 13, 2017
5MV0
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STRUCTURE OF AN N-TERMINAL DOMAIN OF A REPTARENAVIRUS L PROTEIN
Descriptor:L protein, PHOSPHATE ION
Authors:Rosenthal, M., Gogrefe, N., Reguera, J., Vogel, D., Rauschenberger, B., Cusack, S., Gunther, S., Reindl, S.
Deposit date:2017-01-14
Release date:2017-05-17
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structural insights into reptarenavirus cap-snatching machinery.
PLoS Pathog., 13, 2017
6I2N
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HELICAL RNA-BOUND HANTAAN VIRUS NUCLEOCAPSID
Descriptor:RNA (5'-R(P*UP*UP*U)-3'), Nucleoprotein
Authors:Arragain, B., Reguera, J., Desfosses, A., Gutsche, I., Schoehn, G., Malet, H.
Deposit date:2018-11-01
Release date:2019-01-23
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:High resolution cryo-EM structure of the helical RNA-bound Hantaan virus nucleocapsid reveals its assembly mechanisms.
Elife, 8, 2019
6Z6B
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STRUCTURE OF FULL-LENGTH LA CROSSE VIRUS L PROTEIN (POLYMERASE)
Descriptor:RNA (5'-R(P*AP*GP*UP*AP*GP*UP*GP*UP*GP*C)-3'), RNA (5'-R(P*UP*UP*AP*GP*UP*AP*GP*UP*AP*CP*AP*CP*UP*AP*CP*U)-3'), RNA (5'-R(*GP*CP*UP*AP*CP*UP*AP*A)-3'), ...
Authors:Cusack, S., Gerlach, P., Reguera, J.
Deposit date:2020-05-28
Release date:2020-07-29
Method:X-RAY DIFFRACTION (3.961 Å)
Cite:Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes.
Nat Commun, 11, 2020
6Z6G
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CRYO-EM STRUCTURE OF LA CROSSE VIRUS POLYMERASE AT PRE-INITIATION STAGE
Descriptor:5'vRNA 1-10, 5'vRNA 9-16, 3'vRNA 1-16, ...
Authors:Arragain, B., Effantin, G., Gerlach, P., Reguera, J., Schoehn, G., Cusack, S., Malet, H.
Deposit date:2020-05-28
Release date:2020-07-29
Method:ELECTRON MICROSCOPY (3.06 Å)
Cite:Pre-initiation and elongation structures of full-length La Crosse virus polymerase reveal functionally important conformational changes.
Nat Commun, 11, 2020
5LHD
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STRUCTURE OF GLYCOSYLATED HUMAN AMINOPEPTIDASE N
Descriptor:Aminopeptidase N, beta-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Recacha, R., Mudgal, G., Santiago, C., Casasnovas, J.M.
Deposit date:2016-07-11
Release date:2017-04-05
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Allosteric inhibition of aminopeptidase N functions related to tumor growth and virus infection.
Sci Rep, 7, 2017
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167518
PDB entries from 2020-08-12