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2NLL
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BU of 2nll by Molmil
RETINOID X RECEPTOR-THYROID HORMONE RECEPTOR DNA-BINDING DOMAIN HETERODIMER BOUND TO THYROID RESPONSE ELEMENT DNA
Descriptor: DNA (5'-D(*CP*AP*GP*GP*TP*CP*AP*TP*TP*(5IU)P*CP*AP*GP*GP*TP*CP*AP*G)-3'), DNA (5'-D(*CP*TP*GP*AP*CP*CP*TP*GP*AP*AP*AP*TP*GP*AP*CP*CP*T P*G)-3'), PROTEIN (RETINOIC ACID RECEPTOR), ...
Authors:Rastinejad, F, Perlmann, T, Evans, R.M, Sigler, P.B.
Deposit date:1996-11-20
Release date:1997-03-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural determinants of nuclear receptor assembly on DNA direct repeats.
Nature, 375, 1995
1DSZ
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BU of 1dsz by Molmil
STRUCTURE OF THE RXR/RAR DNA-BINDING DOMAIN HETERODIMER IN COMPLEX WITH THE RETINOIC ACID RESPONSE ELEMENT DR1
Descriptor: DNA (5'-D(*CP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*AP*G)-3'), DNA (5'-D(*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*G)-3'), RETINOIC ACID RECEPTOR ALPHA, ...
Authors:Rastinejad, F, Wagner, T, Zhao, Q, Khorasanizadeh, S.
Deposit date:2000-01-10
Release date:2000-07-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of the RXR-RAR DNA-binding complex on the retinoic acid response element DR1.
EMBO J., 19, 2000
1BY4
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BU of 1by4 by Molmil
STRUCTURE AND MECHANISM OF THE HOMODIMERIC ASSEMBLY OF THE RXR ON DNA
Descriptor: DNA (5'-D(*C*TP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*AP*G)-3'), DNA (5'-D(*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*A)-3'), PROTEIN (RETINOIC ACID RECEPTOR RXR-ALPHA), ...
Authors:Zhao, Q, Chasse, S.A, Devarakonda, S, Sierk, M.L, Ahvazi, B, Sigler, P.B, Rastinejad, F.
Deposit date:1998-10-22
Release date:2000-01-12
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of RXR-DNA interactions.
J.Mol.Biol., 296, 2000
1A6Y
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BU of 1a6y by Molmil
REVERBA ORPHAN NUCLEAR RECEPTOR/DNA COMPLEX
Descriptor: DNA (5'-D(*CP*AP*AP*CP*TP*AP*GP*GP*TP*CP*AP*CP*(5IT)P*AP*GP*GP*TP*CP*AP*G)-3'), DNA (5'-D(*CP*TP*GP*AP*CP*CP*TP*AP*GP*TP*GP*AP*CP*CP*TP*AP*GP*TP*TP*G)-3'), ORPHAN NUCLEAR RECEPTOR NR1D1, ...
Authors:Zhao, Q, Khorasanizadeh, S, Rastinejad, F.
Deposit date:1998-03-04
Release date:1998-10-21
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural elements of an orphan nuclear receptor-DNA complex.
Mol.Cell, 1, 1998
1A62
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BU of 1a62 by Molmil
CRYSTAL STRUCTURE OF THE RNA-BINDING DOMAIN OF THE TRANSCRIPTIONAL TERMINATOR PROTEIN RHO
Descriptor: RHO
Authors:Allison, T.J, Wood, T.C, Briercheck, D.M, Rastinejad, F, Richardson, J.P, Rule, G.S.
Deposit date:1998-03-05
Release date:1998-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure of the RNA-binding domain from transcription termination factor rho.
Nat.Struct.Biol., 5, 1998
1HLZ
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BU of 1hlz by Molmil
CRYSTAL STRUCTURE OF THE ORPHAN NUCLEAR RECEPTOR REV-ERB(ALPHA) DNA-BINDING DOMAIN BOUND TO ITS COGNATE RESPONSE ELEMENT
Descriptor: 5'-D(*CP*AP*AP*CP*TP*AP*GP*GP*TP*CP*AP*CP*TP*AP*GP*GP*TP*CP*AP*G)-3', 5'-D(*CP*TP*GP*AP*CP*CP*TP*AP*GP*TP*GP*AP*CP*CP*TP*AP*GP*TP*TP*G)-3', ORPHAN NUCLEAR RECEPTOR NR1D1, ...
Authors:Sierk, M.L, Zhao, Q, Rastinejad, F.
Deposit date:2000-12-04
Release date:2001-11-16
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:DNA Deformability as a Recognition Feature in the RevErb Response Element
Biochemistry, 40, 2001
1GA5
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BU of 1ga5 by Molmil
CRYSTAL STRUCTURE OF THE ORPHAN NUCLEAR RECEPTOR REV-ERB(ALPHA) DNA-BINDING DOMAIN BOUND TO ITS COGNATE RESPONSE ELEMENT
Descriptor: 5'-D(*CP*AP*AP*CP*TP*AP*GP*GP*TP*CP*AP*CP*TP*AP*GP*GP*TP*CP*AP*G)-3', 5'-D(*CP*TP*GP*AP*CP*CP*TP*AP*GP*TP*GP*AP*CP*CP*TP*AP*GP*TP*(5IT)P*G)-3', ORPHAN NUCLEAR RECEPTOR NR1D1, ...
Authors:Sierk, M.L, Zhao, Q, Rastinejad, F.
Deposit date:2000-11-29
Release date:2001-11-16
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:DNA Deformability as a Recognition Feature in the RevErb Response Element
Biochemistry, 40, 2001
4M4X
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BU of 4m4x by Molmil
Structure and Dimerization Properties of the Aryl Hydrocarbon Receptor (AHR) PAS-A Domain
Descriptor: Aryl hydrocarbon receptor
Authors:Wu, D, Potluri, N, Kim, Y, Rastinejad, F.
Deposit date:2013-08-07
Release date:2013-09-18
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.551 Å)
Cite:Structure and dimerization properties of the aryl hydrocarbon receptor PAS-A domain.
Mol.Cell.Biol., 33, 2013
4IQR
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BU of 4iqr by Molmil
Multi-Domain Organization of the HNF4alpha Nuclear Receptor Complex on DNA
Descriptor: DNA (5'-D(*CP*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*AP*GP*TP*TP*C)-3'), DNA (5'-D(*GP*GP*AP*AP*CP*TP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*AP*G)-3'), Hepatocyte nuclear factor 4-alpha, ...
Authors:Chandra, V, Huang, P, Kim, Y, Rastinejad, F.
Deposit date:2013-01-13
Release date:2013-03-20
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Multidomain integration in the structure of the HNF-4 alpha nuclear receptor complex.
Nature, 495, 2013
4S14
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BU of 4s14 by Molmil
Crystal structure of the orphan nuclear receptor RORgamma ligand-binding domain in complex with 4alpha-caboxyl, 4beta-methyl-zymosterol (4ACD8)
Descriptor: (3beta,4alpha,5beta,14beta)-3-hydroxy-4-methylcholesta-8,24-diene-4-carboxylic acid, Nuclear receptor ROR-gamma, Nuclear receptor-interacting protein 1
Authors:Huang, P, Santori, F.R, Littman, D.R, Rastinejad, F.
Deposit date:2015-01-07
Release date:2015-02-11
Last modified:2015-02-25
Method:X-RAY DIFFRACTION (3.542 Å)
Cite:Identification of Natural ROR gamma Ligands that Regulate the Development of Lymphoid Cells.
Cell Metab, 21, 2015
4S15
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BU of 4s15 by Molmil
Crystal structure of the orphan nuclear receptor RORalpha ligand-binding domain in complex with 4alpha-caboxyl, 4beta-methyl-zymosterol (4ACD8)
Descriptor: (3beta,4alpha,5beta,14beta)-3-hydroxy-4-methylcholesta-8,24-diene-4-carboxylic acid, GLYCEROL, Nuclear receptor ROR-alpha, ...
Authors:Huang, P, Santori, F.R, Littman, D.R, Rastinejad, F.
Deposit date:2015-01-08
Release date:2015-02-11
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.897 Å)
Cite:Identification of Natural ROR gamma Ligands that Regulate the Development of Lymphoid Cells.
Cell Metab, 21, 2015
1TJJ
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BU of 1tjj by Molmil
Human GM2 Activator Protein PAF complex
Descriptor: (2R)-2-(acetyloxy)-3-(hexadecyloxy)propyl 2-(trimethylammonio)ethyl phosphate, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:Wright, C.S, Mi, L.-Z, Rastinejad, F.
Deposit date:2004-06-04
Release date:2004-12-07
Last modified:2013-10-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Evidence for lipid packaging in the crystal structure of the GM2-activator complex with platelet activating factor
J.Mol.Biol., 342, 2004
5K3M
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BU of 5k3m by Molmil
Crystal structure of Retinoic acid receptor-related orphan receptor (ROR) gamma ligand binding domain complex with UUA
Descriptor: Nuclear receptor ROR-gamma, Ursolic acid
Authors:Huang, P, Rastinejad, F.
Deposit date:2016-05-19
Release date:2017-05-31
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.894 Å)
Cite:Crystal structure of Retinoic acid receptor-related orphan receptor (ROR) gamma ligand binding domain complex with UUA
To be published
5K6E
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BU of 5k6e by Molmil
Crystal structure of Retinoic acid receptor-related orphan receptor (ROR) gamma ligand binding domain complex with SBI0654919
Descriptor: 2-chloranyl-6-fluoranyl-~{N}-[(2~{R})-4-(4-fluorophenyl)sulfonyl-2-(hydroxymethyl)-2,3-dihydro-1,4-benzoxazin-6-yl]benzamide, Nuclear receptor ROR-gamma
Authors:Lu, J, Rastinejad, F.
Deposit date:2016-05-24
Release date:2017-05-31
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of Retinoic acid receptor-related orphan receptor (ROR) gamma ligand binding domain complex with SBI0654919
To be published
1MT6
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BU of 1mt6 by Molmil
Structure of histone H3 K4-specific methyltransferase SET7/9 with AdoHcy
Descriptor: S-ADENOSYL-L-HOMOCYSTEINE, SET9
Authors:Jacobs, S.A, Harp, J.M, Devarakonda, S, Kim, Y, Rastinejad, F, Khorasanizadeh, S.
Deposit date:2002-09-20
Release date:2002-11-06
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The active site of the SET domain is constructed on a knot
Nat.Struct.Biol., 9, 2002
1G13
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BU of 1g13 by Molmil
HUMAN GM2 ACTIVATOR STRUCTURE
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, GANGLIOSIDE M2 ACTIVATOR PROTEIN
Authors:Wright, C.S, Li, S.C, Rastinejad, F.
Deposit date:2000-10-10
Release date:2001-04-11
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of human GM2-activator protein with a novel beta-cup topology.
J.Mol.Biol., 304, 2000
3M9Q
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BU of 3m9q by Molmil
Drosophila MSL3 chromodomain
Descriptor: Protein male-specific lethal-3
Authors:Kim, D, Huang, P, Rastinejad, F, Khorasanizadeh, S.
Deposit date:2010-03-22
Release date:2010-07-21
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain.
Nat.Struct.Mol.Biol., 17, 2010
3OA6
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BU of 3oa6 by Molmil
Human MSL3 Chromodomain bound to DNA and H4K20me1 peptide
Descriptor: DNA (5'-D(*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*AP*G)-3'), DNA (5'-D(*GP*CP*TP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*A)-3'), H4 peptide monomethylated at lysine 20, ...
Authors:Kim, D, Huang, P, Rastinejad, F, Khorasanizadeh, S.
Deposit date:2010-08-04
Release date:2010-08-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain.
Nat.Struct.Mol.Biol., 17, 2010
3DZU
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BU of 3dzu by Molmil
Intact PPAR gamma - RXR alpha Nuclear Receptor Complex on DNA bound with BVT.13, 9-cis Retinoic Acid and NCOA2 Peptide
Descriptor: (9cis)-retinoic acid, 2-[(2,4-DICHLOROBENZOYL)AMINO]-5-(PYRIMIDIN-2-YLOXY)BENZOIC ACID, DNA (5'-D(*DCP*DAP*DAP*DAP*DCP*DTP*DAP*DGP*DGP*DTP*DCP*DAP*DAP*DAP*DGP*DGP*DTP*DCP*DAP*DG)-3'), ...
Authors:Chandra, V, Huang, P, Hamuro, Y, Raghuram, S, Wang, Y, Burris, T.P, Rastinejad, F.
Deposit date:2008-07-30
Release date:2008-10-28
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA.
Nature, 456, 2008
3E00
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BU of 3e00 by Molmil
Intact PPAR gamma - RXR alpha Nuclear Receptor Complex on DNA bound with GW9662, 9-cis Retinoic Acid and NCOA2 Peptide
Descriptor: (9cis)-retinoic acid, 2-chloro-5-nitro-N-phenylbenzamide, DNA (5'-D(*DCP*DAP*DAP*DAP*DCP*DTP*DAP*DGP*DGP*DTP*DCP*DAP*DAP*DAP*DGP*DGP*DTP*DCP*DAP*DG)-3'), ...
Authors:Chandra, V, Huang, P, Hamuro, Y, Raghuram, S, Wang, Y, Burris, T.P, Rastinejad, F.
Deposit date:2008-07-30
Release date:2008-10-28
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA.
Nature, 456, 2008
3DZY
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BU of 3dzy by Molmil
Intact PPAR gamma - RXR alpha Nuclear Receptor Complex on DNA bound with Rosiglitazone, 9-cis Retinoic Acid and NCOA2 Peptide
Descriptor: (9cis)-retinoic acid, 2,4-THIAZOLIDIINEDIONE, 5-[[4-[2-(METHYL-2-PYRIDINYLAMINO)ETHOXY]PHENYL]METHYL]-(9CL), ...
Authors:Chandra, V, Huang, P, Hamuro, Y, Raghuram, S, Wang, Y, Burris, T.P, Rastinejad, F.
Deposit date:2008-07-30
Release date:2008-10-28
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA.
Nature, 456, 2008
6E3S
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BU of 6e3s by Molmil
Crystal Structure of the Heterodimeric HIF-2 Complex with Antagonist PT2385
Descriptor: 3-{[(1S)-2,2-difluoro-1-hydroxy-7-(methylsulfonyl)-2,3-dihydro-1H-inden-4-yl]oxy}-5-fluorobenzonitrile, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1
Authors:Wu, D, Su, X, Lu, J, Li, S, Hood, B, Vasile, S, Potluri, N, Diao, X, Kim, Y, Khorasanizadeh, S, Rastinejad, F.
Deposit date:2018-07-15
Release date:2019-02-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Bidirectional modulation of HIF-2 activity through chemical ligands.
Nat. Chem. Biol., 15, 2019
6E3T
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BU of 6e3t by Molmil
Crystal Structure of the Heterodimeric HIF-2 Complex with Antagonist T1001
Descriptor: (6S)-6-(4-bromophenyl)-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1
Authors:Wu, D, Su, X, Lu, J, Li, S, Hood, B, Vasile, S, Potluri, N, Diao, X, Kim, Y, Khorasanizadeh, S, Rastinejad, F.
Deposit date:2018-07-15
Release date:2019-02-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Bidirectional modulation of HIF-2 activity through chemical ligands.
Nat. Chem. Biol., 15, 2019
6E3U
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BU of 6e3u by Molmil
Crystal Structure of the Heterodimeric HIF-2 Complex with Agonist M1001
Descriptor: 3-{[2-(pyrrolidin-1-yl)phenyl]amino}-1H-1lambda~6~,2-benzothiazole-1,1-dione, Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1
Authors:Wu, D, Su, X, Lu, J, Li, S, Hood, B, Vasile, S, Potluri, N, Diao, X, Kim, Y, Khorasanizadeh, S, Rastinejad, F.
Deposit date:2018-07-15
Release date:2019-02-13
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Bidirectional modulation of HIF-2 activity through chemical ligands.
Nat. Chem. Biol., 15, 2019
5K38
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BU of 5k38 by Molmil
Crystal structure of Retinoic acid receptor-related orphan receptor (ROR) gamma ligand binding domain
Descriptor: Nuclear receptor ROR-gamma
Authors:Lu, J, Rastinejad, F.
Deposit date:2016-05-19
Release date:2017-05-31
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structure of Retinoic acid receptor-related orphan receptor (ROR) gamma ligand binding domain
To be published

 

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