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Complex of tissue inhibitor of metalloproteinase-1 (TIMP-1) mutant L34G with matrix metalloproteinase-3 catalytic domain (MMP-3cd)
Descriptor:	CALCIUM ION, Metalloproteinase inhibitor 1, Stromelysin-1, ...
Authors:	Raeeszadeh-Sarmazdeh, M, Radisky, E.
Deposit date:	2018-08-28
Release date:	2019-05-15
Last modified:	2023-10-11
Method:	X-RAY DIFFRACTION (2.37 Å)
Cite:	Directed evolution of the metalloproteinase inhibitor TIMP-1 reveals that its N- and C-terminal domains cooperate in matrix metalloproteinase recognition. J.Biol.Chem., 294, 2019

Structure of Human Mesotrypsin in complex with APPI variant T11V/M17R/I18F/F34V
Descriptor:	1,2-ETHANEDIOL, Amyloid-beta A4 protein, PRSS3 protein
Authors:	Shahar, A, Cohen, I, Radisky, E, Papo, N, Naftaly, S.
Deposit date:	2018-04-30
Release date:	2018-09-12
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Mapping protein selectivity landscapes using multi-target selective screening and next-generation sequencing of combinatorial libraries. Nat Commun, 9, 2018

Crystal structure of Mesotrypsin in complex with APPI-M17C/I18F/F34C
Descriptor:	1,2-ETHANEDIOL, Amyloid-beta A4 protein, CALCIUM ION, ...
Authors:	Shahar, A, Cohen, I, Radisky, E, Papo, N.
Deposit date:	2018-08-08
Release date:	2019-02-06
Last modified:	2024-01-17
Method:	X-RAY DIFFRACTION (1.497 Å)
Cite:	Disulfide engineering of human Kunitz-type serine protease inhibitors enhances proteolytic stability and target affinity toward mesotrypsin. J.Biol.Chem., 294, 2019