Author results

6AF0
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STRUCTURE OF CTR9, PAF1 AND CDC73 TERNARY COMPLEX FROM MYCELIOPHTHORA THERMOPHILA
Descriptor:Ctr9 protein, Paf1 protein, Cdc73 protein
Authors:Wang, Z., Deng, P., Zhou, Y.
Deposit date:2018-08-07
Release date:2018-09-19
Last modified:2018-10-17
Method:X-RAY DIFFRACTION (2.88 Å)
Cite:Transcriptional elongation factor Paf1 core complex adopts a spirally wrapped solenoidal topology.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
5V6L
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CRYSTAL STRUCTURE OF RABBIT ANTI-HIV-1 GP120 V3 FAB 10A37 IN COMPLEX WITH V3 PEPTIDE JR-FL
Descriptor:Light chain of Fab fragment of rabbit anti-HIV1 gp120 V3 mAb 10A37, Heavy chain of Fab fragment of rabbit anti-HIV1 gp120 V3 mAb 10A37, Envelope glycoprotein, ...
Authors:Pan, R., Kong, X.-P.
Deposit date:2017-03-17
Release date:2018-01-17
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.549 Å)
Cite:Increased epitope complexity correlated with antibody affinity maturation and a novel binding mode revealed by structures of rabbit antibodies against the third variable loop (V3) of HIV-1 gp120.
J. Virol., 2018
5V6M
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CRYSTAL STRUCTURE OF RABBIT ANTI-HIV-1 GP120 V3 FAB 10A3 IN COMPLEX WITH V3 PEPTIDE CONB
Descriptor:Light chain of Fab fragment of rabbit anti-HIV1 gp120 V3 mAb 10A3, Heavy chain of Fab fragment of rabbit anti-HIV1 gp120 V3 mAb 10A3, Envelope glycoprotein gp120 V3 peptide of Con B sequence, ...
Authors:Pan, R., Kong, X.-P.
Deposit date:2017-03-17
Release date:2018-01-17
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Increased epitope complexity correlated with antibody affinity maturation and a novel binding mode revealed by structures of rabbit antibodies against the third variable loop (V3) of HIV-1 gp120.
J. Virol., 2018
5FVO
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6-(2-(5-(3-METHOXYPROPYLAMINO)PYRIDIN-3-YL)ETHYL)-4- METHYLPYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
5FVP
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 4-METHYL-6-[2-(5-MORPHOLIN-4-YLPYRIDIN-3-YL)ETHYL]PYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
5FVQ
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 4-METHYL-6-(2-(5-(4-METHYLPIPERAZIN-1-YL)PYRIDIN-3-YL) ETHYL)PYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
5FVR
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 4-METHYL-6-(2-(5-(1-METHYLPIPERIDIN-4-YL)PYRIDIN-3-YL) ETHYL)PYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (1.842 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
5FVS
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 4-METHYL-6-(2-(5-(3-(METHYLAMINO)PROPYL)PYRIDIN-3-YL) ETHYL)PYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (1.948 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
5FVT
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6-(2-(5-(3-(DIMETHYLAMINO)PROPYL)PYRIDIN-3-YL)ETHYL)-4- METHYLPYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (1.828 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
5FVU
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STRUCTURE OF HUMAN NNOS R354A G357D MUTANT HEME DOMAIN IN COMPLEX WITH 4-METHYL-6-(2-(5-(4-METHYLPIPERAZIN-1-YL)PYRIDIN-3-YL)ETHYL) PYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (2.224 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
5FVV
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STRUCTURE OF HUMAN NNOS R354A G357D MUTANT HEME DOMAIN IN COMPLEX WITH 4-METHYL-6-(2-(5-(1-METHYLPIPERIDIN-4-YL)PYRIDIN-3-YL)ETHYL) PYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
5FVW
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STRUCTURE OF HUMAN NNOS R354A G357D MUTANT HEME DOMAIN IN COMPLEX WITH 4-METHYL-6-(2-(5-(3-(METHYLAMINO)PROPYL)PYRIDIN-3-YL)ETHYL) PYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
5FVX
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STRUCTURE OF HUMAN NNOS R354A G357D MUTANT HEME DOMAIN IN COMPLEX WITH WITH 6-(2-(5-(3-(DIMETHYLAMINO)PROPYL) PYRIDIN-3-YL)ETHYL)-4-METHYLPYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
5FVY
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STRUCTURE OF BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 4-METHYL-6-(2-(5-(4-METHYLPIPERAZIN-1-YL)PYRIDIN-3-YL) ETHYL)PYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE, ENDOTHELIAL, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (2.098 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
5FVZ
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STRUCTURE OF BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6-(2-(5-(3-(DIMETHYLAMINO)PROPYL)PYRIDIN-3-YL)ETHYL)-4-METHYLPYRIDIN-2-AMINE
Descriptor:ENDOTHELIAL NITRIC OXIDE SYNTHASE, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (2.048 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
5FW0
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6-(2-(5-((2-METHOXYETHYL)(METHYL)AMINO)PYRIDIN-3-YL) ETHYL)-4-METHYLPYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
3JCD
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STRUCTURE OF ESCHERICHIA COLI EF4 IN POSTTRANSLOCATIONAL RIBOSOMES (POST EF4)
Descriptor:30S ribosomal protein S2, 30S ribosomal protein S3, 30S ribosomal protein S4, ...
Authors:Zhang, D., Yan, K., Liu, G., Song, G., Luo, J., Shi, Y., Cheng, E., Wu, S., Jiang, T., Low, J., Gao, N., Qin, Y.
Deposit date:2015-12-01
Release date:2016-01-13
Last modified:2018-10-17
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome
Nat. Struct. Mol. Biol., 23, 2016
3JCE
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STRUCTURE OF ESCHERICHIA COLI EF4 IN PRETRANSLOCATIONAL RIBOSOMES (PRE EF4)
Descriptor:16S ribosomal RNA, 30S ribosomal protein S3, 30S ribosomal protein S4, ...
Authors:Zhang, D., Yan, K., Liu, G., Song, G., Luo, J., Shi, Y., Cheng, E., Wu, S., Jiang, T., Low, J., Gao, N., Qin, Y.
Deposit date:2015-12-01
Release date:2016-01-13
Last modified:2017-02-22
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:EF4 disengages the peptidyl-tRNA CCA end and facilitates back-translocation on the 70S ribosome
Nat. Struct. Mol. Biol., 23, 2016
5ADY
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CRYO-EM STRUCTURES OF THE 50S RIBOSOME SUBUNIT BOUND WITH HFLX
Descriptor:50S RIBOSOMAL PROTEIN L32, 50S RIBOSOMAL PROTEIN L33, 50S RIBOSOMAL PROTEIN L34, ...
Authors:Zhang, Y., Mandava, C.S., Cao, W., Li, X., Zhang, D., Li, N., Zhang, Y., Zhang, X., Qin, Y., Mi, K., Lei, J., Sanyal, S., Gao, N.
Deposit date:2015-08-25
Release date:2015-10-14
Last modified:2018-10-24
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Hflx is a Ribosome Splitting Factor Rescuing Stalled Ribosomes Under Stress Conditions
Nat.Struct.Mol.Biol., 22, 2015
4TZ7
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CRYSTAL STRUCTURE OF TYPE I PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE ALPHA FROM ZEBRAFISH
Descriptor:Phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
Authors:Hu, J., Qin, Y., Wang, J., Li, L., Wu, D., Ha, Y.
Deposit date:2014-07-09
Release date:2015-09-02
Last modified:2015-09-23
Method:X-RAY DIFFRACTION (3.31 Å)
Cite:Resolution of structure of PIP5K1A reveals molecular mechanism for its regulation by dimerization and dishevelled.
Nat Commun, 6, 2015
4PXQ
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CRYSTAL STRUCTURE OF D-GLUCURONYL C5-EPIMERASE IN COMPLEX WITH HEPARIN HEXASACCHARIDE
Descriptor:D-glucuronyl C5 epimerase B, 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid, N,O6-DISULFO-GLUCOSAMINE, ...
Authors:Ke, J., Qin, Y., Gu, X., Tan, J., Brunzelle, J.S., Xu, H.E., Ding, K.
Deposit date:2014-03-24
Release date:2015-01-14
Last modified:2015-03-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and Functional Study of d-Glucuronyl C5-epimerase.
J.Biol.Chem., 290, 2015
4PW2
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CRYSTAL STRUCTURE OF D-GLUCURONYL C5 EPIMERASE
Descriptor:D-glucuronyl C5 epimerase B, CITRIC ACID
Authors:Ke, J., Qin, Y., Gu, X., Brunzelle, J.S., Xu, H.E., Ding, K.
Deposit date:2014-03-18
Release date:2015-01-14
Last modified:2015-03-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Functional Study of d-Glucuronyl C5-epimerase.
J.Biol.Chem., 290, 2015
4MYT
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CRYSTAL STRUCTURE OF ELONGATION FACTOR G (EFG)
Descriptor:Elongation factor G, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Liu, G., Dong, J., Gong, W., Qin, Y.
Deposit date:2013-09-28
Release date:2014-08-06
Method:X-RAY DIFFRACTION (3.505 Å)
Cite:Crystal structure of elongation factor G (EFG)
To be published
4MYU
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CRYSTAL STRUCTURE OF ELONGATION FACTOR G MUTANT(EFG)
Descriptor:Elongation factor G, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Liu, G., Dong, J., Gong, W., Qin, Y.
Deposit date:2013-09-28
Release date:2014-08-06
Method:X-RAY DIFFRACTION (3.004 Å)
Cite:Crystal structure of elongation factor G mutant(EFG)
To be published
4M1K
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CRYSTAL STRUCTURE OF ELONGATION FACTOR G (EFG)
Descriptor:Elongation factor G, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE
Authors:Liu, G., Dong, J., Gong, W., Qin, Y.
Deposit date:2013-08-02
Release date:2014-08-06
Method:X-RAY DIFFRACTION (2.952 Å)
Cite:Crystal structure of elongation factor G (EFG)
To be published
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