Author results

6OVC
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HMCL1 INHIBITOR COMPLEX
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, (2S)-N-(benzylsulfonyl)-4-(cyclobutylmethyl)-2-(2,4-dichlorophenyl)-3,4-dihydro-2H-1,4-benzoxazine-6-carboxamide
Authors:Poppe, L.
Deposit date:2019-05-07
Release date:2019-05-22
Method:SOLUTION NMR
Cite:AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.
Cancer Discov, 8, 2018
2KEF
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SOLUTION NMR STRUCTURES OF HUMAN HEPCIDIN AT 325K
Descriptor:Hepcidin
Authors:Jordan, J.B., Poppe, L., Hainu, M., Arvedson, T., Syed, R., Li, V., Kohno, H., Kim, H., Miranda, L.P., Cheetham, J., Sasu, B.J.
Deposit date:2009-01-29
Release date:2009-06-23
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Hepcidin revisited, disulfide connectivity, dynamics, and structure.
J.Biol.Chem., 284, 2009
2LZG
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NMR STRUCTURE OF MDM2 (6-125) WITH PIP-1
Descriptor:E3 ubiquitin-protein ligase Mdm2, [(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(cyclopropylmethyl)-2-oxopiperidin-3-yl]acetic acid
Authors:Michelsen, K.B., Jordan, J.B., Lewis, J., Long, A.M., Yang, E., Rew, Y., Zhou, J., Yakowec, P., Schnier, P.D., Huang, X., Poppe, L.
Deposit date:2012-10-02
Release date:2012-11-07
Method:SOLUTION NMR
Cite:Ordering of the N-Terminus of Human MDM2 by Small Molecule Inhibitors.
J.Am.Chem.Soc., 134, 2012
2MHS
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NMR STRUCTURE OF HUMAN MCL-1
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1
Authors:Liu, G., Poppe, L., Aoki, K., Yamane, H., Lewis, J., Szyperski, T.
Deposit date:2013-12-04
Release date:2014-05-14
Method:SOLUTION NMR
Cite:High-Quality NMR Structure of Human Anti-Apoptotic Protein Domain Mcl-1(171-327) for Cancer Drug Design.
Plos One, 9, 2014
6O6F
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CO-CRYSTAL STRUCTURE OF MCL1 WITH INHIBITOR
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, (3S)-5'-chloro-5-(cyclobutylmethyl)-2',3',4,5-tetrahydro-2H-spiro[1,5-benzoxazepine-3,1'-indene]-7-carboxylic acid
Authors:Huang, X.
Deposit date:2019-03-06
Release date:2019-05-15
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.
Cancer Discov, 8, 2018
6O6G
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CO-CRYSTAL STRUCTURE OF MCL1 WITH INHIBITOR
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, (3S)-5-(cyclobutylmethyl)-3-(2,4-dichlorophenyl)-2,3,4,5-tetrahydro-1,5-benzoxazepine-7-carboxylic acid
Authors:Huang, X.
Deposit date:2019-03-06
Release date:2019-05-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.
Cancer Discov, 8, 2018
6OQB
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CO-CRYSTAL STRUCTURE OF MCL1 WITH INHIBITOR 10
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, (4S,7aR,9aR,10S,11E,15R)-6'-chloro-15-ethyl-10-hydroxy-3',4',7a,8,9,9a,10,13,14,15-decahydro-2'H,3H,5H-spiro[1,19-(ethanediylidene)-16lambda~6~-cyclobuta[i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-4,1'-naphthalene]-16,16,18(7H,17H)-trione
Authors:Huang, X.
Deposit date:2019-04-26
Release date:2019-05-15
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.
Cancer Discov, 8, 2018
6OQD
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CRYSTAL STRUCTURE OF MCL1 WITH INHIBITOR 8
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, (4S,7aR,9aR,10S,15R)-6'-chloro-10-hydroxy-15-methyl-3',4',7a,8,9,9a,10,11,12,13,14,15-dodecahydro-2'H,3H,5H-spiro[1,19-(ethanediylidene)-16lambda~6~-cyclobuta[i][1,4]oxazepino[3,4-f][1,2,7]thiadiazacyclohexadecine-4,1'-naphthalene]-16,16,18(7H,17H)-trione
Authors:Huang, X.
Deposit date:2019-04-26
Release date:2019-05-15
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.
Cancer Discov, 8, 2018
6OQN
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CRYSTAL STRUCTURE OF MCL1 WITH INHIBITOR 7
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, (4S)-5'-chloro-2',3',7,8,9,10,11,12-octahydro-3H,5H,14H-spiro[1,19-etheno-16lambda~6~-[1,4]oxazepino[3,4-i][1,4,5,10]oxathiadiazacyclohexadecine-4,1'-indene]-16,16,18(15H,17H)-trione
Authors:Huang, X.
Deposit date:2019-04-26
Release date:2019-05-15
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:AMG 176, a Selective MCL1 Inhibitor, Is Effective in Hematologic Cancer Models Alone and in Combination with Established Therapies.
Cancer Discov, 8, 2018
3H0T
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HEPCIDIN-FAB COMPLEX
Descriptor:Fab fragment, Light chain, Heavy chain, ...
Authors:Syed, R., Li, V.
Deposit date:2009-04-10
Release date:2009-06-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Hepcidin revisited, disulfide connectivity, dynamics, and structure.
J.Biol.Chem., 284, 2009
4HBM
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ORDERING OF THE N TERMINUS OF HUMAN MDM2 BY SMALL MOLECULE INHIBITORS
Descriptor:E3 ubiquitin-protein ligase Mdm2, {(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(2S)-1-hydroxybutan-2-yl]-2-oxopiperidin-3-yl}acetic acid
Authors:Huang, X.
Deposit date:2012-09-28
Release date:2012-10-17
Last modified:2013-01-02
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Ordering of the N-terminus of human MDM2 by small molecule inhibitors.
J.Am.Chem.Soc., 134, 2012