Author results

1WLH
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MOLECULAR STRUCTURE OF THE ROD DOMAIN OF DICTYOSTELIUM FILAMIN
分子名称:Gelation factor
著者Popowicz, G.M., Mueller, R., Noegel, A.A., Schleicher, M., Huber, R., Holak, T.A.
登録日2004-06-27
公開日2004-10-05
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Molecular structure of the rod domain of dictyostelium filamin
J.Mol.Biol., 342, 2004
2AS9
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FUNCTIONAL AND STRUCTURAL CHARACTERIZATION OF SPL PROTEASES FROM STAPHYLOCOCCUS AUREUS
分子名称:serine protease, ZINC ION
著者Popowicz, G.M., Dubin, G., Stec-Niemczyk, J., Czarny, A., Dubin, A., Potempa, J., Holak, T.A.
登録日2005-08-23
公開日2005-09-06
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Functional and Structural Characterization of Spl Proteases from Staphylococcus aureus
J.Mol.Biol., 358, 2006
2Z5S
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MOLECULAR BASIS FOR THE INHIBITION OF P53 BY MDMX
分子名称:Mdm4 protein, Cellular tumor antigen p53
著者Popowicz, G.M., Czarna, A., Rothweiler, U., Szwagierczak, A., Holak, T.A.
登録日2007-07-17
公開日2007-11-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Molecular basis for the inhibition of p53 by Mdmx.
Cell Cycle, 6, 2007
2Z5T
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MOLECULAR BASIS FOR THE INHIBITION OF P53 BY MDMX
分子名称:Mdm4 protein, Cellular tumor antigen p53
著者Popowicz, G.M., Czarna, A., Rothweiler, U., Szwagierczak, A., Holak, T.A.
登録日2007-07-17
公開日2007-11-06
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Molecular basis for the inhibition of p53 by Mdmx.
Cell Cycle, 6, 2007
3DAB
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STRUCTURE OF THE HUMAN MDMX PROTEIN BOUND TO THE P53 TUMOR SUPPRESSOR TRANSACTIVATION DOMAIN
分子名称:Mdm4 protein, Cellular tumor antigen p53
著者Popowicz, G.M., Czarna, A., Holak, T.A.
登録日2008-05-29
公開日2008-09-02
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain
Cell Cycle, 7, 2008
3DAC
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STRUCTURE OF THE HUMAN MDMX PROTEIN BOUND TO THE P53 TUMOR SUPPRESSOR TRANSACTIVATION DOMAIN
分子名称:Mdm4 protein, Cellular tumor antigen p53
著者Popowicz, G.M., Czarna, A., Holak, T.A.
登録日2008-05-29
公開日2008-09-02
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain
Cell Cycle, 7, 2008
3LBJ
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STRUCTURE OF HUMAN MDMX PROTEIN IN COMPLEX WITH A SMALL MOLECULE INHIBITOR
分子名称:Protein Mdm4, N-[(3S)-1-({6-chloro-3-[1-(4-chlorobenzyl)-4-phenyl-1H-imidazol-5-yl]-1H-indol-2-yl}carbonyl)pyrrolidin-3-yl]-N,N',N'-trimethylpropane-1,3-diamine, SULFATE ION
著者Popowicz, G.M., Czarna, A., Wolf, S., Holak, T.A.
登録日2010-01-08
公開日2010-03-16
最終更新日2018-10-17
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery
Cell Cycle, 9, 2010
3LBK
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STRUCTURE OF HUMAN MDM2 PROTEIN IN COMPLEX WITH A SMALL MOLECULE INHIBITOR
分子名称:E3 ubiquitin-protein ligase Mdm2, 6-chloro-3-[1-(4-chlorobenzyl)-4-phenyl-1H-imidazol-5-yl]-1H-indole-2-carboxylic acid, SULFATE ION
著者Popowicz, G.M., Czarna, A., Wolf, S., Holak, T.A.
登録日2010-01-08
公開日2010-03-16
最終更新日2018-10-17
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery
Cell Cycle, 9, 2010
3LBL
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STRUCTURE OF HUMAN MDM2 PROTEIN IN COMPLEX WITH MI-63-ANALOG
分子名称:E3 ubiquitin-protein ligase Mdm2, (2'R,3R,4'R,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide
著者Popowicz, G.M., Czarna, A., Wolf, S., Holak, T.A.
登録日2010-01-08
公開日2010-03-16
最終更新日2018-10-17
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery
Cell Cycle, 9, 2010
2ABZ
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CRYSTAL STRUCTURE OF C19A/C43A MUTANT OF LEECH CARBOXYPEPTIDASE INHIBITOR IN COMPLEX WITH BOVINE CARBOXYPEPTIDASE A
分子名称:Carboxypeptidase A1, Metallocarboxypeptidase inhibitor, ZINC ION
著者Arolas, J.L., Popowicz, G.M., Bronsoms, S., Aviles, F.X., Huber, R., Holak, T.A., Ventura, S.
登録日2005-07-18
公開日2006-01-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.16 Å)
主引用文献Study of a major intermediate in the oxidative folding of leech carboxypeptidase inhibitor: contribution of the fourth disulfide bond
J.Mol.Biol., 352, 2005
2VID
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SERINE PROTEASE SPLB FROM STAPHYLOCOCCUS AUREUS AT 1.8A RESOLUTION
分子名称:SERINE PROTEASE SPLB
著者Dubin, G., Stec-Niemczyk, J., Kisielewska, M., Pustelny, K., Popowicz, G.M., Bista, M., Kantyka, T., Boulware, K.T., Stennicke, H.R., Czarna, A., Phopaisarn, M., Daugherty, P.S., Thogersen, I.B., Enghild, J.J., Thornberry, N., Dubin, A., Potempa, J.
登録日2007-11-30
公開日2008-05-13
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Enzymatic Activity of the Staphylococcus Aureus Splb Serine Protease is Induced by Substrates Containing the Sequence Trp-Glu-Leu-Gln.
J.Mol.Biol., 379, 2008
2W7S
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SPLA SERINE PROTEASE OF STAPHYLOCOCCUS AUREUS (1.8A)
分子名称:SERINE PROTEASE SPLA
著者Stec-Niemczyka, J., Pustelny, K., Kisielewska, M., Bista, M., Boulware, K.T., Stennicke, H.R., Thogersen, I.B., Daugherty, P.S., Enghild, J.J., Popowicz, G.M., Dubin, A., Potempa, J., Dubin, G.
登録日2008-12-30
公開日2010-03-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural and Functional Characterization of Spla, an Exclusively Specific Protease of Staphylococcus Aureus
Biochem.J., 419, 2009
2W7U
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SPLA SERINE PROTEASE OF STAPHYLOCOCCUS AUREUS (2.4A)
分子名称:SERINE PROTEASE SPLA
著者Stec-Niemczyka, J., Pustelny, K., Kisielewska, M., Bista, M., Boulware, K.T., Stennicke, H.R., Thogersen, I.B., Daugherty, P.S., Enghild, J.J., Popowicz, G.M., Dubin, A., Potempa, J., Dubin, G.
登録日2008-12-30
公開日2010-03-31
最終更新日2017-07-12
実験手法X-RAY DIFFRACTION (2.43 Å)
主引用文献Structural and Functional Characterization of Spla, an Exclusively Specific Protease of Staphylococcus Aureus.
Biochem.J., 419, 2009
1WQJ
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STRUCTURAL BASIS FOR THE REGULATION OF INSULIN-LIKE GROWTH FACTORS (IGFS) BY IGF BINDING PROTEINS (IGFBPS)
分子名称:Insulin-like growth factor binding protein 4, Insulin-like growth factor IB
著者Siwanowicz, I., Popowicz, G.M., Wisniewska, M., Huber, R., Kuenkele, K.P., Lang, K., Engh, R.A., Holak, T.A.
登録日2004-09-29
公開日2005-03-01
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural basis for the regulation of insulin-like growth factors by IGF binding proteins
Structure, 13, 2005
1YZ5
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THE CRYSTAL STRUCTURE OF 14-3-3-SIGMA AT 2.8 ANGSTROM RESOLUTION
分子名称:14-3-3 protein sigma
著者Benzinger, A., Popowicz, G.M., Holak, T.A., Hermeking, H.
登録日2005-02-28
公開日2005-03-08
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The crystal structure of the non-liganded 14-3-3sigma protein: insights into determinants of isoform specific ligand binding and dimerization.
Cell Res., 15, 2005
1ZFI
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SOLUTION STRUCTURE OF THE LEECH CARBOXYPEPTIDASE INHIBITOR
分子名称:Metallocarboxypeptidase inhibitor
著者Arolas, J.L., D'Silva, L., Popowicz, G.M., Aviles, F.X., Holak, T.A., Ventura, S.
登録日2005-04-20
公開日2005-09-13
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献NMR structural characterization and computational predictions of the major intermediate in oxidative folding of leech carboxypeptidase inhibitor
STRUCTURE, 13, 2005
1ZFL
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SOLUTION STRUCTURE OF III-A, THE MAJOR INTERMEDIATE IN THE OXIDATIVE FOLDING OF LEECH CARBOXYPEPTIDASE INHIBITOR
分子名称:Metallocarboxypeptidase inhibitor
著者Arolas, J.L., D'Silva, L., Popowicz, G.M., Aviles, F.X., Holak, T.A., Ventura, S.
登録日2005-04-20
公開日2005-09-13
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献NMR structural characterization and computational predictions of the major intermediate in oxidative folding of leech carboxypeptidase inhibitor
STRUCTURE, 13, 2005
1ZLH
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CRYSTAL STRUCTURE OF THE TICK CARBOXYPEPTIDASE INHIBITOR IN COMPLEX WITH BOVINE CARBOXYPEPTIDASE A
分子名称:Carboxypeptidase A1, carboxypeptidase inhibitor, ZINC ION
著者Arolas, J.L., Popowicz, G.M., Lorenzo, J., Sommerhoff, C.P., Huber, R., Aviles, F.X., Holak, T.A.
登録日2005-05-06
公開日2005-07-05
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The Three-Dimensional Structures of Tick Carboxypeptidase Inhibitor in Complex with A/B Carboxypeptidases Reveal a Novel Double-headed Binding Mode
J.Mol.Biol., 350, 2005
1ZLI
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CRYSTAL STRUCTURE OF THE TICK CARBOXYPEPTIDASE INHIBITOR IN COMPLEX WITH HUMAN CARBOXYPEPTIDASE B
分子名称:Carboxypeptidase B, carboxypeptidase inhibitor, ZINC ION
著者Arolas, J.L., Popowicz, G.M., Lorenzo, J., Sommerhoff, C.P., Huber, R., Aviles, F.X., Holak, T.A.
登録日2005-05-06
公開日2005-07-05
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献The Three-Dimensional Structures of Tick Carboxypeptidase Inhibitor in Complex with A/B Carboxypeptidases Reveal a Novel Double-headed Binding Mode
J.Mol.Biol., 350, 2005
2DSP
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STRUCTURAL BASIS FOR THE INHIBITION OF INSULIN-LIKE GROWTH FACTORS BY IGF BINDING PROTEINS
分子名称:Insulin-like growth factor-binding protein 4, Insulin-like growth factor IB
著者Sitar, T., Popowicz, G.M., Siwanowicz, I., Huber, R., Holak, T.A.
登録日2006-07-05
公開日2006-08-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2DSQ
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STRUCTURAL BASIS FOR THE INHIBITION OF INSULIN-LIKE GROWTH FACTORS BY IGF BINDING PROTEINS
分子名称:Insulin-like growth factor-binding protein 4, Insulin-like growth factor IB, Insulin-like growth factor-binding protein 1
著者Sitar, T., Popowicz, G.M., Siwanowicz, I., Huber, R., Holak, T.A.
登録日2006-07-05
公開日2006-08-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2DSR
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STRUCTURAL BASIS FOR THE INHIBITION OF INSULIN-LIKE GROWTH FACTORS BY IGF BINDING PROTEINS
分子名称:Insulin-like growth factor-binding protein 4, Insulin-like growth factor IB
著者Sitar, T., Popowicz, G.M., Siwanowicz, I., Huber, R., Holak, T.A.
登録日2006-07-05
公開日2006-08-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for the inhibition of insulin-like growth factors by insulin-like growth factor-binding proteins.
Proc.Natl.Acad.Sci.Usa, 103, 2006
2GRC
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1.5 A STRUCTURE OF BROMODOMAIN FROM HUMAN BRG1 PROTEIN, A CENTRAL ATPASE OF SWI/SNF REMODELING COMPLEX
分子名称:Probable global transcription activator SNF2L4
著者Singh, M., Popowicz, G.M., Krajewski, M., Holak, T.A.
登録日2006-04-24
公開日2007-05-08
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural ramification for acetyl-lysine recognition by the bromodomain of human BRG1 protein, a central ATPase of the SWI/SNF remodeling complex.
Chembiochem, 8, 2007
3FDO
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STRUCTURE OF HUMAN MDMX IN COMPLEX WITH HIGH AFFINITY PEPTIDE
分子名称:Protein Mdm4, Synthetic high affinity peptide, MAGNESIUM ION
著者Czarna, A.L., Popowicz, G.M., Holak, T.A.
登録日2008-11-26
公開日2008-12-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx
Cell Cycle, 8, 2009
3G03
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STRUCTURE OF HUMAN MDM2 IN COMPLEX WITH HIGH AFFINITY PEPTIDE
分子名称:E3 ubiquitin-protein ligase Mdm2, High affinity synthetic peptide
著者Czarna, A.L., Popowicz, G.M., Holak, T.A.
登録日2009-01-27
公開日2009-04-14
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx
Cell Cycle, 8, 2009
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