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3DAC
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BU of 3dac by Molmil
Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain
Descriptor: Cellular tumor antigen p53, Mdm4 protein
Authors:Popowicz, G.M, Czarna, A, Holak, T.A.
Deposit date:2008-05-29
Release date:2008-09-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain.
Cell Cycle, 7, 2008
3DAB
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BU of 3dab by Molmil
Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain
Descriptor: Cellular tumor antigen p53, Mdm4 protein
Authors:Popowicz, G.M, Czarna, A, Holak, T.A.
Deposit date:2008-05-29
Release date:2008-09-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain.
Cell Cycle, 7, 2008
1WLH
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BU of 1wlh by Molmil
Molecular structure of the rod domain of Dictyostelium filamin
Descriptor: Gelation factor
Authors:Popowicz, G.M, Mueller, R, Noegel, A.A, Schleicher, M, Huber, R, Holak, T.A.
Deposit date:2004-06-27
Release date:2004-10-05
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Molecular structure of the rod domain of dictyostelium filamin
J.Mol.Biol., 342, 2004
3LBL
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BU of 3lbl by Molmil
Structure of human MDM2 protein in complex with Mi-63-analog
Descriptor: (2'R,3R,4'R,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide, E3 ubiquitin-protein ligase Mdm2
Authors:Popowicz, G.M, Czarna, A, Wolf, S, Holak, T.A.
Deposit date:2010-01-08
Release date:2010-03-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery
Cell Cycle, 9, 2010
3LBK
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BU of 3lbk by Molmil
Structure of human MDM2 protein in complex with a small molecule inhibitor
Descriptor: 6-chloro-3-[1-(4-chlorobenzyl)-4-phenyl-1H-imidazol-5-yl]-1H-indole-2-carboxylic acid, E3 ubiquitin-protein ligase Mdm2, SULFATE ION
Authors:Popowicz, G.M, Czarna, A, Wolf, S, Holak, T.A.
Deposit date:2010-01-08
Release date:2010-03-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery
Cell Cycle, 9, 2010
2Z5S
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BU of 2z5s by Molmil
Molecular basis for the inhibition of p53 by Mdmx
Descriptor: Cellular tumor antigen p53, Mdm4 protein
Authors:Popowicz, G.M, Czarna, A, Rothweiler, U, Szwagierczak, A, Holak, T.A.
Deposit date:2007-07-17
Release date:2007-11-06
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular basis for the inhibition of p53 by Mdmx.
Cell Cycle, 6, 2007
2Z5T
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BU of 2z5t by Molmil
Molecular basis for the inhibition of p53 by Mdmx
Descriptor: Cellular tumor antigen p53, Mdm4 protein
Authors:Popowicz, G.M, Czarna, A, Rothweiler, U, Szwagierczak, A, Holak, T.A.
Deposit date:2007-07-17
Release date:2007-11-06
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Molecular basis for the inhibition of p53 by Mdmx.
Cell Cycle, 6, 2007
3LBJ
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BU of 3lbj by Molmil
Structure of human MDMX protein in complex with a small molecule inhibitor
Descriptor: N-[(3S)-1-({6-chloro-3-[1-(4-chlorobenzyl)-4-phenyl-1H-imidazol-5-yl]-1H-indol-2-yl}carbonyl)pyrrolidin-3-yl]-N,N',N'-trimethylpropane-1,3-diamine, Protein Mdm4, SULFATE ION
Authors:Popowicz, G.M, Czarna, A, Wolf, S, Holak, T.A.
Deposit date:2010-01-08
Release date:2010-03-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery
Cell Cycle, 9, 2010
2AS9
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BU of 2as9 by Molmil
Functional and structural characterization of Spl proteases from staphylococcus aureus
Descriptor: ZINC ION, serine protease
Authors:Popowicz, G.M, Dubin, G, Stec-Niemczyk, J, Czarny, A, Dubin, A, Potempa, J, Holak, T.A.
Deposit date:2005-08-23
Release date:2005-09-06
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Functional and Structural Characterization of Spl Proteases from Staphylococcus aureus
J.Mol.Biol., 358, 2006
4PYU
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BU of 4pyu by Molmil
The conserved ubiquitin-like protein hub1 plays a critical role in splicing in human cells
Descriptor: U4/U6.U5 tri-snRNP-associated protein 1, Ubiquitin-like protein 5
Authors:Ammon, T, Mishra, S.K, Kowalska, K, Popowicz, G.M, Holak, T.A, Jentsch, S.
Deposit date:2014-03-28
Release date:2014-07-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:The conserved ubiquitin-like protein Hub1 plays a critical role in splicing in human cells.
J Mol Cell Biol, 6, 2014
4QQB
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BU of 4qqb by Molmil
Structural basis for the assembly of the SXL-UNR translation regulatory complex
Descriptor: Protein sex-lethal, Upstream of N-ras, isoform A, ...
Authors:Hennig, J, Popowicz, G.M, Sattler, M.
Deposit date:2014-06-27
Release date:2014-09-03
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for the assembly of the Sxl-Unr translation regulatory complex.
Nature, 515, 2014
7QRC
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BU of 7qrc by Molmil
X-ray structure of Trypanosoma cruzi PEX14 in complex with a PEX5-PEX14 PPI inhibitor
Descriptor: GLYCEROL, Peroxin-14, ~{N}-(5-ethyl-6-oxidanylidene-benzo[b][1,4]benzothiazepin-2-yl)-2-(4-fluorophenyl)ethanamide
Authors:Napolitano, V, Popowicz, G.M, Dawidowski, M, Dubin, G.
Deposit date:2022-01-10
Release date:2022-11-23
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Structure-based design, synthesis and evaluation of a novel family of PEX5-PEX14 interaction inhibitors against Trypanosoma.
Eur.J.Med.Chem., 243, 2022
6SPT
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BU of 6spt by Molmil
High resolution crystal structure of N-terminal domain of PEX14 from Trypanosoma brucei in complex with the fist compound with sub-micromolar trypanocidal activity
Descriptor: 5-[(4-methoxynaphthalen-1-yl)methyl]-1-[2-[(2-methyl-1-oxidanyl-propan-2-yl)amino]ethyl]-~{N}-(naphthalen-1-ylmethyl)-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridine-3-carboxamide, BETA-MERCAPTOETHANOL, CHLORIDE ION, ...
Authors:Napolitano, V, Dawidowski, M, Kalel, V.C, Fino, R, Emmanouilidis, L, Lenhart, D, Ostertag, M, Kaiser, M, Kolonko, M, Schilebs, W, Maser, P, Tetko, I, Hadian, K, Plettenburg, O, Erdmann, R, Sattler, M, Popowicz, G.M, Dubin, G.
Deposit date:2019-09-02
Release date:2020-01-01
Last modified:2020-02-05
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structure-Activity Relationship in Pyrazolo[4,3-c]pyridines, First Inhibitors of PEX14-PEX5 Protein-Protein Interaction with Trypanocidal Activity.
J.Med.Chem., 63, 2020
6F8G
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BU of 6f8g by Molmil
Co-crystal structure of SPOP MATH domain and hamster Pdx1 fragment
Descriptor: Pancreas/duodenum homeobox protein 1, Speckle-type POZ protein
Authors:Ostertag, M.S, Popowicz, G.M, Sattler, M.
Deposit date:2017-12-13
Release date:2018-11-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:The Structure of the SPOP-Pdx1 Interface Reveals Insights into the Phosphorylation-Dependent Binding Regulation.
Structure, 27, 2019
6F8F
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BU of 6f8f by Molmil
Co-crystal structure of SPOP MATH domain and human Pdx1 fragment
Descriptor: Pancreas/duodenum homeobox protein 1, Speckle-type POZ protein
Authors:Ostertag, M.S, Popowicz, G.M, Sattler, M.
Deposit date:2017-12-13
Release date:2018-11-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Structure of the SPOP-Pdx1 Interface Reveals Insights into the Phosphorylation-Dependent Binding Regulation.
Structure, 27, 2019
6YI4
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BU of 6yi4 by Molmil
Structure of IMP-13 metallo-beta-lactamase complexed with citrate anion
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, BETA-MERCAPTOETHANOL, ...
Authors:Zak, K.M, Zhou, R.X, Softley, C.A, Bostock, M.J, Sattler, M, Popowicz, G.M.
Deposit date:2020-03-31
Release date:2020-04-08
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structure of IMP-13 metallo-beta-lactamase complexed with citrate anion
Not published
5L87
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BU of 5l87 by Molmil
Targeting the PEX14-PEX5 interaction by small molecules provides novel therapeutic routes to treat trypanosomiases.
Descriptor: 1,2-ETHANEDIOL, 5-(1~{H}-indol-3-ylmethyl)-1-methyl-~{N}-(naphthalen-1-ylmethyl)-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridine-3-carboxamide, Peroxin 14
Authors:Dawidowski, M, Emmanouilidis, L, Sattler, M, Popowicz, G.M.
Deposit date:2016-06-07
Release date:2017-03-08
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (0.87 Å)
Cite:Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites.
Science, 355, 2017
5L8A
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BU of 5l8a by Molmil
Targeting the PEX14-PEX5 interaction by small molecules provides novel therapeutic routes to treat trypanosomiases.
Descriptor: 1,2-ETHANEDIOL, 1-(2-hydroxyethyl)-5-[(4-methoxynaphthalen-1-yl)methyl]-~{N}-(phenylmethyl)-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridine-3-carboxamide, GLYCINE, ...
Authors:Dawidowski, M, Emmanouilidis, L, Sattler, M, Popowicz, G.M.
Deposit date:2016-06-07
Release date:2017-03-08
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites.
Science, 355, 2017
5N8V
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BU of 5n8v by Molmil
Targeting the PEX14-PEX5 interaction by small molecules provides novel therapeutic routes to treat trypanosomiases.
Descriptor: 1-(2-azanylethyl)-5-[(4-methoxynaphthalen-1-yl)methyl]-~{N}-(naphthalen-1-ylmethyl)-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridine-3-carboxamide, BETA-MERCAPTOETHANOL, CHLORIDE ION, ...
Authors:Dawidowski, M, Emmanouilidis, L, Sattler, M, Popowicz, G.M.
Deposit date:2017-02-24
Release date:2017-03-15
Last modified:2017-04-26
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Inhibitors of PEX14 disrupt protein import into glycosomes and kill Trypanosoma parasites.
Science, 355, 2017
2VID
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BU of 2vid by Molmil
Serine protease SplB from Staphylococcus aureus at 1.8A resolution
Descriptor: SERINE PROTEASE SPLB
Authors:Dubin, G, Stec-Niemczyk, J, Kisielewska, M, Pustelny, K, Popowicz, G.M, Bista, M, Kantyka, T, Boulware, K.T, Stennicke, H.R, Czarna, A, Phopaisarn, M, Daugherty, P.S, Thogersen, I.B, Enghild, J.J, Thornberry, N, Dubin, A, Potempa, J.
Deposit date:2007-11-30
Release date:2008-05-13
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Enzymatic Activity of the Staphylococcus Aureus Splb Serine Protease is Induced by Substrates Containing the Sequence Trp-Glu-Leu-Gln.
J.Mol.Biol., 379, 2008
2W7U
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BU of 2w7u by Molmil
SplA serine protease of Staphylococcus aureus (2.4A)
Descriptor: SERINE PROTEASE SPLA
Authors:Stec-Niemczyka, J, Pustelny, K, Kisielewska, M, Bista, M, Boulware, K.T, Stennicke, H.R, Thogersen, I.B, Daugherty, P.S, Enghild, J.J, Popowicz, G.M, Dubin, A, Potempa, J, Dubin, G.
Deposit date:2008-12-30
Release date:2010-03-31
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Structural and Functional Characterization of Spla, an Exclusively Specific Protease of Staphylococcus Aureus.
Biochem.J., 419, 2009
2W7S
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BU of 2w7s by Molmil
SplA serine protease of Staphylococcus aureus (1.8A)
Descriptor: SERINE PROTEASE SPLA
Authors:Stec-Niemczyka, J, Pustelny, K, Kisielewska, M, Bista, M, Boulware, K.T, Stennicke, H.R, Thogersen, I.B, Daugherty, P.S, Enghild, J.J, Popowicz, G.M, Dubin, A, Potempa, J, Dubin, G.
Deposit date:2008-12-30
Release date:2010-03-31
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural and Functional Characterization of Spla, an Exclusively Specific Protease of Staphylococcus Aureus
Biochem.J., 419, 2009
3FDO
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BU of 3fdo by Molmil
Structure of human MDMX in complex with high affinity peptide
Descriptor: MAGNESIUM ION, Protein Mdm4, Synthetic high affinity peptide
Authors:Czarna, A.L, Popowicz, G.M, Holak, T.A.
Deposit date:2008-11-26
Release date:2008-12-16
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx.
Cell Cycle, 8, 2009
2GRC
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BU of 2grc by Molmil
1.5 A structure of bromodomain from human BRG1 protein, a central ATPase of SWI/SNF remodeling complex
Descriptor: Probable global transcription activator SNF2L4
Authors:Singh, M, Popowicz, G.M, Krajewski, M, Holak, T.A.
Deposit date:2006-04-24
Release date:2007-05-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural ramification for acetyl-lysine recognition by the bromodomain of human BRG1 protein, a central ATPase of the SWI/SNF remodeling complex.
Chembiochem, 8, 2007
1WQJ
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BU of 1wqj by Molmil
Structural Basis for the Regulation of Insulin-Like Growth Factors (IGFs) by IGF Binding Proteins (IGFBPs)
Descriptor: Insulin-like growth factor IB, Insulin-like growth factor binding protein 4
Authors:Siwanowicz, I, Popowicz, G.M, Wisniewska, M, Huber, R, Kuenkele, K.P, Lang, K, Engh, R.A, Holak, T.A.
Deposit date:2004-09-29
Release date:2005-03-01
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural basis for the regulation of insulin-like growth factors by IGF binding proteins
Structure, 13, 2005

217705

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