6N9E | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH A SHORT SUBSTRATE MIMIC CC-PMN AND BOUND TO MRNA AND P-SITE TRNA AT 3.7A RESOLUTION | Descriptor: | 23S Ribosomal RNA, 5S Ribosomal RNA, 50S Ribosomal Protein L2, ... | Authors: | Melnikov, S.V., Khabibullina, N.F., Mairhofer, E., Vargas-Rodriguez, O., Reynolds, N.M., Micura, R., Soll, D., Polikanov, Y.S. | Deposit date: | 2018-12-03 | Release date: | 2018-12-12 | Last modified: | 2018-12-19 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Mechanistic insights into the slow peptide bond formation with D-amino acids in the ribosomal active site. Nucleic Acids Res., 2018
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6N9F | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH A SHORT SUBSTRATE MIMIC ACCA-DPHE AND BOUND TO MRNA AND P-SITE TRNA AT 3.7A RESOLUTION | Descriptor: | 23S Ribosomal RNA, 5S Ribosomal RNA, 50S Ribosomal Protein L2, ... | Authors: | Melnikov, S.V., Khabibullina, N.F., Mairhofer, E., Vargas-Rodriguez, O., Reynolds, N.M., Micura, R., Soll, D., Polikanov, Y.S. | Deposit date: | 2018-12-03 | Release date: | 2018-12-12 | Last modified: | 2018-12-19 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Mechanistic insights into the slow peptide bond formation with D-amino acids in the ribosomal active site. Nucleic Acids Res., 2018
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6CFJ | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH HISTIDYL-CAM AND BOUND TO MRNA AND A-, P-, AND E-SITE TRNAS AT 2.8A RESOLUTION | Descriptor: | 23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ... | Authors: | Tereshchenkov, A.G., Dobosz-Bartoszek, M., Osterman, I.A., Marks, J., Sergeeva, V.A., Kasatsky, P., Komarova, E.S., Stavrianidi, A.N., Rodin, I.A., Konevega, A.L., Sergiev, P.V., Sumbatyan, N.V., Mankin, A.S., Bogdanov, A.A., Polikanov, Y.S. | Deposit date: | 2018-02-15 | Release date: | 2018-03-07 | Last modified: | 2018-03-28 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Binding and Action of Amino Acid Analogs of Chloramphenicol upon the Bacterial Ribosome. J. Mol. Biol., 430, 2018
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6CFK | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH D-HISTIDYL-CAM AND BOUND TO PROTEIN Y (YFIA) AT 2.7A RESOLUTION | Descriptor: | 23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ... | Authors: | Tereshchenkov, A.G., Dobosz-Bartoszek, M., Osterman, I.A., Marks, J., Sergeeva, V.A., Kasatsky, P., Komarova, E.S., Stavrianidi, A.N., Rodin, I.A., Konevega, A.L., Sergiev, P.V., Sumbatyan, N.V., Mankin, A.S., Bogdanov, A.A., Polikanov, Y.S. | Deposit date: | 2018-02-15 | Release date: | 2018-03-07 | Last modified: | 2018-04-11 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Binding and Action of Amino Acid Analogs of Chloramphenicol upon the Bacterial Ribosome. J. Mol. Biol., 430, 2018
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6CFL | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH LYSYL-CAM AND BOUND TO PROTEIN Y (YFIA) AT 2.6A RESOLUTION | Descriptor: | 23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ... | Authors: | Tereshchenkov, A.G., Dobosz-Bartoszek, M., Osterman, I.A., Marks, J., Sergeeva, V.A., Kasatsky, P., Komarova, E.S., Stavrianidi, A.N., Rodin, I.A., Konevega, A.L., Sergiev, P.V., Sumbatyan, N.V., Mankin, A.S., Bogdanov, A.A., Polikanov, Y.S. | Deposit date: | 2018-02-15 | Release date: | 2018-03-07 | Last modified: | 2018-04-11 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Binding and Action of Amino Acid Analogs of Chloramphenicol upon the Bacterial Ribosome. J. Mol. Biol., 430, 2018
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6CAE | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH NOSO-95179 ANTIBIOTIC AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.6A RESOLUTION | Descriptor: | 23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ... | Authors: | Pantel, L., Florin, T., Dobosz-Bartoszek, M., Racine, E., Sarciaux, M., Serri, M., Houard, J., Campagne, J.M., Marcia de Figueiredo, R., Midrier, C., Gaudriault, S., Givaudan, A., Lanois, A., Forst, S., Aumelas, A., Cotteaux-Lautard, C., Bolla, J.M., Vingsbo Lundberg, C., Huseby, D., Hughes, D., Villain-Guillot, P., Mankin, A.S., Polikanov, Y.S., Gualtieri, M. | Deposit date: | 2018-01-30 | Release date: | 2018-04-18 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site. Mol. Cell, 70, 2018
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5WIS | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH METHYMYCIN AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.7A RESOLUTION | Descriptor: | 23S ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ... | Authors: | Almutairi, M.M., Svetlov, M.S., Hansen, D.A., Khabibullina, N.F., Klepacki, D., Kang, H.Y., Sherman, D.H., Vazquez-Laslop, N., Polikanov, Y.S., Mankin, A.S. | Deposit date: | 2017-07-20 | Release date: | 2018-02-14 | Last modified: | 2018-03-21 | Method: | X-RAY DIFFRACTION (2.703 Å) | Cite: | Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins. Nucleic Acids Res., 45, 2017
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5WIT | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH PIKROMYCIN AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.6A RESOLUTION | Descriptor: | 23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ... | Authors: | Almutairi, M.M., Svetlov, M.S., Hansen, D.A., Khabibullina, N.F., Klepacki, D., Kang, H.Y., Sherman, D.H., Vazquez-Laslop, N., Polikanov, Y.S., Mankin, A.S. | Deposit date: | 2017-07-20 | Release date: | 2018-02-14 | Last modified: | 2018-03-21 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Co-produced natural ketolides methymycin and pikromycin inhibit bacterial growth by preventing synthesis of a limited number of proteins. Nucleic Acids Res., 45, 2017
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5W4K | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH KLEBSAZOLICIN AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.7A RESOLUTION | Descriptor: | 23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ... | Authors: | Metelev, M., Osterman, I.A., Ghilarov, D., Khabibullina, N.F., Yakimov, A., Shabalin, K., Utkina, I., Travin, D.Y., Komarova, E.S., Serebryakova, M., Artamonova, T., Khodorkovskii, M., Konevega, A.L., Sergiev, P.V., Severinov, K., Polikanov, Y.S. | Deposit date: | 2017-06-12 | Release date: | 2017-08-30 | Last modified: | 2018-06-06 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Klebsazolicin inhibits 70S ribosome by obstructing the peptide exit tunnel. Nat. Chem. Biol., 13, 2017
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5VP2 | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH MADUMYCIN II AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.8A RESOLUTION | Descriptor: | 23S Ribosomal RNA, 5S ribosomal RNA, 50S ribosomal protein L2, ... | Authors: | Osterman, I.A., Khabibullina, N.F., Komarova, E.S., Kasatsky, P., Kartsev, V.G., Bogdanov, A.A., Dontsova, O.A., Konevega, A.L., Sergiev, P.V., Polikanov, Y.S. | Deposit date: | 2017-05-04 | Release date: | 2017-06-28 | Last modified: | 2017-09-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Madumycin II inhibits peptide bond formation by forcing the peptidyl transferase center into an inactive state. Nucleic Acids Res., 45, 2017
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5KCR | CRYO-EM STRUCTURE OF THE ESCHERICHIA COLI 70S RIBOSOME IN COMPLEX WITH ANTIBIOTIC AVILAMYCIN C, MRNA AND P-SITE TRNA AT 3.6A RESOLUTION | Descriptor: | 23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ... | Authors: | Arenz, S., Juette, M.F., Graf, M., Nguyen, F., Huter, P., Polikanov, Y.S., Blanchard, S.C., Wilson, D.N. | Deposit date: | 2016-06-06 | Release date: | 2016-08-17 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome. Proc.Natl.Acad.Sci.USA, 113, 2016
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5KCS | CRYO-EM STRUCTURE OF THE ESCHERICHIA COLI 70S RIBOSOME IN COMPLEX WITH ANTIBIOTIC EVERNIMYCIN, MRNA, TETM AND P-SITE TRNA AT 3.9A RESOLUTION | Descriptor: | 23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ... | Authors: | Arenz, S., Juette, M.F., Graf, M., Nguyen, F., Huter, P., Polikanov, Y.S., Blanchard, S.C., Wilson, D.N. | Deposit date: | 2016-06-06 | Release date: | 2016-08-17 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structures of the orthosomycin antibiotics avilamycin and evernimicin in complex with the bacterial 70S ribosome. Proc.Natl.Acad.Sci.USA, 113, 2016
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5J4B | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH CISPLATIN (CO-CRYSTALLIZED) AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.6A RESOLUTION | Descriptor: | 23S ribosomal RNA, 5S ribosomal RNA, 50S ribosomal protein L2, ... | Authors: | Melnikov, S.V., Soll, D., Steitz, T.A., Polikanov, Y.S. | Deposit date: | 2016-03-31 | Release date: | 2016-04-27 | Last modified: | 2017-09-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome. Nucleic Acids Res., 44, 2016
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5J4C | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH CISPLATIN (SOAKED) AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.8A RESOLUTION | Descriptor: | 23S ribosomal RNA, 5S ribosomal RNA, 50S ribosomal protein L2, ... | Authors: | Melnikov, S.V., Soll, D., Steitz, T.A., Polikanov, Y.S. | Deposit date: | 2016-03-31 | Release date: | 2016-04-27 | Last modified: | 2017-09-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome. Nucleic Acids Res., 44, 2016
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5DOX | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH HYGROMYCIN-A AT 3.1A RESOLUTION | Descriptor: | 23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ... | Authors: | Polikanov, Y.S., Starosta, A.L., Juette, M.F., Altman, R.B., Terry, D.S., Lu, W., Burnett, B.J., Dinos, G., Reynolds, K., Blanchard, S.C., Steitz, T.A., Wilson, D.N. | Deposit date: | 2015-09-11 | Release date: | 2015-12-30 | Last modified: | 2017-09-27 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A. Mol.Cell, 58, 2015
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5DOY | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH ANTIBIOTIC HYGROMYCIN A, MRNA AND THREE TRNAS IN THE A, P AND E SITES AT 2.6A RESOLUTION | Descriptor: | 23S Ribosomal RNA, 5S Ribosomal RNA, 50S Ribosomal Protein L2, ... | Authors: | Polikanov, Y.S., Starosta, A.L., Juette, M.F., Altman, R.B., Terry, D.S., Lu, W., Burnett, B.J., Dinos, G., Reynolds, K., Blanchard, S.C., Steitz, T.A., Wilson, D.N. | Deposit date: | 2015-09-11 | Release date: | 2015-12-30 | Last modified: | 2017-09-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A. Mol.Cell, 58, 2015
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4Z3S | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH ANTIBIOTIC A201A, MRNA AND THREE TRNAS IN THE A, P AND E SITES AT 2.65A RESOLUTION | Descriptor: | 23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ... | Authors: | Polikanov, Y.S., Starosta, A.L., Juette, M.F., Altman, R.B., Terry, D.S., Lu, W., Burnett, B.J., Dinos, G., Reynolds, K., Blanchard, S.C., Steitz, T.A., Wilson, D.N. | Deposit date: | 2015-03-31 | Release date: | 2015-06-03 | Last modified: | 2017-09-27 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A. Mol.Cell, 58, 2015
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4Y4O | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME WITH RRNA MODIFICATIONS AND BOUND TO PROTEIN Y (YFIA) AT 2.3A RESOLUTION | Descriptor: | 23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ... | Authors: | Polikanov, Y.S., Melnikov, S.V., Soll, D., Steitz, T.A. | Deposit date: | 2015-02-10 | Release date: | 2015-03-18 | Last modified: | 2017-09-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly. Nat.Struct.Mol.Biol., 22, 2015
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4Y4P | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME WITH RRNA MODIFICATIONS AND BOUND TO MRNA AND A-, P- AND E-SITE TRNAS AT 2.5A RESOLUTION | Descriptor: | 23S Ribosomal RNA, 5S Ribosomal RNA, 50S ribosomal protein L2, ... | Authors: | Polikanov, Y.S., Melnikov, S.V., Soll, D., Steitz, T.A. | Deposit date: | 2015-02-10 | Release date: | 2015-03-18 | Last modified: | 2017-09-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly. Nat.Struct.Mol.Biol., 22, 2015
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4W2F | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH AMICOUMACIN, MRNA AND THREE DEACYLATED TRNAS IN THE A, P AND E SITES | Descriptor: | 16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ... | Authors: | Polikanov, Y.S., Osterman, I.A., Szal, T., Tashlitsky, V.N., Serebryakova, M.V., Kusochek, P., Bulkley, D., Malanicheva, I.A., Efimenko, T.A., Efremenkova, O.V., Konevega, A.L., Shaw, K.J., Bogdanov, A.A., Rodnina, M.V., Dontsova, O.A., Mankin, A.S., Steitz, T.A., Sergiev, P.V. | Deposit date: | 2014-09-12 | Release date: | 2014-10-15 | Last modified: | 2015-01-14 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome. Mol.Cell, 56, 2014
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4W2G | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH PACTAMYCIN (SOAKED), MRNA AND THREE DEACYLATED TRNAS IN THE A, P AND E SITES | Descriptor: | 16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ... | Authors: | Polikanov, Y.S., Osterman, I.A., Szal, T., Tashlitsky, V.N., Serebryakova, M.V., Kusochek, P., Bulkley, D., Malanicheva, I.A., Efimenko, T.A., Efremenkova, O.V., Konevega, A.L., Shaw, K.J., Bogdanov, A.A., Rodnina, M.V., Dontsova, O.A., Mankin, A.S., Steitz, T.A., Sergiev, P.V. | Deposit date: | 2014-09-12 | Release date: | 2014-10-15 | Last modified: | 2015-01-14 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome. Mol.Cell, 56, 2014
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4W2H | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH PACTAMYCIN (CO-CRYSTALLIZED), MRNA AND DEACYLATED TRNA IN THE P SITE | Descriptor: | 16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ... | Authors: | Polikanov, Y.S., Osterman, I.A., Szal, T., Tashlitsky, V.N., Serebryakova, M.V., Kusochek, P., Bulkley, D., Malanicheva, I.A., Efimenko, T.A., Efremenkova, O.V., Konevega, A.L., Shaw, K.J., Bogdanov, A.A., Rodnina, M.V., Dontsova, O.A., Mankin, A.S., Steitz, T.A., Sergiev, P.V. | Deposit date: | 2014-09-12 | Release date: | 2014-10-15 | Last modified: | 2015-01-14 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome. Mol.Cell, 56, 2014
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4W2I | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH NEGAMYCIN, MRNA AND THREE DEACYLATED TRNAS IN THE A, P AND E SITES | Descriptor: | 16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ... | Authors: | Polikanov, Y.S., Szal, T., Jiang, F., Gupta, P., Matsuda, R., Shiozuka, M., Steitz, T.A., Vazquez-Laslop, N., Mankin, A.S. | Deposit date: | 2014-09-12 | Release date: | 2014-10-15 | Last modified: | 2018-01-24 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Negamycin Interferes with Decoding and Translocation by Simultaneous Interaction with rRNA and tRNA. Mol.Cell, 56, 2014
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1VY4 | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN THE PRE-ATTACK STATE OF PEPTIDE BOND FORMATION CONTAINING ACYLATED TRNA-SUBSTRATES IN THE A AND P SITES. | Descriptor: | 16S Ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ... | Authors: | Polikanov, Y.S., Steitz, T.A., Innis, C.A. | Deposit date: | 2014-05-13 | Release date: | 2014-08-20 | Last modified: | 2017-05-31 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome. Nat.Struct.Mol.Biol., 21, 2014
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1VY5 | CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN THE POST-CATALYSIS STATE OF PEPTIDE BOND FORMATION CONTAINING DIPEPTYDIL-TRNA IN THE A SITE AND DEACYLATED TRNA IN THE P SITE. | Descriptor: | 16S Ribosomal RNA, 30S ribosomal protein S2, 30S ribosomal protein S3, ... | Authors: | Polikanov, Y.S., Steitz, T.A., Innis, C.A. | Deposit date: | 2014-05-13 | Release date: | 2014-08-20 | Last modified: | 2017-05-31 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome. Nat.Struct.Mol.Biol., 21, 2014
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