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1DS5
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BU of 1ds5 by Molmil
DIMERIC CRYSTAL STRUCTURE OF THE ALPHA SUBUNIT IN COMPLEX WITH TWO BETA PEPTIDES MIMICKING THE ARCHITECTURE OF THE TETRAMERIC PROTEIN KINASE CK2 HOLOENZYME.
Descriptor: ADENOSINE MONOPHOSPHATE, CASEIN KINASE, ALPHA CHAIN, ...
Authors:Battistutta, R, Sarno, S, De Moliner, E, Marin, O, Zanotti, G, Pinna, L.A.
Deposit date:2000-01-07
Release date:2001-01-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.16 Å)
Cite:The crystal structure of the complex of Zea mays alpha subunit with a fragment of human beta subunit provides the clue to the architecture of protein kinase CK2 holoenzyme.
Eur.J.Biochem., 267, 2000
1F0Q
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BU of 1f0q by Molmil
CRYSTAL STRUCTURE OF THE ALPHA SUBUNIT OF PROTEIN KINASE CK2 IN COMPLEX WITH THE NUCLEOTIDE COMPETITIVE INHIBITOR EMODIN
Descriptor: 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE, PROTEIN KINASE CK2, ALPHA SUBUNIT
Authors:Battistutta, R, Sarno, S, De Moliner, E, Papinutto, E, Zanotti, G, Pinna, L.A.
Deposit date:2000-05-17
Release date:2001-05-23
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:The replacement of ATP by the competitive inhibitor emodin induces conformational modifications in the catalytic site of protein kinase CK2.
J.Biol.Chem., 275, 2000
1ZOG
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BU of 1zog by Molmil
Crystal structure of protein kinase CK2 in complex with TBB-derivatives
Descriptor: 4,5,6,7-TETRABROMO-2-(METHYLSULFANYL)-1H-BENZIMIDAZOLE, PROTEIN KINASE CK2, alpha SUBUNIT
Authors:Battistutta, R, Mazzorana, M, Sarno, S, Kazimierczuk, Z, Zanotti, G, Pinna, L.A.
Deposit date:2005-05-13
Release date:2005-11-29
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Inspecting the structure-activity relationship of protein kinase CK2 inhibitors derived from tetrabromo-benzimidazole.
Chem.Biol., 12, 2005
1ZOH
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BU of 1zoh by Molmil
Crystal structure of protein kinase CK2 in complex with TBB-derivatives inhibitors
Descriptor: 1,2-ETHANEDIOL, 5,6,7,8-TETRABROMO-1-METHYL-2,3-DIHYDRO-1H-IMIDAZO[1,2-A]BENZIMIDAZOLE, CHLORIDE ION, ...
Authors:Battistutta, R, Mazzorana, M, Sarno, S, Kazimierczuk, Z, Zanotti, G, Pinna, L.A.
Deposit date:2005-05-13
Release date:2005-11-29
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Inspecting the structure-activity relationship of protein kinase CK2 inhibitors derived from tetrabromo-benzimidazole.
Chem.Biol., 12, 2005
1ZOE
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BU of 1zoe by Molmil
Crystal structure of protein kinase CK2 in complex with TBB-derivatives inhibitors
Descriptor: 4,5,6,7-TETRABROMO-N,N-DIMETHYL-1H-BENZIMIDAZOL-2-AMINE, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
Authors:Battistutta, R, Mazzorana, M, Sarno, S, Kazimierczuk, Z, Zanotti, G, Pinna, L.A.
Deposit date:2005-05-13
Release date:2005-11-29
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Inspecting the structure-activity relationship of protein kinase CK2 inhibitors derived from tetrabromo-benzimidazole.
Chem.Biol., 12, 2005
1J91
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BU of 1j91 by Molmil
Crystal structure of Z. mays CK2 kinase alpha subunit in complex with the ATP-competitive inhibitor 4,5,6,7-tetrabromobenzotriazole
Descriptor: 4,5,6,7-TETRABROMOBENZOTRIAZOLE, CASEIN KINASE II, ALPHA CHAIN
Authors:Battistutta, R, De Moliner, E, Sarno, S, Zanotti, G, Pinna, L.A.
Deposit date:2001-05-23
Release date:2002-05-29
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:Structural features underlying selective inhibition of protein kinase CK2 by ATP site-directed tetrabromo-2-benzotriazole.
Protein Sci., 10, 2001
1JAM
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BU of 1jam by Molmil
Crystal structure of apo-form of Z. Mays CK2 protein kinase alpha subunit
Descriptor: CASEIN KINASE II, ALPHA CHAIN
Authors:Battistutta, R, De Moliner, E, Sarno, S, Zanotti, G, Pinna, L.A.
Deposit date:2001-05-31
Release date:2002-05-31
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Structural features underlying selective inhibition of protein kinase CK2 by ATP site-directed tetrabromo-2-benzotriazole.
Protein Sci., 10, 2001
1M2R
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BU of 1m2r by Molmil
Crystal structure of 5,8-di-amino-1,4-di-hydroxy-anthraquinone/CK2 kinase complex
Descriptor: 5,8-DI-AMINO-1,4-DIHYDROXY-ANTHRAQUINONE, CASEIN kinase II, alpha chain
Authors:De Moliner, E, Moro, S, Sarno, S, Zagotto, G, Zanotti, G, Pinna, L.A, Battistutta, R.
Deposit date:2002-06-25
Release date:2003-06-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Inhibition of protein kinase CK2 by anthraquinone-related compounds. A structural insight
J.Biol.Chem., 278, 2003
1M2P
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BU of 1m2p by Molmil
Crystal structure of 1,8-di-hydroxy-4-nitro-anthraquinone/CK2 kinase complex
Descriptor: 1,8-DI-HYDROXY-4-NITRO-ANTHRAQUINONE, Casein kinase II, alpha chain
Authors:De Moliner, E, Moro, S, Sarno, S, Zagotto, G, Zanotti, G, Pinna, L.A, Battistutta, R.
Deposit date:2002-06-25
Release date:2003-06-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Inhibition of protein kinase CK2 by anthraquinone-related compounds. A structural insight
J.Biol.Chem., 278, 2003
1M2Q
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BU of 1m2q by Molmil
Crystal structure of 1,8-di-hydroxy-4-nitro-xanten-9-one/CK2 kinase complex
Descriptor: 1,8-DI-HYDROXY-4-NITRO-XANTHEN-9-ONE, Casein kinase II, alpha chain
Authors:De Moliner, E, Sarno, S, Moro, S, Zagotto, G, Zanotti, G, Pinna, L.A, Battistutta, R.
Deposit date:2002-06-25
Release date:2003-06-17
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Inhibition of protein kinase CK2 by anthraquinone-related compounds. A structural insight
J.Biol.Chem., 278, 2003
3KXH
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BU of 3kxh by Molmil
Crystal structure of Z. mays CK2 kinase alpha subunit in complex with the inhibitor (2-dymethylammino-4,5,6,7-tetrabromobenzoimidazol-1yl-acetic acid (K66)
Descriptor: Casein kinase II subunit alpha, DI(HYDROXYETHYL)ETHER, [4,5,6,7-tetrabromo-2-(dimethylamino)-1H-benzimidazol-1-yl]acetic acid
Authors:Papinutto, E, Franchin, C, Battistutta, R.
Deposit date:2009-12-03
Release date:2010-11-17
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:ATP site-directed inhibitors of protein kinase CK2: an update.
Curr Top Med Chem, 11, 2011
3KXN
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BU of 3kxn by Molmil
Crystal structure of Z. mays CK2 kinase alpha subunit in complex with the inhibitor tetraiodobenzimidazole (K88)
Descriptor: 4,5,6,7-tetraiodo-1H-benzimidazole, Casein kinase II subunit alpha
Authors:Papinutto, E, Franchin, C, Battistutta, R.
Deposit date:2009-12-03
Release date:2010-11-17
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2 Å)
Cite:ATP site-directed inhibitors of protein kinase CK2: an update.
Curr Top Med Chem, 11, 2011
3KXM
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BU of 3kxm by Molmil
Crystal structure of Z. mays CK2 kinase alpha subunit in complex with the inhibitor K74
Descriptor: Casein kinase II subunit alpha, N-methyl-2-[(4,5,6,7-tetrabromo-1-methyl-1H-benzimidazol-2-yl)sulfanyl]acetamide
Authors:Papinutto, E, Franchin, C, Battistutta, R.
Deposit date:2009-12-03
Release date:2010-11-17
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:ATP site-directed inhibitors of protein kinase CK2: an update.
Curr Top Med Chem, 11, 2011
3KXG
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BU of 3kxg by Molmil
Crystal structure of Z. mays CK2 kinase alpha subunit in complex with the inhibitor 3,4,5,6,7-pentabromo-1H-indazole (K64)
Descriptor: 3,4,5,6,7-pentabromo-1H-indazole, Casein kinase II subunit alpha
Authors:Papinutto, E, Franchin, C, Battistutta, R.
Deposit date:2009-12-03
Release date:2010-11-17
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:ATP site-directed inhibitors of protein kinase CK2: an update.
Curr Top Med Chem, 11, 2011
3FL5
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BU of 3fl5 by Molmil
Protein kinase CK2 in complex with the inhibitor Quinalizarin
Descriptor: 1,2,5,8-tetrahydroxyanthracene-9,10-dione, Casein kinase II subunit alpha, DI(HYDROXYETHYL)ETHER
Authors:Mazzorana, M, Franchin, C, Battistutta, R.
Deposit date:2008-12-18
Release date:2009-08-18
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Quinalizarin as a potent, selective and cell-permeable inhibitor of protein kinase CK2
Biochem.J., 421, 2009
6QS5
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BU of 6qs5 by Molmil
Crystal Structure of maize CK2 in complex with tyrphostin AG99
Descriptor: (~{E})-3-[3,4-bis(oxidanyl)phenyl]-2-cyano-prop-2-enamide, Casein kinase II subunit alpha
Authors:Lolli, G, Mazzorana, M, Battistutta, R.
Deposit date:2019-02-20
Release date:2019-02-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.961 Å)
Cite:Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight.
Biochemistry, 51, 2012
4KWP
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BU of 4kwp by Molmil
Crystal Structure of Human CK2-alpha in complex with a benzimidazole inhibitor (K164) at 1.25 A resolution
Descriptor: 1,2-ETHANEDIOL, 4,5,6,7-tetrabromo-1-(2-deoxy-beta-D-erythro-pentofuranosyl)-1H-benzimidazole, Casein kinase II subunit alpha, ...
Authors:Ranchio, A, Lolli, G, Battistutta, R.
Deposit date:2013-05-24
Release date:2014-04-09
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Cell-permeable dual inhibitors of protein kinases CK2 and PIM-1: structural features and pharmacological potential.
Cell.Mol.Life Sci., 71, 2014
1DAY
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BU of 1day by Molmil
CRYSTAL STRUCTURE OF A BINARY COMPLEX OF PROTEIN KINASE CK2 (ALPHA-SUBUNIT) AND MG-GMPPNP
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, PROTEIN KINASE CK2
Authors:Niefind, K, Puetter, M, Guerra, B, Issinger, O.G, Schomburg, D.
Deposit date:1999-11-01
Release date:2000-05-03
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:GTP plus water mimic ATP in the active site of protein kinase CK2.
Nat.Struct.Biol., 6, 1999
1DAW
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BU of 1daw by Molmil
CRYSTAL STRUCTURE OF A BINARY COMPLEX OF PROTEIN KINASE CK2 (ALPHA-SUBUNIT) AND MG-AMPPNP
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, PROTEIN KINASE CK2
Authors:Niefind, K, Puetter, M, Guerra, B, Issinger, O.G, Schomburg, D.
Deposit date:1999-11-01
Release date:2000-05-03
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:GTP plus water mimic ATP in the active site of protein kinase CK2.
Nat.Struct.Biol., 6, 1999
1LP4
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BU of 1lp4 by Molmil
Crystal structure of a binary complex of the catalytic subunit of protein kinase CK2 with Mg-AMPPNP
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Protein kinase CK2
Authors:Niefind, K, Puetter, M, Guerra, B, Issinger, O.-G, Schomburg, D.
Deposit date:2002-05-07
Release date:2002-05-29
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate.
J.Mol.Biol., 347, 2005
1LPU
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BU of 1lpu by Molmil
Low Temperature Crystal Structure of the Apo-form of the catalytic subunit of protein kinase CK2 from Zea mays
Descriptor: BENZAMIDINE, Protein kinase CK2
Authors:Niefind, K, Puetter, M, Guerra, B, Issinger, O.-G, Schomburg, D.
Deposit date:2002-05-08
Release date:2002-05-29
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate.
J.Mol.Biol., 347, 2005
1LR4
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BU of 1lr4 by Molmil
Room Temperature Crystal Structure of the Apo-form of the catalytic subunit of protein kinase CK2 from Zea mays
Descriptor: BENZAMIDINE, Protein kinase CK2
Authors:Niefind, K, Puetter, M, Guerra, B, Issinger, O.-G, Schomburg, D.
Deposit date:2002-05-14
Release date:2002-05-29
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate.
J.Mol.Biol., 347, 2005
4DGL
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BU of 4dgl by Molmil
Crystal Structure of the CK2 Tetrameric Holoenzyme
Descriptor: Casein kinase II subunit alpha, Casein kinase II subunit beta, ZINC ION
Authors:Lolli, G, Battistutta, R.
Deposit date:2012-01-26
Release date:2012-05-02
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural determinants of protein kinase CK2 regulation by autoinhibitory polymerization.
Acs Chem.Biol., 7, 2012
4DGM
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BU of 4dgm by Molmil
Crystal Structure of maize CK2 in complex with the inhibitor apigenin
Descriptor: 1,2-ETHANEDIOL, 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one, Casein kinase II subunit alpha, ...
Authors:Lolli, G, Mazzorana, M, Battistutta, R.
Deposit date:2012-01-26
Release date:2012-08-01
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight.
Biochemistry, 51, 2012
4DGN
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Crystal Structure of maize CK2 in complex with the inhibitor luteolin
Descriptor: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one, Casein kinase II subunit alpha
Authors:Lolli, G, Mazzorana, M, Battistutta, R.
Deposit date:2012-01-26
Release date:2012-08-01
Last modified:2013-01-02
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Inhibition of protein kinase CK2 by flavonoids and tyrphostins. A structural insight.
Biochemistry, 51, 2012

 

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