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5TVF
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BU of 5tvf by Molmil
Crystal structure of Trypanosoma brucei AdoMetDC/prozyme heterodimer in complex with inhibitor CGP 40215
Descriptor: 1,4-DIAMINOBUTANE, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 3-[C-[N'-(3-CARBAMIMIDOYL-BENZYLIDENIUM)-HYDRAZINO]-[[AMINOMETHYLIDENE]AMINIUM]-IMINOMETHYL]-BENZAMIDINIUM, ...
Authors:Phillips, M.A, Volkov, O.A, Chen, Z, Tomchick, D.R.
Deposit date:2016-11-08
Release date:2017-01-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog.
Elife, 5, 2016
6DFT
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BU of 6dft by Molmil
Trypanosoma brucei deoxyhypusine synthase
Descriptor: Deoxyhypusine synthase, Deoxyhypusine synthase regulatory subunit, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Tomchick, D.R, Phillips, M.A, Afanador, G.A.
Deposit date:2018-05-15
Release date:2018-08-08
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Trypanosomatid Deoxyhypusine Synthase Activity Is Dependent on Shared Active-Site Complementation between Pseudoenzyme Paralogs.
Structure, 26, 2018
6BM7
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BU of 6bm7 by Molmil
Crystal structure of Trypanosoma brucei AdoMetDC/prozyme heterodimer in complex with pyrimidineamine inhibitor UTSAM568
Descriptor: 1,4-DIAMINOBUTANE, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-amino-4-[(3,5-dibromophenyl)amino]-6-methylpyrimidin-1-ium, ...
Authors:Volkov, O.A, Chen, Z, Phillips, M.A.
Deposit date:2017-11-13
Release date:2018-01-03
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:Species-Selective Pyrimidineamine Inhibitors of Trypanosoma brucei S-Adenosylmethionine Decarboxylase.
J. Med. Chem., 61, 2018
6E0B
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BU of 6e0b by Molmil
Plasmodium falciparum dihydroorotate dehydrogenase C276F mutant bound with triazolopyrimidine-based inhibitor DSM1
Descriptor: 5-methyl-7-(naphthalen-2-ylamino)-1H-[1,2,4]triazolo[1,5-a]pyrimidine-3,8-diium, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
Authors:Tomchick, D.R, Phillips, M.A, Deng, X.
Deposit date:2018-07-06
Release date:2018-11-14
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265.
ACS Infect Dis, 5, 2019
1D7K
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BU of 1d7k by Molmil
CRYSTAL STRUCTURE OF HUMAN ORNITHINE DECARBOXYLASE AT 2.1 ANGSTROMS RESOLUTION
Descriptor: HUMAN ORNITHINE DECARBOXYLASE
Authors:Almrud, J.J, Oliveira, M.A, Kern, A.D, Grishin, N.V, Phillips, M.A, Hackert, M.L.
Deposit date:1999-10-18
Release date:2000-10-25
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding.
J.Mol.Biol., 295, 2000
3I6R
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BU of 3i6r by Molmil
Plasmodium falciparum dihydroorotate dehydrogenase bound with triazolopyrimidine-based inhibitor DSM74
Descriptor: 5-methyl-N-[4-(trifluoromethyl)phenyl][1,2,4]triazolo[1,5-a]pyrimidin-7-amine, Dihydroorotate dehydrogenase homolog, mitochondrial, ...
Authors:Deng, X, Phillips, M.A.
Deposit date:2009-07-07
Release date:2009-07-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds.
J.Biol.Chem., 284, 2009
3I65
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BU of 3i65 by Molmil
Plasmodium falciparum dihydroorotate dehydrogenase bound with triazolopyrimidine-based inhibitor DSM1
Descriptor: 5-methyl-7-(naphthalen-2-ylamino)-1H-[1,2,4]triazolo[1,5-a]pyrimidine-3,8-diium, Dihydroorotate dehydrogenase homolog, mitochondrial, ...
Authors:Deng, X, Phillips, M.A.
Deposit date:2009-07-06
Release date:2009-07-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds.
J.Biol.Chem., 284, 2009
3I68
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BU of 3i68 by Molmil
Plasmodium falciparum dihydroorotate dehydrogenase bound with triazolopyrimidine-based inhibitor DSM2
Descriptor: Dihydroorotate dehydrogenase homolog, mitochondrial, FLAVIN MONONUCLEOTIDE, ...
Authors:Deng, X, Phillips, M.A.
Deposit date:2009-07-06
Release date:2009-07-28
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural plasticity of malaria dihydroorotate dehydrogenase allows selective binding of diverse chemical scaffolds.
J.Biol.Chem., 284, 2009
4IGH
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BU of 4igh by Molmil
High resolution crystal structure of human dihydroorotate dehydrogenase bound with 4-quinoline carboxylic acid analog
Descriptor: 3-[decyl(dimethyl)ammonio]propane-1-sulfonate, 6-fluoro-2-[2-methyl-4-phenoxy-5-(propan-2-yl)phenyl]quinoline-4-carboxylic acid, Dihydroorotate dehydrogenase (quinone), ...
Authors:Deng, X, Das, P, Fontoura, B.M.A, Phillips, M.A, De Brabander, J.K.
Deposit date:2012-12-17
Release date:2013-08-21
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:SAR Based Optimization of a 4-Quinoline Carboxylic Acid Analog with Potent Anti-Viral Activity.
ACS MED.CHEM.LETT., 4, 2013
5TVM
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BU of 5tvm by Molmil
Crystal structure of Trypanosoma brucei AdoMetDC/prozyme heterodimer
Descriptor: 1,4-DIAMINOBUTANE, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, S-adenosylmethionine decarboxylase alpha chain, ...
Authors:Volkov, O.A, Chen, Z, Tomchick, D.R, Phillips, M.A.
Deposit date:2016-11-09
Release date:2017-01-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.408 Å)
Cite:Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog.
Elife, 5, 2016
5TVO
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BU of 5tvo by Molmil
Crystal structure of Trypanosoma brucei AdoMetDC-delta26 monomer
Descriptor: PYRUVIC ACID, S-adenosylmethionine decarboxylase proenzyme, SODIUM ION
Authors:Volkov, O.A, Ariagno, C, Chen, Z, Tomchick, D.R, Phillips, M.A.
Deposit date:2016-11-09
Release date:2016-12-28
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.481 Å)
Cite:Relief of autoinhibition by conformational switch explains enzyme activation by a catalytically dead paralog.
Elife, 5, 2016
3N29
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BU of 3n29 by Molmil
Crystal structure of carboxynorspermidine decarboxylase complexed with Norspermidine from Campylobacter jejuni
Descriptor: Carboxynorspermidine decarboxylase, GLYCEROL, N-(3-aminopropyl)propane-1,3-diamine, ...
Authors:Deng, X, Lee, J, Michael, A.J, Tomchick, D.R, Goldsmith, E.J, Phillips, M.A.
Deposit date:2010-05-17
Release date:2010-06-09
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Evolution of substrate specificity within a diverse family of beta/alpha-barrel-fold basic amino acid decarboxylases: X-ray structure determination of enzymes with specificity for L-arginine and carboxynorspermidine.
J.Biol.Chem., 285, 2010
3N2O
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BU of 3n2o by Molmil
X-ray crystal structure of arginine decarboxylase complexed with Arginine from Vibrio vulnificus
Descriptor: AGMATINE, Biosynthetic arginine decarboxylase, PYRIDOXAL-5'-PHOSPHATE
Authors:Deng, X, Lee, J, Michael, A.J, Tomchick, D.R, Goldsmith, E.J, Phillips, M.A.
Deposit date:2010-05-18
Release date:2010-06-09
Last modified:2012-02-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Evolution of substrate specificity within a diverse family of beta/alpha-barrel-fold basic amino acid decarboxylases: X-ray structure determination of enzymes with specificity for L-arginine and carboxynorspermidine.
J.Biol.Chem., 285, 2010
3O8A
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BU of 3o8a by Molmil
Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with novel Inhibitor Genz667348
Descriptor: Dihydroorotate dehydrogenase homolog, mitochondrial, FLAVIN MONONUCLEOTIDE, ...
Authors:Deng, X, Booker, M.L, Phillips, M.A.
Deposit date:2010-08-02
Release date:2010-08-18
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Novel inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase with anti-malarial activity in the mouse model.
J.Biol.Chem., 285, 2010
1SZR
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BU of 1szr by Molmil
A Dimer interface mutant of ornithine decarboxylase reveals structure of gem diamine intermediate
Descriptor: N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE], N~2~-({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)-D-ORNITHINE, Ornithine decarboxylase, ...
Authors:Jackson, L.K, Baldwin, J, Goldsmith, E.J, Phillips, M.A.
Deposit date:2004-04-06
Release date:2004-10-26
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Multiple active site conformations revealed by distant site mutation in ornithine decarboxylase
Biochemistry, 43, 2004
4ORI
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BU of 4ori by Molmil
Rat dihydroorotate dehydrogenase bound with DSM338 (N-[3,5-difluoro-4-(trifluoromethyl)phenyl]-5-methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine)
Descriptor: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ...
Authors:Deng, X, Phillips, M.A.
Deposit date:2014-02-11
Release date:2014-06-04
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors.
J.Med.Chem., 57, 2014
4OQV
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BU of 4oqv by Molmil
High resolution crystal structure of human dihydroorotate dehydrogenase bound with DSM338 (N-[3,5-difluoro-4-(trifluoromethyl)phenyl]-5-methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine)
Descriptor: ACETIC ACID, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
Authors:Deng, X, Phillips, M.A.
Deposit date:2014-02-10
Release date:2014-06-04
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.23 Å)
Cite:Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors.
J.Med.Chem., 57, 2014
4ORM
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BU of 4orm by Molmil
Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM338 (N-[3,5-difluoro-4-(trifluoromethyl)phenyl]-5-methyl-2-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyrimidin-7-amine)
Descriptor: Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, ...
Authors:Deng, X, Phillips, M.A.
Deposit date:2014-02-11
Release date:2014-06-04
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Fluorine Modulates Species Selectivity in the Triazolopyrimidine Class of Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors.
J.Med.Chem., 57, 2014
1F3T
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BU of 1f3t by Molmil
CRYSTAL STRUCTURE OF TRYPANOSOMA BRUCEI ORNITHINE DECARBOXYLASE (ODC) COMPLEXED WITH PUTRESCINE, ODC'S REACTION PRODUCT.
Descriptor: 1,4-DIAMINOBUTANE, ORNITHINE DECARBOXYLASE, PYRIDOXAL-5'-PHOSPHATE
Authors:Jackson, L.K, Brooks, H.B, Osterman, A.L, Goldsmith, E.J, Phillips, M.A.
Deposit date:2000-06-06
Release date:2000-11-22
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Altering the reaction specificity of eukaryotic ornithine decarboxylase.
Biochemistry, 39, 2000
1NJJ
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BU of 1njj by Molmil
Crystal structure determination of T. brucei ornithine decarboxylase bound to D-ornithine and to G418
Descriptor: GENETICIN, N~2~-({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)-D-ORNITHINE, ornithine decarboxylase
Authors:Jackson, L.K, Goldsmith, E.J, Phillips, M.A.
Deposit date:2002-12-31
Release date:2003-08-26
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:X-ray Structure Determination of Trypanosoma brucei Ornithine Decarboxylase Bound to D-Ornithine and to G418: INSIGHTS INTO SUBSTRATE BINDING AND ODC CONFORMATIONAL FLEXIBILITY.
J.Biol.Chem., 278, 2003
1QU4
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BU of 1qu4 by Molmil
CRYSTAL STRUCTURE OF TRYPANOSOMA BRUCEI ORNITHINE DECARBOXYLASE
Descriptor: ORNITHINE DECARBOXYLASE, PYRIDOXAL-5'-PHOSPHATE
Authors:Grishin, N.V, Osterman, A.L, Brooks, H.B, Phillips, M.A, Goldsmith, E.J.
Deposit date:1999-07-06
Release date:1999-11-17
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:X-ray structure of ornithine decarboxylase from Trypanosoma brucei: the native structure and the structure in complex with alpha-difluoromethylornithine.
Biochemistry, 38, 1999
1RKU
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BU of 1rku by Molmil
Crystal Structure of ThrH gene product of Pseudomonas Aeruginosa
Descriptor: 1,2-ETHANEDIOL, MAGNESIUM ION, homoserine kinase
Authors:Singh, S.K, Yang, K, Subramanian, K, Karthikeyan, S, Huynh, T, Zhang, X, Phillips, M.A, Zhang, H.
Deposit date:2003-11-23
Release date:2004-03-30
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:The thrH Gene Product of Pseudomonas aeruginosa Is a Dual Activity Enzyme with a Novel Phosphoserine:Homoserine Phosphotransferase Activity.
J.Biol.Chem., 279, 2004
1RKV
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BU of 1rkv by Molmil
Structure of Phosphate complex of ThrH from Pseudomonas aeruginosa
Descriptor: 1,2-ETHANEDIOL, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Singh, S.K, Yang, K, Subramanian, K, Karthikeyan, S, Huynh, T, Zhang, X, Phillips, M.A, Zhang, H.
Deposit date:2003-11-23
Release date:2004-03-30
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The thrH Gene Product of Pseudomonas aeruginosa Is a Dual Activity Enzyme with a Novel Phosphoserine:Homoserine Phosphotransferase Activity.
J.Biol.Chem., 279, 2004
2NVA
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BU of 2nva by Molmil
The X-ray crystal structure of the Paramecium bursaria Chlorella virus arginine decarboxylase bound to agmatine
Descriptor: (4-{[(4-{[AMINO(IMINO)METHYL]AMINO}BUTYL)AMINO]METHYL}-5-HYDROXY-6-METHYLPYRIDIN-3-YL)METHYL DIHYDROGEN PHOSPHATE, arginine decarboxylase, A207R protein
Authors:Shah, R.H, Akella, R, Goldsmith, E, Phillips, M.A.
Deposit date:2006-11-11
Release date:2007-03-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:X-ray Structure of Paramecium bursaria Chlorella Virus Arginine Decarboxylase: Insight into the Structural Basis for Substrate Specificity.
Biochemistry, 46, 2007
2NV9
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BU of 2nv9 by Molmil
The X-ray Crystal Structure of the Paramecium bursaria Chlorella virus arginine decarboxylase
Descriptor: A207R protein, arginine decarboxylase, PYRIDOXAL-5'-PHOSPHATE
Authors:Shah, R.H, Akella, R, Goldsmith, E, Phillips, M.A.
Deposit date:2006-11-11
Release date:2007-03-20
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:X-ray Structure of Paramecium bursaria Chlorella Virus Arginine Decarboxylase: Insight into the Structural Basis for Substrate Specificity.
Biochemistry, 46, 2007

 

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