Author results

5Y41
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CRYSTAL STRUCTURE OF LIGAND-BOUND NURR1-LBD
Descriptor:Nuclear receptor subfamily 4 group A member 2, (13E,15S)-15-hydroxy-9-oxoprosta-10,13-dien-1-oic acid, TRIETHYLENE GLYCOL, ...
Authors:Sreekanth, R., Lescar, J., Yoon, H.S.
Deposit date:2017-07-31
Release date:2018-12-26
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Co-crystal structure and function of Nurr1 bound to the cyclopentenone prostaglandin A1
To be published
6DHB
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CRYSTAL STRUCTURE OF THE HUMAN TIM-3 WITH BOUND CALCIUM
Descriptor:Hepatitis A virus cellular receptor 2, CALCIUM ION, BENZOIC ACID, ...
Authors:Gandhi, A.K., Kim, W.M., Huang, Y.H., Bonsor, D., Sundberg, E., Sun, Z.-Y., Petsko, G.A., Kuchroo, V., Blumberg, R.S.
Deposit date:2018-05-19
Release date:2018-12-12
Last modified:2018-12-19
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:High resolution X-ray and NMR structural study of human T-cell immunoglobulin and mucin domain containing protein-3.
Sci Rep, 8, 2018
6C2H
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CRYSTAL STRUCTURES OF CYSTATHIONINE BETA-SYNTHASE FROM SACCHAROMYCES CEREVISIAE: THE STRUCTURE OF THE CATALYTIC CORE
Descriptor:Cystathionine beta-synthase, PYRIDOXAL-5'-PHOSPHATE, ACETATE ION, ...
Authors:Kreinbring, C.A., Tu, Y., Liu, D., Petsko, G.A., Ringe, D.
Deposit date:2018-01-08
Release date:2018-04-25
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Crystal Structures of Cystathionine beta-Synthase from Saccharomyces cerevisiae: One Enzymatic Step at a Time.
Biochemistry, 57, 2018
6C2Q
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CRYSTAL STRUCTURES OF CYSTATHIONINE BETA-SYNTHASE FROM SACCHAROMYCES CEREVISIAE: THE STRUCTURE OF THE PLP-L-SERINE INTERMEDIATE
Descriptor:Cystathionine beta-synthase, L-Serine, N-[[3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]-4-pyridinyl]methylene], ...
Authors:Kreinbring, C.A., Tu, Y., Liu, D., Petsko, G.A., Ringe, D.
Deposit date:2018-01-08
Release date:2018-04-25
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Crystal Structures of Cystathionine beta-Synthase from Saccharomyces cerevisiae: One Enzymatic Step at a Time.
Biochemistry, 57, 2018
6C2Z
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CRYSTAL STRUCTURES OF CYSTATHIONINE BETA-SYNTHASE FROM SACCHAROMYCES CEREVISIAE: THE STRUCTURE OF THE PLP-AMINOACRYLATE INTERMEDIATE
Descriptor:Cystathionine beta-synthase, 2-[({3-HYDROXY-2-METHYL-5-[(PHOSPHONOOXY)METHYL]PYRIDIN-4-YL}METHYL)AMINO]ACRYLIC ACID, CALCIUM ION, ...
Authors:Kreinbring, C.A., Tu, Y., Liu, D., Petsko, G.A., Ringe, D.
Deposit date:2018-01-09
Release date:2018-04-25
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (1.37 Å)
Cite:Crystal Structures of Cystathionine beta-Synthase from Saccharomyces cerevisiae: One Enzymatic Step at a Time.
Biochemistry, 57, 2018
6C4P
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CRYSTAL STRUCTURES OF CYSTATHIONINE BETA-SYNTHASE FROM SACCHAROMYCES CEREVISIAE: THE STRUCTURE OF THE PMP COMPLEX
Descriptor:Cystathionine beta-synthase, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, CALCIUM ION, ...
Authors:Kreinbring, C.A., Tu, Y., Liu, D., Berkowitz, D.B., Petsko, G.A., Ringe, D.
Deposit date:2018-01-12
Release date:2018-04-25
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structures of Cystathionine beta-Synthase from Saccharomyces cerevisiae: One Enzymatic Step at a Time.
Biochemistry, 57, 2018
5WJ2
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CRYSTAL STRUCTURE OF THE GREEN FLUORESCENT PROTEIN CLOVER
Descriptor:Green fluorescent protein
Authors:Liu, C., Campbell, B.C., Petsko, G.A.
Deposit date:2017-07-21
Release date:2018-01-17
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (2.409 Å)
Cite:Crystal Structure of Green Fluorescent Protein Clover and Design of Clover-Based Redox Sensors.
Structure, 26, 2018
5WJ3
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CRYSTAL STRUCTURE OF GREEN FLUORESCENT PROTEIN CLOVER MUTANT S147C/Q204C
Descriptor:Green fluorescent protein
Authors:Liu, C., Campbell, B.C., Petsko, G.A.
Deposit date:2017-07-21
Release date:2018-01-17
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (1.351 Å)
Cite:Crystal Structure of Green Fluorescent Protein Clover and Design of Clover-Based Redox Sensors.
Structure, 26, 2018
5WJ4
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CRYSTAL STRUCTURE OF REDOX-SENSITIVE GREEN FLUORESCENT PROTEIN CLOVER MUTANT ROCLOVER1
Descriptor:Green fluorescent protein
Authors:Liu, C., Campbell, B.C., Petsko, G.A.
Deposit date:2017-07-21
Release date:2018-01-17
Last modified:2018-02-14
Method:X-RAY DIFFRACTION (1.631 Å)
Cite:Crystal Structure of Green Fluorescent Protein Clover and Design of Clover-Based Redox Sensors.
Structure, 26, 2018
5UCD
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BENZALDEHYDE DEHYDROGENASE, A CLASS 3 ALDEHYDE DEHYDROGENASE, WITH BOUND NADP+ AND BENZOATE ADDUCT
Descriptor:NAD(P)-dependent benzaldehyde dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Zahniser, M.P.D., Prasad, S., Kneen, M.M., Kreinbring, C.A., Petsko, G.A., Ringe, D., McLeish, M.J.
Deposit date:2016-12-22
Release date:2017-04-12
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Structure and mechanism of benzaldehyde dehydrogenase from Pseudomonas putida ATCC 12633, a member of the Class 3 aldehyde dehydrogenase superfamily.
Protein Eng. Des. Sel., 30, 2017
5UGQ
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CRYSTAL STRUCTURE OF HIP1 (RV2224C)
Descriptor:Carboxylesterase A
Authors:Naffin-Olivos, J.L., Daab, A., White, A., Goldfarb, N., Milne, A.C., Liu, D., Dunn, B.M., Rengarajan, J., Petsko, G.A., Ringe, D.
Deposit date:2017-01-09
Release date:2017-04-12
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.609 Å)
Cite:Structure Determination of Mycobacterium tuberculosis Serine Protease Hip1 (Rv2224c).
Biochemistry, 56, 2017
5UNO
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CRYSTAL STRUCTURE OF HIP1 (RV2224C)
Descriptor:Carboxylesterase A
Authors:Naffin-Olivos, J.L., Daab, A., White, A., Goldfarb, N., Milne, A.C., Liu, D., Dunn, B.M., Rengarajan, J., Petsko, G.A., Ringe, D.
Deposit date:2017-01-31
Release date:2017-04-12
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.603 Å)
Cite:Structure Determination of Mycobacterium tuberculosis Serine Protease Hip1 (Rv2224c).
Biochemistry, 56, 2017
5UOH
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CRYSTAL STRUCTURE OF HIP1 (RV2224C) T466A MUTANT
Descriptor:Carboxylesterase A
Authors:Naffin-Olivos, J.L., Daab, A., White, A., Goldfarb, N., Milne, A.C., Liu, D., Baikovitz, J., Dunn, B.M., Rengarajan, J., Petsko, G.A., Ringe, D.
Deposit date:2017-01-31
Release date:2017-04-12
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.609 Å)
Cite:Structure Determination of Mycobacterium tuberculosis Serine Protease Hip1 (Rv2224c).
Biochemistry, 56, 2017
5T4J
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PLP AND GABA TRIGGER GABR-MEDIATED TRANSCRIPTION REGULATION IN BACILLUS SUBSIDIES VIA EXTERNAL ALDIMINE FORMATION
Descriptor:HTH-type transcriptional regulatory protein GabR, PYRIDOXAL-5'-PHOSPHATE, GAMMA-AMINO-BUTANOIC ACID
Authors:Wu, R., Sanishvili, R., Belitsky, B.R., Juncosa, J.I., Le, H.V., Lehrer, H.J.S., Farley, M., Silverman, R.B., Petsko, G.A., Ringe, D., Liu, D.
Deposit date:2016-08-29
Release date:2017-03-29
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.231 Å)
Cite:PLP and GABA trigger GabR-mediated transcription regulation in Bacillus subtilis via external aldimine formation.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5T4K
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PLP AND GABA TRIGGER GABR-MEDIATED TRANSCRIPTION REGULATION IN BACILLUS SUBSIDIES VIA EXTERNAL ALDIMINE FORMATION
Descriptor:HTH-type transcriptional regulatory protein GabR, (4S)-5-fluoro-4-[({3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methyl)amino]pentanoic acid
Authors:Wu, R., Sanishvili, R., Belitsky, B.R., Juncosa, J.I., Le, H.V., Lehrer, H.J.S., Farley, M., Silverman, R.B., Petsko, G.A., Ringe, D., Liu, D.
Deposit date:2016-08-29
Release date:2017-03-29
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.245 Å)
Cite:PLP and GABA trigger GabR-mediated transcription regulation in Bacillus subtilis via external aldimine formation.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5T4L
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PLP AND GABA TRIGGER GABR-MEDIATED TRANSCRIPTION REGULATION IN BACILLUS SUBSIDIES VIA EXTERNAL ALDIMINE FORMATION
Descriptor:Aspartate aminotransferase, (4R)-4-amino-6-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}hexanoic acid
Authors:Wu, R., Sanishvili, R., Belitsky, B.R., Juncosa, J.I., Le, H.V., Lehrer, H.J.S., Farley, M., Silverman, R.B., Petsko, G.A., Ringe, D., Liu, D.
Deposit date:2016-08-29
Release date:2017-03-29
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:PLP and GABA trigger GabR-mediated transcription regulation in Bacillus subtilis via external aldimine formation.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5T1J
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CRYSTAL STRUCTURE OF THE TBOX DNA BINDING DOMAIN OF THE TRANSCRIPTION FACTOR T-BET
Descriptor:T-box transcription factor TBX21, DNA
Authors:Liu, C.F., Brandt, G.S., Hoang, Q., Hwang, E.S., Naumova, N., Lazarevic, V., Dekker, J., Glimcher, L.H., Ringe, D., Petsko, G.A.
Deposit date:2016-08-19
Release date:2016-10-26
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.947 Å)
Cite:Crystal structure of the DNA binding domain of the transcription factor T-bet suggests simultaneous recognition of distant genome sites.
Proc.Natl.Acad.Sci.USA, 113, 2016
5I8S
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STRUCTURE OF MOUSE ACIREDUCTONE DIOXYGENASE WITH NI2+ ION AND PENTANOIC ACID IN THE ACTIVE SITE
Descriptor:1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, NICKEL (II) ION, PENTANOIC ACID
Authors:Deshpande, A.R., Wagenpfeil, K., Pochapsky, T.C., Petsko, G.A., Ringe, D.
Deposit date:2016-02-19
Release date:2016-03-09
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Metal-Dependent Function of a Mammalian Acireductone Dioxygenase.
Biochemistry, 55, 2016
5I8T
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STRUCTURE OF MOUSE ACIREDUCTONE DIOXYGENASE WITH NI2+ ION AND D-LACTIC ACID IN THE ACTIVE SITE
Descriptor:1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, NICKEL (II) ION, LACTIC ACID, ...
Authors:Deshpande, A.R., Wagenpfeil, K., Pochapsky, T.C., Petsko, G.A., Ringe, D.
Deposit date:2016-02-19
Release date:2016-03-09
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.751 Å)
Cite:Metal-Dependent Function of a Mammalian Acireductone Dioxygenase.
Biochemistry, 55, 2016
5I8Y
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STRCUTURE OF MOUSE ACIREDUCTONE DIOXYGENASE BOUND TO CO2+ AND 2-KETO-4-(METHYLTHIO)-BUTYRIC ACID
Descriptor:1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, COBALT (II) ION, 4-(METHYLSULFANYL)-2-OXOBUTANOIC ACID
Authors:Deshpande, A.R., Wagenpfeil, K., Pochapsky, T.C., Petsko, G.A., Ringe, D.
Deposit date:2016-02-19
Release date:2016-03-09
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.942 Å)
Cite:Metal-Dependent Function of a Mammalian Acireductone Dioxygenase.
Biochemistry, 55, 2016
5I91
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STRUCTURE OF MOUSE ACIRECUTONE DIOXYGENASE WITH TO NI2+ AND 2-KETO-4-(METHYLTHIO)-BUTYRIC ACID IN THE ACTIVE SITE
Descriptor:1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, NICKEL (II) ION, 4-(METHYLSULFANYL)-2-OXOBUTANOIC ACID
Authors:Deshpande, A.R., Robinson, H., Wagenpfeil, K., Pochapsky, T.C., Petsko, G.A., Ringe, D.
Deposit date:2016-02-19
Release date:2016-03-09
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Metal-Dependent Function of a Mammalian Acireductone Dioxygenase.
Biochemistry, 55, 2016
5I93
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STRUCTURE OF MOUSE ACIREDUCTONE DIOXYGENASE WITH NI2+ AND 2-KETOPENTANOIC ACID IN THE ACTIVE SITE
Descriptor:1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase, NICKEL (II) ION, 2-oxopentanoic acid
Authors:Deshpande, A.R., Wagenpfeil, K., Pochapsky, T.C., Petsko, G.A., Ringe, D.
Deposit date:2016-02-19
Release date:2016-03-09
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.236 Å)
Cite:Metal-Dependent Function of a Mammalian Acireductone Dioxygenase.
Biochemistry, 55, 2016
5DZL
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CRYSTAL STRUCTURE OF THE PROTEIN HUMAN CEACAM1
Descriptor:Carcinoembryonic antigen-related cell adhesion molecule 1
Authors:Huang, Y.H., Russell, A., Gandhi, A.K., Kondo, Y., Chen, Q., Petsko, G.A., Blumberg, R.S.
Deposit date:2015-09-25
Release date:2015-10-07
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.4006 Å)
Cite:CEACAM1 regulates TIM-3-mediated tolerance and exhaustion.
Nature, 517, 2015
4RKW
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CRYSTAL STRUCTURE OF DJ-1
Descriptor:Protein DJ-1
Authors:Liddington, R.C.
Deposit date:2014-10-14
Release date:2015-08-26
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models.
J.Neurosci., 34, 2014
4RKY
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CRYSTAL STRUCTURE OF DJ-1 ISOFORM X1
Descriptor:Protein DJ-1
Authors:Liddington, R.C.
Deposit date:2014-10-14
Release date:2015-08-26
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Transnitrosylation from DJ-1 to PTEN attenuates neuronal cell death in parkinson's disease models.
J.Neurosci., 34, 2014