Author results

1QNL
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AMIDE RECEPTOR/NEGATIVE REGULATOR OF THE AMIDASE OPERON OF PSEUDOMONAS AERUGINOSA (AMIC) COMPLEXED WITH BUTYRAMIDE
Descriptor:ALIPHATIC AMIDASE EXPRESSION-REGULATING PROTEIN, BUTYRAMIDE
Authors:Pearl, L.H., O'Hara, B.P., Roe, S.M.
Deposit date:1999-10-19
Release date:1999-12-23
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Adaptation to Selective Pressure for Altered Ligand Specificity in the Pseudomonas Aeruginosa Amide Receptor, Amic
Protein Eng., 13, 2000
1QO0
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AMIDE RECEPTOR OF THE AMIDASE OPERON OF PSEUDOMONAS AERUGINOSA (AMIC) COMPLEXED WITH THE NEGATIVE REGULATOR AMIR.
Descriptor:AMIC, AMIR, BUTYRAMIDE
Authors:Pearl, L.H., O'Hara, B.P., Roe, S.M.
Deposit date:1999-10-26
Release date:1999-12-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal Structure and Induction Mechanism of Amic-Amir: A Ligand-Regulated Transcription Antitermination Complex
Embo J., 18, 1999
1UDI
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NUCLEOTIDE MIMICRY IN THE CRYSTAL STRUCTURE OF THE URACIL-DNA GLYCOSYLASE-URACIL GLYCOSYLASE INHIBITOR PROTEIN COMPLEX
Descriptor:URACIL-DNA GLYCOSYLASE, URACIL-DNA GLYCOSYLASE INHIBITOR PROTEIN
Authors:Pearl, L.H., Savva, R.
Deposit date:1995-10-30
Release date:1996-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Nucleotide mimicry in the crystal structure of the uracil-DNA glycosylase-uracil glycosylase inhibitor protein complex.
Nat.Struct.Biol., 2, 1995
1AM1
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ATP BINDING SITE IN THE HSP90 MOLECULAR CHAPERONE
Descriptor:HEAT SHOCK PROTEIN 90, ADENOSINE-5'-DIPHOSPHATE
Authors:Pearl, L.H., Roe, S.M., Prodromou, C.
Deposit date:1997-06-20
Release date:1998-06-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
Cell(Cambridge,Mass.), 90, 1997
1AMW
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ADP BINDING SITE IN THE HSP90 MOLECULAR CHAPERONE
Descriptor:HEAT SHOCK PROTEIN 90, ADENOSINE-5'-DIPHOSPHATE
Authors:Pearl, L.H., Roe, S.M., Prodromou, C.
Deposit date:1997-06-19
Release date:1998-06-24
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
Cell(Cambridge,Mass.), 90, 1997
1GOW
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BETA-GLYCOSIDASE FROM SULFOLOBUS SOLFATARICUS
Descriptor:BETA-GLYCOSIDASE
Authors:Pearl, L.H., Aguilar, C.F., Sanderson, I.
Deposit date:1996-09-19
Release date:1997-08-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of the beta-glycosidase from the hyperthermophilic archeon Sulfolobus solfataricus: resilience as a key factor in thermostability.
J.Mol.Biol., 271, 1997
1PEA
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AMIDE RECEPTOR/NEGATIVE REGULATOR OF THE AMIDASE OPERON OF PSEUDOMONAS AERUGINOSA (AMIC) COMPLEXED WITH ACETAMIDE
Descriptor:AMIDASE OPERON, ACETAMIDE
Authors:Pearl, L.H., O'Hara, B.P.
Deposit date:1995-11-16
Release date:1996-04-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of AmiC: the controller of transcription antitermination in the amidase operon of Pseudomonas aeruginosa.
EMBO J., 13, 1994
1GXR
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WD40 REGION OF HUMAN GROUCHO/TLE1
Descriptor:TRANSDUCIN-LIKE ENHANCER PROTEIN 1, CALCIUM ION
Authors:Pearl, L.H., Roe, S.M., Pickles, L.M.
Deposit date:2002-04-10
Release date:2002-06-13
Last modified:2013-02-06
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal Structure of the C-Terminal Wd40 Repeat Domain of the Human Groucho/Tle1 Transcriptional Corepressor
Structure, 10, 2002
1LAU
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URACIL-DNA GLYCOSYLASE
Descriptor:DNA (5'-D(*TP*TP*T)-3'), PROTEIN (URACIL-DNA GLYCOSYLASE (E.C.3.2.2.-))
Authors:Pearl, L.H., Savva, R.
Deposit date:1996-01-03
Release date:1996-06-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The structural basis of specific base-excision repair by uracil-DNA glycosylase.
Nature, 373, 1995
1UDG
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THE STRUCTURAL BASIS OF SPECIFIC BASE EXCISION REPAIR BY URACIL-DNA GLYCOSYLASE
Descriptor:URACIL-DNA GLYCOSYLASE, SULFATE ION
Authors:Pearl, L.H., Savva, R.
Deposit date:1995-06-23
Release date:1996-01-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The structural basis of specific base-excision repair by uracil-DNA glycosylase.
Nature, 373, 1995
1UDH
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THE STRUCTURAL BASIS OF SPECIFIC BASE EXCISION REPAIR BY URACIL-DNA GLYCOSYLASE
Descriptor:URACIL-DNA GLYCOSYLASE, SULFATE ION, URACIL
Authors:Pearl, L.H., Savva, R.
Deposit date:1995-10-30
Release date:1996-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The structural basis of specific base-excision repair by uracil-DNA glycosylase.
Nature, 373, 1995
4APE
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THE ACTIVE SITE OF ASPARTIC PROTEINASES
Descriptor:ENDOTHIAPEPSIN
Authors:Pearl, L.H., Sewell, B.T., Jenkins, J.A., Cooper, J.B., Blundell, T.L.
Deposit date:1986-06-09
Release date:1986-07-14
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Active Site of Aspartic Proteinases
FEBS Lett., 174, 1984
1BGQ
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RADICICOL BOUND TO THE ATP BINDING SITE OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE
Descriptor:HEAT SHOCK PROTEIN 90, RADICICOL
Authors:Roe, S.M., Prodromou, C., Pearl, L.H.
Deposit date:1998-05-29
Release date:1999-06-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin.
J.Med.Chem., 42, 1999
1AH6
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STRUCTURE OF THE TETRAGONAL FORM OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE
Descriptor:HEAT SHOCK PROTEIN 90
Authors:Prodromou, C., Roe, S.M., Pearl, L.H.
Deposit date:1997-04-14
Release date:1997-10-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone.
Nat.Struct.Biol., 4, 1997
1AH8
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STRUCTURE OF THE ORTHORHOMBIC FORM OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE
Descriptor:HEAT SHOCK PROTEIN 90, GLYCEROL
Authors:Prodromou, C., Roe, S.M., Pearl, L.H.
Deposit date:1997-04-14
Release date:1997-10-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A molecular clamp in the crystal structure of the N-terminal domain of the yeast Hsp90 chaperone.
Nat.Struct.Biol., 4, 1997
2CE8
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AN EH1 PEPTIDE BOUND TO THE GROUCHO-TLE WD40 DOMAIN.
Descriptor:TRANSDUCIN-LIKE ENHANCER PROTEIN 1, EH1 PEPTIDE
Authors:Pickles, L.M., Roe, S.M., Pearl, L.H.
Deposit date:2006-02-03
Release date:2006-06-14
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Molecular Recognition of Transcriptional Repressor Motifs by the Wd Domain of the Groucho/Tle Corepressor.
Mol.Cell, 22, 2006
2CE9
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A WRPW PEPTIDE BOUND TO THE GROUCHO-TLE WD40 DOMAIN.
Descriptor:TRANSDUCIN-LIKE ENHANCER PROTEIN 1, WRPW PEPTIDE
Authors:Pickles, L.M., Roe, S.M., Pearl, L.H.
Deposit date:2006-02-03
Release date:2006-06-14
Last modified:2017-07-05
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Molecular Recognition of Transcriptional Repressor Motifs by the Wd Domain of the Groucho/Tle Corepressor.
Mol.Cell, 22, 2006
5LOH
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KINASE DOMAIN OF HUMAN GREATWALL
Descriptor:Serine/threonine-protein kinase greatwall,Serine/threonine-protein kinase greatwall, STAUROSPORINE, CHLORIDE ION, ...
Authors:Rajasekaran, M.B., Pearl, L.H., Oliver, A.W.
Deposit date:2016-08-09
Release date:2016-09-07
Last modified:2017-01-18
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:A first generation inhibitor of human Greatwall kinase, enabled by structural and functional characterisation of a minimal kinase domain construct.
Oncotarget, 7, 2016
1A4H
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STRUCTURE OF THE N-TERMINAL DOMAIN OF THE YEAST HSP90 CHAPERONE IN COMPLEX WITH GELDANAMYCIN
Descriptor:HEAT SHOCK PROTEIN 90, GELDANAMYCIN
Authors:Prodromou, C., Roe, S.M., Pearl, L.H.
Deposit date:1998-01-29
Release date:1998-08-05
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone
Cell(Cambridge,Mass.), 90, 1997
1BVS
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RUVA COMPLEXED TO A HOLLIDAY JUNCTION.
Descriptor:PROTEIN (HOLLIDAY JUNCTION DNA HELICASE RUVA)
Authors:Roe, S.M., Pearl, L.H.
Deposit date:1998-09-17
Release date:1998-09-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of an octameric RuvA-Holliday junction complex.
Mol.Cell, 2, 1998
1GEC
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GLYCYL ENDOPEPTIDASE-COMPLEX WITH BENZYLOXYCARBONYL-LEUCINE-VALINE-GLYCINE-METHYLENE COVALENTLY BOUND TO CYSTEINE 25
Descriptor:GLYCYL ENDOPEPTIDASE, BENZYLOXYCARBONYL-LEUCINE-VALINE-GLYCINE-METHYLENE INHIBITOR
Authors:Ohara, B.P., Hemmings, A.M., Buttle, D.J., Pearl, L.H.
Deposit date:1995-05-25
Release date:1995-12-07
Last modified:2012-12-12
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of glycyl endopeptidase from Carica papaya: a cysteine endopeptidase of unusual substrate specificity.
Biochemistry, 34, 1995
1GML
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CRYSTAL STRUCTURE OF THE MOUSE CCT GAMMA APICAL DOMAIN (TRICLINIC)
Descriptor:T-COMPLEX PROTEIN 1 SUBUNIT GAMMA, GLYCEROL
Authors:Pappenberger, G., Wilsher, J.A., Roe, S.M., Willison, K.R., Pearl, L.H.
Deposit date:2001-09-17
Release date:2002-06-18
Last modified:2011-09-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of the Cct Gamma Apical Domain:: Implications for Substrate Binding to the Eukaryotic Cytosolic Chaperonin
J.Mol.Biol., 318, 2002
1GN1
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CRYSTAL STRUCTURE OF THE MOUSE CCT GAMMA APICAL DOMAIN (MONOCLINIC)
Descriptor:CCT-GAMMA, CALCIUM ION
Authors:Pappenberger, G., Wilsher, J.A., Roe, S.M., Willison, K.R., Pearl, L.H.
Deposit date:2001-10-01
Release date:2002-06-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of the Cct Gamma Apical Domain:: Implications for Substrate Binding to the Eukaryotic Cytosolic Chaperonin
J.Mol.Biol., 318, 2002
1GS0
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CRYSTAL STRUCTURE OF THE CATALYTIC FRAGMENT OF MURINE POLY(ADP-RIBOSE) POLYMERASE-2
Descriptor:POLY (ADP-RIBOSE) POLYMERASE-2
Authors:Oliver, A.W., Roe, S.M., Pearl, L.H.
Deposit date:2001-12-19
Release date:2002-12-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of the Catalytic Fragment of Murine Poly(Adp-Ribose) Polymerase-2
Nucleic Acids Res., 32, 2004
1H0C
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THE CRYSTAL STRUCTURE OF HUMAN ALANINE:GLYOXYLATE AMINOTRANSFERASE
Descriptor:SERINE--GLYOXYLATE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE, (AMINOOXY)ACETIC ACID, ...
Authors:Zhang, X., Danpure, C.J., Roe, S.M., Pearl, L.H.
Deposit date:2002-06-17
Release date:2003-06-12
Last modified:2011-10-12
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structure of Alanine:Glyoxylate Aminotransferase and the Relationship between Genotype and Enzymatic Phenotype in Primary Hyperoxaluria Type 1.
J.Mol.Biol., 331, 2003