Author results

5FII
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STRUCTURE OF A HUMAN ASPARTATE KINASE, CHORISMATE MUTASE AND TYRA DOMAIN.
分子名称:PHENYLALANINE-4-HYDROXYLASE, PHENYLALANINE
著者Patel, D., Kopec, J., Shrestha, L., Fitzpatrick, F., Pinkas, D., Chaikuad, A., Dixon-Clarke, S., McCorvie, T.J., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
登録日2015-09-25
公開日2016-03-30
最終更新日2016-10-05
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural Basis for Ligand-Dependent Dimerization of Phenylalanine Hydroxylase Regulatory Domain.
Sci.Rep., 6, 2016
5J9G
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STRUCTURE OF LACTOBACILLUS ACIDOPHILUS GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE AT 2.21 ANGSTROM RESOLUTION
分子名称:Glyceraldehyde-3-p dehydrogenase
著者Patel, D., Pappachan, A., Singh, D.D.
登録日2016-04-10
公開日2017-04-19
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Structure of Lactobacillus acidophilus glyceraldehyde-3-phosphate dehydrogenase at 2.21 angstrom resolution.
To Be Published
5KRS
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HIV-1 INTEGRASE CATALYTIC CORE DOMAIN IN COMPLEX WITH AN ALLOSTERIC INHIBITOR, 3-(1H-PYRROL-1-YL)-2-THIOPHENECARBOXYLIC ACID
分子名称:Integrase, DIMETHYL SULFOXIDE, 3-pyrrol-1-ylthiophene-2-carboxylic acid
著者Patel, D., Bauman, J.D., Arnold, E.
登録日2016-07-07
公開日2016-09-28
最終更新日2016-11-16
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain.
J.Biol.Chem., 291, 2016
5KRT
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HIV-1 INTEGRASE CATALYTIC CORE DOMAIN (CCD) IN COMPLEX WITH A FRAGMENT-DERIVED ALLOSTERIC INHIBITOR
分子名称:Integrase, 3-[2,5-bis(chloranyl)pyrrol-1-yl]thiophene-2-carboxylic acid
著者Patel, D., Bauman, J.D., Arnold, E.
登録日2016-07-07
公開日2016-09-28
最終更新日2017-09-20
実験手法X-RAY DIFFRACTION (1.651 Å)
主引用文献A New Class of Allosteric HIV-1 Integrase Inhibitors Identified by Crystallographic Fragment Screening of the Catalytic Core Domain.
J.Biol.Chem., 291, 2016
4I2P
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH RILPIVIRINE (TMC278) BASED ANALOGUE
分子名称:Gag-Pol polyprotein, (2E)-3-[4-({6-[(4-methoxyphenyl)amino]-7H-purin-2-yl}amino)-3,5-dimethylphenyl]prop-2-enenitrile
著者Patel, D., Bauman, J.D., Das, K., Arnold, E.
登録日2012-11-22
公開日2013-01-16
最終更新日2017-04-19
実験手法X-RAY DIFFRACTION (2.2964 Å)
主引用文献A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants.
Retrovirology, 9, 2012
4I2Q
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CRYSTAL STRUCTURE OF K103N/Y181C MUTANT OF HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH RILPIVIRINE (TMC278) ANALOGUE
分子名称:Gag-Pol polyprotein, (2E)-3-(4-{[6-(1,3-benzothiazol-5-ylamino)-9H-purin-2-yl]amino}-3,5-dimethylphenyl)prop-2-enenitrile, 1,2-ETHANEDIOL
著者Patel, D., Bauman, J.D., Das, K., Arnold, E.
登録日2012-11-22
公開日2013-01-16
実験手法X-RAY DIFFRACTION (2.7004 Å)
主引用文献A comparison of the ability of rilpivirine (TMC278) and selected analogues to inhibit clinically relevant HIV-1 reverse transcriptase mutants.
Retrovirology, 9, 2012
4DIU
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CRYSTAL STRUCTURE OF ENGINEERED PROTEIN. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET OR94
分子名称:Engineered Protein PF00326
著者Seetharaman, J., Lew, S., Wang, D., Kohan, E., Patel, D., Whitehead, T., Fleishman, S., Ciccosanti, C., Xiao, R., Everett, J.K., Acton, T.B., Baker, D., Montelione, G.T., Tong, L., Hunt, J.F., Northeast Structural Genomics Consortium (NESG)
登録日2012-01-31
公開日2012-04-11
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structure of Engineered Protein. Northeast Structural Genomics Consortium Target OR94
To be Published
2L69
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SOLUTION NMR STRUCTURE OF DE NOVO DESIGNED PROTEIN, P-LOOP NTPASE FOLD, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET OR28
分子名称:Rossmann 2x3 fold protein
著者Liu, G., Koga, N., Koga, R., Xiao, R., Mao, A., Mao, B., Patel, D., Ciccosanti, C., Hamilton, K., Acton, T.B., Baker, D., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
登録日2010-11-17
公開日2011-01-12
最終更新日2012-02-22
実験手法SOLUTION NMR
主引用文献Solution NMR structure of de novo designed rossmann 2x3 fold protein, Northeast Structural Genomics Consortium Target OR28
To be Published
3MGJ
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CRYSTAL STRUCTURE OF THE SACCHAROP_DH_N DOMAIN OF MJ1480 PROTEIN FROM METHANOCOCCUS JANNASCHII. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET MJR83A.
分子名称:Uncharacterized protein MJ1480
著者Vorobiev, S., Neely, H., Seetharaman, J., Lee, D., Patel, D., Ciccosanti, C., Xiao, R., Acton, T.B., Everett, J.K., Montelione, G.T., Hunt, J.F., Tong, L., Northeast Structural Genomics Consortium (NESG)
登録日2010-04-06
公開日2010-04-21
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.703 Å)
主引用文献Crystal structure of the Saccharop_dh_N domain of MJ1480 protein from Methanococcus jannaschii.
To be Published
4N6C
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CRYSTAL STRUCTURE OF THE B1RZQ2 PROTEIN FROM STREPTOCOCCUS PNEUMONIAE. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM (NESG) TARGET SPR36.
分子名称:uncharacterized protein, BROMIDE ION
著者Vorobiev, S., Seetharaman, J., Patel, D., Xiao, R., Ciccosanti, C., Wang, D., Everett, J.K., Acton, T.B., Montelione, G.T., Tong, L., Hunt, J.F., Northeast Structural Genomics Consortium (NESG)
登録日2013-10-11
公開日2013-10-30
実験手法X-RAY DIFFRACTION (1.548 Å)
主引用文献Crystal Structure of the B1RZQ2 protein from Streptococcus pneumoniae.
To be Published
1HDJ
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HUMAN HSP40 (HDJ-1), NMR
分子名称:HUMAN HSP40
著者Qian, Y.Q., Patel, D., Hartl, F.-U., Mccoll, D.J.
登録日1996-05-09
公開日1996-11-08
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Nuclear magnetic resonance solution structure of the human Hsp40 (HDJ-1) J-domain.
J.Mol.Biol., 260, 1996
1MV5
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CRYSTAL STRUCTURE OF LMRA ATP-BINDING DOMAIN
分子名称:Multidrug resistance ABC transporter ATP-binding and permease protein, ADENOSINE-5'-TRIPHOSPHATE, ADENOSINE-5'-DIPHOSPHATE, ...
著者Yuan, Y., Chen, H., Patel, D.
登録日2002-09-24
公開日2003-12-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Crystal structure of LmrA ATP-binding domain reveals the two-site alternating mechanism at molecular level
To be Published
1W0H
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CRYSTALLOGRAPHIC STRUCTURE OF THE NUCLEASE DOMAIN OF 3'HEXO, A DEDDH FAMILY MEMBER, BOUND TO RAMP
分子名称:3'-5' EXONUCLEASE ERI1, MAGNESIUM ION, ADENOSINE MONOPHOSPHATE
著者Cheng, Y., Patel, D.
登録日2004-06-04
公開日2004-09-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献Crystallographic Structure of the Nuclease Domain of 3'Hexo, a Deddh Family Member, Bound to Ramp
J.Mol.Biol., 343, 2004
2KRT
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SOLUTION NMR STRUCTURE OF A CONSERVED HYPOTHETICAL MEMBRANE LIPOPROTEIN OBTAINED FROM UREAPLASMA PARVUM: NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET UUR17A (139-239)
分子名称:Conserved hypothetical membrane lipoprotein
著者Mani, R., Swapna, G., Janjua, H., Ciccosanti, C., Huang, Y., Patel, D., Xiao, R., Acton, T., Everett, J., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
登録日2009-12-22
公開日2010-01-05
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献NMR Solution Structure of a Conserved Hypothetical Membrane Lipoprotein obtained from Ureaplasma parvum : Northeast Structural Genomics Consortium Target UuR17A (139-239)
To be Published
2L81
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SOLUTION NMR STRUCTURE OF THE SERINE-RICH DOMAIN OF HEF1 (ENHANCER OF FILAMENTATION 1) FROM HOMO SAPIENS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET HR5554A
分子名称:Enhancer of filamentation 1
著者Liu, G., Xiao, R., Huang, Y.J., Patel, D., Ciccosanti, C.T., Acton, T.B., Tong, S., Everett, J.T., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
登録日2010-12-31
公開日2011-02-09
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Northeast Structural Genomics Consortium Target HR5554A
To be Published
3RRU
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X-RAY CRYSTAL STRUCTURE OF THE VHS DOMAIN OF HUMAN TOM1-LIKE PROTEIN, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET HR3050E
分子名称:TOM1L1 protein
著者Forouhar, F., Lew, S., Seetharaman, J., Wang, H., Ciccosanti, C., Patel, D., Acton, T.B., Xiao, R., Everett, J.K., Montelione, G.T., Hunt, J.F., Tong, L., Northeast Structural Genomics Consortium (NESG)
登録日2011-04-30
公開日2011-06-08
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献X-ray crystal structure of the VHS domain of human TOM1-like protein, Northeast Structural Genomics Consortium Target HR3050E
To be Published
4G1Q
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH RILPIVIRINE (TMC278, EDURANT), A NON-NUCLEOSIDE RT-INHIBITING DRUG
分子名称:Reverse transcriptase/ribonuclease H, p51 RT, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ...
著者Bauman, J.D., Patel, D., Das, K., Arnold, E.
登録日2012-07-11
公開日2013-02-06
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (1.51 Å)
主引用文献Snapshot of the equilibrium dynamics of a drug bound to HIV-1 reverse transcriptase.
Nat Chem, 5, 2013
4ICL
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HIV-1 REVERSE TRANSCRIPTASE WITH BOUND FRAGMENT AT THE INCOMING DNTP BINDING SITE
分子名称:Reverse transcriptase/ribonuclease H, p51 RT, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ...
著者Bauman, J.D., Patel, D., Arnold, E.
登録日2012-12-10
公開日2013-02-06
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-ray Crystallographic Fragment Screening.
J.Med.Chem., 56, 2013
4ID5
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HIV-1 REVERSE TRANSCRIPTASE WITH BOUND FRAGMENT AT THE RNASE H PRIMER GRIP SITE
分子名称:Reverse transcriptase/ribonuclease H, P51 RT, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ...
著者Bauman, J.D., Patel, D., Arnold, E.
登録日2012-12-11
公開日2013-02-06
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-ray Crystallographic Fragment Screening.
J.Med.Chem., 56, 2013
4IDK
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HIV-1 REVERSE TRANSCRIPTASE WITH BOUND FRAGMENT AT THE 428 SITE
分子名称:Reverse transcriptase/ribonuclease H, p51 RT, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ...
著者Bauman, J.D., Patel, D., Arnold, E.
登録日2012-12-12
公開日2013-02-06
最終更新日2015-06-17
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-ray Crystallographic Fragment Screening.
J.Med.Chem., 56, 2013
4IFV
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DETECTING ALLOSTERIC SITES OF HIV-1 REVERSE TRANSCRIPTASE BY X-RAY CRYSTALLOGRAPHIC FRAGMENT SCREENING
分子名称:Exoribonuclease H, p66 RT, Gag-Pol polyprotein, ...
著者Bauman, J.D., Patel, D., Fromer, M., Arnold, E.
登録日2012-12-15
公開日2013-02-06
最終更新日2015-06-17
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-ray Crystallographic Fragment Screening.
J.Med.Chem., 56, 2013
4IFY
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HIV-1 REVERSE TRANSCRIPTASE WITH BOUND FRAGMENT AT THE KNUCKLES SITE
分子名称:REVERSE TRANSCRIPTASE/RIBONUCLEASE H, p51 RT, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ...
著者Bauman, J.D., Patel, D., Arnold, E.
登録日2012-12-15
公開日2013-02-06
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-ray Crystallographic Fragment Screening.
J.Med.Chem., 56, 2013
4IG0
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HIV-1 REVERSE TRANSCRIPTASE WITH BOUND FRAGMENT AT THE 507 SITE
分子名称:Reverse transcriptase/ribonuclease H, P51 RT, 2-({[2-(3,4-dihydroquinolin-1(2H)-yl)-2-oxoethyl](methyl)amino}methyl)quinazolin-4(1H)-one, ...
著者Bauman, J.D., Patel, D., Arnold, E.
登録日2012-12-15
公開日2013-02-06
最終更新日2013-04-24
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-ray Crystallographic Fragment Screening.
J.Med.Chem., 56, 2013
4IG3
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HIV-1 REVERSE TRANSCRIPTASE WITH BOUND FRAGMENT NEAR KNUCKLES SITE
分子名称:Reverse transcriptase/ribonuclease H, P51 RT, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ...
著者Bauman, J.D., Patel, D., Arnold, E.
登録日2012-12-15
公開日2013-02-06
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-ray Crystallographic Fragment Screening.
J.Med.Chem., 56, 2013
4KFB
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HIV-1 REVERSE TRANSCRIPTASE WITH BOUND FRAGMENT AT NNRTI ADJACENT SITE
分子名称:REVERSE TRANSCRIPTASE/RIBONUCLEASE H, EXORIBONUCLEA P66 RT, P51 RT, ...
著者Bauman, J.D., Patel, D., Arnold, E.
登録日2013-04-26
公開日2013-05-15
最終更新日2015-06-17
実験手法X-RAY DIFFRACTION (1.854 Å)
主引用文献Detecting Allosteric Sites of HIV-1 Reverse Transcriptase by X-Ray Crystallographic Fragment Screening.
J.Med.Chem., 56, 2013
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