Author results

6OPF
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CRYSTAL STRUCTURE OF DMNXF2 UBA DOMAIN FUSED WITH PANORAMIX HELIX
分子名称:Nuclear RNA export factor 2, Panoramix fusion
著者Wang, J., Patel, D.J.
登録日2019-04-24
公開日2019-07-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A nascent RNA binding complex licenses piRNA-guided heterochromatin formation
To Be Published
6O47
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HUMAN CGAS CORE DOMAIN (K427E/K428E) BOUND WITH RU-521
分子名称:Cyclic GMP-AMP synthase, CITRIC ACID, ZINC ION, ...
著者Xie, W., Lama, L., Adura, C., Glickman, J.F., Tuschl, T., Patel, D.J.
登録日2019-02-28
公開日2019-05-29
最終更新日2019-06-26
実験手法X-RAY DIFFRACTION (2.196 Å)
主引用文献Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation.
Proc.Natl.Acad.Sci.USA, 116, 2019
6NXF
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CRYSTAL STRUCTURE OF MOUSE REC114 PH DOMAIN IN COMPLEX WITH ANKRD31 C TERMINUS
分子名称:Meiotic recombination protein REC114, Ankyrin repeat domain 31
著者Wang, J., Patel, D.J.
登録日2019-02-08
公開日2019-04-24
最終更新日2019-06-19
実験手法X-RAY DIFFRACTION (2.791 Å)
主引用文献REC114 Partner ANKRD31 Controls Number, Timing, and Location of Meiotic DNA Breaks.
Mol.Cell, 74, 2019
6MUU
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CRYO-EM STRUCTURE OF CSM-CRRNA BINARY COMPLEX IN TYPE III-A CRISPR-CAS SYSTEM
分子名称:Uncharacterized protein Csm1, Uncharacterized protein Csm2, Uncharacterized protein Csm3, ...
著者Jia, N., Wang, C., Eng, E.T., Patel, D.J.
登録日2018-10-23
公開日2018-12-19
最終更新日2019-01-30
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity.
Mol. Cell, 73, 2019
6MUT
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CRYO-EM STRUCTURE OF TERNARY CSM-CRRNA-TARGET RNA WITH ANTI-TAG SEQUENCE COMPLEX IN TYPE III-A CRISPR-CAS SYSTEM
分子名称:Uncharacterized protein Csm1, Uncharacterized protein Csm2, Uncharacterized protein Csm3, ...
著者Jia, N., Wang, C., Eng, E.T., Patel, D.J.
登録日2018-10-23
公開日2018-12-12
最終更新日2019-01-30
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity.
Mol. Cell, 73, 2019
6MUS
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CRYO-EM STRUCTURE OF LARGER CSM-CRRNA-TARGET RNA TERNARY COMPLEX IN TYPE III-A CRISPR-CAS SYSTEM
分子名称:Uncharacterized protein Csm1, Uncharacterized protein Csm2, Uncharacterized protein Csm3, ...
著者Jia, N., Wang, C., Eng, E.T.
登録日2018-10-23
公開日2018-12-12
最終更新日2019-01-30
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity.
Mol. Cell, 73, 2019
6MUR
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CRYO-EM STRUCTURE OF CSM-CRRNA-TARGET RNA TERNARY COMPLEX IN TYPE III-A CRISPR-CAS SYSTEM
分子名称:Uncharacterized protein, Uncharacterized protein Csm3, RNA (27-MER), ...
著者Jia, N., Wang, C., Eng, E.T., Patel, D.J.
登録日2018-10-23
公開日2018-12-12
最終更新日2019-01-30
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity.
Mol. Cell, 73, 2019
6MUA
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CRYSTAL STRUCTURE OF CSM1-CSM4 SUBCOMPLEX IN THE TYPE III-A CRISPR-CSM INTERFERENCE COMPLEX
分子名称:Uncharacterized protein Csm1, Uncharacterized protein Csm4
著者Jia, N., Patel, D.J.
登録日2018-10-22
公開日2019-01-09
最終更新日2019-01-30
実験手法X-RAY DIFFRACTION (2.91 Å)
主引用文献Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity.
Mol. Cell, 73, 2019
6MRK
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CRYSTAL STRUCTURE OF DMNXF2 NTF2-LIKE DOMAIN IN COMPLEX WITH NXT1/P15
分子名称:Nuclear RNA export factor 2, NTF2-related export protein
著者Wang, J., Patel, D.J.
登録日2018-10-13
公開日2019-07-03
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The nascent RNA binding complex SFiNX licenses piRNA-guided heterochromatin formation
Nat.Struct.Mol.Biol., 2019
6MJX
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HUMAN CGAS CATALYTIC DOMAIN BOUND WITH CGAMP
分子名称:Cyclic GMP-AMP synthase, cGAMP, ZINC ION
著者Lama, L., Adura, C., Xie, W., Tomita, D., Kamei, T., Kuryavyi, V., Gogakos, T., Steinberg, J.I., Miller, M., Ramos-Espiritu, L., Asano, Y., Hashizume, S., Aida, J., Imaeda, T., Okamoto, R., Jennings, A.J., Michinom, M., Kuroita, T., Stamford, A., Gao, P., Meinke, P., Glickman, J.F., Patel, D.J., Tuschl, T.
登録日2018-09-23
公開日2019-05-29
最終更新日2019-06-05
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression.
Nat Commun, 10, 2019
6MJW
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HUMAN CGAS CATALYTIC DOMAIN BOUND WITH THE INHIBITOR G150
分子名称:Cyclic GMP-AMP synthase, ZINC ION, 1-[9-(6-aminopyridin-3-yl)-6,7-dichloro-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethan-1-one
著者Lama, L., Adura, C., Xie, W., Tomita, D., Kamei, T., Kuryavyi, V., Gogakos, T., Steinberg, J.I., Miller, M., Ramos-Espiritu, L., Asano, Y., Hashizume, S., Aida, J., Imaeda, T., Okamoto, R., Jennings, A.J., Michinom, M., Kuroita, T., Stamford, A., Gao, P., Meinke, P., Glickman, J.F., Patel, D.J., Tuschl, T.
登録日2018-09-23
公開日2019-05-29
最終更新日2019-06-05
実験手法X-RAY DIFFRACTION (2.405 Å)
主引用文献Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression.
Nat Commun, 10, 2019
6MJU
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HUMAN CGAS CATALYTIC DOMAIN BOUND WITH THE INHIBITOR G108
分子名称:Cyclic GMP-AMP synthase, 1-[6,7-dichloro-9-(1H-pyrazol-4-yl)-1,3,4,5-tetrahydro-2H-pyrido[4,3-b]indol-2-yl]-2-hydroxyethan-1-one, ZINC ION
著者Lama, L., Adura, C., Xie, W., Tomita, D., Kamei, T., Kuryavyi, V., Gogakos, T., Steinberg, J.I., Miller, M., Ramos-Espiritu, L., Asano, Y., Hashizume, S., Aida, J., Imaeda, T., Okamoto, R., Jennings, A.J., Michinom, M., Kuroita, T., Stamford, A., Gao, P., Meinke, P., Glickman, J.F., Patel, D.J., Tuschl, T.
登録日2018-09-22
公開日2019-05-29
最終更新日2019-06-05
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Development of human cGAS-specific small-molecule inhibitors for repression of dsDNA-triggered interferon expression.
Nat Commun, 10, 2019
6JQ6
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HATCHET RIBOZYME STRUCTURE SOAKING WITH IR(NH3)6+
分子名称:RNA (81-MER), IRIDIUM HEXAMMINE ION
著者Ren, A., Zheng, L.
登録日2019-03-29
公開日2019-06-12
実験手法X-RAY DIFFRACTION (2.626 Å)
主引用文献Hatchet ribozyme structure and implications for cleavage mechanism.
Proc.Natl.Acad.Sci.USA, 116, 2019
6JQ5
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THE STRUCTURE OF HATCHET RIBOZYME
分子名称:RNA (82-MER), MAGNESIUM ION
著者Ren, A., Zheng, L.
登録日2019-03-29
公開日2019-06-12
実験手法X-RAY DIFFRACTION (2.059 Å)
主引用文献Hatchet ribozyme structure and implications for cleavage mechanism.
Proc.Natl.Acad.Sci.USA, 116, 2019
6J23
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CRYSTAL STRUCTURE OF ARABIDOPSIS ADAL COMPLEXED WITH GMP
分子名称:Adenosine/AMP deaminase family protein, GUANOSINE-5'-MONOPHOSPHATE, ZINC ION
著者Wu, B.X., Zhang, D., Nie, H.B., Shen, S.L., Li, S.S., Patel, D.J.
登録日2018-12-30
公開日2019-02-27
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of arabidopsis N6-mAMP deaminase MAPDA
To Be Published
6IV5
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CRYSTAL STRUCTURE OF ARABIDOPSIS N6-MAMP DEAMINASE MAPDA
分子名称:Adenosine/AMP deaminase family protein, PHOSPHATE ION, ZINC ION
著者Wu, B.X., Zhang, D., Nie, H.B., Shen, S.L., Li, S.S., Patel, D.J.
登録日2018-12-02
公開日2019-02-27
実験手法X-RAY DIFFRACTION (1.749 Å)
主引用文献Crystal structure of arabidopsis N6-mAMP deaminase MAPDA
To Be Published
6IEJ
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THE C2 DOMAIN OF CYTOSOLIC PHOSPHOLIPASE A2 ALPHA BOUND TO PHOSPHATIDYLCHOLINE
分子名称:Cytosolic phospholipase A2, CALCIUM ION, MAGNESIUM ION, ...
著者Hirano, Y., Gao, Y.G., Stephenson, D.J., Vu, N.T., Malinina, L., Chalfant, C.E., Patel, D.J., Brown, R.E.
登録日2018-09-14
公開日2019-05-22
実験手法X-RAY DIFFRACTION (2.206 Å)
主引用文献Structural basis of phosphatidylcholine recognition by the C2-domain of cytosolic phospholipase A2alpha.
Elife, 8, 2019
6EDC
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HCGAS-16BP DSDNA COMPLEX
分子名称:Cyclic GMP-AMP synthase, DNA (5'-D(*AP*AP*AP*TP*TP*GP*CP*CP*GP*AP*AP*GP*AP*CP*GP*AP*A)-3'), DNA (5'-D(*TP*TP*CP*GP*TP*CP*TP*TP*CP*GP*GP*CP*AP*AP*T)-3'), ...
著者Xie, W., Lama, L., Adura, C., Glickman, J.F., Tuschl, T., Patel, D.J.
登録日2018-08-09
公開日2019-05-29
最終更新日2019-06-26
実験手法X-RAY DIFFRACTION (2.712 Å)
主引用文献Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation.
Proc.Natl.Acad.Sci.USA, 116, 2019
6EDB
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CRYSTAL STRUCTURE OF SRY.HCGAS-21BP DSDNA COMPLEX
分子名称:Sex-determining region Y protein,Cyclic GMP-AMP synthase, DNA (5'-D(*CP*GP*AP*TP*CP*CP*GP*GP*GP*AP*TP*CP*TP*AP*AP*AP*CP*AP*AP*TP*G)-3'), DNA (5'-D(*GP*CP*AP*TP*TP*GP*TP*TP*TP*AP*GP*AP*TP*CP*CP*CP*GP*GP*AP*TP*C)-3'), ...
著者Xie, W., Lama, L., Adura, C., Glickman, J.F., Tuschl, T., Patel, D.J.
登録日2018-08-09
公開日2019-05-29
最終更新日2019-06-26
実験手法X-RAY DIFFRACTION (3.209 Å)
主引用文献Human cGAS catalytic domain has an additional DNA-binding interface that enhances enzymatic activity and liquid-phase condensation.
Proc.Natl.Acad.Sci.USA, 116, 2019
6DBP
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RNA-RECOGNITION MOTIF 1 OF HUMAN MSI2
分子名称:RNA-binding protein Musashi homolog 2
著者Goldgur, Y., Kharas, M.G., Minuesa, G.
登録日2018-05-03
公開日2019-05-08
最終更新日2019-07-03
実験手法X-RAY DIFFRACTION (1.603 Å)
主引用文献Small-molecule targeting of MUSASHI RNA-binding activity in acute myeloid leukemia.
Nat Commun, 10, 2019
6D9L
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TERNARY RSAGO COMPLEX WITH GUIDE RNA AND TARGET DNA CONTAINING G-A NON-CANONICAL PAIR
分子名称:Uncharacterized protein, RNA (5'-R(P*UP*UP*AP*CP*UP*GP*CP*GP*CP*AP*GP*GP*UP*GP*AP*CP*GP*A)-3'), DNA (5'-D(P*TP*CP*GP*TP*CP*AP*CP*CP*TP*GP*AP*GP*CP*AP*GP*TP*AP*AP*C)-3'), ...
著者Liu, Y., Esyunina, D., Olovnikov, I., Teplova, M., Patel, D.J.
登録日2018-04-30
公開日2018-07-25
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Accommodation of Helical Imperfections in Rhodobacter sphaeroides Argonaute Ternary Complexes with Guide RNA and Target DNA.
Cell Rep, 24, 2018
6D9K
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TERNARY RSAGO COMPLEX WITH GUIDE RNA AND TARGET DNA CONTAINING A-G NON-CANONICAL PAIR
分子名称:Uncharacterized protein, RNA (5'-R(P*UP*UP*AP*CP*UP*GP*CP*AP*CP*AP*GP*GP*UP*GP*AP*CP*GP*A)-3'), DNA (5'-D(P*TP*CP*GP*TP*CP*AP*CP*CP*TP*GP*GP*GP*CP*AP*GP*TP*AP*AP*C)-3'), ...
著者Liu, Y., Esyunina, D., Olovnikov, I., Teplova, M., Patel, D.J.
登録日2018-04-30
公開日2018-07-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Accommodation of Helical Imperfections in Rhodobacter sphaeroides Argonaute Ternary Complexes with Guide RNA and Target DNA.
Cell Rep, 24, 2018
6D95
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TERNARY RSAGO COMPLEX WITH GUIDE RNA PAIRED AND TARGET DNA CONTAINING A8-A8' NON-CANONICAL PAIR
分子名称:Uncharacterized protein, RNA (5'-R(P*UP*UP*AP*CP*UP*GP*CP*AP*CP*AP*GP*GP*UP*GP*AP*CP*GP*A)-3'), DNA 24-Mer, ...
著者Liu, Y., Esyunina, D., Olovnikov, I., Teplova, M., Patel, D.J.
登録日2018-04-27
公開日2018-08-08
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Accommodation of Helical Imperfections in Rhodobacter sphaeroides Argonaute Ternary Complexes with Guide RNA and Target DNA.
Cell Rep, 24, 2018
6D92
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TERNARY RSAGO COMPLEX WITH GUIDE RNA AND TARGET DNA CONTAINING A-A NON-CANONICAL PAIR AT POSITION 3
分子名称:Uncharacterized protein, RNA (5'-R(P*UP*UP*AP*CP*UP*GP*CP*AP*CP*AP*GP*GP*UP*GP*AP*CP*GP*A)-3'), DNA (5'-D(P*TP*CP*GP*TP*CP*AP*CP*CP*TP*GP*TP*GP*CP*AP*GP*AP*AP*AP*C)-3'), ...
著者Liu, Y., Esyunina, D., Olovnikov, I., Teplova, M., Patel, D.J.
登録日2018-04-27
公開日2018-07-25
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献Accommodation of Helical Imperfections in Rhodobacter sphaeroides Argonaute Ternary Complexes with Guide RNA and Target DNA.
Cell Rep, 24, 2018
6D8P
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TERNARY RSAGO COMPLEX CONTAINING GUIDE RNA PAIRED WITH TARGET DNA
分子名称:Uncharacterized protein, RNA (5'-R(P*UP*UP*AP*CP*UP*GP*CP*AP*CP*AP*GP*GP*UP*GP*AP*CP*GP*A)-3'), DNA (5'-D(P*TP*CP*GP*TP*CP*AP*CP*CP*TP*GP*TP*GP*CP*AP*GP*TP*AP*AP*C)-3'), ...
著者Liu, Y., Esyunina, D., Olovnikov, I., Teplova, M., Patel, D.J.
登録日2018-04-26
公開日2018-07-25
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Accommodation of Helical Imperfections in Rhodobacter sphaeroides Argonaute Ternary Complexes with Guide RNA and Target DNA.
Cell Rep, 24, 2018