Author results

4CYI
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CHAETOMIUM THERMOPHILUM PAN3
Descriptor:PAB-DEPENDENT POLY(A)-SPECIFIC RIBONUCLEASE SUBUNIT PAN3-LIKE PROTEIN, PAB-DEPENDENT POLY(A)-SPECIFIC RIBONUCLEASE SUBUNIT PAN3-L PROTEIN, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Wolf, J., Valkov, E., Allen, M.D., Meineke, B., Gordiyenko, Y., McLaughlin, S.H., Olsen, T.M., Robinson, C.V., Bycroft, M., Stewart, M., Passmore, L.A.
Deposit date:2014-04-11
Release date:2014-06-11
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Structural Basis for Pan3 Binding to Pan2 and its Function in Mrna Recruitment and Deadenylation
Embo J., 33, 2014
4CYJ
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CHAETOMIUM THERMOPHILUM PAN2:PAN3 COMPLEX
Descriptor:PAB-DEPENDENT POLY(A)-SPECIFIC RIBONUCLEASE SUBUNIT PAN3-LIKE PROTEIN, PAN2, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:Wolf, J., Valkov, E., Allen, M.D., Meineke, B., Gordiyenko, Y., McLaughlin, S.H., Olsen, T.M., Robinson, C.V., Bycroft, M., Stewart, M., Passmore, L.A.
Deposit date:2014-04-11
Release date:2014-06-11
Last modified:2014-07-30
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structural Basis for Pan3 Binding to Pan2 and its Function in Mrna Recruitment and Deadenylation
Embo J., 33, 2014
4CYK
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STRUCTURAL BASIS FOR BINDING OF PAN3 TO PAN2 AND ITS FUNCTION IN MRNA RECRUITMENT AND DEADENYLATION
Descriptor:PAB-DEPENDENT POLY(A)-SPECIFIC RIBONUCLEASE SUBUNIT PAN3, ZINC ION
Authors:Wolf, J., Valkov, E., Allen, M.D., Meineke, B., Gordiyenko, Y., McLaughlin, S.H., Olsen, T.M., Robinson, C.V., Bycroft, M., Stewart, M., Passmore, L.A.
Deposit date:2014-04-11
Release date:2014-05-21
Last modified:2016-04-27
Method:SOLUTION NMR
Cite:Structural Basis for Pan3 Binding to Pan2 and its Function in Mrna Recruitment and Deadenylation.
Embo J., 33, 2014
4V1W
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3D STRUCTURE OF HORSE SPLEEN APOFERRITIN DETERMINED BY ELECTRON CRYOMICROSCOPY
Descriptor:FERRITIN LIGHT CHAIN
Authors:Russo, C.J., Passmore, L.A.
Deposit date:2014-10-02
Release date:2014-12-10
Last modified:2017-08-02
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Electron Microscopy. Ultrastable Gold Substrates for Electron Cryomicroscopy.
Science, 346, 2014
6FPP
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STRUCTURE OF S. POMBE MMI1
Descriptor:YTH domain-containing protein mmi1, GLYCEROL, MAGNESIUM ION
Authors:Stowell, J.A.W., Hill, C.H., Yu, M., Wagstaff, J.L., McLaughlin, S.H., Freund, S.M.V., Passmore, L.A.
Deposit date:2018-02-11
Release date:2018-05-09
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:A low-complexity region in the YTH domain protein Mmi1 enhances RNA binding.
J. Biol. Chem., 293, 2018
6FPQ
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STRUCTURE OF S. POMBE MMI1 IN COMPLEX WITH 7-MER RNA
Descriptor:YTH domain-containing protein mmi1, RNA (5'-R(*UP*UP*AP*AP*AP*CP*C)-3'), (4R)-2-METHYLPENTANE-2,4-DIOL
Authors:Stowell, J.A.W., Hill, C.H., Yu, M., Wagstaff, J.L., McLaughlin, S.H., Freund, S.M.V., Passmore, L.A.
Deposit date:2018-02-11
Release date:2018-05-09
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:A low-complexity region in the YTH domain protein Mmi1 enhances RNA binding.
J. Biol. Chem., 293, 2018
6FPX
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STRUCTURE OF S. POMBE MMI1 IN COMPLEX WITH 11-MER RNA
Descriptor:YTH domain-containing protein mmi1, RNA (5'-R(P*UP*UP*UP*AP*AP*AP*CP*CP*UP*A)-3'), GLYCEROL
Authors:Stowell, J.A.W., Hill, C.H., Yu, M., Wagstaff, J.L., McLaughlin, S.H., Freund, S.M.V., Passmore, L.A.
Deposit date:2018-02-12
Release date:2018-05-09
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:A low-complexity region in the YTH domain protein Mmi1 enhances RNA binding.
J. Biol. Chem., 293, 2018
6I1D
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STRUCTURE OF THE YSH1-MPE1 NUCLEASE COMPLEX FROM S.CEREVISIAE
Descriptor:Endoribonuclease YSH1, Protein MPE1, ZINC ION, ...
Authors:Hill, C.H., Boreikaite, V., Kumar, A., Casanal, A., Kubik, P., Degliesposti, G., Maslen, S., Mariani, A., von Loeffelholz, O., Girbig, M., Skehel, M., Passmore, L.A.
Deposit date:2018-10-28
Release date:2019-02-13
Last modified:2019-04-03
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Activation of the Endonuclease that Defines mRNA 3' Ends Requires Incorporation into an 8-Subunit Core Cleavage and Polyadenylation Factor Complex.
Mol.Cell, 73, 2019
6R9I
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STRUCTURE OF SACCHAROMYCES CEREVISIAE APO PAN2 PSEUDOUBIQUITIN HYDROLASE-RNA EXONUCLEASE (UCH-EXO) MODULE
Descriptor:PAN2-PAN3 deadenylation complex catalytic subunit PAN2
Authors:Tang, T.T.L., Stowell, J.A.W., Hill, C.H., Passmore, L.A.
Deposit date:2019-04-03
Release date:2019-05-22
Last modified:2020-01-29
Method:X-RAY DIFFRACTION (3 Å)
Cite:The intrinsic structure of poly(A) RNA determines the specificity of Pan2 and Caf1 deadenylases.
Nat.Struct.Mol.Biol., 26, 2019
6R9J
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STRUCTURE OF SACCHAROMYCES CEREVISIAE APO PAN2 PSEUDOUBIQUITIN HYDROLASE-RNA EXONUCLEASE (UCH-EXO) MODULE IN COMPLEX WITH A7 RNA
Descriptor:PAN2-PAN3 deadenylation complex catalytic subunit PAN2, A7 RNA
Authors:Tang, T.T.L., Stowell, J.A.W., Hill, C.H., Passmore, L.A.
Deposit date:2019-04-03
Release date:2019-05-22
Last modified:2019-08-21
Method:X-RAY DIFFRACTION (3.326 Å)
Cite:The intrinsic structure of poly(A) RNA determines the specificity of Pan2 and Caf1 deadenylases.
Nat.Struct.Mol.Biol., 26, 2019
6R9M
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STRUCTURE OF SACCHAROMYCES CEREVISIAE APO PAN2 PSEUDOUBIQUITIN HYDROLASE-RNA EXONUCLEASE (UCH-EXO) MODULE IN COMPLEX WITH AAGGAA RNA
Descriptor:PAN2-PAN3 deadenylation complex catalytic subunit PAN2, AAGGAA RNA
Authors:Tang, T.T.L., Stowell, J.A.W., Hill, C.H., Passmore, L.A.
Deposit date:2019-04-03
Release date:2019-05-22
Last modified:2019-08-21
Method:X-RAY DIFFRACTION (3.329 Å)
Cite:The intrinsic structure of poly(A) RNA determines the specificity of Pan2 and Caf1 deadenylases.
Nat.Struct.Mol.Biol., 26, 2019
6R9O
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STRUCTURE OF SACCHAROMYCES CEREVISIAE APO PAN2 PSEUDOUBIQUITIN HYDROLASE-RNA EXONUCLEASE (UCH-EXO) MODULE IN COMPLEX WITH AAGGA RNA
Descriptor:PAN2-PAN3 deadenylation complex catalytic subunit PAN2, AAGGA RNA
Authors:Tang, T.T.L., Stowell, J.A.W., Hill, C.H., Passmore, L.A.
Deposit date:2019-04-03
Release date:2019-05-22
Last modified:2019-08-21
Method:X-RAY DIFFRACTION (3.319 Å)
Cite:The intrinsic structure of poly(A) RNA determines the specificity of Pan2 and Caf1 deadenylases.
Nat.Struct.Mol.Biol., 26, 2019
6R9P
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STRUCTURE OF SACCHAROMYCES CEREVISIAE APO PAN2 PSEUDOUBIQUITIN HYDROLASE-RNA EXONUCLEASE (UCH-EXO) MODULE IN COMPLEX WITH AAUUAA RNA
Descriptor:PAN2-PAN3 deadenylation complex catalytic subunit PAN2, AAUUAA RNA
Authors:Tang, T.T.L., Stowell, J.A.W., Hill, C.H., Passmore, L.A.
Deposit date:2019-04-03
Release date:2019-05-22
Last modified:2019-08-21
Method:X-RAY DIFFRACTION (2.98 Å)
Cite:The intrinsic structure of poly(A) RNA determines the specificity of Pan2 and Caf1 deadenylases.
Nat.Struct.Mol.Biol., 26, 2019
6R9Q
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STRUCTURE OF SACCHAROMYCES CEREVISIAE APO PAN2 PSEUDOUBIQUITIN HYDROLASE-RNA EXONUCLEASE (UCH-EXO) MODULE IN COMPLEX WITH AACCAA RNA
Descriptor:PAN2-PAN3 deadenylation complex catalytic subunit PAN2, AACCAA
Authors:Tang, T.T.L., Stowell, J.A.W., Hill, C.H., Passmore, L.A.
Deposit date:2019-04-03
Release date:2019-05-22
Last modified:2019-08-21
Method:X-RAY DIFFRACTION (3.079 Å)
Cite:The intrinsic structure of poly(A) RNA determines the specificity of Pan2 and Caf1 deadenylases.
Nat.Struct.Mol.Biol., 26, 2019
6SRI
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STRUCTURE OF THE FANCONI ANAEMIA CORE COMPLEX
Descriptor:Unassigned secondary structure elements (central region, proposed FANCB-FAAP100: chain A,a; base region, proposed FANCC-FANC-E-FANCF: chain 3), ...
Authors:Shakeel, S., Rajendra, E., Alcon, P., He, S., Scheres, S.H.W., Passmore, L.A.
Deposit date:2019-09-05
Release date:2019-11-06
Last modified:2019-11-20
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structure of the Fanconi anaemia monoubiquitin ligase complex.
Nature, 575, 2019
6SRS
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STRUCTURE OF THE FANCONI ANAEMIA CORE SUBCOMPLEX
Descriptor:Unassigned secondary structure elements (central region, proposed FANCB-FAAP100), Unassigned secondary structure elements (proposed FANCB), ...
Authors:Shakeel, S., Rajendra, E., Alcon, P., He, S., Scheres, S.H.W., Passmore, L.A.
Deposit date:2019-09-05
Release date:2019-11-06
Last modified:2019-11-20
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Structure of the Fanconi anaemia monoubiquitin ligase complex.
Nature, 575, 2019
6TNF
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STRUCTURE OF MONOUBIQUITINATED FANCD2 IN COMPLEX WITH FANCI AND DNA
Descriptor:FANCD2, Fanconi anemia complementation group I, Polyubiquitin-C, ...
Authors:Alcon, P., Shakeel, S., Passmore, L.A.
Deposit date:2019-12-07
Release date:2020-02-19
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:FANCD2-FANCI is a clamp stabilized on DNA by monoubiquitination during DNA repair
To Be Published
6TNG
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STRUCTURE OF FANCD2 IN COMPLEX WITH FANCI
Descriptor:Uncharacterized protein, Fanconi anemia complementation group I
Authors:Alcon, P., Shakeel, S., Passmore, L.A.
Deposit date:2019-12-07
Release date:2020-02-19
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:FANCD2-FANCI is a clamp stabilized on DNA by monoubiquitination during DNA repair
To Be Published
6TNI
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STRUCTURE OF FANCD2 HOMODIMER
Descriptor:Uncharacterized protein
Authors:Alcon, P., Shakeel, S., Passmore, L.A.
Deposit date:2019-12-08
Release date:2020-02-19
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:FANCD2-FANCI is a clamp stabilized on DNA by monoubiquitination during DNA repair
To Be Published
6EOJ
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POLYA POLYMERASE MODULE OF THE CLEAVAGE AND POLYADENYLATION FACTOR (CPF) FROM SACCHAROMYCES CEREVISIAE
Descriptor:Protein CFT1, mRNA 3'-end-processing protein YTH1, Polyadenylation factor subunit 2,Polyadenylation factor subunit 2, ...
Authors:Casanal, A., Kumar, A., Hill, C.H., Emsley, P., Passmore, L.
Deposit date:2017-10-09
Release date:2017-11-15
Last modified:2018-01-31
Method:ELECTRON MICROSCOPY (3.55 Å)
Cite:Architecture of eukaryotic mRNA 3'-end processing machinery.
Science, 358, 2017
4FXE
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CRYSTAL STRUCTURE OF THE INTACT E. COLI RELBE TOXIN-ANTITOXIN COMPLEX
Descriptor:Antitoxin RelB, mRNA interferase RelE, SULFATE ION
Authors:Brodersen, D.E., Boggild, A., Sofos, N.
Deposit date:2012-07-03
Release date:2012-08-29
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.7503 Å)
Cite:The crystal structure of the intact E. coli RelBE toxin-antitoxin complex provides the structural basis for conditional cooperativity.
Structure, 20, 2012
4FXH
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CRYSTAL STRUCTURE OF THE ISOLATED E. COLI RELE TOXIN, P212121 FORM
Descriptor:mRNA interferase RelE, SULFATE ION
Authors:Brodersen, D.E., Boggild, A., Sofos, N.
Deposit date:2012-07-03
Release date:2012-08-29
Last modified:2012-12-26
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The crystal structure of the intact E. coli RelBE toxin-antitoxin complex provides the structural basis for conditional cooperativity.
Structure, 20, 2012
4FXI
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CRYSTAL STRUCTURE OF THE ISOLATED E. COLI RELE TOXIN, P21 FORM
Descriptor:mRNA interferase RelE, SULFATE ION
Authors:Brodersen, D.E., Boggild, A., Sofos, N.
Deposit date:2012-07-03
Release date:2012-08-29
Last modified:2012-12-26
Method:X-RAY DIFFRACTION (1.8003 Å)
Cite:The crystal structure of the intact E. coli RelBE toxin-antitoxin complex provides the structural basis for conditional cooperativity.
Structure, 20, 2012
4XB6
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STRUCTURE OF THE E. COLI C-P LYASE CORE COMPLEX
Descriptor:Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnG, Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnH, Alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase subunit PhnI, ...
Authors:Brodersen, D.E.
Deposit date:2014-12-16
Release date:2015-08-19
Last modified:2015-09-09
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural insights into the bacterial carbon-phosphorus lyase machinery.
Nature, 525, 2015
6M8Q
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CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR SUBUNIT 3 (CPSF3) IN COMPLEX WITH NVP-LTM531
Descriptor:Cleavage and polyadenylation specificity factor subunit 3, ZINC ION, N-{3,5-dichloro-2-hydroxy-4-[2-(4-methylpiperazin-1-yl)ethoxy]benzene-1-carbonyl}-L-phenylalanine, ...
Authors:Weihofen, W.A., Salcius, M., Michaud, G.
Deposit date:2018-08-22
Release date:2019-11-27
Last modified:2020-01-01
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:CPSF3-dependent pre-mRNA processing as a druggable node in AML and Ewing's sarcoma.
Nat.Chem.Biol., 16, 2020