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7P9U
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BU of 7p9u by Molmil
Cryo EM structure of System XC- in complex with glutamate
Descriptor: 4F2 cell-surface antigen heavy chain, Cystine/glutamate transporter, GLUTAMIC ACID
Authors:Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S.
Deposit date:2021-07-28
Release date:2021-11-17
Last modified:2022-02-02
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Molecular basis for redox control by the human cystine/glutamate antiporter system xc .
Nat Commun, 12, 2021
7P9V
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BU of 7p9v by Molmil
Cryo EM structure of System XC-
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4F2 cell-surface antigen heavy chain, Cystine/glutamate transporter
Authors:Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S.
Deposit date:2021-07-28
Release date:2021-11-17
Last modified:2022-02-02
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Molecular basis for redox control by the human cystine/glutamate antiporter system xc .
Nat Commun, 12, 2021
7BC6
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BU of 7bc6 by Molmil
Cryo-EM structure of the outward open proton coupled folate transporter at pH 7.5
Descriptor: Proton-coupled folate transporter, nanobody
Authors:Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S.
Deposit date:2020-12-18
Release date:2021-05-12
Last modified:2021-08-11
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural basis of antifolate recognition and transport by PCFT.
Nature, 595, 2021
7BC7
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BU of 7bc7 by Molmil
Cryo-EM structure of the proton coupled folate transporter at pH 6.0 bound to pemetrexed
Descriptor: 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID, Proton-coupled folate transporter, nanobody
Authors:Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S.
Deposit date:2020-12-18
Release date:2021-05-12
Last modified:2021-08-11
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structural basis of antifolate recognition and transport by PCFT.
Nature, 595, 2021
8P6A
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BU of 8p6a by Molmil
cryo-EM structure of human SLC15A4 in outward-open state
Descriptor: Solute carrier family 15 member 4
Authors:Parker, J.L, Kato, T, Newstead, S.
Deposit date:2023-05-25
Release date:2023-06-07
Method:ELECTRON MICROSCOPY (3.63 Å)
Cite:cryo-EM structure of human SLC15A4 PHT1 in outward-open state
To be published
8OMU
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BU of 8omu by Molmil
Cryo-EM structure of rat SLC22A6 bound to alpha-ketoglutaric acid in a low occupancy state
Descriptor: Solute carrier family 22 member 6, Synthetic nanobody (Sybody)
Authors:Parker, J.L, Kato, T, Newstead, S.
Deposit date:2023-03-31
Release date:2023-07-19
Last modified:2023-11-22
Method:ELECTRON MICROSCOPY (3.43 Å)
Cite:Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1.
Nat.Struct.Mol.Biol., 30, 2023
8APY
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BU of 8apy by Molmil
Crystal structure of the H12A variant of the KDEL receptor bound to sybody
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ER lumen protein-retaining receptor 2, Synthetic nanobody
Authors:Parker, J.L, Smith, K, Newstead, S.
Deposit date:2022-08-10
Release date:2023-08-23
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:Crystal structure of the H12A variant of the KDEL receptor bound to sybody
To Be Published
8BVS
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BU of 8bvs by Molmil
Cryo-EM structure of rat SLC22A6 bound to tenofovir
Descriptor: CHLORIDE ION, Solute carrier family 22 member 6, Synthetic nanobody (Sybody), ...
Authors:Parker, J.L, Kato, T, Newstead, S.
Deposit date:2022-12-05
Release date:2023-07-19
Last modified:2023-11-22
Method:ELECTRON MICROSCOPY (3.61 Å)
Cite:Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1.
Nat.Struct.Mol.Biol., 30, 2023
8BW7
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BU of 8bw7 by Molmil
Cryo-EM structure of rat SLC22A6 bound to alpha-ketoglutaric acid
Descriptor: 2-OXOGLUTARIC ACID, CHLORIDE ION, Solute carrier family 22 member 6, ...
Authors:Parker, J.L, Kato, T, Newstead, S.
Deposit date:2022-12-06
Release date:2023-07-19
Last modified:2023-11-22
Method:ELECTRON MICROSCOPY (3.53 Å)
Cite:Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1.
Nat.Struct.Mol.Biol., 30, 2023
8BVT
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BU of 8bvt by Molmil
Cryo-EM structure of rat SLC22A6 bound to probenecid
Descriptor: 4-(dipropylsulfamoyl)benzoic acid, Solute carrier family 22 member 6, Synthetic nanobody (Sybody)
Authors:Parker, J.L, Kato, T, Newstead, S.
Deposit date:2022-12-06
Release date:2023-07-19
Last modified:2023-11-22
Method:ELECTRON MICROSCOPY (3.94 Å)
Cite:Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1.
Nat.Struct.Mol.Biol., 30, 2023
8BVR
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BU of 8bvr by Molmil
Cryo-EM structure of rat SLC22A6 in the apo state
Descriptor: PHOSPHATE ION, Solute carrier family 22 member 6, Synthetic nanobody (Sybody)
Authors:Parker, J.L, Kato, T, Newstead, S.
Deposit date:2022-12-05
Release date:2023-07-19
Last modified:2023-11-22
Method:ELECTRON MICROSCOPY (3.52 Å)
Cite:Molecular basis for selective uptake and elimination of organic anions in the kidney by OAT1.
Nat.Struct.Mol.Biol., 30, 2023
7NQK
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BU of 7nqk by Molmil
Cryo-EM structure of the mammalian peptide transporter PepT2
Descriptor: Solute carrier family 15 member 2, nanobody
Authors:Parker, J.L, Deme, J.C, Lea, S.M, Newstead, S.
Deposit date:2021-03-01
Release date:2021-07-07
Last modified:2021-10-13
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Cryo-EM structure of PepT2 reveals structural basis for proton-coupled peptide and prodrug transport in mammals.
Sci Adv, 7, 2021
5A2O
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BU of 5a2o by Molmil
Crystal structure of the nitrate transporter NRT1.1 from Arabidopsis thaliana in complex with nitrate.
Descriptor: NITRATE ION, NITRATE TRANSPORTER 1.1
Authors:Parker, J.L, Newstead, S.
Deposit date:2015-05-20
Release date:2015-06-17
Last modified:2019-07-10
Method:X-RAY DIFFRACTION (3.71 Å)
Cite:Molecular Basis of Nitrate Uptake by the Plant Nitrate Transporter Nrt1.1.
Nature, 507, 2014
5A2N
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BU of 5a2n by Molmil
Crystal structure of the nitrate transporter NRT1.1 from Arabidopsis thaliana.
Descriptor: PROTEIN NRT1/ PTR FAMILY 6.3
Authors:Parker, J.L, Newstead, S.
Deposit date:2015-05-20
Release date:2015-06-17
Last modified:2019-02-27
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Molecular Basis of Nitrate Uptake by the Plant Nitrate Transporter Nrt1.1.
Nature, 507, 2014
7ZKW
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BU of 7zkw by Molmil
Crystal structure of cystinosin from Arabidopsis thaliana in complex with Cystine and sybody
Descriptor: Cystinosin homolog, L-cystine, sybody
Authors:Parker, J.L, Loebel, M, Newstead, S.
Deposit date:2022-04-13
Release date:2022-08-31
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.372 Å)
Cite:Structural basis for proton coupled cystine transport by cystinosin.
Nat Commun, 13, 2022
6QSK
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BU of 6qsk by Molmil
Crystal structure of a nucleotide sugar transporter with bound nucleotide monophosphate.
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, GDP-mannose transporter 1, GUANOSINE-5'-MONOPHOSPHATE, ...
Authors:Newstead, S, Parker, J.L.
Deposit date:2019-02-21
Release date:2019-10-02
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.394 Å)
Cite:Structural basis for substrate specificity and regulation of nucleotide sugar transporters in the lipid bilayer.
Nat Commun, 10, 2019
5OGK
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BU of 5ogk by Molmil
Crystal structure of a nucleotide sugar transporter with bound nucleotide sugar.
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, GDP-mannose transporter 1, GUANOSINE-5'-DIPHOSPHATE-ALPHA-D-MANNOSE
Authors:Newstead, S, Parker, J.L.
Deposit date:2017-07-13
Release date:2017-11-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structural basis of nucleotide sugar transport across the Golgi membrane.
Nature, 551, 2017
5OGE
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BU of 5oge by Molmil
Crystal structure of a nucleotide sugar transporter
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, GDP-mannose transporter 1
Authors:Newstead, S, Parker, J.L.
Deposit date:2017-07-12
Release date:2017-11-22
Last modified:2017-12-06
Method:X-RAY DIFFRACTION (3.22 Å)
Cite:Structural basis of nucleotide sugar transport across the Golgi membrane.
Nature, 551, 2017
7OXE
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BU of 7oxe by Molmil
Crystal structure of the KDEL receptor bound to HDEF peptide at pH 6.0
Descriptor: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ER lumen protein-retaining receptor 2, THR-ALA-GLU-HIS-ASP-GLU-PHE
Authors:Newstead, S, Parker, J.L.
Deposit date:2021-06-22
Release date:2022-07-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.283 Å)
Cite:Crystal structure of the KDEL receptor bound to HDEF peptide at pH 6.0
To Be Published
6ZXR
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BU of 6zxr by Molmil
Crystal structure of the KDEL receptor bound to RDEL peptide at pH 6.0
Descriptor: ALA-GLU-ARG-ASP-GLU-LEU, ER lumen protein-retaining receptor 2
Authors:Newstead, S, Parker, J.L.
Deposit date:2020-07-30
Release date:2021-02-24
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:A signal capture and proofreading mechanism for the KDEL-receptor explains selectivity and dynamic range in ER retrieval.
Elife, 10, 2021
7NVH
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BU of 7nvh by Molmil
Cryo-EM structure of the mycolic acid transporter MmpL3 from M. tuberculosis
Descriptor: 2-decyl-2-{[(4-O-alpha-D-glucopyranosyl-beta-D-glucopyranosyl)oxy]methyl}dodecyl 4-O-alpha-D-glucopyranosyl-beta-D-glucopyranoside, Trehalose monomycolate exporter MmpL3
Authors:Adams, O, Deme, J.C, Parker, J.L, Lea, S.M, Newstead, S.
Deposit date:2021-03-15
Release date:2021-06-16
Last modified:2022-12-21
Method:ELECTRON MICROSCOPY (3.02 Å)
Cite:Cryo-EM structure and resistance landscape of M. tuberculosis MmpL3: An emergent therapeutic target.
Structure, 29, 2021
4D2B
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BU of 4d2b by Molmil
Structure of a ligand free POT family peptide transporter
Descriptor: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, DI-OR TRIPEPTIDE:H+ SYMPORTER, ...
Authors:Lyons, J.A, Parker, J.L, Solcan, N, Brinth, A, Li, D, Shah, S.T.A, Caffrey, M, Newstead, S.
Deposit date:2014-05-09
Release date:2014-06-25
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural Basis for Polyspecificity in the Pot Family of Proton-Coupled Oligopeptide Transporters.
Embo Rep., 15, 2014
4D2C
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BU of 4d2c by Molmil
Structure of a di peptide bound POT family peptide transporter
Descriptor: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, ALANINE, ...
Authors:Lyons, J.A, Parker, J.L, Solcan, N, Brinth, A, Li, D, Shah, S.T.A, Caffrey, M, Newstead, S.
Deposit date:2014-05-09
Release date:2014-06-25
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Structural Basis for Polyspecificity in the Pot Family of Proton-Coupled Oligopeptide Transporters.
Embo Rep., 15, 2014
4D2D
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BU of 4d2d by Molmil
Structure of a tri peptide bound POT family peptide transporter
Descriptor: (2R)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, (2S)-2,3-DIHYDROXYPROPYL(7Z)-PENTADEC-7-ENOATE, ALANINE-TRIPEPTIDE, ...
Authors:Lyons, J.A, Parker, J.L, Solcan, N, Brinth, A, Li, D, Shah, S.T.A, Caffrey, M, Newstead, S.
Deposit date:2014-05-09
Release date:2014-06-25
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.522 Å)
Cite:Structural Basis for Polyspecificity in the Pot Family of Proton-Coupled Oligopeptide Transporters.
Embo Rep., 15, 2014
1OB8
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BU of 1ob8 by Molmil
Holliday Junction Resolving Enzyme
Descriptor: 1,2-ETHANEDIOL, HOLLIDAY-JUNCTION RESOLVASE, SULFATE ION
Authors:Middleton, C.L, Parker, J.L, Richard, D.J, White, M.F, Bond, C.S.
Deposit date:2003-01-28
Release date:2004-10-15
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Substrate Recognition and Catalysis by the Holliday Junction Resolving Enzyme Hje.
Nucleic Acids Res., 32, 2004

 

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