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4R3P
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CRYSTAL STRUCTURES OF EGFR IN COMPLEX WITH MIG6
Descriptor:Epidermal growth factor receptor, peptide from ERBB receptor feedback inhibitor 1
Authors:Park, E., Kim, N., Yi, Z., Cho, A., Kim, K., Ficarro, S.B., Park, A., Park, W.Y., Murray, B., Meyerson, M., Beroukim, R., Marto, J.A., Cho, J., Eck, M.J.
Deposit date:2014-08-17
Release date:2015-08-12
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (2.905 Å)
Cite:Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6.
Nat.Struct.Mol.Biol., 22, 2015
4R3R
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CRYSTAL STRUCTURES OF EGFR IN COMPLEX WITH MIG6
Descriptor:Epidermal growth factor receptor, peptide from ERBB receptor feedback inhibitor 1'
Authors:Park, E., Kim, N., Yi, Z., Cho, A., Kim, K., Ficarro, S.B., Park, A., Park, W.Y., Murray, B., Meyerson, M., Beroukim, R., Marto, J.A., Cho, J., Eck, M.J.
Deposit date:2014-08-17
Release date:2015-08-12
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6.
Nat.Struct.Mol.Biol., 22, 2015
5TQQ
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CRYO-ELECTRON MICROSCOPY STRUCTURE OF A BOVINE CLC-K CHLORIDE CHANNEL, MAIN (CLASS 1) CONFORMATION
Descriptor:Chloride channel protein, Monoclonal antibody, Fab fragment, ...
Authors:Park, E., MacKinnon, R.
Deposit date:2016-10-24
Release date:2017-01-04
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.76 Å)
Cite:Structure of a CLC chloride ion channel by cryo-electron microscopy.
Nature, 541, 2017
5TR1
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CRYO-ELECTRON MICROSCOPY STRUCTURE OF A BOVINE CLC-K CHLORIDE CHANNEL, ALTERNATE (CLASS 2) CONFORMATION
Descriptor:Chloride channel protein, Monoclonal antibody, Fab fragment, ...
Authors:Park, E., MacKinnon, R.
Deposit date:2016-10-25
Release date:2017-01-11
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.95 Å)
Cite:Structure of a CLC chloride ion channel by cryo-electron microscopy.
Nature, 541, 2017
6COY
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HUMAN CLC-1 CHLORIDE ION CHANNEL, TRANSMEMBRANE DOMAIN
Descriptor:Chloride channel protein 1, CHLORIDE ION
Authors:Park, E., MacKinnon, R.
Deposit date:2018-03-13
Release date:2018-06-13
Method:ELECTRON MICROSCOPY (3.36 Å)
Cite:Structure of the CLC-1 chloride channel fromHomo sapiens.
Elife, 7, 2018
6COZ
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HUMAN CLC-1 CHLORIDE ION CHANNEL, C-TERMINAL CYTOSOLIC DOMAIN
Descriptor:Chloride channel protein 1
Authors:Park, E., MacKinnon, R.
Deposit date:2018-03-13
Release date:2018-06-13
Method:ELECTRON MICROSCOPY (3.36 Å)
Cite:Structure of the CLC-1 chloride channel fromHomo sapiens.
Elife, 7, 2018
4ZJV
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CRYSTAL STRUCTURE OF EGFR KINASE DOMAIN IN COMPLEX WITH MITOGEN-INDUCIBLE GENE 6 PROTEIN
Descriptor:Epidermal growth factor receptor, ERBB receptor feedback inhibitor 1
Authors:Eck, M.J., Park, E., Lee, B.
Deposit date:2015-04-29
Release date:2015-08-12
Last modified:2015-09-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6.
Nat.Struct.Mol.Biol., 22, 2015
3J45
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STRUCTURE OF A NON-TRANSLOCATING SECY PROTEIN CHANNEL WITH THE 70S RIBOSOME
Descriptor:Protein translocase subunit SecY, Preprotein translocase subunit SecE, Protein-export membrane protein SecG, ...
Authors:Menetret, J.F., Park, E., Gumbart, J.C., Ludtke, S.J., Li, W., Whynot, A., Rapoport, T.A., Akey, C.W.
Deposit date:2013-06-18
Release date:2013-10-23
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (9.5 Å)
Cite:Structure of the SecY channel during initiation of protein translocation.
Nature, 506, 2013
3J46
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STRUCTURE OF THE SECY PROTEIN TRANSLOCATION CHANNEL IN ACTION
Descriptor:Protein translocase subunit SecY, Preprotein translocase subunit SecE, Protein-export membrane protein SecG, ...
Authors:Akey, C.W., Park, E., Menetret, J.F., Gumbart, J.C., Ludtke, S.J., Li, W., Whynot, A., Rapoport, T.A.
Deposit date:2013-06-18
Release date:2013-10-23
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (10.1 Å)
Cite:Structure of the SecY channel during initiation of protein translocation.
Nature, 506, 2013
4G4E
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CRYSTAL STRUCTURE OF THE L88A MUTANT OF HSLV FROM ESCHERICHIA COLI
Descriptor:ATP-dependent protease subunit HslV
Authors:Lee, J.W., Park, E., Yoo, H.M., Ha, B.H., An, J.Y., Jeon, Y.J., Seol, J.H., Eom, S.H., Chung, C.H.
Deposit date:2012-07-16
Release date:2013-06-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.888 Å)
Cite:Structural Alteration in the Pore Motif of the Bacterial 20S Proteasome Homolog HslV Leads to Uncontrolled Protein Degradation
J.Mol.Biol., 425, 2013
4V4N
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STRUCTURE OF THE METHANOCOCCUS JANNASCHII RIBOSOME-SECYEBETA CHANNEL COMPLEX
Descriptor:Preprotein translocase subunit SecE, Preprotein translocase subunit SecG, 50S ribosomal protein L39E, ...
Authors:Menetret, J.F., Park, E., Gumbart, J.C., Ludtke, S.J., Li, W., Whynot, A., Rapoport, T.A., Akey, C.W.
Deposit date:2013-06-17
Release date:2014-07-09
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (9 Å)
Cite:Structure of the SecY channel during initiation of protein translocation.
Nature, 506, 2013
4WYB
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STRUCTURE OF THE BUD6 FLANK DOMAIN IN COMPLEX WITH ACTIN
Descriptor:Actin, alpha skeletal muscle, Bud site selection protein 6, ...
Authors:Eck, M.J., Park, E., Zheng, W.
Deposit date:2014-11-17
Release date:2015-08-19
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.493 Å)
Cite:Structure of a Bud6/Actin Complex Reveals a Novel WH2-like Actin Monomer Recruitment Motif.
Structure, 23, 2015
6D8E
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DISCOVERY OF A HIGHLY POTENT AND BROADLY EFFECTIVE EGFR AND HER2 EXON 20 INSERTION MUTANT INHIBITOR
Descriptor:Epidermal growth factor receptor, (4-fluorophenyl)methyl {2-[(1-methyl-1H-pyrazol-3-yl)amino]pyrimidin-4-yl}[3-(propanoylamino)phenyl]carbamate
Authors:Park, E., Eck, M.J.
Deposit date:2018-04-26
Release date:2018-07-18
Last modified:2018-09-12
Method:X-RAY DIFFRACTION (2.537 Å)
Cite:Discovery of a Highly Potent and Broadly Effective Epidermal Growth Factor Receptor and HER2 Exon 20 Insertion Mutant Inhibitor.
Angew. Chem. Int. Ed. Engl., 57, 2018
6N3Q
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CRYO-EM STRUCTURE OF THE YEAST SEC COMPLEX
Descriptor:Protein transport protein SEC61, Protein transport protein SSS1, Protein transport protein SBH1, ...
Authors:Park, E., Itskanov, S.
Deposit date:2018-11-16
Release date:2018-12-19
Last modified:2019-01-16
Method:ELECTRON MICROSCOPY (3.68 Å)
Cite:Structure of the posttranslational Sec protein-translocation channel complex from yeast.
Science, 363, 2019
5D41
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EGFR KINASE DOMAIN IN COMPLEX WITH MUTANT SELECTIVE ALLOSTERIC INHIBITOR
Descriptor:Epidermal growth factor receptor, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Yun, C.-H., Park, E., Eck, M.J.
Deposit date:2015-08-07
Release date:2016-06-08
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Overcoming EGFR(T790M) and EGFR(C797S) resistance with mutant-selective allosteric inhibitors.
Nature, 534, 2016
5EUL
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STRUCTURE OF THE SECA-SECY COMPLEX WITH A TRANSLOCATING POLYPEPTIDE SUBSTRATE
Descriptor:Protein translocase subunit SecA, Insertion Peptide Chimera, Protein translocase subunit SecY, ...
Authors:Li, L., Park, E., Ling, J., Ingram, J., Ploegh, H., Rapoport, T.A.
Deposit date:2015-11-18
Release date:2016-03-09
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Crystal structure of a substrate-engaged SecY protein-translocation channel.
Nature, 531, 2016
1KOZ
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SOLUTION STRUCTURE OF OMEGA-GRAMMOTOXIN SIA
Descriptor:Voltage-dependent Channel Inhibitor
Authors:Takeuchi, K., Park, E.J., Lee, C.W., Kim, J.I., Takahashi, H., Swartz, K.J., Shimada, I.
Deposit date:2001-12-25
Release date:2002-08-28
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of omega-grammotoxin SIA, a gating modifier of P/Q and N-type Ca(2+) channel.
J.Mol.Biol., 321, 2002
5VND
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CRYSTAL STRUCTURE OF FGFR1-Y563C (FGFR4 SURROGATE) COVALENTLY BOUND TO H3B-6527
Descriptor:Fibroblast growth factor receptor 1, N-{2-[(6-{[(2,6-dichloro-3,5-dimethoxyphenyl)carbamoyl](methyl)amino}pyrimidin-4-yl)amino]-5-(4-ethylpiperazin-1-yl)phenyl}propanamide, SULFATE ION, ...
Authors:Tsai, J.H.C., Reynolds, D., Fekkes, P., Smith, P., Larsen, N.A.
Deposit date:2017-04-30
Release date:2017-05-24
Last modified:2018-12-05
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:H3B-6527 Is a Potent and Selective Inhibitor of FGFR4 in FGF19-Driven Hepatocellular Carcinoma.
Cancer Res., 77, 2017
5WIJ
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JAK2 PSEUDOKINASE IN COMPLEX WITH NU6140
Descriptor:Tyrosine-protein kinase JAK2, 4-{[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino}-N,N-diethylbenzamide
Authors:Li, Q., Eck, M.J., Li, K., Park, E.
Deposit date:2017-07-19
Release date:2018-08-01
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Discovery and structural characterization of ATP-site ligands for the wild-type and V617F-mutant JAK2 pseudokinase domain.
ACS Chem. Biol., 2019
5WIK
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JAK2 PSEUDOKINASE IN COMPLEX WITH BI-D1870
Descriptor:Tyrosine-protein kinase JAK2, (7R)-2-[(3,5-difluoro-4-hydroxyphenyl)amino]-5,7-dimethyl-8-(3-methylbutyl)-7,8-dihydropteridin-6(5H)-one
Authors:Li, Q., Eck, M.J., Li, K., Park, E.
Deposit date:2017-07-19
Release date:2018-08-01
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery and structural characterization of ATP-site ligands for the wild-type and V617F-mutant JAK2 pseudokinase domain.
ACS Chem. Biol., 2019
5WIL
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JAK2 PSEUDOKINASE IN COMPLEX WITH AZD7762
Descriptor:Tyrosine-protein kinase JAK2, 5-(3-fluorophenyl)-N-[(3S)-3-piperidyl]-3-ureido-thiophene-2-carboxamide
Authors:Li, Q., Eck, M.J., Li, K., Park, E.
Deposit date:2017-07-19
Release date:2018-08-01
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery and structural characterization of ATP-site ligands for the wild-type and V617F-mutant JAK2 pseudokinase domain.
ACS Chem. Biol., 2019
5WIM
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JAK2 PSEUDOKINASE IN COMPLEX WITH AT9283
Descriptor:Tyrosine-protein kinase JAK2, 1-cyclopropyl-3-{3-[5-(morpholin-4-ylmethyl)-1H-benzimidazol-2-yl]-1H-pyrazol-4-yl}urea
Authors:Li, Q., Eck, M.J., Li, K., Park, E.
Deposit date:2017-07-19
Release date:2018-08-01
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Discovery and structural characterization of ATP-site ligands for the wild-type and V617F-mutant JAK2 pseudokinase domain.
ACS Chem. Biol., 2019
5WIN
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JAK2 PSEUDOKINASE IN COMPLEX WITH JNJ7706621
Descriptor:Tyrosine-protein kinase JAK2, 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzenesulfonamide
Authors:Li, Q., Eck, M.J., Li, K., Park, E.
Deposit date:2017-07-19
Release date:2018-08-01
Last modified:2019-03-20
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Discovery and structural characterization of ATP-site ligands for the wild-type and V617F-mutant JAK2 pseudokinase domain.
ACS Chem. Biol., 2019
3BO0
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RIBOSOME-SECY COMPLEX
Descriptor:23S RIBOSOMAL RNA, PREPROTEIN TRANSLOCASE SecY SUBUNIT, PREPROTEIN TRANSLOCASE SecE SUBUNIT, ...
Authors:Akey, C.W., Menetret, J.F.
Deposit date:2007-12-15
Release date:2008-12-09
Last modified:2011-07-13
Method:ELECTRON MICROSCOPY (9.6 Å)
Cite:Ribosome binding of a single copy of the SecY complex: implications for protein translocation
Mol.Cell, 28, 2007
3BO1
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RIBOSOME-SECY COMPLEX
Descriptor:23S RIBOSOMAL RNA, PREPROTEIN TRANSLOCASE SecY SUBUNIT, PREPROTEIN TRANSLOCASE SecE SUBUNIT, ...
Authors:Akey, C.W., Menetret, J.F.
Deposit date:2007-12-15
Release date:2008-12-09
Last modified:2011-07-13
Method:ELECTRON MICROSCOPY (9.6 Å)
Cite:Ribosome binding of a single copy of the SecY complex: implications for protein translocation
Mol.Cell, 28, 2007
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