Author results

5P21
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REFINED CRYSTAL STRUCTURE OF THE TRIPHOSPHATE CONFORMATION OF H-RAS P21 AT 1.35 ANGSTROMS RESOLUTION: IMPLICATIONS FOR THE MECHANISM OF GTP HYDROLYSIS
分子名称:C-H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
著者Pai, E.F., Wittinghofer, A., Kabsch, W.
登録日1990-04-30
公開日1992-01-15
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.
EMBO J., 9, 1990
1GRT
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HUMAN GLUTATHIONE REDUCTASE A34E/R37W MUTANT
分子名称:GLUTATHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE
著者Stoll, V.S., Simpson, S.J., Krauth-Siegel, R.L., Walsh, C.T., Pai, E.F.
登録日1996-12-17
公開日1997-06-16
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity.
Biochemistry, 36, 1997
2GRT
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HUMAN GLUTATHIONE REDUCTASE A34E, R37W MUTANT, OXIDIZED GLUTATHIONE COMPLEX
分子名称:GLUTATHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, OXIDIZED GLUTATHIONE DISULFIDE
著者Stoll, V.S., Simpson, S.J., Krauth-Siegel, R.L., Walsh, C.T., Pai, E.F.
登録日1997-02-12
公開日1997-08-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity.
Biochemistry, 36, 1997
3GRT
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HUMAN GLUTATHIONE REDUCTASE A34E, R37W MUTANT, OXIDIZED TRYPANOTHIONE COMPLEX
分子名称:GLUTATHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, 2-AMINO-4-[4-(4-AMINO-4-CARBOXY-BUTYRYLAMINO)-5,8,19,22-TETRAOXO-1,2-DITHIA-6,9,13,18,21-PENTAAZA-CYCLOTETRACOS-23-YLCARBAMOYL]-BUTYRIC ACID
著者Stoll, V.S., Simpson, S.J., Krauth-Siegel, R.L., Walsh, C.T., Pai, E.F.
登録日1997-02-12
公開日1997-08-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity.
Biochemistry, 36, 1997
4GRT
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HUMAN GLUTATHIONE REDUCTASE A34E, R37W MUTANT, MIXED DISULFIDE BETWEEN TRYPANOTHIONE AND THE ENZYME
分子名称:GLUTATHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, BIS(GAMMA-GLUTAMYL-CYSTEINYL-GLYCINYL)SPERMIDINE
著者Stoll, V.S., Simpson, S.J., Krauth-Siegel, R.L., Walsh, C.T., Pai, E.F.
登録日1997-02-12
公開日1997-08-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity.
Biochemistry, 36, 1997
5GRT
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HUMAN GLUTATHIONE REDUCTASE A34E, R37W MUTANT, GLUTATHIONYLSPERMIDINE COMPLEX
分子名称:GLUTATHIONE REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, GLUTATHIONYLSPERMIDINE DISULFIDE
著者Stoll, V.S., Simpson, S.J., Krauth-Siegel, R.L., Walsh, C.T., Pai, E.F.
登録日1997-02-12
公開日1997-08-12
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity.
Biochemistry, 36, 1997
3BDJ
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CRYSTAL STRUCTURE OF BOVINE MILK XANTHINE DEHYDROGENASE WITH A COVALENTLY BOUND OXIPURINOL INHIBITOR
分子名称:Xanthine dehydrogenase/oxidase, CALCIUM ION, FE2/S2 (INORGANIC) CLUSTER, ...
著者Eger, B.T., Okamoto, K., Nishino, T., Pai, E.F., Nishino, T.
登録日2007-11-14
公開日2008-11-25
最終更新日2014-09-10
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Mechanism of inhibition of xanthine oxidoreductase by allopurinol: crystal structure of reduced bovine milk xanthine oxidoreductase bound with oxipurinol.
Nucleosides Nucleotides Nucleic Acids, 27, 2008
821P
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THREE-DIMENSIONAL STRUCTURES AND PROPERTIES OF A TRANSFORMING AND A NONTRANSFORMING GLYCINE-12 MUTANT OF P21H-RAS
分子名称:C-H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
著者Scheidig, A.J., Krengel, U., Pai, E.F., Kabsch, W., Wittinghofer, A., Goody, R.S.
登録日1993-03-29
公開日1994-01-31
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras.
Biochemistry, 32, 1993
1GNP
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X-RAY CRYSTAL STRUCTURE ANALYSIS OF THE CATALYTIC DOMAIN OF THE ONCOGENE PRODUCT P21H-RAS COMPLEXED WITH CAGED GTP AND MANT DGPPNHP
分子名称:C-H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID 3'-O-(N-METHYLANTHRANILOYL-2'-DEOXYGUANYLATE ESTER
著者Scheidig, A., Franken, S.M., Corrie, J.E.T., Reid, G.P., Wittinghofer, A., Pai, E.F., Goody, R.S.
登録日1995-05-11
公開日1995-07-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp.
J.Mol.Biol., 253, 1995
521P
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THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES
分子名称:H-RAS P21 PROTEIN, MAGNESIUM ION, GUANOSINE-5'-TRIPHOSPHATE
著者Schlichting, I., Krengel, U., Kabsch, W., Wittinghofer, A., Pai, E.F.
登録日1991-06-06
公開日1994-01-31
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules.
Cell(Cambridge,Mass.), 62, 1990
1E2A
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ENZYME IIA FROM THE LACTOSE SPECIFIC PTS FROM LACTOCOCCUS LACTIS
分子名称:ENZYME IIA, MAGNESIUM ION
著者Sliz, P., Engelmann, R., Hengstenberg, W., Pai, E.F.
登録日1997-04-25
公開日1998-04-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The structure of enzyme IIAlactose from Lactococcus lactis reveals a new fold and points to possible interactions of a multicomponent system.
Structure, 5, 1997
1EKJ
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THE X-RAY CRYSTALLOGRAPHIC STRUCTURE OF BETA CARBONIC ANHYDRASE FROM THE C3 DICOT PISUM SATIVUM
分子名称:BETA-CARBONIC ANHYDRASE, ACETATE ION, AZIDE ION, ...
著者Kimber, M.S., Pai, E.F.
登録日2000-03-08
公開日2000-06-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献The active site architecture of Pisum sativum beta-carbonic anhydrase is a mirror image of that of alpha-carbonic anhydrases.
EMBO J., 19, 2000
1GNQ
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X-RAY CRYSTAL STRUCTURE ANALYSIS OF THE CATALYTIC DOMAIN OF THE ONCOGENE PRODUCT P21H-RAS COMPLEXED WITH CAGED GTP AND MANT DGPPNHP
分子名称:C-H-RAS P21 PROTEIN, MAGNESIUM ION, GUANOSINE 5'-TRIPHOSPHATE P3-[1-(2-NITROPHENYL)ETHYL ESTER]
著者Scheidig, A., Franken, S.M., Corrie, J.E.T., Reid, G.P., Wittinghofer, A., Pai, E.F., Goody, R.S.
登録日1995-05-11
公開日1995-07-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp.
J.Mol.Biol., 253, 1995
1GNR
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X-RAY CRYSTAL STRUCTURE ANALYSIS OF THE CATALYTIC DOMAIN OF THE ONCOGENE PRODUCT P21H-RAS COMPLEXED WITH CAGED GTP AND MANT DGPPNHP
分子名称:C-H-RAS P21 PROTEIN, MAGNESIUM ION, GUANOSINE 5'-TRIPHOSPHATE P3-[1-(2-NITROPHENYL)ETHYL ESTER]
著者Scheidig, A., Franken, S.M., Corrie, J.E.T., Reid, G.P., Wittinghofer, A., Pai, E.F., Goody, R.S.
登録日1995-05-11
公開日1995-07-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献X-ray crystal structure analysis of the catalytic domain of the oncogene product p21H-ras complexed with caged GTP and mant dGppNHp.
J.Mol.Biol., 253, 1995
1NDA
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THE STRUCTURE OF TRYPANOSOMA CRUZI TRYPANOTHIONE REDUCTASE IN THE OXIDIZED AND NADPH REDUCED STATE
分子名称:TRYPANOTHIONE OXIDOREDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE
著者Lantwin, C.B., Kabsch, W., Pai, E.F., Schlichting, I., Krauth-Siegel, R.L.
登録日1993-07-02
公開日1994-09-30
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献The structure of Trypanosoma cruzi trypanothione reductase in the oxidized and NADPH reduced state.
Proteins, 18, 1994
1PLJ
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CRYSTALLOGRAPHIC STUDIES ON P21H-RAS USING SYNCHROTRON LAUE METHOD: IMPROVEMENT OF CRYSTAL QUALITY AND MONITORING OF THE GTPASE REACTION AT DIFFERENT TIME POINTS
分子名称:C-H-RAS P21 PROTEIN, MAGNESIUM ION, GUANOSINE 5'-TRIPHOSPHATE P3-[1-(2-NITROPHENYL)ETHYL ESTER]
著者Scheidig, A., Sanchez-Llorente, A., Lautwein, A., Pai, E.F., Corrie, J.E.T., Reid, G.P., Wittinghofer, A., Goody, R.S.
登録日1994-03-13
公開日1994-07-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystallographic studies on p21(H-ras) using the synchrotron Laue method: improvement of crystal quality and monitoring of the GTPase reaction at different time points.
Acta Crystallogr.,Sect.D, 50, 1994
1PLK
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CRYSTALLOGRAPHIC STUDIES ON P21H-RAS USING SYNCHROTRON LAUE METHOD: IMPROVEMENT OF CRYSTAL QUALITY AND MONITORING OF THE GTPASE REACTION AT DIFFERENT TIME POINTS
分子名称:C-H-RAS P21 PROTEIN, MAGNESIUM ION, GUANOSINE-5'-TRIPHOSPHATE
著者Scheidig, A., Sanchez-Llorente, A., Lautwein, A., Pai, E.F., Corrie, J.E.T., Reid, G.P., Wittinghofer, A., Goody, R.S.
登録日1994-03-13
公開日1994-07-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystallographic studies on p21(H-ras) using the synchrotron Laue method: improvement of crystal quality and monitoring of the GTPase reaction at different time points.
Acta Crystallogr.,Sect.D, 50, 1994
1PLL
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CRYSTALLOGRAPHIC STUDIES ON P21H-RAS USING SYNCHROTRON LAUE METHOD: IMPROVEMENT OF CRYSTAL QUALITY AND MONITORING OF THE GTPASE REACTION AT DIFFERENT TIME POINTS
分子名称:C-H-RAS P21 PROTEIN, GUANOSINE-5'-DIPHOSPHATE
著者Scheidig, A., Sanchez-Llorente, A., Lautwein, A., Pai, E.F., Corrie, J.E.T., Reid, G.P., Wittinghofer, A., Goody, R.S.
登録日1994-03-13
公開日1994-07-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystallographic studies on p21(H-ras) using the synchrotron Laue method: improvement of crystal quality and monitoring of the GTPase reaction at different time points.
Acta Crystallogr.,Sect.D, 50, 1994
221P
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THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES
分子名称:H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
著者Krengel, U., Scherer, A., Kabsch, W., Wittinghofer, A., Pai, E.F.
登録日1991-06-06
公開日1994-01-31
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules.
Cell(Cambridge,Mass.), 62, 1990
2E2A
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ASP81LEU ENZYME IIA FROM THE LACTOSE SPECIFIC PTS FROM LACTOCOCCUS LACTIS
分子名称:PROTEIN (ENZYME IIA)
著者Sliz, P., Koch, B., Hengstenberg, W., Pai, E.F.
登録日1999-05-14
公開日2003-06-17
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structure of Asp81Leu Enzyme Iia from the Lactose Specific Pts from Lactococcus Lactis
To be Published
3N75
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X-RAY CRYSTAL STRUCTURE OF THE ESCHERICHIA COLI INDUCIBLE LYSINE DECARBOXYLASE LDCI
分子名称:Lysine decarboxylase, inducible, GUANOSINE-5',3'-TETRAPHOSPHATE, ...
著者Kanjee, U., Alexopoulos, E., Pai, E.F., Houry, W.A.
登録日2010-05-26
公開日2011-02-16
最終更新日2011-07-27
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Linkage between the bacterial acid stress and stringent responses: the structure of the inducible lysine decarboxylase.
Embo J., 30, 2011
3SEC
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CRYSTAL STRUCTURE OF METHANOTHERMOBACTER THERMAUTOTROPHICUS OROTIDINE 5'-MONOPHOSPHATE DECARBOXYLASE COMPLEXED WITH PYRAZOFURIN MONOPHOSPHATE
分子名称:Orotidine 5'-phosphate decarboxylase, GLYCEROL, (1S)-1,4-anhydro-1-(5-carbamoyl-4-hydroxy-1H-pyrazol-3-yl)-5-O-phosphono-D-ribitol
著者Liu, Y., Kotra, L.P., Pai, E.F.
登録日2011-06-10
公開日2012-04-25
最終更新日2012-05-09
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure of methanococcus thermolithotrophicus orotidine 5'-monophosphate decarboxylase complexed with pyrazofurin monophosphate
To be Published
421P
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THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES
分子名称:H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
著者Krengel, U., John, J., Scherer, A., Kabsch, W., Wittinghofer, A., Pai, E.F.
登録日1991-06-06
公開日1994-01-31
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules.
Cell(Cambridge,Mass.), 62, 1990
621P
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THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES
分子名称:H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
著者Krengel, U., Scherer, A., Kabsch, W., Wittinghofer, A., Pai, E.F.
登録日1991-06-06
公開日1994-01-31
最終更新日2017-11-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules.
Cell(Cambridge,Mass.), 62, 1990
6BTL
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CRYSTAL STRUCTURE OF TRYPANOTHIONE REDUCTASE FROM TRYPANOSOMA BRUCEI IN COMPLEX WITH INHIBITOR RD117 1-[2-(PIPERAZIN-1-YL)ETHYL]-5-{5-[1-(PYRROLIDIN-1-YL)CYCLOHEXYL]-1,3-THIAZOL-2-YL}-1H-INDOLE
分子名称:Trypanothione reductase, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, ...
著者Bryson, S., De Gasparo, R., Krauth-Siegel, R.L., Diederich, F., Pai, E.F.
登録日2017-12-06
公開日2018-06-06
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (2.797 Å)
主引用文献Biological Evaluation and X-ray Co-crystal Structures of Cyclohexylpyrrolidine Ligands for Trypanothione Reductase, an Enzyme from the Redox Metabolism of Trypanosoma.
ChemMedChem, 13, 2018