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1URN
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BU of 1urn by Molmil
U1A MUTANT/RNA COMPLEX + GLYCEROL
Descriptor: CHLORIDE ION, GLYCEROL, PROTEIN (U1A), ...
Authors:Oubridge, C, Ito, N, Evans, P.R, Teo, C.-H, Nagai, K.
Deposit date:1995-01-04
Release date:1996-03-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Crystal structure at 1.92 A resolution of the RNA-binding domain of the U1A spliceosomal protein complexed with an RNA hairpin.
Nature, 372, 1994
1L9A
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BU of 1l9a by Molmil
CRYSTAL STRUCTURE OF SRP19 IN COMPLEX WITH THE S DOMAIN OF SIGNAL RECOGNITION PARTICLE RNA
Descriptor: MAGNESIUM ION, METHYL MERCURY ION, SIGNAL RECOGNITION PARTICLE 19 KDA PROTEIN, ...
Authors:Oubridge, C, Kuglstatter, A, Jovine, L, Nagai, K.
Deposit date:2002-03-22
Release date:2002-06-28
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of SRP19 in complex with the S domain of SRP RNA and its implication for the assembly of the signal recognition particle.
Mol.Cell, 9, 2002
4PKD
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BU of 4pkd by Molmil
U1-70k in complex with U1 snRNA stem-loops 1 and U1-A RRM in complex with stem-loop 2
Descriptor: IMIDAZOLE, MAGNESIUM ION, U1 small nuclear ribonucleoprotein A,U1 small nuclear ribonucleoprotein 70 kDa, ...
Authors:Oubridge, C, Kondo, Y, van Roon, A.M, Nagai, K.
Deposit date:2014-05-14
Release date:2014-12-31
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition.
Elife, 4, 2015
3CW1
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BU of 3cw1 by Molmil
Crystal Structure of Human Spliceosomal U1 snRNP
Descriptor: Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, Small nuclear ribonucleoprotein G, ...
Authors:Pomeranz Krummel, D.A, Oubridge, C, Leung, A.K, Li, J, Nagai, K.
Deposit date:2008-04-21
Release date:2009-03-24
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (5.493 Å)
Cite:Crystal structure of human spliceosomal U1 snRNP at 5.5 A resolution.
Nature, 458, 2009
2VRD
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BU of 2vrd by Molmil
THE STRUCTURE OF THE ZINC FINGER FROM THE HUMAN SPLICEOSOMAL PROTEIN U1C
Descriptor: U1 SMALL NUCLEAR RIBONUCLEOPROTEIN C, ZINC ION
Authors:Muto, Y, Pomeranz-Krummel, D, Oubridge, C, Hernandez, H, Robinson, C, Neuhaus, D, Nagai, K.
Deposit date:2008-03-31
Release date:2008-04-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:The Structure and Biochemical Properties of the Human Spliceosomal Protein U1C
J.Mol.Biol., 341, 2004
1DUH
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BU of 1duh by Molmil
CRYSTAL STRUCTURE OF THE CONSERVED DOMAIN IV OF E. COLI 4.5S RNA
Descriptor: 4.5S RNA DOMAIN IV, LUTETIUM (III) ION, MAGNESIUM ION, ...
Authors:Jovine, L, Hainzl, T, Oubridge, C, Scott, W.G, Li, J, Sixma, T.K, Wonacott, A, Skarzynski, T, Nagai, K.
Deposit date:2000-01-17
Release date:2000-05-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of the ffh and EF-G binding sites in the conserved domain IV of Escherichia coli 4.5S RNA.
Structure Fold.Des., 8, 2000
6QDV
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BU of 6qdv by Molmil
Human post-catalytic P complex spliceosome
Descriptor: 116 kDa U5 small nuclear ribonucleoprotein component, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent RNA helicase DHX8, ...
Authors:Fica, S.M, Oubridge, C, Wilkinson, M.E, Newman, A.J, Nagai, K.
Deposit date:2019-01-03
Release date:2019-02-20
Last modified:2020-10-07
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:A human postcatalytic spliceosome structure reveals essential roles of metazoan factors for exon ligation.
Science, 363, 2019
4I43
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BU of 4i43 by Molmil
Crystal structure of Prp8:Aar2 complex
Descriptor: A1 cistron-splicing factor AAR2, Pre-mRNA-splicing factor 8
Authors:Galej, W.P, Oubridge, C, Newman, A.J, Nagai, K.
Deposit date:2012-11-27
Release date:2013-01-23
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of Prp8 reveals active site cavity of the spliceosome.
Nature, 493, 2013
3KL4
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BU of 3kl4 by Molmil
Recognition of a signal peptide by the signal recognition particle
Descriptor: Signal peptide of yeast dipeptidyl aminopeptidase B, Signal recognition 54 kDa protein
Authors:Janda, C.Y, Nagai, K, Li, J, Oubridge, C.
Deposit date:2009-11-06
Release date:2010-03-31
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Recognition of a signal peptide by the signal recognition particle.
Nature, 465, 2010
3ZEF
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BU of 3zef by Molmil
Crystal structure of Prp8:Aar2 complex: second crystal form at 3.1 Angstrom resolution
Descriptor: A1 CISTRON-SPLICING FACTOR AAR2, PRE-MRNA-SPLICING FACTOR 8
Authors:Galej, W.P, Oubridge, C, Newman, A.J, Nagai, K.
Deposit date:2012-12-05
Release date:2013-01-30
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Crystal Structure of Prp8 Reveals Active Site Cavity of the Spliceosome
Nature, 493, 2013
5MPS
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BU of 5mps by Molmil
Structure of a spliceosome remodeled for exon ligation
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, MAGNESIUM ION, ...
Authors:Fica, S.M, Oubridge, C, Galej, W.P, Wilkinson, M.E, Newman, A.J, Bai, X.-C, Nagai, K.
Deposit date:2016-12-18
Release date:2017-01-18
Last modified:2020-10-07
Method:ELECTRON MICROSCOPY (3.85 Å)
Cite:Structure of a spliceosome remodelled for exon ligation.
Nature, 542, 2017
5MQ0
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BU of 5mq0 by Molmil
Structure of a spliceosome remodeled for exon ligation
Descriptor: 3'-EXON OF UBC4 PRE-MRNA, BOUND BY PRP22 HELICASE, 5'-EXON OF UBC4 PRE-MRNA, ...
Authors:Fica, S.M, Oubridge, C, Galej, W.P, Wilkinson, M.E, Newman, A.J, Bai, X.-C, Nagai, K.
Deposit date:2016-12-19
Release date:2017-01-18
Last modified:2020-10-07
Method:ELECTRON MICROSCOPY (4.17 Å)
Cite:Structure of a spliceosome remodelled for exon ligation.
Nature, 542, 2017
1MFQ
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BU of 1mfq by Molmil
Crystal Structure Analysis of a Ternary S-Domain Complex of Human Signal Recognition Particle
Descriptor: 7S RNA of human SRP, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Kuglstatter, A, Oubridge, C, Nagai, K.
Deposit date:2002-08-13
Release date:2002-09-20
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Induced structural changes of 7SL RNA during the assembly of human signal recognition particle
Nat.Struct.Biol., 9, 2002
4PJO
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BU of 4pjo by Molmil
Minimal U1 snRNP
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CHLORIDE ION, ETHANOL, ...
Authors:Kondo, Y, Oubridge, C, van Roon, A.M, Nagai, K.
Deposit date:2014-05-12
Release date:2014-12-31
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Crystal structure of human U1 snRNP, a small nuclear ribonucleoprotein particle, reveals the mechanism of 5' splice site recognition.
Elife, 4, 2015
5GAO
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BU of 5gao by Molmil
Head region of the yeast spliceosomal U4/U6.U5 tri-snRNP
Descriptor: Pre-mRNA-splicing factor 8, Pre-mRNA-splicing helicase BRR2, Saccharomyces cerevisiae strain UOA_M2 chromosome 5 sequence, ...
Authors:Nguyen, T.H.D, Galej, W.P, Bai, X.C, Oubridge, C, Scheres, S.H.W, Newman, A.J, Nagai, K.
Deposit date:2015-12-15
Release date:2016-01-27
Last modified:2019-10-02
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution.
Nature, 530, 2016
5GAM
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BU of 5gam by Molmil
Foot region of the yeast spliceosomal U4/U6.U5 tri-snRNP
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, Pre-mRNA-splicing factor 8, Pre-mRNA-splicing factor SNU114, ...
Authors:Nguyen, T.H.D, Galej, W.P, Bai, X.C, Oubridge, C, Scheres, S.H.W, Newman, A.J, Nagai, K.
Deposit date:2015-12-15
Release date:2016-02-03
Last modified:2019-10-02
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Angstrom resolution
Nature, 530, 2016
5GAN
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BU of 5gan by Molmil
The overall structure of the yeast spliceosomal U4/U6.U5 tri-snRNP at 3.7 Angstrom
Descriptor: 13 kDa ribonucleoprotein-associated protein, GUANOSINE-5'-TRIPHOSPHATE, Pre-mRNA-processing factor 31, ...
Authors:Nguyen, T.H.D, Galej, W.P, Bai, X.C, Oubridge, C, Scheres, S.H.W, Newman, A.J, Nagai, K.
Deposit date:2015-12-15
Release date:2016-01-27
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution.
Nature, 530, 2016
5GAP
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BU of 5gap by Molmil
Body region of the U4/U6.U5 tri-snRNP
Descriptor: 13 kDa ribonucleoprotein-associated protein, Pre-mRNA-processing factor 31, Pre-mRNA-splicing factor 6, ...
Authors:Nguyen, T.H.D, Galej, W.P, Oubridge, C, Bai, X.C, Newman, A, Scheres, S, Nagai, K.
Deposit date:2015-12-15
Release date:2016-01-27
Last modified:2019-10-02
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 angstrom resolution.
Nature, 530, 2016
5LJ3
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BU of 5lj3 by Molmil
Structure of the core of the yeast spliceosome immediately after branching
Descriptor: CEF1, CLF1, CWC15, ...
Authors:Galej, W.P, Wilkinson, M.F, Fica, S.M, Oubridge, C, Newman, A.J, Nagai, K.
Deposit date:2016-07-17
Release date:2016-08-03
Last modified:2019-10-23
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM structure of the spliceosome immediately after branching.
Nature, 537, 2016
5LSB
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BU of 5lsb by Molmil
Crystal structure of yeast Hsh49p in complex with Cus1p binding domain.
Descriptor: Cold sensitive U2 snRNA suppressor 1, Protein HSH49
Authors:van Roon, A.M, Obayashi, E, Sposito, B, Oubridge, C, Nagai, K.
Deposit date:2016-08-24
Release date:2017-04-12
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of U2 snRNP SF3b components: Hsh49p in complex with Cus1p-binding domain.
RNA, 23, 2017
5LSL
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BU of 5lsl by Molmil
Crystal structure of yeast Hsh49p in complex with Cus1p binding domain.
Descriptor: Cold sensitive U2 snRNA suppressor 1, Protein HSH49
Authors:van Roon, A.M, Obayashi, E, Sposito, B, Oubridge, C, Nagai, K.
Deposit date:2016-09-02
Release date:2017-04-12
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of U2 snRNP SF3b components: Hsh49p in complex with Cus1p-binding domain.
RNA, 23, 2017
5LJ5
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BU of 5lj5 by Molmil
Overall structure of the yeast spliceosome immediately after branching.
Descriptor: CWC15, CWC22, Exon 1 (5' exon) of UBC4 pre-mRNA, ...
Authors:Galej, W.P, Wilkinson, M.F, Fica, S.M, Oubridge, C, Newman, A.J, Nagai, K.
Deposit date:2016-07-17
Release date:2016-08-31
Last modified:2019-12-11
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM structure of the spliceosome immediately after branching.
Nature, 537, 2016
4WZJ
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BU of 4wzj by Molmil
Spliceosomal U4 snRNP core domain
Descriptor: Small nuclear ribonucleoprotein E, Small nuclear ribonucleoprotein F, Small nuclear ribonucleoprotein G, ...
Authors:Leung, A.K.W, Nagai, K, Li, J.
Deposit date:2014-11-19
Release date:2015-01-14
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Structure of the spliceosomal U4 snRNP core domain and its implication for snRNP biogenesis.
Nature, 473, 2011
2SXL
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BU of 2sxl by Molmil
SEX-LETHAL RBD1, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor: SEX-LETHAL PROTEIN
Authors:Inoue, M, Muto, Y, Sakamoto, H, Kigawa, T, Takio, K, Shimura, Y, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:1997-07-16
Release date:1998-07-22
Last modified:2021-11-03
Method:SOLUTION NMR
Cite:A characteristic arrangement of aromatic amino acid residues in the solution structure of the amino-terminal RNA-binding domain of Drosophila sex-lethal.
J.Mol.Biol., 272, 1997
1FHT
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BU of 1fht by Molmil
RNA-BINDING DOMAIN OF THE U1A SPLICEOSOMAL PROTEIN U1A117, NMR, 43 STRUCTURES
Descriptor: U1 SMALL NUCLEAR RIBONUCLEOPROTEIN A
Authors:Allain, F.H.-T, Gubser, C.C, Howe, P.W.A, Nagai, K, Neuhaus, D, Varani, G.
Deposit date:1996-02-21
Release date:1996-07-11
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:Solution structure of the N-terminal RNP domain of U1A protein: the role of C-terminal residues in structure stability and RNA binding.
J.Mol.Biol., 257, 1996

 

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