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7KC0
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BU of 7kc0 by Molmil
Structure of the Saccharomyces cerevisiae replicative polymerase delta in complex with a primer/template and the PCNA clamp
Descriptor: 2',3'-DIDEOXY-THYMIDINE-5'-TRIPHOSPHATE, DNA (25-MER), DNA (5'-D(P*AP*TP*GP*AP*CP*CP*AP*TP*GP*AP*TP*TP*AP*CP*GP*AP*AP*TP*TP*GP*C)-3'), ...
Authors:Zheng, F, Georgescu, R, Li, H, O'Donnell, M.E.
Deposit date:2020-10-04
Release date:2020-12-02
Last modified:2020-12-16
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure of eukaryotic DNA polymerase delta bound to the PCNA clamp while encircling DNA.
Proc.Natl.Acad.Sci.USA, 117, 2020
5U8S
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BU of 5u8s by Molmil
Structure of eukaryotic CMG helicase at a replication fork
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, DNA (26-MER), ...
Authors:Li, H, Li, B, Georgescu, R, Yuan, Z, Santos, R, Sun, J, Zhang, D, Yurieva, O, O'Donnell, M.E.
Deposit date:2016-12-14
Release date:2017-01-25
Last modified:2020-01-01
Method:ELECTRON MICROSCOPY (6.101 Å)
Cite:Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5U8T
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BU of 5u8t by Molmil
Structure of Eukaryotic CMG Helicase at a Replication Fork and Implications
Descriptor: Cell division control protein 45, DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), DNA replication complex GINS protein PSF1, ...
Authors:Li, B, Georgescu, R, Yuan, Z, Santos, R, Sun, J, Zhang, D, Yurieva, O, Li, H, O'Donnell, M.E.
Deposit date:2016-12-15
Release date:2017-02-08
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Structure of eukaryotic CMG helicase at a replication fork and implications to replisome architecture and origin initiation.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
7SGZ
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BU of 7sgz by Molmil
Structure of the yeast Rad24-RFC loader bound to DNA and the closed 9-1-1 clamp
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, Crick strand, ...
Authors:Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H.
Deposit date:2021-10-07
Release date:2022-03-23
Last modified:2022-04-27
Method:ELECTRON MICROSCOPY (3.17 Å)
Cite:DNA is loaded through the 9-1-1 DNA checkpoint clamp in the opposite direction of the PCNA clamp.
Nat.Struct.Mol.Biol., 29, 2022
7SH2
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BU of 7sh2 by Molmil
Structure of the yeast Rad24-RFC loader bound to DNA and the open 9-1-1 clamp
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, Crick strand, ...
Authors:Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H.
Deposit date:2021-10-07
Release date:2022-03-23
Last modified:2022-04-27
Method:ELECTRON MICROSCOPY (3.23 Å)
Cite:DNA is loaded through the 9-1-1 DNA checkpoint clamp in the opposite direction of the PCNA clamp.
Nat.Struct.Mol.Biol., 29, 2022
7TFH
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BU of 7tfh by Molmil
Atomic model of the S. cerevisiae clamp-clamp loader complex PCNA-RFC bound to two DNA molecules, one at the 5'-recessed end and the other at the 3'-recessed end
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H.
Deposit date:2022-01-06
Release date:2022-11-16
Method:ELECTRON MICROSCOPY (3.09 Å)
Cite:Cryo-EM structures reveal that RFC recognizes both the 3'- and 5'-DNA ends to load PCNA onto gaps for DNA repair.
Elife, 11, 2022
7TFK
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BU of 7tfk by Molmil
Atomic model of S. cerevisiae clamp loader RFC bound to two DNA molecules, one at the 5'-recessed end and the other at the 3'-recessed end
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H.
Deposit date:2022-01-06
Release date:2022-11-16
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:Cryo-EM structures reveal that RFC recognizes both the 3'- and 5'-DNA ends to load PCNA onto gaps for DNA repair.
Elife, 11, 2022
7TFL
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BU of 7tfl by Molmil
Atomic model of S. cerevisiae clamp loader RFC bound to DNA
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H.
Deposit date:2022-01-06
Release date:2022-11-16
Method:ELECTRON MICROSCOPY (3.33 Å)
Cite:Cryo-EM structures reveal that RFC recognizes both the 3'- and 5'-DNA ends to load PCNA onto gaps for DNA repair.
Elife, 11, 2022
7TFI
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BU of 7tfi by Molmil
Atomic model of the S. cerevisiae clamp-clamp loader complex PCNA-RFC bound to DNA with an open clamp
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H.
Deposit date:2022-01-06
Release date:2022-11-16
Method:ELECTRON MICROSCOPY (3.41 Å)
Cite:Cryo-EM structures reveal that RFC recognizes both the 3'- and 5'-DNA ends to load PCNA onto gaps for DNA repair.
Elife, 11, 2022
7TFJ
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BU of 7tfj by Molmil
Atomic model of S. cerevisiae clamp-clamp loader complex PCNA-RFC bound to DNA with a closed clamp ring
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ...
Authors:Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H.
Deposit date:2022-01-06
Release date:2022-11-16
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structures reveal that RFC recognizes both the 3'- and 5'-DNA ends to load PCNA onto gaps for DNA repair.
Elife, 11, 2022
8FS6
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BU of 8fs6 by Molmil
Structure of S. cerevisiae Rad24-RFC loading the 9-1-1 clamp onto a 10-nt gapped DNA in step 4 (partially closed 9-1-1 and stably bound chamber DNA)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, DDC1 isoform 1, ...
Authors:Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H.
Deposit date:2023-01-09
Release date:2023-06-14
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structures of 9-1-1 DNA checkpoint clamp loading at gaps from start to finish and ramification to biology.
Biorxiv, 2023
8FS4
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BU of 8fs4 by Molmil
Structure of S. cerevisiae Rad24-RFC loading the 9-1-1 clamp onto a 10-nt gapped DNA in step 2 (open 9-1-1 ring and flexibly bound chamber DNA)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, DDC1 isoform 1, ...
Authors:Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H.
Deposit date:2023-01-09
Release date:2023-06-14
Method:ELECTRON MICROSCOPY (2.94 Å)
Cite:Structures of 9-1-1 DNA checkpoint clamp loading at gaps from start to finish and ramification to biology.
Biorxiv, 2023
8FS7
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BU of 8fs7 by Molmil
Structure of S. cerevisiae Rad24-RFC loading the 9-1-1 clamp onto a 10-nt gapped DNA in step 5 (closed 9-1-1 and stably bound chamber DNA)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, DDC1 isoform 1, ...
Authors:Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H.
Deposit date:2023-01-09
Release date:2023-06-14
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:Structures of 9-1-1 DNA checkpoint clamp loading at gaps from start to finish and ramification to biology.
Biorxiv, 2023
8FS8
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BU of 8fs8 by Molmil
Structure of S. cerevisiae Rad24-RFC loading the 9-1-1 clamp onto a 5-nt gapped DNA (9-1-1 encircling fully bound DNA)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, DDC1 isoform 1, ...
Authors:Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H.
Deposit date:2023-01-09
Release date:2023-06-14
Method:ELECTRON MICROSCOPY (3.04 Å)
Cite:Structures of 9-1-1 DNA checkpoint clamp loading at gaps from start to finish and ramification to biology.
Biorxiv, 2023
8FS5
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BU of 8fs5 by Molmil
Structure of S. cerevisiae Rad24-RFC loading the 9-1-1 clamp onto a 10-nt gapped DNA in step 3 (open 9-1-1 and stably bound chamber DNA)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, DDC1 isoform 1, ...
Authors:Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H.
Deposit date:2023-01-09
Release date:2023-06-14
Method:ELECTRON MICROSCOPY (2.76 Å)
Cite:Structures of 9-1-1 DNA checkpoint clamp loading at gaps from start to finish and ramification to biology.
Biorxiv, 2023
8FS3
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BU of 8fs3 by Molmil
Structure of S. cerevisiae Rad24-RFC loading the 9-1-1 clamp onto a 10-nt gapped DNA in step 1 (open 9-1-1 and shoulder bound DNA only)
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Checkpoint protein RAD24, DDC1 isoform 1, ...
Authors:Zheng, F, Georgescu, R, Yao, Y.N, O'Donnell, M.E, Li, H.
Deposit date:2023-01-09
Release date:2023-06-14
Method:ELECTRON MICROSCOPY (2.93 Å)
Cite:Structures of 9-1-1 DNA checkpoint clamp loading at gaps from start to finish and ramification to biology.
Biorxiv, 2023
3JC7
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BU of 3jc7 by Molmil
Structure of the eukaryotic replicative CMG helicase and pumpjack motion
Descriptor: Cell division control protein 45, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ...
Authors:Li, H, Bai, L, Yuan, Z, Sun, J, Georgescu, R.E, Liu, J, O'Donnell, M.E.
Deposit date:2015-11-24
Release date:2016-02-10
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation.
Nat.Struct.Mol.Biol., 23, 2016
3JC5
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BU of 3jc5 by Molmil
Structure of the eukaryotic replicative CMG helicase and pumpjack motion
Descriptor: Cell division control protein 45, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ...
Authors:Li, H, Bai, L, Yuan, Z, Sun, J, Georgescu, R.E, Liu, J, O'Donnell, M.E.
Deposit date:2015-11-24
Release date:2016-02-10
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (4.7 Å)
Cite:Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation.
Nat.Struct.Mol.Biol., 23, 2016
3JC6
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BU of 3jc6 by Molmil
Structure of the eukaryotic replicative CMG helicase and pumpjack motion
Descriptor: Cell division control protein 45, DNA replication complex GINS protein PSF1, DNA replication complex GINS protein PSF2, ...
Authors:Li, H, Bai, L, Yuan, Z, Sun, J, Georgescu, R.E, Liu, J, O'Donnell, M.E.
Deposit date:2015-11-24
Release date:2016-02-10
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structure of the eukaryotic replicative CMG helicase suggests a pumpjack motion for translocation.
Nat.Struct.Mol.Biol., 23, 2016
6PTO
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BU of 6pto by Molmil
Structure of Ctf4 trimer in complex with three CMG helicases
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, DNA polymerase alpha-binding protein, ...
Authors:Yuan, Z, Georgescu, R, Bai, L, Santos, R, Donnell, M, Li, H.
Deposit date:2019-07-16
Release date:2019-11-20
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (7 Å)
Cite:Ctf4 organizes sister replisomes and Pol alpha into a replication factory.
Elife, 8, 2019
6PTN
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BU of 6ptn by Molmil
Structure of Ctf4 trimer in complex with two CMG helicases
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell division control protein 45, DNA polymerase alpha-binding protein, ...
Authors:Yuan, Z, Georgescu, R, Bai, L, Santos, R, Donnell, M, Li, H.
Deposit date:2019-07-16
Release date:2019-11-20
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (5.8 Å)
Cite:Ctf4 organizes sister replisomes and Pol alpha into a replication factory.
Elife, 8, 2019
8FOH
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BU of 8foh by Molmil
Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the RNA synthesis state
Descriptor: DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ...
Authors:Yuan, Z, Georgescu, R, Li, H, O'Donnell, M.
Deposit date:2022-12-30
Release date:2023-05-31
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase.
Nat Commun, 14, 2023
8FOJ
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BU of 8foj by Molmil
Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in the post RNA handoff state
Descriptor: DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ...
Authors:Yuan, Z, Georgescu, R, Li, H, O'Donnell, M.
Deposit date:2022-12-30
Release date:2023-05-31
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase.
Nat Commun, 14, 2023
8FOD
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BU of 8fod by Molmil
Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex in Apo state conformation II
Descriptor: DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ...
Authors:Yuan, Z, Georgescu, R, Li, H, O'Donnell, M.
Deposit date:2022-12-30
Release date:2023-05-31
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase.
Nat Commun, 14, 2023
8FOE
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BU of 8foe by Molmil
Cryo-EM structure of S. cerevisiae DNA polymerase alpha-primase complex bound to a template DNA
Descriptor: DNA polymerase, DNA polymerase alpha subunit B, DNA primase, ...
Authors:Yuan, Z, Georgescu, R, Li, H, O'Donnell, M.
Deposit date:2022-12-30
Release date:2023-05-31
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (5.6 Å)
Cite:Molecular choreography of primer synthesis by the eukaryotic Pol alpha-primase.
Nat Commun, 14, 2023

 

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