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3BSU
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BU of 3bsu by Molmil
Hybrid-binding domain of human RNase H1 in complex with 12-mer RNA/DNA
Descriptor: DNA (5'-D(*DGP*DAP*DAP*DTP*DCP*DAP*DGP*DGP*(5IU)P*DGP*DTP*DC)-3'), MAGNESIUM ION, RNA (5'-R(*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*C)-3'), ...
Authors:Nowotny, M, Cerritelli, S.M, Ghirlando, R, Gaidamakov, S.A, Crouch, R.J, Yang, W.
Deposit date:2007-12-26
Release date:2008-03-25
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Specific recognition of RNA/DNA hybrid and enhancement of human RNase H1 activity by HBD.
Embo J., 27, 2008
2QK9
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BU of 2qk9 by Molmil
Human RNase H catalytic domain mutant D210N in complex with 18-mer RNA/DNA hybrid
Descriptor: 5'-D(*GP*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*CP*GP*CP*AP*CP*T)-3', 5'-R(*AP*GP*UP*GP*CP*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*CP*C)-3', CITRATE ANION, ...
Authors:Nowotny, M, Gaidamakov, S.A, Ghirlando, R, Cerritelli, S.M, Crouch, R.J, Yang, W.
Deposit date:2007-07-10
Release date:2007-11-13
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription
Mol.Cell, 28, 2007
2QKB
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BU of 2qkb by Molmil
Human RNase H catalytic domain mutant D210N in complex with 20-mer RNA/DNA hybrid
Descriptor: 1,2-ETHANEDIOL, 5'-D(*DGP*DGP*DAP*DAP*DTP*DCP*DAP*DGP*DGP*DTP*DGP*DTP*DCP*DGP*DCP*DAP*DCP*DTP*DCP*DT)-3', 5'-R(*GP*GP*AP*GP*UP*GP*CP*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*CP*C)-3'), ...
Authors:Nowotny, M, Gaidamakov, S.A, Ghirlando, R, Cerritelli, S.M, Crouch, R.J, Yang, W.
Deposit date:2007-07-10
Release date:2007-11-13
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription
Mol.Cell, 28, 2007
2QKK
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BU of 2qkk by Molmil
Human RNase H catalytic domain mutant D210N in complex with 14-mer RNA/DNA hybrid
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 5'-D(*GP*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*CP*G)-3', ...
Authors:Nowotny, M, Gaidamakov, S.A, Ghirlando, R, Cerritelli, S.M, Crouch, R.J, Yang, W.
Deposit date:2007-07-11
Release date:2007-11-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription
Mol.Cell, 28, 2007
1ZBI
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BU of 1zbi by Molmil
Bacillus halodurans RNase H catalytic domain mutant D132N in complex with 12-mer RNA/DNA hybrid
Descriptor: 5'-D(*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*C)-3', 5'-R(*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*C)-3', MAGNESIUM ION, ...
Authors:Nowotny, M, Gaidamakov, S.A, Crouch, R.J, Yang, W.
Deposit date:2005-04-08
Release date:2005-07-12
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structures of RNase H Bound to an RNA/DNA Hybrid: Substrate Specificity and Metal-Dependent Catalysis.
Cell(Cambridge,Mass.), 121, 2005
1ZBF
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BU of 1zbf by Molmil
Crystal structure of B. halodurans RNase H catalytic domain mutant D132N
Descriptor: SULFATE ION, ribonuclease H-related protein
Authors:Nowotny, M, Gaidamakov, S.A, Crouch, R.J, Yang, W.
Deposit date:2005-04-08
Release date:2005-07-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal Structures of RNase H Bound to an RNA/DNA Hybrid: Substrate Specificity and Metal-Dependent Catalysis.
Cell(Cambridge,Mass.), 121, 2005
1ZBL
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BU of 1zbl by Molmil
Bacillus halodurans RNase H catalytic domain mutant D192N in complex with 12-mer RNA/DNA hybrid
Descriptor: 5'-D(*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*C)-3', 5'-R(*GP*AP*CP*AP*CP*CP*UP*GP*AP*UP*UP*C)-3', MAGNESIUM ION, ...
Authors:Nowotny, M, Gaidamakov, S.A, Crouch, R.J, Yang, W.
Deposit date:2005-04-08
Release date:2005-07-12
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structures of RNase H Bound to an RNA/DNA Hybrid: Substrate Specificity and Metal-Dependent Catalysis.
Cell(Cambridge,Mass.), 121, 2005
2G8I
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BU of 2g8i by Molmil
B. halodurans RNase H catalytic domain D192N mutant in complex with Mn2+ and RNA/DNA hybrid (non-P nick at the active site)
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 5'-D(*AP*TP*GP*TP*CP*G)-3', 5'-R(*UP*CP*GP*AP*CP*A)-3', ...
Authors:Nowotny, M, Yang, W.
Deposit date:2006-03-02
Release date:2006-04-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release.
Embo J., 25, 2006
2G8W
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BU of 2g8w by Molmil
B. halodurans RNase H catalytic domain E188A mutant in complex with Ca2+ and RNA/DNA hybrid
Descriptor: 5'-D(*AP*TP*GP*TP*CP*G)-3', 5'-R(P*UP*CP*GP*AP*CP*A)-3', CALCIUM ION, ...
Authors:Nowotny, M, Yang, W.
Deposit date:2006-03-03
Release date:2006-04-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release.
Embo J., 25, 2006
2G8V
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BU of 2g8v by Molmil
B. halodurans RNase H catalytic domain E188A mutant in complex with Mg2+ and RNA/DNA hybrid (reaction product)
Descriptor: 5'-D(*AP*TP*GP*TP*CP*G)-3', 5'-R(P*UP*CP*GP*AP*CP*A)-3', ETHANOL, ...
Authors:Nowotny, M, Yang, W.
Deposit date:2006-03-03
Release date:2006-04-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release.
Embo J., 25, 2006
2G8K
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BU of 2g8k by Molmil
B. halodurans RNase H catalytic domain D192N mutant in complex with Ca2+ and RNA/DNA hybrid (non-P nick at the active site)
Descriptor: 5'-D(*AP*TP*GP*TP*CP*G)-3', 5'-R(*UP*CP*GP*AP*CP*A)-3', CALCIUM ION, ...
Authors:Nowotny, M, Yang, W.
Deposit date:2006-03-02
Release date:2006-04-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release.
Embo J., 25, 2006
2G8H
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BU of 2g8h by Molmil
B. halodurans RNase H catalytic domain D192N mutant in complex with Mg2+ and RNA/DNA hybrid (non-P nick at the active site)
Descriptor: 5'-D(*AP*TP*GP*TP*CP*G)-3', 5'-R(*UP*CP*GP*AP*CP*A)-3', MAGNESIUM ION, ...
Authors:Nowotny, M, Yang, W.
Deposit date:2006-03-02
Release date:2006-04-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release.
Embo J., 25, 2006
2G8F
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BU of 2g8f by Molmil
B. halodurans RNase H catalytic domain E188A mutant in complex with Mg2+ and RNA/DNA hybrid (non-P nick at the active site)
Descriptor: 5'-D(*AP*TP*GP*TP*CP*G)-3', 5'-R(*UP*CP*GP*AP*CP*A)-3', CHLORIDE ION, ...
Authors:Nowotny, M, Yang, W.
Deposit date:2006-03-02
Release date:2006-04-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release.
Embo J., 25, 2006
2G8U
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BU of 2g8u by Molmil
B. halodurans RNase H catalytic domain D132N mutant in complex with Mg2+ and RNA/DNA hybrid (non-P nick at the active site)
Descriptor: 5'-D(*AP*TP*GP*TP*CP*G)-3', 5'-R(*UP*CP*GP*AP*CP*A)-3', MAGNESIUM ION, ...
Authors:Nowotny, M, Yang, W.
Deposit date:2006-03-03
Release date:2006-04-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Stepwise analyses of metal ions in RNase H catalysis from substrate destabilization to product release.
Embo J., 25, 2006
6ZE8
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BU of 6ze8 by Molmil
Crystal structure of human chitotriosidase-1 (hCHIT) catalytic domain in complex with compound OATD-01
Descriptor: 5-(4-((2S,5S)-5-(4-chlorobenzyl)-2-methylmorpholino)piperidin-1-yl)-4H-1,2,4-triazol-3-amine, Chitotriosidase-1, GLYCEROL, ...
Authors:Nowotny, M, Bartlomiejczak, A, Napiorkowska-Gromadzka, A.
Deposit date:2020-06-16
Release date:2020-11-11
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Discovery of OATD-01 , a First-in-Class Chitinase Inhibitor as Potential New Therapeutics for Idiopathic Pulmonary Fibrosis.
J.Med.Chem., 63, 2020
7O24
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BU of 7o24 by Molmil
Structure of the foamy viral protease-reverse transcriptase in complex with dsDNA.
Descriptor: DNA (5'-D(*AP*AP*CP*AP*GP*AP*GP*TP*GP*CP*GP*AP*CP*AP*CP*CP*TP*GP*AP*TP*TP*CP*CP*A)-3'), DNA (5'-D(*TP*GP*GP*AP*AP*TP*CP*AP*GP*GP*TP*GP*TP*CP*GP*CP*AP*CP*TP*CP*TP*G)-3'), Pr125Pol
Authors:Nowotny, M, Czarnocki-Cieciura, M.
Deposit date:2021-03-30
Release date:2021-06-30
Last modified:2022-01-19
Method:ELECTRON MICROSCOPY (4.8 Å)
Cite:Structures of Substrate Complexes of Foamy Viral Protease-Reverse Transcriptase.
J.Virol., 95, 2021
7ZVX
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BU of 7zvx by Molmil
Crystal structure of human Annexin A2 in complex with full phosphorothioate 5-10 2'-methoxyethyl DNA gapmer antisense oligonucleotide solved at 2.4 A resolution
Descriptor: 1,2-ETHANEDIOL, 2'-methoxyethyl DNA gapmer antisense oligonucleotide, Annexin A2, ...
Authors:Hyjek-Skladanowska, M, Anderson, B, Mykhaylyk, V, Orr, C, Wagner, A, Skowronek, K, Seth, P, Nowotny, M.
Deposit date:2022-05-17
Release date:2022-09-14
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structures of annexin A2-PS DNA complexes show dominance of hydrophobic interactions in phosphorothioate binding.
Nucleic Acids Res., 51, 2023
7ZVN
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BU of 7zvn by Molmil
Crystal structure of human Annexin A2 in complex with full phosphorothioate 5-10 2'-methoxyethyl DNA gapmer antisense oligonucleotide solved at 1.87 A resolution
Descriptor: 2'-methoxyethyl DNA gapmer antisense oligonucleotide, Annexin A2, CALCIUM ION, ...
Authors:Hyjek-Skladanowska, M, Anderson, B, Mykhaylyk, V, Orr, C, Wagner, A, Skowronek, K, Seth, P, Nowotny, M.
Deposit date:2022-05-16
Release date:2022-09-14
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Structures of annexin A2-PS DNA complexes show dominance of hydrophobic interactions in phosphorothioate binding.
Nucleic Acids Res., 51, 2023
8P00
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BU of 8p00 by Molmil
Cryo-EM structure of Rotavirus B NSP2
Descriptor: Non-structural protein 2
Authors:Chamera, S, Nowotny, M.
Deposit date:2023-05-09
Release date:2024-02-28
Last modified:2024-03-27
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM structure of rotavirus B NSP2 reveals its unique tertiary architecture.
J.Virol., 98, 2024
8R42
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BU of 8r42 by Molmil
Structure of CHI3L1 in complex with inhibititor 2
Descriptor: 1,2-ETHANEDIOL, 2-[4-[(2~{R})-2-[(4-chlorophenyl)methyl]pyrrolidin-1-yl]piperidin-1-yl]pyridine, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Nowak, E, Napiorkowska-Gromadzka, A, Nowotny, M.
Deposit date:2023-11-10
Release date:2024-03-13
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Structure-Based Discovery of High-Affinity Small Molecule Ligands and Development of Tool Probes to Study the Role of Chitinase-3-Like Protein 1.
J.Med.Chem., 67, 2024
7R08
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BU of 7r08 by Molmil
Abortive infection DNA polymerase Abi-P2
Descriptor: Reverse transcriptase
Authors:Gapinska, M.A, Figiel, M, Czarnocki Cieciura, M, Nowotny, M, Zajko, W.
Deposit date:2022-02-01
Release date:2022-09-07
Last modified:2022-10-05
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Mechanism of protein-primed template-independent DNA synthesis by Abi polymerases.
Nucleic Acids Res., 50, 2022
7R07
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BU of 7r07 by Molmil
Abortive infection DNA polymerase AbiK from Lactococcus lactis
Descriptor: AbiK, DNA (5'-D(*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*C)-3'), MAGNESIUM ION
Authors:Figiel, M, Gapinska, M, Czarnocki-Cieciura, M, Zajko, W, Nowotny, M.
Deposit date:2022-02-01
Release date:2022-09-07
Last modified:2022-10-05
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Mechanism of protein-primed template-independent DNA synthesis by Abi polymerases.
Nucleic Acids Res., 50, 2022
7R06
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BU of 7r06 by Molmil
Abortive infection DNA polymerase AbiK from Lactococcus lactis
Descriptor: AbiK, DNA (5'-D(*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*CP*C)-3')
Authors:Figiel, M, Nowotny, M, Gapinska, M, Czarnocki-Cieciura, M, Zajko, W.
Deposit date:2022-02-01
Release date:2022-09-07
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (2.27 Å)
Cite:Mechanism of protein-primed template-independent DNA synthesis by Abi polymerases.
Nucleic Acids Res., 50, 2022
7PIK
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BU of 7pik by Molmil
Cryo-EM structure of E. coli TnsB in complex with right end fragment of Tn7 transposon
Descriptor: Right end fragment of Tn7 transposon, Transposon Tn7 transposition protein TnsB
Authors:Kaczmarska, Z, Czarnocki-Cieciura, M, Rawski, M, Nowotny, M.
Deposit date:2021-08-20
Release date:2022-06-15
Last modified:2022-08-03
Method:ELECTRON MICROSCOPY (2.68 Å)
Cite:Structural basis of transposon end recognition explains central features of Tn7 transposition systems.
Mol.Cell, 82, 2022
7Z0Z
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BU of 7z0z by Molmil
Abortive infection DNA polymerase AbiK from Lactococcus lactis, Y44F variant
Descriptor: AbiK
Authors:Figiel, M, Gapinska, M, Czarnocki-Cieciura, M, Zajko, W, Nowotny, M.
Deposit date:2022-02-24
Release date:2022-09-07
Last modified:2022-10-05
Method:ELECTRON MICROSCOPY (2.68 Å)
Cite:Mechanism of protein-primed template-independent DNA synthesis by Abi polymerases.
Nucleic Acids Res., 50, 2022

 

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