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1KL9
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CRYSTAL STRUCTURE OF THE N-TERMINAL SEGMENT OF HUMAN EUKARYOTIC INITIATION FACTOR 2ALPHA
分子名称:EUKARYOTIC TRANSLATION INITIATION FACTOR 2 SUBUNIT 1, ZINC ION
著者Nonato, M.C., Widom, J., Clardy, J.
登録日2001-12-11
公開日2002-03-11
最終更新日2018-01-31
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of the N-terminal segment of human eukaryotic translation initiation factor 2alpha
J.Biol.Chem., 277, 2002
1KQ0
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HUMAN METHIONINE AMINOPEPTIDASE TYPE II IN COMPLEX WITH D-METHIONINE
分子名称:Methionine aminopeptidase 2, ZINC ION, D-METHIONINE, ...
著者Nonato, M.C., Widom, J., Clardy, J.
登録日2002-01-03
公開日2003-12-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Human methionine aminopeptidase type 2 in complex with L- and D-methionine
Bioorg.Med.Chem.Lett., 16, 2006
1KQ9
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HUMAN METHIONINE AMINOPEPTIDASE TYPE II IN COMPLEX WITH L-METHIONINE
分子名称:Methionine aminopeptidase 2, ZINC ION, METHIONINE, ...
著者Nonato, M.C., Widom, J., Clardy, J.
登録日2002-01-04
公開日2003-12-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Human methionine aminopeptidase type 2 in complex with L- and D-methionine
Bioorg.Med.Chem.Lett., 16, 2006
1PJA
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THE CRYSTAL STRUCTURE OF PALMITOYL PROTEIN THIOESTERASE-2 REVEALS THE BASIS FOR DIVERGENT SUBSTRATE SPECIFICITIES OF THE TWO LYSOSOMAL THIOESTERASES (PPT1 AND PPT2)
分子名称:Palmitoyl-protein thioesterase 2 precursor, N-ACETYL-D-GLUCOSAMINE, GLYCEROL
著者Calero, G., Gupta, P., Nonato, M.C., Tandel, S., Biehl, E.R., Hofmann, S.L., Clardy, J.
登録日2003-06-02
公開日2003-09-02
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The crystal structure of palmitoyl protein thioesterase-2 (PPT2) reveals the basis for divergent substrate specificities of the two lysosomal thioesterases, PPT1 and PPT2.
J.Biol.Chem., 278, 2003
1S8G
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CRYSTAL STRUCTURE OF LYS49-PHOSPHOLIPASE A2 FROM AGKISTRODON CONTORTRIX LATICINCTUS, FATTY ACID BOUND FORM
分子名称:Phospholipase A2 homolog, SULFATE ION, LAURIC ACID, ...
著者Ambrosio, A.L.B., de Souza, D.H.F., Nonato, M.C., Selistre de Araujo, H.S., Ownby, C.L., Garratt, R.C.
登録日2004-02-02
公開日2004-02-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献A Molecular Mechanism for Lys49-Phospholipase A2 Activity Based on Ligand-induced Conformational Change.
J.Biol.Chem., 280, 2005
1S8H
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CRYSTAL STRUCTURE OF LYS49-PHOSPHOLIPASE A2 FROM AGKISTRODON CONTORTRIX LATICINCTUS, FIRST FATTY ACID FREE FORM
分子名称:Phospholipase A2 homolog, SULFATE ION
著者Ambrosio, A.L.B., de Souza, D.H.F., Nonato, M.C., Selistre de Araujo, H.S., Ownby, C.L., Garratt, R.C.
登録日2004-02-02
公開日2004-02-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献A Molecular Mechanism for Lys49-Phospholipase A2 Activity Based on Ligand-induced Conformational Change.
J.Biol.Chem., 280, 2005
1S8I
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CRYSTAL STRUCTURE OF LYS49-PHOSPHOLIPASE A2 FROM AGKISTRODON CONTORTRIX LATICINCTUS, SECOND FATTY ACID FREE FORM
分子名称:Phospholipase A2 homolog, SULFATE ION
著者Ambrosio, A.L.B., de Souza, D.H.F., Nonato, M.C., Selistre de Araujo, H.S., Ownby, C.L., Garratt, R.C.
登録日2004-02-02
公開日2004-02-10
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.609 Å)
主引用文献A Molecular Mechanism for Lys49-Phospholipase A2 Activity Based on Ligand-induced Conformational Change.
J.Biol.Chem., 280, 2005
3GYE
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DIDYDROOROTATE DEHYDROGENASE FROM LEISHMANIA MAJOR
分子名称:Dihydroorotate dehydrogenase, putative, FLAVIN MONONUCLEOTIDE, ...
著者Cordeiro, A.T., Feliciano, P.R., Nonato, M.C.
登録日2009-04-03
公開日2010-04-07
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal Structure of Leishmania major Dihydroorotate dehydrogenase
To be Published
3GZ3
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LEISHMANIA MAJOR DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH OROTATE
分子名称:Dihydroorotate dehydrogenase, putative, FLAVIN MONONUCLEOTIDE, ...
著者Cordeiro, A.T., Feliciano, P.R., Nonato, M.C.
登録日2009-04-06
公開日2010-04-28
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Leismania major dihydroorotate in complex with orotate
To be Published
3MHU
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CRYSTAL STRUCTURE OF DIHYDROOROTATE DEHYDROGENASE FROM LEISHMANIA MAJOR IN COMPLEX WITH 5-NITROOROTIC ACID
分子名称:Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, 5-nitro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, ...
著者Pinheiro, M.P., Rocha, J.R., Cheleski, J., Montanari, C.A., Nonato, M.C.
登録日2010-04-08
公開日2011-02-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Novel insights for dihydroorotate dehydrogenase class 1A inhibitors discovery.
Eur.J.Med.Chem., 45, 2010
3MJY
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CRYSTAL STRUCTURE OF DIHYDROOROTATE DEHYDROGENASE FROM LEISHMANIA MAJOR IN COMPLEX WITH 5-AMINOOROTIC ACID
分子名称:Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, 5-amino-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid, ...
著者Pinheiro, M.P., Rocha, J.R., Cheleski, J., Montanari, C.A., Nonato, M.C.
登録日2010-04-13
公開日2011-02-23
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Novel insights for dihydroorotate dehydrogenase class 1A inhibitors discovery.
Eur.J.Med.Chem., 45, 2010
3TH1
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CRYSTAL STRUCTURE OF CHLOROCATECHOL 1,2-DIOXYGENASE FROM PSEUDOMONAS PUTIDA
分子名称:Chlorocatechol 1,2-dioxygenase, FE (III) ION, DITHIANE DIOL, ...
著者Rustiguel, J.K., Nonato, M.C.
登録日2011-08-18
公開日2012-08-22
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Crystal Structure of chlorocatechol 1,2-dioxygenase from Pseudomonas putida
To be Published
3TJX
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CRYSTAL STRUCTURE OF LEISHMANIA MAJOR DIHYDROOROTATE DEHYDROGENASE MUTANT H174A
分子名称:Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, GLYCEROL, ...
著者de Souza, A.L., Nonato, M.C., Pinheiro, M.P.
登録日2011-08-25
公開日2012-09-12
実験手法X-RAY DIFFRACTION (1.64 Å)
主引用文献Crystal Structure of Leishmania major dihydroorotate dehydrogenase mutant H174A
To be Published
3TQ0
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CRYSTAL STRUCTURE OF LEISHMANIA MAJOR DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH FUMARATE
分子名称:Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, FUMARIC ACID, ...
著者Cordeiro, A.T., Feliciano, P.R., Nonato, M.C.
登録日2011-09-08
公開日2012-05-16
最終更新日2012-07-25
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of dihydroorotate dehydrogenase from Leishmania major.
Biochimie, 94, 2012
3TRO
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CRYSTAL STRUCTURE OF LEISHMANIA MAJOR DIHYDROOROTATE DEHYDROGENASE MUTANT D171A
分子名称:Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, SULFATE ION, ...
著者de Souza, A.L., Pinheiro, M.P., Nonato, M.C.
登録日2011-09-09
公開日2012-09-12
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Crystal Structure of Leishmania major dihydroorotate dehydrogenase mutant D171A
To be Published
4EF8
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CRYSTAL STRUCTURE OF DIHYDROOROTATE DEHYDROGENASE FROM LEISHMANIA MAJOR IN COMPLEX WITH PHENYL ISOTHIOCYANATE
分子名称:Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, N-phenylthioformamide, ...
著者Pinheiro, M.P., Emery, F.S., Nonato, M.C.
登録日2012-03-29
公開日2012-12-12
最終更新日2013-05-22
実験手法X-RAY DIFFRACTION (1.56 Å)
主引用文献Target sites for the design of anti-trypanosomatid drugs based on the structure of dihydroorotate dehydrogenase.
Curr.Pharm.Des., 19, 2013
4EF9
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CRYSTAL STRUCTURE OF DIHYDROOROTATE DEHYDROGENASE FROM LEISHMANIA MAJOR IN COMPLEX WITH 4-NITROPHENYL ISOTHIOCYANATE
分子名称:Dihydroorotate dehydrogenase, N-(4-nitrophenyl)thioformamide, FLAVIN MONONUCLEOTIDE, ...
著者Pinheiro, M.P., Emery, F.S., Nonato, M.C.
登録日2012-03-29
公開日2012-12-12
最終更新日2013-05-22
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Target sites for the design of anti-trypanosomatid drugs based on the structure of dihydroorotate dehydrogenase.
Curr.Pharm.Des., 19, 2013
4LBQ
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CRYSTAL STRUCTURE OF MOUSE GALECTIN-1
分子名称:Galectin-1, GLYCEROL
著者Rustiguel, J.K., Trabuco, A.C., Del Cistia Andrade, C., Stowell, S.R., Cummings, R.D., Dias-Baruffi, M., Nonato, M.C.
登録日2013-06-20
公開日2014-07-02
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of mouse galectin-1
To be Published
4WZH
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DIHYDROOROTATE DEHYDROGENASE FROM LEISHMANIA VIANNIA BRAZILIENSIS
分子名称:Dihydroorotate dehydrogenase, FLAVIN MONONUCLEOTIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
著者Reis, R.A.G., Lorenzato, E., Silva, V.C., Nonato, M.C.
登録日2014-11-19
公開日2015-05-13
最終更新日2019-04-17
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Recombinant production, crystallization and crystal structure determination of dihydroorotate dehydrogenase from Leishmania (Viannia) braziliensis.
Acta Crystallogr.,Sect.F, 71, 2015
4XZP
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CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF HUMAN GALECTIN-4
分子名称:Galectin-4, CALCIUM ION
著者Rustiguel, J.K., Nonato, M.C.
登録日2015-02-04
公開日2016-03-02
最終更新日2019-04-17
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Full-length model of the human galectin-4 and insights into dynamics of inter-domain communication.
Sci Rep, 6, 2016
5CBL
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CRYSTAL STRUCTURE OF THE C-TERMINAL DOMAIN OF HUMAN GALECTIN-4 WITH LACTOSE
分子名称:Galectin-4, BETA-LACTOSE, BETA-MERCAPTOETHANOL, ...
著者Rustiguel, J.K., Nonato, M.C.
登録日2015-07-01
公開日2015-11-04
最終更新日2019-04-17
実験手法X-RAY DIFFRACTION (1.781 Å)
主引用文献Recombinant expression, purification and preliminary biophysical and structural studies of C-terminal carbohydrate recognition domain from human galectin-4.
Protein Expr.Purif., 118, 2015
5D6B
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HUMAN FUMARASE (WILD TYPE)
分子名称:Fumarate hydratase, mitochondrial
著者Pereira de Padua, R.A., Nonato, M.C.
登録日2015-08-11
公開日2016-08-24
最終更新日2019-04-17
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Cloning, expression, purification, crystallization and preliminary X-ray diffraction analysis of recombinant human fumarase.
Acta Crystallogr F Struct Biol Commun, 70, 2014
5F2Q
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C-TYPE LECTIN FROM BOTHROPS JARARACUSSU
分子名称:C-type lectin BJcuL, CALCIUM ION, SODIUM ION
著者de Padua, R.A.P., Pinheiro, M.P., Sartim, M.A., Sampaio, S.V., Nonato, M.C.
登録日2015-12-02
公開日2016-12-07
最終更新日2019-04-17
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献C-type lectin from Bothrops jararacussu
To Be Published
5K9C
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CRYSTAL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE WITH ML390
分子名称:Dihydroorotate dehydrogenase (quinone), mitochondrial, 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, ...
著者Lewis, T.A., Sykes, D.B., Law, J.M., Munoz, B., Scadden, D.T., Rustiguel, J.K., Nonato, M.C., Schreiber, S.L.
登録日2016-05-31
公開日2016-10-12
最終更新日2017-01-04
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia.
ACS Med Chem Lett, 7, 2016
5K9D
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CRYSTAL STRUCTURE OF HUMAN DIHYDROOROTATE DEHYDROGENASE AT 1.7 A RESOLUTION
分子名称:Dihydroorotate dehydrogenase (quinone), mitochondrial, 1-DEOXY-1-(7,8-DIMETHYL-2,4-DIOXO-3,4-DIHYDRO-2H-BENZO[G]PTERIDIN-1-ID-10(5H)-YL)-5-O-PHOSPHONATO-D-RIBITOL, ...
著者Lewis, T.A., Sykes, D.B., Law, J.M., Munoz, B., Scadden, D.T., Rustiguel, J.K., Nonato, M.C., Schreiber, S.L.
登録日2016-05-31
公開日2016-10-12
最終更新日2017-01-04
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Development of ML390: A Human DHODH Inhibitor That Induces Differentiation in Acute Myeloid Leukemia.
ACS Med Chem Lett, 7, 2016
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