5YIL
| Hoisting-loop in bacterial multidrug exporter AcrB is a highly flexible hinge that enables the large motion of the subdomains | Descriptor: | Multidrug efflux pump subunit AcrB | Authors: | Zwama, M, Sakurai, K, Hayashi, K, Nakashima, R, Kitagawa, K, Nishino, K, Yamaguchi, A. | Deposit date: | 2017-10-05 | Release date: | 2017-11-15 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Hoisting-Loop in Bacterial Multidrug Exporter AcrB Is a Highly Flexible Hinge That Enables the Large Motion of the Subdomains. Front Microbiol, 8, 2017
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6IE9
| RamR in complex with chenodeoxycholic acid | Descriptor: | CHENODEOXYCHOLIC ACID, Regulatory protein, SULFATE ION | Authors: | Nakashima, R, Sakurai, K, Yamasaki, S, Nishino, K. | Deposit date: | 2018-09-13 | Release date: | 2019-02-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.78 Å) | Cite: | Crystal structure of the multidrug resistance regulator RamR complexed with bile acids. Sci Rep, 9, 2019
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6IE8
| RamR in complex with cholic acid | Descriptor: | CHOLIC ACID, Regulatory protein, SULFATE ION | Authors: | Nakashima, R, Sakurai, K, Yamasaki, S, Nishino, K. | Deposit date: | 2018-09-13 | Release date: | 2019-02-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the multidrug resistance regulator RamR complexed with bile acids. Sci Rep, 9, 2019
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6KO7
| Crystal structure of the Ethidium bound RamR determined with XtaLAB Synergy | Descriptor: | ETHIDIUM, Putative regulatory protein, SULFATE ION | Authors: | Matsumoto, T, Nakashima, R, Yamano, A, Nishino, K. | Deposit date: | 2019-08-08 | Release date: | 2019-10-09 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Development of a structure determination method using a multidrug-resistance regulator protein as a framework. Biochem.Biophys.Res.Commun., 518, 2019
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6KO9
| Crystal structure of the Gefitinib Intermediate 1 bound RamR determined with XtaLAB Synergy | Descriptor: | 4-[(3-chloranyl-4-fluoranyl-phenyl)amino]-7-methoxy-quinazolin-6-ol, Putative regulatory protein, SULFATE ION | Authors: | Matsumoto, T, Nakashima, R, Yamano, A, Nishino, K. | Deposit date: | 2019-08-08 | Release date: | 2019-10-09 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Development of a structure determination method using a multidrug-resistance regulator protein as a framework. Biochem.Biophys.Res.Commun., 518, 2019
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6KO8
| Crystal structure of the Cholic acid bound RamR determined with XtaLAB Synergy | Descriptor: | CHOLIC ACID, Putative regulatory protein, SULFATE ION | Authors: | Matsumoto, T, Nakashima, R, Yamano, A, Nishino, K. | Deposit date: | 2019-08-08 | Release date: | 2019-10-09 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Development of a structure determination method using a multidrug-resistance regulator protein as a framework. Biochem.Biophys.Res.Commun., 518, 2019
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3VVZ
| Crystal Strucuture of The Rhodamine 6G-Bound Form of RamR (Transcriptional Regurator of TetR Family) from Salmonella Typhimurium | Descriptor: | Putative regulatory protein, RHODAMINE 6G, SULFATE ION | Authors: | Sakurai, K, Nikaido, E, Nakashima, R, Yamasaki, S, Yamaguchi, A, Nishino, K. | Deposit date: | 2012-07-30 | Release date: | 2013-07-03 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.51 Å) | Cite: | The crystal structure of multidrug-resistance regulator RamR with multiple drugs Nat Commun, 4, 2013
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3VVY
| Crystal Strucuture of The Ethidium-Bound Form of RamR (Transcriptional Regurator of TetR Family) from Salmonella Typhimurium | Descriptor: | ETHIDIUM, Putative regulatory protein | Authors: | Sakurai, K, Nikaido, E, Nakashima, R, Yamasaki, S, Yamaguchi, A, Nishino, K. | Deposit date: | 2012-07-30 | Release date: | 2013-07-03 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | The crystal structure of multidrug-resistance regulator RamR with multiple drugs Nat Commun, 4, 2013
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3VVX
| Crystal Strucuture of RamR (Transcriptional Regurator of TetR Family) from Salmonella Typhimurium | Descriptor: | Putative regulatory protein, SULFATE ION | Authors: | Sakurai, K, Nikaido, E, Nakashima, R, Yamasaki, S, Yamaguchi, A, Nishino, K. | Deposit date: | 2012-07-30 | Release date: | 2013-07-03 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | The crystal structure of multidrug-resistance regulator RamR with multiple drugs Nat Commun, 4, 2013
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3VW1
| Crystal Strucuture of the Crystal Violet-Bound Form of RamR (Transcriptional Regurator of TetR Family) from Salmonella Typhimurium | Descriptor: | CHLORIDE ION, CRYSTAL VIOLET, Putative regulatory protein, ... | Authors: | Sakurai, K, Yamasaki, S, Nakashima, R, Nikaido, E, Yamaguchi, A, Nishino, K. | Deposit date: | 2012-07-30 | Release date: | 2013-07-03 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.21 Å) | Cite: | The crystal structure of multidrug-resistance regulator RamR with multiple drugs Nat Commun, 4, 2013
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3VW0
| Crystal Structure of The Dequalinum-bound Form of RamR (Transcriptional Regulator of TetR Family) From Salmonella Typhimurium | Descriptor: | DEQUALINIUM, Putative regulatory protein, SULFATE ION | Authors: | Sakurai, K, Yamasaki, S, Nakashima, R, Nikaido, E, Yamaguchi, A, Nishino, K. | Deposit date: | 2012-07-30 | Release date: | 2013-07-03 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | The crystal structure of multidrug-resistance regulator RamR with multiple drugs Nat Commun, 4, 2013
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3VW2
| Crystal Strucuture of The Berberine-bound Form of RamR (Transcriptional Regurator of TetR Family) from Salmonella Typhimurium | Descriptor: | BERBERINE, Putative regulatory protein, SULFATE ION | Authors: | Sakurai, K, Nikaido, E, Nakashima, R, Yamasaki, S, Yamaguchi, A, Nishino, K. | Deposit date: | 2012-07-30 | Release date: | 2013-07-03 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.34 Å) | Cite: | The crystal structure of multidrug-resistance regulator RamR with multiple drugs Nat Commun, 4, 2013
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7DQ6
| Crystal structure of HitB in complex with (S)-beta-3-Br-phenylalanine sulfamoyladenosine | Descriptor: | CALCIUM ION, Putative ATP-dependent b-aminoacyl-ACP synthetase, [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl N-[(3S)-3-azanyl-3-(3-bromophenyl)propanoyl]sulfamate | Authors: | Kudo, F, Takahashi, S, Miyanaga, A, Nakazawa, Y, Eguchi, T. | Deposit date: | 2020-12-22 | Release date: | 2021-03-03 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Mutational Biosynthesis of Hitachimycin Analogs Controlled by the beta-Amino Acid-Selective Adenylation Enzyme HitB. Acs Chem.Biol., 16, 2021
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7DQ5
| Crystal structure of HitB in complex with (S)-beta-phenylalanine sulfamoyladenosine | Descriptor: | CALCIUM ION, Putative ATP-dependent b-aminoacyl-ACP synthetase, [(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl ~{N}-[(3~{S})-3-azanyl-3-phenyl-propanoyl]sulfamate | Authors: | Kudo, F, Takahashi, S, Miyanaga, A, Nakazawa, Y, Eguchi, T. | Deposit date: | 2020-12-22 | Release date: | 2021-03-03 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.45 Å) | Cite: | Mutational Biosynthesis of Hitachimycin Analogs Controlled by the beta-Amino Acid-Selective Adenylation Enzyme HitB. Acs Chem.Biol., 16, 2021
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6IIA
| MexB in complex with LMNG | Descriptor: | Lauryl Maltose Neopentyl Glycol, Multidrug resistance protein MexB | Authors: | Nakashima, R, Sakurai, K, Nakao, K. | Deposit date: | 2018-10-04 | Release date: | 2019-03-27 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.91 Å) | Cite: | Crystal structures of multidrug efflux pump MexB bound with high-molecular-mass compounds. Sci Rep, 9, 2019
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8IAU
| Crystal structure of Streptococcus pneumoniae pyruvate kinase in complex with oxalate and fructose 1,6-bisphosphate | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ... | Authors: | Nakashima, R, Taguchi, A. | Deposit date: | 2023-02-09 | Release date: | 2023-06-14 | Last modified: | 2023-07-19 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Functional and structural characterization of Streptococcus pneumoniae pyruvate kinase involved in fosfomycin resistance. J.Biol.Chem., 299, 2023
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8IAV
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8IAS
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8IAW
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8IAT
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8IAX
| Crystal structure of Streptococcus pneumoniae pyruvate kinase in complex with phosphoenolpyruvate and fructose 1,6-bisphosphate | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, MAGNESIUM ION, PHOSPHOENOLPYRUVATE, ... | Authors: | Nakashima, R, Taguchi, A. | Deposit date: | 2023-02-09 | Release date: | 2023-06-14 | Last modified: | 2023-07-19 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Functional and structural characterization of Streptococcus pneumoniae pyruvate kinase involved in fosfomycin resistance. J.Biol.Chem., 299, 2023
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3AOD
| Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket | Descriptor: | (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2- CARBOXAMIDE, Acriflavine resistance protein B, RIFAMPICIN | Authors: | Nakashima, R, Sakurai, K, Yamaguchi, A. | Deposit date: | 2010-09-23 | Release date: | 2011-11-30 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structures of the multidrug exporter AcrB reveal a proximal multisite drug-binding pocket Nature, 480, 2011
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3AOA
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3AOB
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3AOC
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