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1NZO
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BU of 1nzo by Molmil
The crystal structure of wild type penicillin-binding protein 5 from E. coli
Descriptor: BETA-MERCAPTOETHANOL, Penicillin-binding protein 5
Authors:Nicholas, R.A, Krings, S, Tomberg, J, Nicola, G, Davies, C.
Deposit date:2003-02-19
Release date:2004-01-13
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of wild-type penicillin-binding protein 5 from Escherichia coli: implications for deacylation of the acyl-enzyme complex.
J.Biol.Chem., 278, 2003
1NJ4
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BU of 1nj4 by Molmil
Crystal structure of a deacylation-defective mutant of penicillin-binding protein 5 at 1.9 A resolution
Descriptor: Penicillin-binding protein 5
Authors:Nicola, G, Nicholas, R.A, Davies, C.
Deposit date:2002-12-30
Release date:2003-01-07
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of wild-type penicillin-binding protein 5 from Escherichia coli: implications for deacylation of the acyl-enzyme complex.
J.Biol.Chem., 278, 2003
1HD8
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BU of 1hd8 by Molmil
Crystal structure of a deacylation-defective mutant of penicillin-binding protein 5 at 2.3 A resolution
Descriptor: PENICILLIN-BINDING PROTEIN 5
Authors:Davies, C, White, S.W, Nicholas, R.A.
Deposit date:2000-11-11
Release date:2001-11-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of a Deacylation-Defective Mutant of Penicillin-Binding Protein 5 at 2.3-A Resolution
J.Biol.Chem., 276, 2001
1Z6F
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BU of 1z6f by Molmil
Crystal structure of penicillin-binding protein 5 from E. coli in complex with a boronic acid inhibitor
Descriptor: GLYCEROL, N1-[(1R)-1-(DIHYDROXYBORYL)ETHYL]-N2-[(TERT-BUTOXYCARBONYL)-D-GAMMA-GLUTAMYL]-N6-[(BENZYLOXY)CARBONYL-L-LYSINAMIDE, Penicillin-binding protein 5
Authors:Nicola, G, Peddi, S, Stefanova, M, Nicholas, R.A, Gutheil, W.G, Davies, C.
Deposit date:2005-03-22
Release date:2005-06-21
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structure of Escherichia coli Penicillin-Binding Protein 5 Bound to a Tripeptide Boronic Acid Inhibitor: A Role for Ser-110 in Deacylation.
Biochemistry, 44, 2005
1SDN
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BU of 1sdn by Molmil
CRYSTAL STRUCTURE OF A DEACYLATION-DEFECTIVE MUTANT OF PENICILLIN-BINDING PROTEIN 5 MODIFIED BY MERCURY
Descriptor: MERCURY (II) ION, Penicillin-binding protein 5
Authors:Nicola, G, Nicholas, R.A, Davies, C.
Deposit date:2004-02-13
Release date:2005-02-22
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A large displacement of the SXN motif of Cys115-modified penicillin-binding protein 5 from Escherichia coli.
Biochem.J., 392, 2005
3EQU
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BU of 3equ by Molmil
Crystal structure of penicillin-binding protein 2 from Neisseria gonorrhoeae
Descriptor: GLYCEROL, Penicillin-binding protein 2, SULFATE ION
Authors:Powell, A.J, Deacon, A.M, Nicholas, R.A, Davies, C.
Deposit date:2008-10-01
Release date:2008-10-21
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structures of Penicillin-binding Protein 2 from Penicillin-susceptible and -resistant Strains of Neisseria gonorrhoeae Reveal an Unexpectedly Subtle Mechanism for Antibiotic Resistance.
J.Biol.Chem., 284, 2009
3EQV
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BU of 3eqv by Molmil
Crystal structure of penicillin-binding protein 2 from Neisseria gonorrhoeae containing four mutations associated with penicillin resistance
Descriptor: GLYCEROL, Penicillin-binding protein 2, SULFATE ION
Authors:Powell, A.J, Deacon, A.M, Nicholas, R.A, Davies, C.
Deposit date:2008-10-01
Release date:2008-10-21
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structures of Penicillin-binding Protein 2 from Penicillin-susceptible and -resistant Strains of Neisseria gonorrhoeae Reveal an Unexpectedly Subtle Mechanism for Antibiotic Resistance.
J.Biol.Chem., 284, 2009
1NZU
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BU of 1nzu by Molmil
Wild-type penicillin-binding protein 5 from E. coli modified by beta-mercaptoethanol
Descriptor: BETA-MERCAPTOETHANOL, Penicillin-binding protein 5
Authors:Nicola, G, Nicholas, R.A, Davies, C.
Deposit date:2003-02-19
Release date:2004-03-02
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:A large displacement of the SXN motif of Cys115-modified penicillin-binding protein 5 from Escherichia coli.
Biochem.J., 392, 2005
2GAE
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BU of 2gae by Molmil
Crystal structure of MltA from E. coli
Descriptor: Membrane-bound lytic murein transglycosylase A
Authors:Powell, A.J, Liu, Z.J, Nicholas, R.A, Davies, C.
Deposit date:2006-03-08
Release date:2006-05-09
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal Structures of the Lytic Transglycosylase MltA from N.gonorrhoeae and E.coli: Insights into Interdomain Movements and Substrate Binding.
J.Mol.Biol., 359, 2006
2G6G
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BU of 2g6g by Molmil
Crystal structure of MltA from Neisseria gonorrhoeae
Descriptor: GLYCEROL, GNA33, SULFATE ION
Authors:Powell, A.J, Liu, Z.J, Nicholas, R.A, Davies, C.
Deposit date:2006-02-24
Release date:2006-05-02
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structures of the Lytic Transglycosylase MltA from N.gonorrhoeae and E.coli: Insights into Interdomain Movements and Substrate Binding.
J.Mol.Biol., 359, 2006
3MZF
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BU of 3mzf by Molmil
Structure of penicillin-binding protein 5 from E. coli: imipenem acyl-enzyme complex
Descriptor: (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox ylic acid, D-alanyl-D-alanine carboxypeptidase dacA, GLYCEROL
Authors:Nicola, G, Tomberg, J, Pratt, R.F, Nicholas, R.A, Davies, C.
Deposit date:2010-05-12
Release date:2011-03-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structures of covalent complexes of beta-lactam antibiotics with Escherichia coli penicillin-binding protein 5: toward an understanding of antibiotic specificity
Biochemistry, 49, 2010
3MZD
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BU of 3mzd by Molmil
Structure of penicillin-binding protein 5 from E. coli: cloxacillin acyl-enzyme complex
Descriptor: (2R,4S)-2-[(1S)-1-({[3-(2-chlorophenyl)-5-methyl-1,2-oxazol-4-yl]carbonyl}amino)-2-oxoethyl]-5,5-dimethyl-1,3-thiazolid ine-4-carboxylic acid, D-alanyl-D-alanine carboxypeptidase dacA, GLYCEROL
Authors:Nicola, G, Tomberg, J, Pratt, R.F, Nicholas, R.A, Davies, C.
Deposit date:2010-05-12
Release date:2011-03-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structures of covalent complexes of beta-lactam antibiotics with Escherichia coli penicillin-binding protein 5: toward an understanding of antibiotic specificity
Biochemistry, 49, 2010
3MZE
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BU of 3mze by Molmil
Structure of penicillin-binding protein 5 from E.coli: cefoxitin acyl-enzyme complex
Descriptor: (2R)-5-[(carbamoyloxy)methyl]-2-{(1S)-1-methoxy-2-oxo-1-[(thiophen-2-ylacetyl)amino]ethyl}-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, D-alanyl-D-alanine carboxypeptidase dacA, GLYCEROL
Authors:Nicola, G, Tomberg, J, Pratt, R.F, Nicholas, R.A, Davies, C.
Deposit date:2010-05-12
Release date:2011-03-16
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of covalent complexes of beta-lactam antibiotics with Escherichia coli penicillin-binding protein 5: toward an understanding of antibiotic specificity
Biochemistry, 49, 2010
2GK2
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BU of 2gk2 by Molmil
Crystal structure of the N terminal domain of human CEACAM1
Descriptor: Carcinoembryonic antigen-related cell adhesion molecule 1, GLYCEROL, NICKEL (II) ION
Authors:Fedarovich, A, Tomberg, J, Nicholas, R.A, Davies, C.
Deposit date:2006-03-31
Release date:2006-09-05
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the N-terminal domain of human CEACAM1: binding target of the opacity proteins during invasion of Neisseria meningitidis and N. gonorrhoeae.
Acta Crystallogr.,Sect.D, 62, 2006
5KSH
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BU of 5ksh by Molmil
Crystal structure of penicillin-binding protein 2 from Neisseria gonorrhoeae containing an A501T mutation associated with cephalosporin resistance
Descriptor: GLYCEROL, Penicillin-binding protein 2, SULFATE ION
Authors:Fedarovich, A, Davies, C.
Deposit date:2016-07-08
Release date:2017-03-01
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Alanine 501 Mutations in Penicillin-Binding Protein 2 from Neisseria gonorrhoeae: Structure, Mechanism, and Effects on Cephalosporin Resistance and Biological Fitness.
Biochemistry, 56, 2017
4U3T
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BU of 4u3t by Molmil
Crystal structure of the transpeptidase domain of Neisseria gonorrhoeae penicillin-binding protein 2 derived from the penicillin-resistant strain 6140
Descriptor: Penicillin-binding protein 2
Authors:Fedarovich, A, Davies, C.
Deposit date:2014-07-22
Release date:2014-12-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural Effect of the Asp345a Insertion in Penicillin-Binding Protein 2 from Penicillin-Resistant Strains of Neisseria gonorrhoeae.
Biochemistry, 53, 2014
3UN7
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BU of 3un7 by Molmil
Crystal structure of PBPA from MYCOBACTERIUM TUBERCULOSIS
Descriptor: Penicillin-binding protein A
Authors:Fedarovich, A, Davies, C.
Deposit date:2011-11-15
Release date:2012-10-24
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The role of the beta5-alpha11 loop in the active-site dynamics of acylated penicillin-binding protein A from Mycobacterium tuberculosis
J.Mol.Biol., 418, 2012
3UPP
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BU of 3upp by Molmil
Structure of penicillin-binding protein A from M. tuberculosis: ceftrixaone acyl-enzyme complex
Descriptor: CEFOTAXIME, C3' cleaved, open, ...
Authors:Davies, C, Fedorovich, A.
Deposit date:2011-11-18
Release date:2012-10-24
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The role of the beta5-alpha11 loop in the active-site dynamics of acylated penicillin-binding protein A from Mycobacterium tuberculosis
J.Mol.Biol., 418, 2012
3UPN
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BU of 3upn by Molmil
Structure of penicillin-binding protein A from M. tuberculosis: imipenem acyl-enzyme complex
Descriptor: (5R)-5-[(1S,2R)-1-formyl-2-hydroxypropyl]-3-[(2-{[(E)-iminomethyl]amino}ethyl)sulfanyl]-4,5-dihydro-1H-pyrrole-2-carbox ylic acid, Penicillin-binding protein A
Authors:Davies, C, Fedorovich, A.
Deposit date:2011-11-18
Release date:2012-10-24
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The role of the beta5-alpha11 loop in the active-site dynamics of acylated penicillin-binding protein A from Mycobacterium tuberculosis
J.Mol.Biol., 418, 2012
3UPO
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BU of 3upo by Molmil
Structure of penicillin-binding protein A from M. tuberculosis: penicillin G acyl-enzyme complex
Descriptor: OPEN FORM - PENICILLIN G, Penicillin-binding protein A
Authors:Davies, C, Fedorovich, A.
Deposit date:2011-11-18
Release date:2012-10-24
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The role of the beta5-alpha11 loop in the active-site dynamics of acylated penicillin-binding protein A from Mycobacterium tuberculosis
J.Mol.Biol., 418, 2012
6XQV
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BU of 6xqv by Molmil
Crystal structure of the catalytic domain of PBP2 S310A from Neisseria gonorrhoeae in a pre-acylation complex with ceftriaxone
Descriptor: CHLORIDE ION, Ceftriaxone, Probable peptidoglycan D,D-transpeptidase PenA, ...
Authors:Fenton, B.A, Zhou, P, Davies, C.
Deposit date:2020-07-10
Release date:2021-07-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Mutations in PBP2 from ceftriaxone-resistant Neisseria gonorrhoeae alter the dynamics of the beta 3-beta 4 loop to favor a low-affinity drug-binding state.
J.Biol.Chem., 297, 2021
6XQZ
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BU of 6xqz by Molmil
Crystal structure of the catalytic domain of PBP2 S310A from Neisseria gonorrhoeae at pH 7.5
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, Peptidoglycan D,D-transpeptidase PenA, ...
Authors:Fenton, B.A, Zhou, P, Davies, C.
Deposit date:2020-07-10
Release date:2021-07-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Mutations in PBP2 from ceftriaxone-resistant Neisseria gonorrhoeae alter the dynamics of the beta 3-beta 4 loop to favor a low-affinity drug-binding state.
J.Biol.Chem., 297, 2021
6XQY
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Crystal structure of the catalytic domain of PBP2 S310A from Neisseria gonorrhoeae at pH 9.5
Descriptor: CHLORIDE ION, Probable peptidoglycan D,D-transpeptidase PenA
Authors:Fenton, B.A, Zhou, P, Davies, C.
Deposit date:2020-07-10
Release date:2021-07-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Mutations in PBP2 from ceftriaxone-resistant Neisseria gonorrhoeae alter the dynamics of the beta 3-beta 4 loop to favor a low-affinity drug-binding state.
J.Biol.Chem., 297, 2021
6XQX
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BU of 6xqx by Molmil
Crystal structure of the catalytic domain of PBP2 S310A from Neisseria gonorrhoeae with the H514A mutation at pH 7.5
Descriptor: 1,2-ETHANEDIOL, Probable peptidoglycan D,D-transpeptidase PenA, SULFATE ION
Authors:Fenton, B.A, Zhou, P, Davies, C.
Deposit date:2020-07-10
Release date:2021-07-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Mutations in PBP2 from ceftriaxone-resistant Neisseria gonorrhoeae alter the dynamics of the beta 3-beta 4 loop to favor a low-affinity drug-binding state.
J.Biol.Chem., 297, 2021
6VBC
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BU of 6vbc by Molmil
Crystal structure of transpeptidase domain of PBP2 from Neisseria gonorrhoeae cephalosporin-resistant strain H041
Descriptor: Probable peptidoglycan D,D-transpeptidase PenA
Authors:Singh, A, Davies, C.
Deposit date:2019-12-18
Release date:2020-04-15
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Mutations in Neisseria gonorrhoeae penicillin-binding protein 2 associated with extended-spectrum cephalosporin resistance create an energetic barrier against acylation via restriction of protein dynamics
J.Biol.Chem., 2020

 

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