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1C3D
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BU of 1c3d by Molmil
X-RAY CRYSTAL STRUCTURE OF C3D: A C3 FRAGMENT AND LIGAND FOR COMPLEMENT RECEPTOR 2
Descriptor: C3D, GLYCEROL
Authors:Nagar, B, Jones, R.G, Diefenbach, R.J, Isenman, D.E, Rini, J.M.
Deposit date:1998-05-19
Release date:1998-10-07
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:X-ray crystal structure of C3d: a C3 fragment and ligand for complement receptor 2.
Science, 280, 1998
1EDH
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BU of 1edh by Molmil
E-CADHERIN DOMAINS 1 AND 2 IN COMPLEX WITH CALCIUM
Descriptor: CALCIUM ION, E-CADHERIN, MERCURY (II) ION
Authors:Nagar, B, Overduin, M, Ikura, M, Rini, J.M.
Deposit date:1996-05-15
Release date:1997-01-11
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis of calcium-induced E-cadherin rigidification and dimerization.
Nature, 380, 1996
1IEP
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BU of 1iep by Molmil
CRYSTAL STRUCTURE OF THE C-ABL KINASE DOMAIN IN COMPLEX WITH STI-571.
Descriptor: 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, CHLORIDE ION, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL
Authors:Nagar, B, Bornmann, W, Schindler, T, Clarkson, B, Kuriyan, J.
Deposit date:2001-04-10
Release date:2001-04-18
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of the kinase domain of c-Abl in complex with the small molecule inhibitors PD173955 and imatinib (STI-571)
Cancer Res., 62, 2002
1M52
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BU of 1m52 by Molmil
Crystal Structure of the c-Abl Kinase domain in complex with PD173955
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-(2,6-DICHLORO-PHENYL)-8-METHYL-2-(3-METHYLSULFANYL-PHENYLAMINO)-8H-PYRIDO[2,3-D]PYRIMIDIN-7-ONE, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ABL1
Authors:Nagar, B, Bornmann, W, Pellicena, P, Schindler, T, Veach, D, Miller, W.T, Clarkson, B, Kuriyan, J.
Deposit date:2002-07-08
Release date:2002-09-18
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structures of the Kinase Domain of c-Abl in Complex with the Small Molecule Inhibitors PD173955 and Imatinib (STI-571)
Cancer Res., 62, 2002
2FO0
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BU of 2fo0 by Molmil
Organization of the SH3-SH2 Unit in Active and Inactive Forms of the c-Abl Tyrosine Kinase
Descriptor: 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, GLYCEROL, MYRISTIC ACID, ...
Authors:Nagar, B, Hantschel, O, Seeliger, M, Davies, J.M, Weis, W.I, Superti-Furga, G, Kuriyan, J.
Deposit date:2006-01-12
Release date:2006-03-21
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Organization of the SH3-SH2 unit in active and inactive forms of the c-Abl tyrosine kinase.
Mol.Cell, 21, 2006
1OPK
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BU of 1opk by Molmil
Structural basis for the auto-inhibition of c-Abl tyrosine kinase
Descriptor: 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, GLYCEROL, MYRISTIC ACID, ...
Authors:Nagar, B, Hantschel, O, Young, M.A, Scheffzek, K, Veach, D, Bornmann, W, Clarkson, B, Superti-Furga, G, Kuriyan, J.
Deposit date:2003-03-06
Release date:2003-04-08
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for the autoinhibition of c-Abl tyrosine kinase
Cell(Cambridge,Mass.), 112, 2003
1OPJ
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BU of 1opj by Molmil
Structural basis for the auto-inhibition of c-Abl tyrosine kinase
Descriptor: 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, CHLORIDE ION, MYRISTIC ACID, ...
Authors:Nagar, B, Hantschel, O, Young, M.A, Scheffzek, K, Veach, D, Bornmann, W, Clarkson, B, Superti-Furga, G, Kuriyan, J.
Deposit date:2003-03-06
Release date:2003-04-08
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural basis for the autoinhibition of c-Abl tyrosine kinase
Cell(Cambridge,Mass.), 112, 2003
1OPL
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BU of 1opl by Molmil
Structural basis for the auto-inhibition of c-Abl tyrosine kinase
Descriptor: 6-(2,6-DICHLOROPHENYL)-2-{[3-(HYDROXYMETHYL)PHENYL]AMINO}-8-METHYLPYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONE, MYRISTIC ACID, proto-oncogene tyrosine-protein kinase
Authors:Nagar, B, Hantschel, O, Young, M.A, Scheffzek, K, Veach, D, Bornmann, W, Clarkson, B, Superti-Furga, G, Kuriyan, J.
Deposit date:2003-03-06
Release date:2003-04-08
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (3.42 Å)
Cite:Structural basis for the autoinhibition of c-Abl tyrosine kinase
Cell(Cambridge,Mass.), 112, 2003
8DU5
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BU of 8du5 by Molmil
Murine sialidase-1 (NEU1)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Sialidase-1, ...
Authors:Gorelik, A, Illes, K, Nagar, B.
Deposit date:2022-07-26
Release date:2023-05-31
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structure of the immunoregulatory sialidase NEU1.
Sci Adv, 9, 2023
7SJ2
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BU of 7sj2 by Molmil
N-acetylglucosamine-1-phosphotransferase (GNPT) alpha and beta subunits (GNPTAB) catalytic domain, from zebrafish, in complex with uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) and magnesium
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Gorelik, A, Illes, K, Nagar, B.
Deposit date:2021-10-15
Release date:2022-05-25
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structures of the mannose-6-phosphate pathway enzyme, GlcNAc-1-phosphotransferase.
Proc.Natl.Acad.Sci.USA, 119, 2022
2OIQ
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BU of 2oiq by Molmil
Crystal Structure of chicken c-Src kinase domain in complex with the cancer drug imatinib.
Descriptor: 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, GLYCEROL, Proto-oncogene tyrosine-protein kinase Src
Authors:Seeliger, M.A, Nagar, B, Frank, F, Cao, X, Henderson, M.N, Kuriyan, J.
Deposit date:2007-01-11
Release date:2007-03-20
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:c-Src Binds to the Cancer Drug Imatinib with an Inactive Abl/c-Kit Conformation and a Distributed Thermodynamic Penalty.
Structure, 15, 2007
6WG5
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BU of 6wg5 by Molmil
Human ectonucleoside triphosphate diphosphohydrolase 4 (ENTPD4, NTPDase 4)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ectonucleoside triphosphate diphosphohydrolase 4
Authors:Gorelik, A, Labriola, J.M, Illes, K, Nagar, B.
Deposit date:2020-04-04
Release date:2020-08-12
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of the nucleotide-metabolizing enzyme NTPDase4.
Protein Sci., 29, 2020
5HQN
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BU of 5hqn by Molmil
Catalytic domain of murine Acid Sphingomyelinase (ASMase, ASM, SMPD1)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gorelik, A, Illes, K, Heinz, L.X, Superti-Furga, G, Nagar, B.
Deposit date:2016-01-21
Release date:2016-07-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of mammalian acid sphingomyelinase.
Nat Commun, 7, 2016
6XKI
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BU of 6xki by Molmil
Crystal structure of eIF4A-I in complex with RNA bound to des-MePateA, a pateamine A analog
Descriptor: (3S,6Z,8E,11S,15R)-15-amino-3-[(1E,3E,5E)-7-(dimethylamino)-2,5-dimethylhepta-1,3,5-trien-1-yl]-9,11-dimethyl-4,12-dioxa-20-thia-21-azabicyclo[16.2.1]henicosa-1(21),6,8,18-tetraene-5,13-dione, Eukaryotic initiation factor 4A-I, MAGNESIUM ION, ...
Authors:Liang, J, Naineni, S.K, Pelletier, J, Nagar, B.
Deposit date:2020-06-26
Release date:2021-01-06
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:Functional mimicry revealed by the crystal structure of an eIF4A:RNA complex bound to the interfacial inhibitor, desmethyl pateamine A.
Cell Chem Biol, 28, 2021
5KAS
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BU of 5kas by Molmil
Murine acid sphingomyelinase-like phosphodiesterase 3b (SMPDL3B) with phosphocholine
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Acid sphingomyelinase-like phosphodiesterase 3b, ...
Authors:Gorelik, A, Illes, K, Heinz, L.X, Superti-Furga, G, Nagar, B.
Deposit date:2016-06-02
Release date:2016-10-05
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.619 Å)
Cite:Crystal Structure of the Acid Sphingomyelinase-like Phosphodiesterase SMPDL3B Provides Insights into Determinants of Substrate Specificity.
J.Biol.Chem., 291, 2016
6U11
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BU of 6u11 by Molmil
Xenopus laevis N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (NAGPA) (C46S C219S C453S C480S C486S) with CTD mostly flexible
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gorelik, A, Illes, K, Nagar, B.
Deposit date:2019-08-15
Release date:2020-02-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of the Mannose-6-Phosphate Uncovering Enzyme.
Structure, 28, 2020
7KDV
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BU of 7kdv by Molmil
Murine core lysosomal multienzyme complex (LMC) composed of acid beta-galactosidase (GLB1) and protective protein cathepsin A (PPCA, CTSA)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-galactosidase, ...
Authors:Gorelik, A, Illes, K, Hasan, S.M.N, Nagar, B, Mazhab-Jafari, M.T.
Deposit date:2020-10-09
Release date:2021-03-17
Last modified:2021-05-26
Method:ELECTRON MICROSCOPY (4.59 Å)
Cite:Structure of the murine lysosomal multienzyme complex core.
Sci Adv, 7, 2021
3LUD
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BU of 3lud by Molmil
Crystal structure of MID domain from hAGO2 in complex with AMP
Descriptor: ADENOSINE MONOPHOSPHATE, PHOSPHATE ION, Protein argonaute-2
Authors:Frank, F, Sonenberg, N, Nagar, B.
Deposit date:2010-02-17
Release date:2010-05-26
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.095 Å)
Cite:Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2.
Nature, 465, 2010
3LUK
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BU of 3luk by Molmil
Crystal structure of MID domain from hAGO2
Descriptor: GLYCEROL, PHOSPHATE ION, Protein argonaute-2
Authors:Frank, F, Sonenberg, N, Nagar, B.
Deposit date:2010-02-17
Release date:2010-05-26
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for 5'-nucleotide base-specific recognition of guide RNA by human AGO2.
Nature, 465, 2010
4K95
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BU of 4k95 by Molmil
Crystal Structure of Parkin
Descriptor: E3 ubiquitin-protein ligase parkin, ZINC ION
Authors:Seirafi, M, Menade, M, Sauve, V, Kozlov, G, Trempe, J.-F, Nagar, B, Gehring, K.
Deposit date:2013-04-19
Release date:2013-05-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (6.499 Å)
Cite:Structure of parkin reveals mechanisms for ubiquitin ligase activation.
Science, 340, 2013
7S6N
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BU of 7s6n by Molmil
N-acetylglucosamine-1-phosphotransferase (GNPT) alpha and beta subunits (GNPTAB) catalytic domain, from zebrafish
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Gorelik, A, Illes, K, Nagar, B.
Deposit date:2021-09-14
Release date:2022-05-25
Last modified:2022-08-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structures of the mannose-6-phosphate pathway enzyme, GlcNAc-1-phosphotransferase.
Proc.Natl.Acad.Sci.USA, 119, 2022
7S69
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BU of 7s69 by Molmil
N-acetylglucosamine-1-phosphotransferase (GNPT) gamma subunit (GNPTG), from clawed frog
Descriptor: CHLORIDE ION, N-acetylglucosamine-1-phosphotransferase gamma subunit, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gorelik, A, Illes, K, Nagar, B.
Deposit date:2021-09-13
Release date:2022-05-25
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.04 Å)
Cite:Structures of the mannose-6-phosphate pathway enzyme, GlcNAc-1-phosphotransferase.
Proc.Natl.Acad.Sci.USA, 119, 2022
1JZN
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BU of 1jzn by Molmil
crystal structure of a galactose-specific C-type lectin
Descriptor: CALCIUM ION, CHLORIDE ION, Galactose-specific lectin, ...
Authors:Walker, J.R, Nagar, B, Young, N.M, Hirama, T, Rini, J.M.
Deposit date:2001-09-16
Release date:2003-07-01
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:X-ray Crystal Structure of a Galactose-Specific C-Type Lectin Possessing a Novel Decameric Quaternary Structure.
Biochemistry, 43, 2004
6PKY
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BU of 6pky by Molmil
Guinea pig N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (NAGPA) catalytic domain auto-inhibited by pro-peptide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, BROMIDE ION, ...
Authors:Gorelik, A, Illes, K, Nagar, B.
Deposit date:2019-06-30
Release date:2020-02-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal Structure of the Mannose-6-Phosphate Uncovering Enzyme.
Structure, 28, 2020
6PKG
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BU of 6pkg by Molmil
Zebrafish N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase (NAGPA) catalytic domain auto-inhibited by pro-peptide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, HEXAETHYLENE GLYCOL, IODIDE ION, ...
Authors:Gorelik, A, Illes, K, Nagar, B.
Deposit date:2019-06-29
Release date:2020-02-19
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of the Mannose-6-Phosphate Uncovering Enzyme.
Structure, 28, 2020

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