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1XLU
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X-RAY STRUCTURE OF DI-ISOPROPYL-PHOSPHORO-FLUORIDATE (DFP) INHIBITED BUTYRYLCHOLINESTERASE AFTER AGING
Descriptor:BUTYRYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, BETA-L-FUCOSE, ...
Authors:Nachon, F., Asojo, O.A., Borgstahl, G.E.O., Masson, P., Lockridge, O.
Deposit date:2004-09-30
Release date:2005-02-01
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.198 Å)
Cite:Role of Water in Aging of Human Butyrylcholinesterase Inhibited by Echothiophate: The Crystal Structure Suggests Two Alternative Mechanisms of Aging
Biochemistry, 44, 2005
1XLV
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ETHYLPHOSPHORYLATED BUTYRYLCHOLINESTERASE (AGED) OBTAINED BY REACTION WITH ECHOTHIOPHATE
Descriptor:BUTYRYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, BETA-L-FUCOSE, ...
Authors:Nachon, F., Asojo, O.A., Borgstahl, G.E.O., Masson, P., Lockridge, O.
Deposit date:2004-09-30
Release date:2005-02-01
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.247 Å)
Cite:Role of Water in Aging of Human Butyrylcholinesterase Inhibited by Echothiophate: The Crystal Structure Suggests Two Alternative Mechanisms of Aging
Biochemistry, 44, 2005
1XLW
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DIETHYLPHOSPHORYLATED BUTYRYLCHOLINESTERASE (NONAGED) OBTAINED BY REACTION WITH ECHOTHIOPHATE
Descriptor:BUTYRYLCHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, BETA-L-FUCOSE, ...
Authors:Nachon, F., Asojo, O.A., Borgstahl, G.E.O., Masson, P., Lockridge, O.
Deposit date:2004-09-30
Release date:2005-02-01
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Role of Water in Aging of Human Butyrylcholinesterase Inhibited by Echothiophate: The Crystal Structure Suggests Two Alternative Mechanisms of Aging
Biochemistry, 44, 2005
2XMB
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G117H MUTANT OF HUMAN BUTYRYLCHOLINESTERASE IN COMPLEX WITH SULFATE
Descriptor:CHOLINESTERASE, UNKNOWN ATOM OR ION, CHLORIDE ION, ...
Authors:Nachon, F., Carletti, E., Wandhammer, M., Nicolet, Y., Schopfer, L.M., Masson, P., Lockridge, O.
Deposit date:2010-07-27
Release date:2010-12-01
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:X-Ray Crystallographic Snapshots of Reaction Intermediates in the G117H Mutant of Human Butyrylcholinesterase, a Nerve Agent Target Engineered Into a Catalytic Bioscavenge
Biochem.J., 434, 2011
2XMC
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G117H MUTANT OF HUMAN BUTYRYLCHOLINESTERASE IN COMPLEX WITH FLUORIDE ANION
Descriptor:CHOLINESTERASE, UNKNOWN ATOM OR ION, FLUORIDE ION, ...
Authors:Nachon, F., Carletti, E., Wandhammer, M., Nicolet, Y., Schopfer, L.M., Masson, P., Lockridge, O.
Deposit date:2010-07-27
Release date:2010-12-01
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:X-Ray Crystallographic Snapshots of Reaction Intermediates in the G117H Mutant of Human Butyrylcholinesterase, a Nerve Agent Target Engineered Into a Catalytic Bioscavenge
Biochem.J., 434, 2011
2XMD
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G117H MUTANT OF HUMAN BUTYRYLCHOLINESTERASE IN COMPLEX WITH ECHOTHIOPHATE
Descriptor:CHOLINESTERASE, UNKNOWN ATOM OR ION, DIETHYL PHOSPHONATE, ...
Authors:Nachon, F., Carletti, E., Wandhammer, M., Nicolet, Y., Schopfer, L.M., Masson, P., Lockridge, O.
Deposit date:2010-07-27
Release date:2010-12-01
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:X-Ray Crystallographic Snapshots of Reaction Intermediates in the G117H Mutant of Human Butyrylcholinesterase, a Nerve Agent Target Engineered Into a Catalytic Bioscavenge
Biochem.J., 434, 2011
2XMG
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G117H MUTANT OF HUMAN BUTYRYLCHOLINESTERASE IN COMPLEX WITH VX
Descriptor:CHOLINESTERASE, UNKNOWN ATOM OR ION, O-ETHYLMETHYLPHOSPHONIC ACID ESTER GROUP, ...
Authors:Nachon, F., Carletti, E., Wandhammer, M., Nicolet, Y., Schopfer, L.M., Masson, P., Lockridge, O.
Deposit date:2010-07-27
Release date:2010-12-01
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:X-Ray Crystallographic Snapshots of Reaction Intermediates in the G117H Mutant of Human Butyrylcholinesterase, a Nerve Agent Target Engineered Into a Catalytic Bioscavenge
Biochem.J., 434, 2011
4BDS
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HUMAN BUTYRYLCHOLINESTERASE IN COMPLEX WITH TACRINE
Descriptor:CHOLINESTERASE, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Nachon, F., Carletti, E., Ronco, C., Trovaslet, M., Nicolet, Y., Jean, L., Renard, P.-Y.
Deposit date:2012-10-06
Release date:2013-05-29
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structures of Human Cholinesterases in Complex with Huprine W and Tacrine: Elements of Specificity for Anti-Alzheimer'S Drugs Targeting Acetyl- and Butyrylcholinesterase.
Biochem.J., 453, 2013
4BDT
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HUMAN ACETYLCHOLINESTERASE IN COMPLEX WITH HUPRINE W AND FASCICULIN 2
Descriptor:ACETYLCHOLINESTERASE, FASCICULIN-2, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Nachon, F., Carletti, E., Ronco, C., Trovaslet, M., Nicolet, Y., Jean, L., Renard, P.-Y.
Deposit date:2012-10-06
Release date:2013-05-29
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (3.104 Å)
Cite:Crystal structures of human cholinesterases in complex with huprine W and tacrine: elements of specificity for anti-Alzheimer's drugs targeting acetyl- and butyryl-cholinesterase.
Biochem. J., 453, 2013
3DKK
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AGED FORM OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY TABUN
Descriptor:Cholinesterase, N-ACETYL-D-GLUCOSAMINE, BETA-L-FUCOSE, ...
Authors:Nachon, F., Carletti, E.
Deposit date:2008-06-25
Release date:2008-12-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Aging of Cholinesterases Phosphylated by Tabun Proceeds through O-Dealkylation.
J.Am.Chem.Soc., 130, 2008
6EP4
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HUMAN BUTYRYLCHOLINESTERASE IN COMPLEX WITH DECAMETHONIUM
Descriptor:Cholinesterase, DECAMETHONIUM ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Nachon, F., Brazzolotto, X., Wandhammer, M., Trovaslet-Leroy, M., Rosenberry, T.L., Macdonald, I.R., Darvesh, S.
Deposit date:2017-10-10
Release date:2017-12-13
Method:X-RAY DIFFRACTION (2.300054 Å)
Cite:Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study.
Molecules, 22, 2017
6EQP
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HUMAN BUTYRYLCHOLINESTERASE IN COMPLEX WITH ETHOPROPAZINE
Descriptor:Cholinesterase, R-ethopropazine, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Nachon, F., Brazzolotto, X., Wandhammer, M., Trovaslet-Leroy, M., Rosenberry, T.L., Macdonald, I.R., Darvesh, S.
Deposit date:2017-10-14
Release date:2017-12-13
Method:X-RAY DIFFRACTION (2.349417 Å)
Cite:Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study.
Molecules, 22, 2017
6EQQ
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HUMAN BUTYRYLCHOLINESTERASE IN COMPLEX WITH HUPRINE 19
Descriptor:Cholinesterase, huprine 19, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Nachon, F., Brazzolotto, X., Wandhammer, M., Trovaslet-Leroy, M., Rosenberry, T.L., Macdonald, I.R., Darvesh, S.
Deposit date:2017-10-15
Release date:2017-12-13
Method:X-RAY DIFFRACTION (2.400004 Å)
Cite:Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study.
Molecules, 22, 2017
6ESJ
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HUMAN BUTYRYLCHOLINESTERASE IN COMPLEX WITH PROPIDIUM
Descriptor:Cholinesterase, N-ACETYL-D-GLUCOSAMINE, 3,8-DIAMINO-5[3-(DIETHYLMETHYLAMMONIO)PROPYL]-6-PHENYLPHENANTHRIDINIUM, ...
Authors:Nachon, F., Brazzolotto, X., Wandhammer, M., Trovaslet-Leroy, M., Macdonald, I.R., Darvesh, S., Rosenberry, T.L.
Deposit date:2017-10-20
Release date:2017-12-13
Method:X-RAY DIFFRACTION (2.979845 Å)
Cite:Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study.
Molecules, 22, 2017
6ESY
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HUMAN BUTYRYLCHOLINESTERASE IN COMPLEX WITH THIOFLAVINE T
Descriptor:Cholinesterase, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Nachon, F., Brazzolotto, X., Wandhammer, M., Trovaslet-Leroy, M., Macdonald, I.R., Darvesh, S., Rosenberry, T.L.
Deposit date:2017-10-24
Release date:2017-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Comparison of the Binding of Reversible Inhibitors to Human Butyrylcholinesterase and Acetylcholinesterase: A Crystallographic, Kinetic and Calorimetric Study.
Molecules, 22, 2017
1P0I
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CRYSTAL STRUCTURE OF HUMAN BUTYRYL CHOLINESTERASE
Descriptor:Cholinesterase, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Nicolet, Y., Lockridge, O., Masson, P., Fontecilla-Camps, J.C., Nachon, F.
Deposit date:2003-04-10
Release date:2003-08-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products.
J.Biol.Chem., 278, 2003
1P0M
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CRYSTAL STRUCTURE OF HUMAN BUTYRYL CHOLINESTERASE IN COMPLEX WITH A CHOLINE MOLECULE
Descriptor:Cholinesterase, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Nicolet, Y., Lockridge, O., Masson, P., Fontecilla-Camps, J.C., Nachon, F.
Deposit date:2003-04-10
Release date:2003-08-05
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products.
J.Biol.Chem., 278, 2003
1P0P
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CRYSTAL STRUCTURE OF SOMAN-AGED HUMAN BUTYRYL CHOLINESTERASE IN COMPLEX WITH THE SUBSTRATE ANALOG BUTYRYLTHIOCHOLINE
Descriptor:Cholinesterase, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Nicolet, Y., Lockridge, O., Masson, P., Fontecilla-Camps, J.C., Nachon, F.
Deposit date:2003-04-10
Release date:2003-08-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products.
J.Biol.Chem., 278, 2003
1P0Q
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CRYSTAL STRUCTURE OF SOMAN-AGED HUMAN BUTYRYL CHOLINESTERASE
Descriptor:Cholinesterase, N-ACETYL-D-GLUCOSAMINE, ALPHA-L-FUCOSE, ...
Authors:Nicolet, Y., Lockridge, O., Masson, P., Fontecilla-Camps, J.C., Nachon, F.
Deposit date:2003-04-10
Release date:2003-08-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products.
J.Biol.Chem., 278, 2003
2WID
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NONAGED FORM OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY TABUN ANALOGUE TA1
Descriptor:CHOLINESTERASE, ETHYL HYDROGEN DIETHYLAMIDOPHOSPHATE, SODIUM ION, ...
Authors:Carletti, E., Aurbek, N., Gillon, E., Loiodice, M., Nicolet, Y., Fontecilla, J., Masson, P., Thiermann, H., Nachon, F., Worek, F.
Deposit date:2009-05-11
Release date:2009-05-19
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun.
Biochem. J., 421, 2009
2WIF
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AGED FORM OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY TABUN ANALOGUE TA1
Descriptor:CHOLINESTERASE, SODIUM ION, CHLORIDE ION, ...
Authors:Carletti, E., Aurbek, N., Gillon, E., Loiodice, M., Nicolet, Y., Fontecilla, J., Masson, P., Thiermann, H., Nachon, F., Worek, F.
Deposit date:2009-05-11
Release date:2009-05-19
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun.
Biochem. J., 421, 2009
2WIG
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NONAGED FORM OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY TABUN ANALOGUE TA4
Descriptor:CHOLINESTERASE, ETHYL HYDROGEN METHYLAMIDOPHOSPHATE, SODIUM ION, ...
Authors:Carletti, E., Aurbek, N., Gillon, E., Loiodice, M., Nicolet, Y., Fontecilla, J., Masson, P., Thiermann, H., Nachon, F., Worek, F.
Deposit date:2009-05-11
Release date:2009-05-19
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun.
Biochem. J., 421, 2009
2WIJ
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NONAGED FORM OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY TABUN ANALOGUE TA5
Descriptor:CHOLINESTERASE, ethyl hydrogen ethylamidophosphate, SODIUM ION, ...
Authors:Carletti, E., Aurbek, N., Gillon, E., Loiodice, M., Nicolet, Y., Fontecilla, J., Masson, P., Thiermann, H., Nachon, F., Worek, F.
Deposit date:2009-05-12
Release date:2009-05-19
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun.
Biochem. J., 421, 2009
2WIK
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NONAGED FORM OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY TABUN ANALOGUE TA6
Descriptor:CHOLINESTERASE, ETHYL HYDROGEN PROPYLAMIDOPHOSPHATE, CHLORIDE ION, ...
Authors:Carletti, E., Aurbek, N., Gillon, E., Loiodice, M., Nicolet, Y., Fontecilla, J., Masson, P., Thiermann, H., Nachon, F., Worek, F.
Deposit date:2009-05-12
Release date:2009-05-19
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure-activity analysis of aging and reactivation of human butyrylcholinesterase inhibited by analogues of tabun.
Biochem. J., 421, 2009
2WIL
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AGED FORM OF HUMAN BUTYRYLCHOLINESTERASE INHIBITED BY TABUN ANALOGUE TA5
Descriptor:CHOLINESTERASE, ethylphosphoramidic acid, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Carletti, E., Aurbek, N., Gillon, E., Loiodice, M., Nicolet, Y., Fontecilla, J., Masson, P., Thiermann, H., Nachon, F., Worek, F.
Deposit date:2009-05-12
Release date:2009-05-26
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure-Activity Analysis of Aging and Reactivation of Human Butyrylcholinesterase Inhibited by Analogues of Tabun
Biochem.J., 421, 2009