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2MPF
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BU of 2mpf by Molmil
Solution structure human HCN2 CNBD in the cAMP-unbound state
Descriptor: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Authors:Saponaro, A, Pauleta, S.R, Cantini, F, Matzapetakis, M, Hammann, C, Banci, L, Thiel, G, Santoro, B, Moroni, A.
Deposit date:2014-05-16
Release date:2014-09-03
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural basis for the mutual antagonism of cAMP and TRIP8b in regulating HCN channel function.
Proc.Natl.Acad.Sci.USA, 111, 2014
7NP4
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BU of 7np4 by Molmil
cAMP-bound rabbit HCN4 stabilized in LMNG-CHS detergent mixture
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Authors:Giese, H, Chaves-Sanjuan, A, Saponaro, A, Clarke, O, Bolognesi, M, Mancia, F, Hendrickson, W.A, Thiel, G, Santoro, B, Moroni, A.
Deposit date:2021-02-26
Release date:2021-08-11
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Gating movements and ion permeation in HCN4 pacemaker channels.
Mol.Cell, 81, 2021
7NP3
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BU of 7np3 by Molmil
cAMP-free rabbit HCN4 stabilized in LMNG-CHS detergent mixture
Descriptor: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4,Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Authors:Giese, H.M, Chaves-Sanjuan, A, Saponaro, A, Clarke, O, Bolognesi, M, Mancia, F, Hendrickson, W.A, Thiel, G, Santoro, B, Moroni, A.
Deposit date:2021-02-26
Release date:2021-08-11
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Gating movements and ion permeation in HCN4 pacemaker channels.
Mol.Cell, 81, 2021
6SWR
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BU of 6swr by Molmil
Crystal structure of the lysosomal potassium channel MtTMEM175 T38A mutant soaked with zinc
Descriptor: DODECYL-BETA-D-MALTOSIDE, Nanobody, Maltose/maltodextrin-binding periplasmic protein,Maltodextrin-binding protein,Maltose/maltodextrin-binding periplasmic protein, ...
Authors:Brunner, J.D, Jakob, R.P, Schulze, T, Neldner, Y, Moroni, A, Thiel, G, Maier, T, Schenck, S.
Deposit date:2019-09-23
Release date:2020-04-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for ion selectivity in TMEM175 K + channels.
Elife, 9, 2020
4KL1
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BU of 4kl1 by Molmil
HCN4 CNBD in complex with cGMP
Descriptor: ACETATE ION, CYCLIC GUANOSINE MONOPHOSPHATE, GLYCEROL, ...
Authors:Lolicato, M, Arrigoni, C, Zucca, S, Nardini, M, Bucchi, A, Schroeder, I, Simmons, K, Bolognesi, M, DiFrancesco, D, Schwede, F, Fishwick, C.W.G, Johnson, A.P.K, Thiel, G, Moroni, A.
Deposit date:2013-05-07
Release date:2014-04-30
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Cyclic dinucleotides bind the C-linker of HCN4 to control channel cAMP responsiveness.
Nat.Chem.Biol., 10, 2014
4NVP
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BU of 4nvp by Molmil
Structure of the cyclic nucleotide-binding domain of HCN4 channel complexed with 7-CH-cAMP
Descriptor: (2S,4aR,6R,7R,7aS)-6-(4-amino-7H-pyrrolo[2,3-d]pyrimidin-7-yl)tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol 2-oxide, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Authors:Alfieri, A, Moroni, A.
Deposit date:2013-12-05
Release date:2014-03-19
Last modified:2014-05-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Cyclic Nucleotide Mapping of Hyperpolarization-Activated Cyclic Nucleotide-Gated (HCN) Channels.
Acs Chem.Biol., 9, 2014
6HD8
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BU of 6hd8 by Molmil
Crystal structure of the potassium channel MtTMEM175 in complex with a Nanobody-MBP fusion protein
Descriptor: DODECYL-BETA-D-MALTOSIDE, Nanobody,Maltose/maltodextrin-binding periplasmic protein, POTASSIUM ION, ...
Authors:Brunner, J.D, Jakob, R.P, Schulze, T, Neldner, Y, Moroni, A, Thiel, G, Maier, T, Schenck, S.
Deposit date:2018-08-17
Release date:2019-08-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis for ion selectivity in TMEM175 K+channels.
Elife, 9, 2020
6HDC
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BU of 6hdc by Molmil
Crystal structure of the potassium channel MtTMEM175 T38A variant in complex with a Nanobody-MBP fusion protein
Descriptor: DODECYL-BETA-D-MALTOSIDE, Nanobody,Maltose/maltodextrin-binding periplasmic protein,Maltose/maltodextrin-binding periplasmic protein, POTASSIUM ION, ...
Authors:Brunner, J.D, Jakob, R.P, Schulze, T, Neldner, Y, Moroni, A, Thiel, G, Maier, T, Schenck, S.
Deposit date:2018-08-17
Release date:2019-08-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structural basis for ion selectivity in TMEM175 K+channels.
Elife, 9, 2020
6HDB
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BU of 6hdb by Molmil
Crystal structure of the potassium channel MtTMEM175 with zinc
Descriptor: DODECYL-BETA-D-MALTOSIDE, Nanobody,Maltose/maltodextrin-binding periplasmic protein, POTASSIUM ION, ...
Authors:Brunner, J.D, Jakob, R.P, Schulze, T, Neldner, Y, Moroni, A, Thiel, G, Maier, T, Schenck, S.
Deposit date:2018-08-17
Release date:2019-08-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural basis for ion selectivity in TMEM175 K+channels.
Elife, 9, 2020
6HD9
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BU of 6hd9 by Molmil
Crystal structure of the potassium channel MtTMEM175 with rubidium
Descriptor: DODECYL-BETA-D-MALTOSIDE, Nanobody,Maltose/maltodextrin-binding periplasmic protein, RUBIDIUM ION, ...
Authors:Brunner, J.D, Jakob, R.P, Schulze, T, Neldner, Y, Moroni, A, Thiel, G, Maier, T, Schenck, S.
Deposit date:2018-08-17
Release date:2019-08-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Structural basis for ion selectivity in TMEM175 K+channels.
Elife, 9, 2020
6HDA
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BU of 6hda by Molmil
Crystal structure of the potassium channel MtTMEM175 with cesium
Descriptor: CESIUM ION, DODECYL-BETA-D-MALTOSIDE, Nanobody,Maltose/maltodextrin-binding periplasmic protein, ...
Authors:Brunner, J.D, Jakob, R.P, Schulze, T, Neldner, Y, Moroni, A, Thiel, G, Maier, T, Schenck, S.
Deposit date:2018-08-17
Release date:2019-08-28
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structural basis for ion selectivity in TMEM175 K+channels.
Elife, 9, 2020
5NWI
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BU of 5nwi by Molmil
14-3-3c in complex with CPP
Descriptor: 14-3-3 c-1 protein, ACETATE ION, Potassium channel KAT1
Authors:Saponaro, A, Porro, A, Chaves-Sanjuan, A, Nardini, M, Thiel, G, Moroni, A.
Deposit date:2017-05-06
Release date:2017-11-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Fusicoccin Activates KAT1 Channels by Stabilizing Their Interaction with 14-3-3 Proteins.
Plant Cell, 29, 2017
5NWK
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BU of 5nwk by Molmil
14-3-3c in complex with CPP and fusicoccin
Descriptor: 14-3-3 c-1 protein, FUSICOCCIN, PHOSPHOSERINE, ...
Authors:Saponaro, A, Porro, A, Chaves-Sanjuan, A, Nardini, M, Thiel, G, Moroni, A.
Deposit date:2017-05-06
Release date:2017-11-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Fusicoccin Activates KAT1 Channels by Stabilizing Their Interaction with 14-3-3 Proteins.
Plant Cell, 29, 2017
5NWJ
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BU of 5nwj by Molmil
14-3-3c in complex with CPP7
Descriptor: 14-3-3-like protein C, ACETATE ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Saponaro, A, Porro, A, Chaves-Sanjuan, A, Nardini, M, Thiel, G, Moroni, A.
Deposit date:2017-05-06
Release date:2017-11-22
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Fusicoccin Activates KAT1 Channels by Stabilizing Their Interaction with 14-3-3 Proteins.
Plant Cell, 29, 2017
3U10
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BU of 3u10 by Molmil
Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2
Authors:Lolicato, M, Nardini, M, Gazzarrini, S, Moller, S, Bertinetti, D, Herberg, F.W, Bolognesi, M, Martin, H, Fasolini, M, Bertrand, J.A, Arrigoni, C, Thiel, G, Moroni, A.
Deposit date:2011-09-29
Release date:2011-10-26
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.
J.Biol.Chem., 286, 2011
3U0Z
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BU of 3u0z by Molmil
Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
Authors:Lolicato, M, Nardini, M, Gazzarrini, S, Moller, S, Bertinetti, D, Herberg, F.W, Bolognesi, M, Martin, H, Fasolini, M, Bertrand, J.A, Arrigoni, C, Thiel, G, Moroni, A.
Deposit date:2011-09-29
Release date:2011-10-26
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.
J.Biol.Chem., 286, 2011
3U11
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BU of 3u11 by Molmil
Tetramerization dynamics of the C-terminus underlies isoform-specific cAMP-gating in HCN channels
Descriptor: ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, GLYCEROL, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4
Authors:Lolicato, M, Nardini, M, Gazzarrini, S, Moller, S, Bertinetti, D, Herberg, F.W, Bolognesi, M, Martin, H, Fasolini, M, Bertrand, J.A, Arrigoni, C, Thiel, G, Moroni, A.
Deposit date:2011-09-29
Release date:2011-10-26
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels.
J.Biol.Chem., 286, 2011
7NMN
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BU of 7nmn by Molmil
Rabbit HCN4 stabilised in amphipol A8-35
Descriptor: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4,Rabbit HCN4
Authors:Chaves-Sanjuan, A.
Deposit date:2021-02-23
Release date:2021-06-30
Last modified:2021-07-28
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Gating movements and ion permeation in HCN4 pacemaker channels.
Mol.Cell, 81, 2021

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