Author results

4Z2M
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CRYSTAL STRUCTURE OF HUMAN SPT16 MID-AID/H3-H4 TETRAMER FACT HISTONE COMPLEX
Descriptor:FACT complex subunit SPT16, Histone H3.1, Histone H4
Authors:Tsunaka, Y., Fujiwara, Y., Oyama, T., Hirose, S., Morikawa, K.
Deposit date:2015-03-30
Release date:2016-03-09
Last modified:2016-03-30
Method:X-RAY DIFFRACTION (2.981 Å)
Cite:Integrated molecular mechanism directing nucleosome reorganization by human FACT.
Genes Dev., 30, 2016
4Z2N
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CRYSTAL STRUCTURE OF HUMAN FACT SPT16 MIDDLE DOMAIN
Descriptor:FACT complex subunit SPT16
Authors:Tsunaka, Y., Fujiwara, Y., Oyama, T., Hirose, S., Morikawa, K.
Deposit date:2015-03-30
Release date:2016-03-09
Last modified:2016-03-30
Method:X-RAY DIFFRACTION (1.923 Å)
Cite:Integrated molecular mechanism directing nucleosome reorganization by human FACT.
Genes Dev., 30, 2016
3VSO
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HUMAN PPAR GAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH A GAMMA SELECTIVE AGONIST MEKT21
Descriptor:Peroxisome proliferator-activated receptor gamma, (2R)-2-benzyl-3-[4-propoxy-3-({[4-(pyrimidin-2-yl)benzoyl]amino}methyl)phenyl]propanoic acid
Authors:Oyama, T., Waku, T., Ohashi, M., Morikawa, K., Miyachi, H.
Deposit date:2012-04-30
Release date:2013-05-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design and synthesis of a series of alpha-benzyl phenylpropanoic acid-type peroxisome proliferator-activated receptor (PPAR) gamma partial agonists with improved aqueous solubility
Bioorg.Med.Chem., 21, 2013
3VSP
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HUMAN PPAR GAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH A GAMMA SELECTIVE AGONIST MEKT28
Descriptor:Peroxisome proliferator-activated receptor gamma, (2R)-2-benzyl-3-[3-({[4-(piperidin-1-yl)benzoyl]amino}methyl)-4-propoxyphenyl]propanoic acid
Authors:Oyama, T., Waku, T., Ohashi, M., Morikawa, K., Miyachi, H.
Deposit date:2012-04-30
Release date:2013-05-01
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Human PPAR gamma ligand binding domain in complex with a gamma selective agonist mekt28
To be Published
3W0K
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CRYSTAL STRUCTURE OF A GLYCOSIDE HYDROLASE
Descriptor:Bifunctional endomannanase/endoglucanase, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Oyama, T., Nakamura, H., Morikawa, K., Cann, I.K.O.
Deposit date:2012-10-31
Release date:2013-02-20
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal structure of a glycoside hydrolase
To be Published
3VI8
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HUMAN PPAR ALPHA LIGAND BINDING DOMAIN IN COMPLEX WITH A SYNTHETIC AGONIST APHM13
Descriptor:Peroxisome proliferator-activated receptor alpha, (2S)-2-(4-methoxy-3-{[(pyren-1-ylcarbonyl)amino]methyl}benzyl)butanoic acid
Authors:Oyama, T., Miyachi, H., Morikawa, K.
Deposit date:2011-09-25
Release date:2012-08-29
Last modified:2016-03-02
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Peroxisome proliferator-activated receptors (PPARs) have multiple binding points that accommodate ligands in various conformations: phenylpropanoic acid-type PPAR ligands bind to PPAR in different conformations, depending on the subtype
J.Med.Chem., 55, 2012
4EIW
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WHOLE CYTOSOLIC REGION OF ATP-DEPENDENT METALLOPROTEASE FTSH (G399L)
Descriptor:ATP-dependent zinc metalloprotease FtsH, ADENOSINE-5'-DIPHOSPHATE
Authors:Suno, R., Niwa, H., Tsuchiya, D., Yoshida, M., Morikawa, K.
Deposit date:2012-04-06
Release date:2012-06-06
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Structure of the whole cytosolic region of ATP-dependent protease FtsH
Mol.Cell, 22, 2006
3B0B
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CRYSTAL STRUCTURE OF THE CHICKEN CENP-S/CENP-X COMPLEX
Descriptor:Centromere protein S, Centromere protein X
Authors:Nishino, T., Takeuchi, K., Gascoigne, K.E., Suzuki, A., Hori, T., Oyama, T., Morikawa, K., Cheeseman, I.M., Fukagawa, T.
Deposit date:2011-06-08
Release date:2012-03-07
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:CENP-T-W-S-X Forms a Unique Centromeric Chromatin Structure with a Histone-like Fold.
Cell(Cambridge,Mass.), 148, 2012
3B0C
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CRYSTAL STRUCTURE OF THE CHICKEN CENP-T HISTONE FOLD/CENP-W COMPLEX, CRYSTAL FORM I
Descriptor:Centromere protein T, Centromere protein W, CITRIC ACID
Authors:Nishino, T., Takeuchi, K., Gascoigne, K.E., Suzuki, A., Hori, T., Oyama, T., Morikawa, K., Cheeseman, I.M., Fukagawa, T.
Deposit date:2011-06-08
Release date:2012-03-07
Method:X-RAY DIFFRACTION (2.201 Å)
Cite:CENP-T-W-S-X Forms a Unique Centromeric Chromatin Structure with a Histone-like Fold.
Cell(Cambridge,Mass.), 148, 2012
3B0D
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CRYSTAL STRUCTURE OF THE CHICKEN CENP-T HISTONE FOLD/CENP-W COMPLEX, CRYSTAL FORM II
Descriptor:Centromere protein T, Centromere protein W, CITRIC ACID
Authors:Nishino, T., Takeuchi, K., Gascoigne, K.E., Suzuki, A., Hori, T., Oyama, T., Morikawa, K., Cheeseman, I.M., Fukagawa, T.
Deposit date:2011-06-08
Release date:2012-03-07
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.197 Å)
Cite:CENP-T-W-S-X Forms a Unique Centromeric Chromatin Structure with a Histone-like Fold.
Cell(Cambridge,Mass.), 148, 2012
3VH5
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CRYSTAL STRUCTURE OF THE CHICKEN CENP-T HISTONE FOLD/CENP-W/CENP-S/CENP-X HETEROTETRAMERIC COMPLEX, CRYSTAL FORM I
Descriptor:CENP-S, CENP-X, CENP-T, ...
Authors:Nishino, T., Takeuchi, K., Gascoigne, K.E., Suzuki, A., Hori, T., Oyama, T., Morikawa, K., Cheeseman, I.M., Fukagawa, T.
Deposit date:2011-08-23
Release date:2012-03-07
Method:X-RAY DIFFRACTION (2.402 Å)
Cite:CENP-T-W-S-X Forms a Unique Centromeric Chromatin Structure with a Histone-like Fold
Cell(Cambridge,Mass.), 148, 2012
3VH6
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CRYSTAL STRUCTURE OF THE CHICKEN CENP-T HISTONE FOLD/CENP-W/CENP-S/CENP-X HETEROTETRAMERIC COMPLEX, CRYSTAL FORM II
Descriptor:CENP-S, CENP-X, CENP-T, ...
Authors:Nishino, T., Takeuchi, K., Gascoigne, K.E., Suzuki, A., Hori, T., Oyama, T., Morikawa, K., Cheeseman, I.M., Fukagawa, T.
Deposit date:2011-08-23
Release date:2012-03-07
Method:X-RAY DIFFRACTION (3.351 Å)
Cite:CENP-T-W-S-X Forms a Unique Centromeric Chromatin Structure with a Histone-like Fold
Cell(Cambridge,Mass.), 148, 2012
3AN3
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HUMAN PPAR GAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH A GAMMA SELECTIVE AGONIST MO3S
Descriptor:Peroxisome proliferator-activated receptor gamma, (2S)-2-benzyl-3-(4-propoxy-3-{[({4-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]phenyl}carbonyl)amino]methyl}phenyl)propanoic acid
Authors:Oyama, T., Ohashi, M., Waku, T., Miyachi, H., Morikawa, K.
Deposit date:2010-08-30
Release date:2011-07-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design, Synthesis, and Structural Analysis of Phenylpropanoic Acid-Type PPAR gamma-Selective Agonists: Discovery of Reversed Stereochemistry-Activity Relationship
J.Med.Chem., 54, 2011
3AN4
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HUMAN PPAR GAMMA LIGAND BINDING DOMAIN IN COMPLEX WITH A GAMMA SELECTIVE AGONIST MO4R
Descriptor:Peroxisome proliferator-activated receptor gamma, (2R)-2-benzyl-3-(4-propoxy-3-{[({4-[(3S,5S,7S)-tricyclo[3.3.1.1~3,7~]dec-1-yl]phenyl}carbonyl)amino]methyl}phenyl)propanoic acid
Authors:Oyama, T., Ohashi, M., Waku, T., Miyachi, H., Morikawa, K.
Deposit date:2010-08-30
Release date:2011-07-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Design, Synthesis, and Structural Analysis of Phenylpropanoic Acid-Type PPAR gamma-Selective Agonists: Discovery of Reversed Stereochemistry-Activity Relationship
J.Med.Chem., 54, 2011
3ANW
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A PROTEIN COMPLEX ESSENTIAL INITIATION OF DNA REPLICATION
Descriptor:Putative uncharacterized protein
Authors:Oyama, T., Shirai, T., Nagasawa, N., Ishino, Y., Morikawa, K.
Deposit date:2010-09-10
Release date:2011-07-27
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Architectures of archaeal GINS complexes, essential DNA replication initiation factors
Bmc Biol., 9, 2011
3ADS
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HUMAN PPARGAMMA LIGAND-BINDING DOMAIN IN COMPLEX WITH INDOMETHACIN
Descriptor:Peroxisome proliferator-activated receptor gamma, INDOMETHACIN
Authors:Waku, T., Shiraki, T., Oyama, T., Morikawa, K.
Deposit date:2010-01-29
Release date:2010-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The nuclear receptor PPARgamma individually responds to serotonin- and fatty acid-metabolites
Embo J., 29, 2010
3ADT
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HUMAN PPARGAMMA LIGAND-BINDING DOMAIN IN COMPLEX WITH 5-HYDROXY-INDOLE ACETATE
Descriptor:Peroxisome proliferator-activated receptor gamma, (5-hydroxy-1H-indol-3-yl)acetic acid
Authors:Waku, T., Shiraki, T., Oyama, T., Morikawa, K.
Deposit date:2010-01-29
Release date:2010-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The nuclear receptor PPARgamma individually responds to serotonin- and fatty acid-metabolites
Embo J., 29, 2010
3ADU
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HUMAN PPARGAMMA LIGAND-BINDING DOMAIN IN COMPLEX WITH 5-METHOXY-INDOLE ACETATE
Descriptor:Peroxisome proliferator-activated receptor gamma, (5-methoxy-1H-indol-3-yl)acetic acid
Authors:Waku, T., Shiraki, T., Oyama, T., Morikawa, K.
Deposit date:2010-01-29
Release date:2010-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:The nuclear receptor PPARgamma individually responds to serotonin- and fatty acid-metabolites
Embo J., 29, 2010
3ADV
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HUMAN PPARGAMMA LIGAND-BINDING DOMAIN IN COMPLEX WITH SEROTONIN
Descriptor:Peroxisome proliferator-activated receptor gamma, SEROTONIN
Authors:Waku, T., Shiraki, T., Oyama, T., Morikawa, K.
Deposit date:2010-01-29
Release date:2010-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:The nuclear receptor PPARgamma individually responds to serotonin- and fatty acid-metabolites
Embo J., 29, 2010
3ADW
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HUMAN PPARGAMMA LIGAND-BINDING DOMAIN IN COMPLEX WITH 5-METHOXY-INDOLE ACETATE AND 15-OXO-EICOSATETRAENOIC ACID
Descriptor:Peroxisome proliferator-activated receptor gamma, (5-methoxy-1H-indol-3-yl)acetic acid, (5E,8E,11Z,13E)-15-oxoicosa-5,8,11,13-tetraenoic acid
Authors:Waku, T., Shiraki, T., Oyama, T., Morikawa, K.
Deposit date:2010-01-29
Release date:2010-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:The nuclear receptor PPARgamma individually responds to serotonin- and fatty acid-metabolites
Embo J., 29, 2010
3ADX
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HUMAN PPARGAMMA LIGAND-BINDING DOMAIN IN COMPLEX WITH INDOMETHACIN AND NITRO-233
Descriptor:Peroxisome proliferator-activated receptor gamma, 3-[5-(2-nitropent-1-en-1-yl)furan-2-yl]benzoic acid, INDOMETHACIN
Authors:Waku, T., Shiraki, T., Oyama, T., Morikawa, K.
Deposit date:2010-01-29
Release date:2010-12-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The nuclear receptor PPARgamma individually responds to serotonin- and fatty acid-metabolites
Embo J., 29, 2010
3A2F
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CRYSTAL STRUCTURE OF PYROCOCCUS FURIOSUS DNA POLYMERASE/PCNA MONOMER MUTANT COMPLEX
Descriptor:DNA polymerase, DNA polymerase sliding clamp
Authors:Nishida, H., Ishino, Y., Morikawa, K.
Deposit date:2009-05-15
Release date:2009-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Structural determinant for switching between the polymerase and exonuclease modes in the PCNA-replicative DNA polymerase complex
To be Published
2ZVT
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CYS285SER MUTANT PPARGAMMA LIGAND-BINDING DOMAIN COMPLEXED WITH 15-DEOXY-DELTA12,14-PROSTAGLANDIN J2
Descriptor:Peroxisome proliferator-activated receptor gamma, (5E,14E)-11-oxoprosta-5,9,12,14-tetraen-1-oic acid
Authors:Waku, T., Oyama, T., Shiraki, T., Morikawa, K.
Deposit date:2008-11-19
Release date:2009-10-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Atomic structure of mutant PPARgamma LBD complexed with 15d-PGJ2: novel modulation mechanism of PPARgamma/RXRalpha function by covalently bound ligands
Febs Lett., 583, 2009
2ZVV
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CRYSTAL STRUCTURE OF PROLIFERATING CELLULAR NUCLEAR ANTIGEN 1 AND SHORT PEPTIDE FROM HUMAN P21
Descriptor:Proliferating cellular nuclear antigen 1, Cyclin-dependent kinase inhibitor 1, SULFATE ION
Authors:Strzalka, W., Oyama, T., Tori, K., Morikawa, K.
Deposit date:2008-11-21
Release date:2009-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of the Arabidopsis thaliana proliferating cell nuclear antigen 1 and 2 proteins complexed with the human p21 C-terminal segment
Protein Sci., 18, 2009
2ZVW
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CRYSTAL STRUCTURE OF PROLIFERATING CELL NUCLEAR ANTIGEN 2 AND SHORT PEPTIDE FROM HUMAN P21
Descriptor:Proliferating cell nuclear antigen 2, Cyclin-dependent kinase inhibitor 1, SULFATE ION
Authors:Strzalka, W., Oyama, T., Tori, K., Morikawa, K.
Deposit date:2008-11-21
Release date:2009-06-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of the Arabidopsis thaliana proliferating cell nuclear antigen 1 and 2 proteins complexed with the human p21 C-terminal segment
Protein Sci., 18, 2009