Author results

1K54
  • Download 1k54
  • View 1k54
Molmil generated image of 1k54
OXA-10 CLASS D BETA-LACTAMASE PARTIALLY ACYLATED WITH REACTED 6BETA-(1-HYDROXY-1-METHYLETHYL) PENICILLANIC ACID
Descriptor:Beta lactamase OXA-10, SULFATE ION, (1R)-2-(1-CARBOXY-2-HYDROXY-2-METHYL-PROPYL)-5,5-DIMETHYL-THIAZOLIDINE-4-CARBOXYLIC ACID, ...
Authors:Golemi, D., Maveyraud, L., Vakulenko, S., Samama, J.P., Mobashery, S.
Deposit date:2001-10-10
Release date:2001-11-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Critical involvement of a carbamylated lysine in catalytic function of class D beta-lactamases.
Proc.Natl.Acad.Sci.USA, 98, 2001
1K55
  • Download 1k55
  • View 1k55
Molmil generated image of 1k55
OXA 10 CLASS D BETA-LACTAMASE AT PH 7.5
Descriptor:Beta lactamase OXA-10, SULFATE ION, 1,2-ETHANEDIOL
Authors:Golemi, D., Maveyraud, L., Vakulenko, S., Samama, J.P., Mobashery, S.
Deposit date:2001-10-10
Release date:2001-11-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.39 Å)
Cite:Critical involvement of a carbamylated lysine in catalytic function of class D beta-lactamases.
Proc.Natl.Acad.Sci.USA, 98, 2001
1K56
  • Download 1k56
  • View 1k56
Molmil generated image of 1k56
OXA 10 CLASS D BETA-LACTAMASE AT PH 6.5
Descriptor:OXA10 beta-lactamase, SULFATE ION
Authors:Golemi, D., Maveyraud, L., Vakulenko, S., Samama, J.P., Mobashery, S.
Deposit date:2001-10-10
Release date:2001-11-07
Last modified:2014-02-05
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Critical involvement of a carbamylated lysine in catalytic function of class D beta-lactamases.
Proc.Natl.Acad.Sci.USA, 98, 2001
1K57
  • Download 1k57
  • View 1k57
Molmil generated image of 1k57
OXA 10 CLASS D BETA-LACTAMASE AT PH 6.0
Descriptor:BETA LACTAMASE OXA-10, SULFATE ION
Authors:Golemi, D., Maveyraud, L., Vakulenko, S., Samama, J.P., Mobashery, S.
Deposit date:2001-10-10
Release date:2001-11-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Critical involvement of a carbamylated lysine in catalytic function of class D beta-lactamases.
Proc.Natl.Acad.Sci.USA, 98, 2001
1TEM
  • Download 1tem
  • View 1tem
Molmil generated image of 1tem
6 ALPHA HYDROXYMETHYL PENICILLOIC ACID ACYLATED ON THE TEM-1 BETA-LACTAMASE FROM ESCHERICHIA COLI
Descriptor:TEM-1 BETA LACTAMASE, 2-(1-CARBOXY-2-HYDROXY-ETHYL)-5,5-DIMETHYL-THIAZOLIDINE-4-CARBOXYLIC ACID
Authors:Maveyraud, L., Massova, I., Samama, J.P., Mobashery, S.
Deposit date:1996-05-28
Release date:1997-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure of 6Alpha-Hydroxymethylpenicillanate Complexed to the Tem-1 Beta-Lactamase from Escherichia Coli: Evidence on the Mechanism of Action of a Novel Inhibitor Designed by a Computer-Aided Process
J.Am.Chem.Soc., 118, 1996
1E3U
  • Download 1e3u
  • View 1e3u
Molmil generated image of 1e3u
MAD STRUCTURE OF OXA10 CLASS D BETA-LACTAMASE
Descriptor:BETA-LACTAMASE OXA-10, GOLD (I) CYANIDE ION, SULFATE ION, ...
Authors:Maveyraud, L., Golemi, D., Kotra, L.P., Tranier, S., Vakulenko, S., Mobashery, S., Samama, J.P.
Deposit date:2000-06-23
Release date:2001-01-12
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Insights Into Class D Beta-Lactamases are Revealed by the Crystal Structure of the Oxa10 Enzyme from Pseudomonas Aeruginosa
Structure, 8, 2000
1E4D
  • Download 1e4d
  • View 1e4d
Molmil generated image of 1e4d
STRUCTURE OF OXA10 BETA-LACTAMASE AT PH 8.3
Descriptor:BETA-LACTAMASE OXA-10, SULFATE ION, 1,2-ETHANEDIOL
Authors:Maveyraud, L., Golemi, D., Kotra, L.P., Tranier, S., Vakulenko, S., Mobashery, S., Samama, J.P.
Deposit date:2000-07-03
Release date:2001-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Insights Into Class D Beta-Lactamases are Revealed by the Crystal Structure of the Oxa10 Enzyme from Pseudomonas Aeruginosa
Structure, 8, 2000
1EWZ
  • Download 1ewz
  • View 1ewz
Molmil generated image of 1ewz
CRYSTAL STRUCTURE OF THE OXA-10 BETA-LACTAMASE FROM PSEUDOMONAS AERUGINOSA
Descriptor:BETA LACTAMASE OXA-10
Authors:Golemi, D., Maveyraud, L., Vakulenko, S., Tranier, S., Ishiwata, A., Kotra, L.P., Samama, J.P., Mobashery, S.
Deposit date:2000-04-28
Release date:2000-11-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The First Structural and Mechanistic Insights for Class D beta-Lactamases: Evidence for a Novel Catalytic Process for Turnover of beta-Lactam Antibiotics
J.Am.Chem.Soc., 122, 2000
1XKZ
  • Download 1xkz
  • View 1xkz
Molmil generated image of 1xkz
CRYSTAL STRUCTURE OF THE ACYLATED BETA-LACTAM SENSOR DOMAIN OF BLAR1 FROM S. AUREUS
Descriptor:Regulatory protein blaR1, ACYLATED CEFTAZIDIME, SULFATE ION, ...
Authors:Birck, C., Cha, J.Y., Cross, J., Schulze-Briese, C., Meroueh, S.O., Schlegel, H.B., Mobashery, S., Samama, J.-P.
Deposit date:2004-09-30
Release date:2004-11-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:X-ray crystal structure of the acylated beta-lactam sensor domain of BlaR1 from Staphylococcus aureus and the mechanism of receptor activation for signal transduction
J.Am.Chem.Soc., 126, 2004
2VYU
  • Download 2vyu
  • View 2vyu
Molmil generated image of 2vyu
CRYSTAL STRUCTURE OF CHOLINE BINDING PROTEIN F FROM STREPTOCOCCUS PNEUMONIAE IN THE PRESENCE OF A PEPTIDOGLYCAN ANALOGUE (TETRASACCHARIDE-PENTAPEPTIDE)
Descriptor:CHOLINE BINDING PROTEIN F, CHOLINE ION
Authors:Perez-Dorado, I., Molina, R., Hermoso, J.A., Mobashery, S.
Deposit date:2008-07-28
Release date:2009-02-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Crystal Structure of Cbpf, a Bifunctional Choline-Binding Protein and Autolysis Regulator from Streptococcus Pneumoniae.
Embo Rep., 10, 2009
2Y28
  • Download 2y28
  • View 2y28
Molmil generated image of 2y28
CRYSTAL STRUCTURE OF SE-MET AMPD DERIVATIVE
Descriptor:1,6-ANHYDRO-N-ACETYLMURAMYL-L-ALANINE AMIDASE AMPD, ZINC ION
Authors:Carrasco-Lopez, C., Rojas-Altuve, A., Zhang, W., Hesek, D., Lee, M., Barbe, S., Andre, I., Silva-Martin, N., Martinez-Ripoll, M., Mobashery, S., Hermoso, J.A.
Deposit date:2010-12-14
Release date:2011-07-20
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structures of Bacterial Peptidoglycan Amidase Ampd and an Unprecedented Activation Mechanism.
J.Biol.Chem., 286, 2011
2Y2B
  • Download 2y2b
  • View 2y2b
Molmil generated image of 2y2b
CRYSTAL STRUCTURE OF AMPD IN COMPLEX WITH REACTION PRODUCTS
Descriptor:1,6-ANHYDRO-N-ACETYLMURAMYL-L-ALANINE AMIDASE AMPD, 2-(2-ACETYLAMINO-4-HYDROXY-6,8-DIOXA-BICYCLO[3.2.1]OCT-3-YLOXY)-PROPIONIC ACID, L-ALA-GAMMA-D-GLU-MESO-DIAMINOPIMELIC ACID, ...
Authors:Carrasco-Lopez, C., Rojas-Altuve, A., Zhang, W., Hesek, D., Lee, M., Barbe, S., Andre, I., Silva-Martin, N., Martinez-Ripoll, M., Mobashery, S., Hermoso, J.A.
Deposit date:2010-12-14
Release date:2011-07-20
Last modified:2011-09-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structures of Bacterial Peptidoglycan Amidase Ampd and an Unprecedented Activation Mechanism.
J.Biol.Chem., 286, 2011
2Y2C
  • Download 2y2c
  • View 2y2c
Molmil generated image of 2y2c
CRYSTAL STRUCTURE OF AMPD APOENZYME
Descriptor:1,6-ANHYDRO-N-ACETYLMURAMYL-L-ALANINE AMIDASE AMPD
Authors:Carrasco-Lopez, C., Rojas-Altuve, A., Zhang, W., Hesek, D., Lee, M., Barbe, S., Andre, I., Silva-Martin, N., Martinez-Ripoll, M., Mobashery, S., Hermoso, J.A.
Deposit date:2010-12-14
Release date:2011-07-20
Last modified:2011-09-14
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:Crystal Structures of Bacterial Peptidoglycan Amidase Ampd and an Unprecedented Activation Mechanism.
J.Biol.Chem., 286, 2011
2Y2D
  • Download 2y2d
  • View 2y2d
Molmil generated image of 2y2d
CRYSTAL STRUCTURE OF AMPD HOLOENZYME
Descriptor:1,6-ANHYDRO-N-ACETYLMURAMYL-L-ALANINE AMIDASE AMPD, ZINC ION
Authors:Carrasco-Lopez, C., Rojas-Altuve, A., Zhang, W., Hesek, D., Lee, M., Barbe, S., Andre, I., Silva-Martin, N., Martinez-Ripoll, M., Mobashery, S., Hermoso, J.A.
Deposit date:2010-12-14
Release date:2011-07-20
Last modified:2011-09-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of Bacterial Peptidoglycan Amidase Ampd and an Unprecedented Activation Mechanism.
J.Biol.Chem., 286, 2011
2Y2E
  • Download 2y2e
  • View 2y2e
Molmil generated image of 2y2e
CRYSTAL STRUCTURE OF AMPD GROWN AT PH 5.5
Descriptor:1,6-ANHYDRO-N-ACETYLMURAMYL-L-ALANINE AMIDASE AMPD, ZINC ION
Authors:Carrasco-Lopez, C., Rojas-Altuve, A., Zhang, W., Hesek, D., Lee, M., Barbe, S., Andre, I., Silva-Martin, N., Martinez-Ripoll, M., Mobashery, S., Hermoso, J.A.
Deposit date:2010-12-14
Release date:2011-07-20
Last modified:2011-09-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of Bacterial Peptidoglycan Amidase Ampd and an Unprecedented Activation Mechanism.
J.Biol.Chem., 286, 2011
4BOL
  • Download 4bol
  • View 4bol
Molmil generated image of 4bol
CRYSTAL STRUCTURE OF AMPDH2 FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH PENTAPEPTIDE
Descriptor:AMPDH2, D-alanyl-N-[(2S,6R)-6-amino-6-carboxy-1-{[(1R)-1-carboxyethyl]amino}-1-oxohexan-2-yl]-D-glutamine, ZINC ION
Authors:Artola-Recolons, C., Martinez-Caballero, S., Lee, M., Carrasco-Lopez, C., Hesek, D., Spink, E.E., Lastochkin, E., Zhang, W., Hellman, L.M., Boggess, B., Mobashery, S., Hermoso, J.A.
Deposit date:2013-05-21
Release date:2013-07-17
Last modified:2013-07-31
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Reaction Products and the X-Ray Structure of Ampdh2, a Virulence Determinant of Pseudomonas Aeruginosa.
J.Am.Chem.Soc., 135, 2013
4BPA
  • Download 4bpa
  • View 4bpa
Molmil generated image of 4bpa
CRYSTAL STRUCTURE OF AMPDH2 FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH NAG-NAM-NAG-NAM TETRASACCHARIDE
Descriptor:AMPDH2, ZINC ION, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Artola-Recolons, C., Martinez-Caballero, S., Lee, M., Carrasco-Lopez, C., Hesek, D., Spink, E., Lastochkin, E., Zhang, W., Hellman, L., Boggess, B., Mobashery, S., Hermoso, J.A.
Deposit date:2013-05-23
Release date:2013-07-17
Last modified:2013-07-31
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Reaction Products and the X-Ray Structure of Ampdh2, a Virulence Determinant of Pseudomonas Aeruginosa.
J.Am.Chem.Soc., 135, 2013
4K91
  • Download 4k91
  • View 4k91
Molmil generated image of 4k91
CRYSTAL STRUCTURE OF PENICILLIN-BINDING PROTEIN 5 (PBP5) FROM PSEUDOMONAS AERUGINOSA IN APO STATE
Descriptor:D-ala-D-ala-carboxypeptidase, SUCCINIC ACID
Authors:Smith, J., Toth, M., Vakulenko, S., Mobashery, S., Chen, Y.
Deposit date:2013-04-19
Release date:2013-09-25
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural analysis of the role of Pseudomonas aeruginosa penicillin-binding protein 5 in beta-lactam resistance.
Antimicrob.Agents Chemother., 57, 2013
5G1M
  • Download 5g1m
  • View 5g1m
Molmil generated image of 5g1m
CRYSTAL STRUCTURE OF NAGZ FROM PSEUDOMONAS AERUGINOSA
Descriptor:BETA-HEXOSAMINIDASE, CHLORIDE ION, ACETATE ION, ...
Authors:Acebron, I., Artola-Recolons, C., Mahasenan, K., Mobashery, S., Hermoso, J.A.
Deposit date:2016-03-28
Release date:2017-04-12
Last modified:2017-05-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Catalytic Cycle of the N-Acetylglucosaminidase NagZ from Pseudomonas aeruginosa.
J. Am. Chem. Soc., 139, 2017
5G2M
  • Download 5g2m
  • View 5g2m
Molmil generated image of 5g2m
CRYSTAL STRUCTURE OF NAGZ FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH N-ACETYLGLUCOSAMINE
Descriptor:BETA-HEXOSAMINIDASE, N-ACETYL-D-GLUCOSAMINE
Authors:Acebron, I., Artola-Recolons, C., Mahasenan, K., Mobashery, S., Hermoso, J.A.
Deposit date:2016-04-09
Release date:2017-05-17
Last modified:2017-05-31
Method:X-RAY DIFFRACTION (3 Å)
Cite:Catalytic Cycle of the N-Acetylglucosaminidase NagZ from Pseudomonas aeruginosa.
J. Am. Chem. Soc., 139, 2017
5G3R
  • Download 5g3r
  • View 5g3r
Molmil generated image of 5g3r
CRYSTAL STRUCTURE OF NAGZ FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH N-ACETYLGLUCOSAMINE AND L-ALA-1,6-ANHYDROMURNAC
Descriptor:N-ACETYL-D-GLUCOSAMINE, 2-[[(2R)-2-[[(1R,2S,3R,4R,5R)-4-acetamido-2-oxidanyl-6,8-dioxabicyclo[3.2.1]octan-3-yl]oxy]propanoyl]amino]propanamide, DI(HYDROXYETHYL)ETHER
Authors:Acebron, I., Artola-Recolons, C., Mahasenan, K., Mobashery, S., Hermoso, J.A.
Deposit date:2016-04-30
Release date:2017-05-17
Last modified:2017-05-31
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Catalytic Cycle of the N-Acetylglucosaminidase NagZ from Pseudomonas aeruginosa.
J. Am. Chem. Soc., 139, 2017
5G5K
  • Download 5g5k
  • View 5g5k
Molmil generated image of 5g5k
CRYSTAL STRUCTURE OF NAGZ FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH THE INHIBITOR 2-ACETAMIDO-1,2-DIDEOXYNOJIRIMYCIN
Descriptor:BETA-HEXOSAMINIDASE, 2-ACETAMIDO-1,2-DIDEOXYNOJIRMYCIN
Authors:Acebron, I., Artola-Recolons, C., Mahasenan, K., Mobashery, S., Hermoso, J.A.
Deposit date:2016-05-25
Release date:2017-05-17
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Catalytic Cycle of the N-Acetylglucosaminidase NagZ from Pseudomonas aeruginosa.
J. Am. Chem. Soc., 139, 2017
5G5U
  • Download 5g5u
  • View 5g5u
Molmil generated image of 5g5u
CRYSTAL STRUCTURE OF NAGZ H174A MUTANT FROM PSEUDOMONAS AERUGINOSA
Descriptor:BETA-HEXOSAMINIDASE
Authors:Acebron, I., Artola-Recolons, C., Mahasenan, K., Mobashery, S., Hermoso, J.A.
Deposit date:2016-06-05
Release date:2017-05-17
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Catalytic Cycle of the N-Acetylglucosaminidase NagZ from Pseudomonas aeruginosa.
J. Am. Chem. Soc., 139, 2017
5G6T
  • Download 5g6t
  • View 5g6t
Molmil generated image of 5g6t
CRYSTAL STRUCTURE OF ZN-CONTAINING NAGZ H174A MUTANT FROM PSEUDOMONAS AERUGINOSA
Descriptor:BETA-HEXOSAMINIDASE, ZINC ION, DI(HYDROXYETHYL)ETHER
Authors:Acebron, I., Artola-Recolons, C., Mahasenan, K., Mobashery, S., Hermoso, J.A.
Deposit date:2016-07-15
Release date:2017-05-17
Last modified:2017-05-31
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Catalytic Cycle of the N-Acetylglucosaminidase NagZ from Pseudomonas aeruginosa.
J. Am. Chem. Soc., 139, 2017
5LY7
  • Download 5ly7
  • View 5ly7
Molmil generated image of 5ly7
CRYSTAL STRUCTURE OF NAGZ H174A MUTANT FROM PSEUDOMONAS AERUGINOSA IN COMPLEX WITH THE INHIBITOR 2-ACETAMIDO-1,2-DIDEOXYNOJIRIMYCIN
Descriptor:Beta-hexosaminidase, DI(HYDROXYETHYL)ETHER, 2-ACETAMIDO-1,2-DIDEOXYNOJIRMYCIN
Authors:Acebron, I., Artola-Recolons, C., Mahasenan, K., Mobashery, S., Hermoso, J.A.
Deposit date:2016-09-25
Release date:2017-05-17
Last modified:2017-05-31
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Catalytic Cycle of the N-Acetylglucosaminidase NagZ from Pseudomonas aeruginosa.
J. Am. Chem. Soc., 139, 2017