Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
1YWN
DownloadVisualize
BU of 1ywn by Molmil
Vegfr2 in complex with a novel 4-amino-furo[2,3-d]pyrimidine
Descriptor: N-{4-[4-AMINO-6-(4-METHOXYPHENYL)FURO[2,3-D]PYRIMIDIN-5-YL]PHENYL}-N'-[2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]UREA, Vascular endothelial growth factor receptor 2
Authors:Miyazaki, Y, Matsunaga, S, Tang, J, Maeda, Y, Nakano, M, Philippe, R.J, Shibahara, M, Liu, W, Sato, H, Wang, L, Nolte, R.T.
Deposit date:2005-02-18
Release date:2005-08-23
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Novel 4-amino-furo[2,3-d]pyrimidines as Tie-2 and VEGFR2 dual inhibitors
Bioorg.Med.Chem.Lett., 15, 2005
5ZFB
DownloadVisualize
BU of 5zfb by Molmil
Structure of human dihydroorotate dehydrogenase in complex with ascofuranone (open-form)
Descriptor: 3-chloro-4,6-dihydroxy-5-[(2Z,6Z,8E)-11-hydroxy-3,7,11-trimethyl-10-oxododeca-2,6,8-trien-1-yl]-2-methylbenzaldehyde, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
Authors:Miyazaki, Y, Inaoka, K.D, Shiba, T, Saimoto, H, Amalia, E, Kido, Y, Sakai, C, Nakamura, M, Moore, L.A, Harada, S, Kita, K.
Deposit date:2018-03-02
Release date:2018-09-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions.
Front Pharmacol, 9, 2018
5ZF4
DownloadVisualize
BU of 5zf4 by Molmil
Structure of human dihydroorotate dehydrogenase in complex with 275-10-COOMe
Descriptor: ACETATE ION, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
Authors:Miyazaki, Y, Inaoka, K.D, Shiba, T, Saimoto, H, Amalia, E, Kido, Y, Sakai, C, Nakamura, M, Moore, L.A, Harada, S, Kita, K.
Deposit date:2018-03-02
Release date:2018-09-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions.
Front Pharmacol, 9, 2018
5ZFA
DownloadVisualize
BU of 5zfa by Molmil
Structure of human dihydroorotate dehydrogenase in complex with 287-12-OCOiPr
Descriptor: (2E,6E)-8-(3-chloro-5-formyl-2,6-dihydroxy-4-methylphenyl)-3,6-dimethylocta-2,6-dien-1-yl 2-methylpropanoate, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
Authors:Miyazaki, Y, Inaoka, K.D, Shiba, T, Saimoto, H, Amalia, E, Kido, Y, Sakai, C, Nakamura, M, Moore, L.A, Harada, S, Kita, K.
Deposit date:2018-03-02
Release date:2018-09-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions.
Front Pharmacol, 9, 2018
5ZF8
DownloadVisualize
BU of 5zf8 by Molmil
Structure of human dihydroorotate dehydrogenase in complex with 277-11-OAc
Descriptor: (2S,3E,7E)-9-(3-chloro-5-formyl-2,6-dihydroxy-4-methylphenyl)-3,7-dimethylnona-3,7-dien-2-yl acetate, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
Authors:Miyazaki, Y, Inaoka, K.D, Shiba, T, Saimoto, H, Amalia, E, Kido, Y, Sakai, C, Nakamura, M, Moore, L.A, Harada, S, Kita, K.
Deposit date:2018-03-02
Release date:2018-09-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions.
Front Pharmacol, 9, 2018
5ZF7
DownloadVisualize
BU of 5zf7 by Molmil
Structure of human dihydroorotate dehydrogenase in complex with 277-9-OH
Descriptor: 3-chloro-4,6-dihydroxy-5-[(2E,6E,8S)-8-hydroxy-3,7-dimethylnona-2,6-dien-1-yl]-2-methylbenzaldehyde, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
Authors:Miyazaki, Y, Inaoka, K.D, Shiba, T, Saimoto, H, Amalia, E, Kido, Y, Sakai, C, Nakamura, M, Moore, L.A, Harada, S, Kita, K.
Deposit date:2018-03-02
Release date:2018-09-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions.
Front Pharmacol, 9, 2018
5ZF9
DownloadVisualize
BU of 5zf9 by Molmil
Structure of human dihydroorotate dehydrogenase in complex with 280-12
Descriptor: 3-chloro-4,6-dihydroxy-2-methyl-5-[(2E,6E)-3,7,11-trimethyldodeca-2,6,10-trien-1-yl]benzaldehyde, ACETATE ION, Dihydroorotate dehydrogenase (quinone), ...
Authors:Miyazaki, Y, Inaoka, K.D, Shiba, T, Saimoto, H, Amalia, E, Kido, Y, Sakai, C, Nakamura, M, Moore, L.A, Harada, S, Kita, K.
Deposit date:2018-03-02
Release date:2018-09-26
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions.
Front Pharmacol, 9, 2018
2L1F
DownloadVisualize
BU of 2l1f by Molmil
Structure of a conserved retroviral RNA packaging element by NMR spectroscopy and cryo-electron tomography
Descriptor: RNA (65-MER), RNA (66-MER)
Authors:Summers, M.F, Irobalieva, R.N, Tolbert, B, Smalls-Manty, A, Iyalla, K, Loeliger, K, D'Souza, V, Khant, H, Schmid, M, Garcia, E, Telesnitsky, A, Chiu, W, Miyazaki, Y.
Deposit date:2010-07-28
Release date:2010-10-27
Last modified:2020-02-05
Method:SOLUTION NMR
Cite:Structure of a conserved retroviral RNA packaging element by NMR spectroscopy and cryo-electron tomography.
J.Mol.Biol., 404, 2010
2KYD
DownloadVisualize
BU of 2kyd by Molmil
RDC and RCSA refinement of an A-form RNA: Improvements in Major Groove Width
Descriptor: RNA (5'-R(*CP*UP*AP*GP*UP*UP*AP*GP*CP*UP*AP*AP*CP*UP*AP*G)-3')
Authors:Tolbert, B.S, Summers, M.F, Miyazaki, Y, Barton, S, Kinde, B, Stark, P, Singh, R, Bax, A, Case, D.
Deposit date:2010-05-24
Release date:2010-07-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Major groove width variations in RNA structures determined by NMR and impact of 13C residual chemical shift anisotropy and 1H-13C residual dipolar coupling on refinement.
J.Biomol.Nmr, 47, 2010
3WQT
DownloadVisualize
BU of 3wqt by Molmil
Staphylococcus aureus FtsA complexed with AMPPNP
Descriptor: CHLORIDE ION, Cell division protein FtsA, MAGNESIUM ION, ...
Authors:Fujita, J, Maeda, Y, Miyazaki, Y, Inoue, T, Matsumura, H.
Deposit date:2014-02-01
Release date:2014-10-08
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of FtsA from Staphylococcus aureus
FEBS Lett., 588, 2014
3WQU
DownloadVisualize
BU of 3wqu by Molmil
Staphylococcus aureus FtsA complexed with ATP
Descriptor: ADENOSINE-5'-TRIPHOSPHATE, Cell division protein FtsA, MAGNESIUM ION
Authors:Fujita, J, Maeda, Y, Miyazaki, Y, Inoue, T, Matsumura, H.
Deposit date:2014-02-01
Release date:2014-10-08
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of FtsA from Staphylococcus aureus
FEBS Lett., 588, 2014
3WR7
DownloadVisualize
BU of 3wr7 by Molmil
Crystal Structure of Spermidine Acetyltransferase from Escherichia coli
Descriptor: COENZYME A, SPERMIDINE, Spermidine N1-acetyltransferase
Authors:Sugiyama, S, Ishikawa, S, Tomitori, S, Niiyama, M, Hirose, M, Miyazaki, Y, Higashi, K, Adachi, H, Takano, K, Murakami, S, Inoue, T, Mori, Y, Kashiwagi, K, Igarashi, K, Matsumura, H.
Deposit date:2014-02-20
Release date:2015-09-02
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Molecular mechanism underlying promiscuous polyamine recognition by spermidine acetyltransferase
Int.J.Biochem.Cell Biol., 76, 2016
3VHK
DownloadVisualize
BU of 3vhk by Molmil
Crystal structure of the VEGFR2 kinase domain in complex with a back pocket binder
Descriptor: 1,2-ETHANEDIOL, Vascular endothelial growth factor receptor 2, {3-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]phenyl}methanol
Authors:Iwata, H, Oki, H, Okada, K, Takagi, T, Tawada, M, Miyazaki, Y, Imamura, S, Hori, A, Hixon, M.S, Kimura, H, Miki, H.
Deposit date:2011-08-25
Release date:2012-09-05
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:A Back-to-Front Fragment-Based Drug Design Search Strategy Targeting the DFG-Out Pocket of Protein Tyrosine Kinases.
ACS MED.CHEM.LETT., 3, 2012
3VID
DownloadVisualize
BU of 3vid by Molmil
Crystal structure of human VEGFR2 kinase domain with Compound A.
Descriptor: 4,5,6,11-tetrahydro-1H-pyrazolo[4',3':6,7]cyclohepta[1,2-b]indole, Vascular endothelial growth factor receptor 2
Authors:Iwata, H, Oki, H, Okada, K, Takagi, T, Tawada, M, Miyazaki, Y, Imamura, S, Hori, A, Hixon, M.S, Kimura, H, Miki, H.
Deposit date:2011-09-29
Release date:2012-08-15
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A Back-to-Front Fragment-Based Drug Design Search Strategy Targeting the DFG-Out Pocket of Protein Tyrosine Kinases.
ACS MED.CHEM.LETT., 3, 2012
7FHT
DownloadVisualize
BU of 7fht by Molmil
Crystal structure of DYRK1A in complex with RD0448
Descriptor: (5~{Z})-5-[(3-ethynyl-4-methoxy-phenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one, Dual specificity tyrosine-phosphorylation-regulated kinase 1A
Authors:Kikuchi, M, Sumida, Y, Hosoya, T, Kii, I, Umehara, T.
Deposit date:2021-07-30
Release date:2022-03-23
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A.
Eur.J.Med.Chem., 227, 2022
7FHS
DownloadVisualize
BU of 7fhs by Molmil
Crystal structure of DYRK1A in complex with RD0392
Descriptor: (5~{Z})-5-[(3-ethoxy-4-oxidanyl-phenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one, Dual specificity tyrosine-phosphorylation-regulated kinase 1A, GLYCEROL
Authors:Kikuchi, M, Sumida, T, Hosoya, T, Kii, I, Umehara, T.
Deposit date:2021-07-30
Release date:2022-03-23
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Structure-activity relationship for the folding intermediate-selective inhibition of DYRK1A.
Eur.J.Med.Chem., 227, 2022
7EXE
DownloadVisualize
BU of 7exe by Molmil
Crystal structure of mouse 14-3-3zeta in complex with doubly phosphorylated ADAM22 peptide
Descriptor: 14-3-3 protein zeta/delta, Disintegrin and metalloproteinase domain-containing protein 22
Authors:Yan, L, Okatsu, K, Fukai, S.
Deposit date:2021-05-27
Release date:2021-11-24
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:LGI1-ADAM22 levels regulate seizure thresholds through 14-3-3 in mice
Cell Rep, 2021
1V4W
DownloadVisualize
BU of 1v4w by Molmil
Crystal structure of bluefin tuna hemoglobin deoxy form at pH7.5
Descriptor: PROTOPORPHYRIN IX CONTAINING FE, hemoglobin alpha chain, hemoglobin beta chain
Authors:Yokoyama, T, Chong, K.T, Miyazaki, Y, Nakatsukasa, T, Unzai, S, Miyazaki, G, Morimoto, H, Jeremy, R.H.T, Park, S.Y.
Deposit date:2003-11-19
Release date:2004-07-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Novel Mechanisms of pH Sensitivity in Tuna Hemoglobin: A STRUCTURAL EXPLANATION OF THE ROOT EFFECT
J.Biol.Chem., 279, 2004
1V4U
DownloadVisualize
BU of 1v4u by Molmil
Crystal structure of bluefin tuna carbonmonoxy-hemoglobin
Descriptor: CARBON MONOXIDE, PROTOPORPHYRIN IX CONTAINING FE, hemoglobin alpha chain, ...
Authors:Yokoyama, T, Chong, K.T, Miyazaki, Y, Nakatsukasa, T, Unzai, S, Miyazaki, G, Morimoto, H, Jeremy, R.H.T, Park, S.Y.
Deposit date:2003-11-19
Release date:2004-07-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Novel Mechanisms of pH Sensitivity in Tuna Hemoglobin: A STRUCTURAL EXPLANATION OF THE ROOT EFFECT
J.Biol.Chem., 279, 2004
1V4X
DownloadVisualize
BU of 1v4x by Molmil
Crystal structure of bluefin tuna hemoglobin deoxy form at pH5.0
Descriptor: PROTOPORPHYRIN IX CONTAINING FE, hemoglobin alpha chain, hemoglobin beta chain
Authors:Yokoyama, T, Chong, K.T, Miyazaki, Y, Nakatsukasa, T, Unzai, S, Miyazaki, G, Morimoto, H, Jeremy, R.H.T, Park, S.Y.
Deposit date:2003-11-19
Release date:2004-07-06
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Novel Mechanisms of pH Sensitivity in Tuna Hemoglobin: A STRUCTURAL EXPLANATION OF THE ROOT EFFECT
J.Biol.Chem., 279, 2004
3AX3
DownloadVisualize
BU of 3ax3 by Molmil
Crystal structure of rat TOM20-ALDH presequence complex: a complex (form2) between Tom20 and a disulfide-bridged presequence peptide containing D-Cys and L-Cys at the i and i+3 positions.
Descriptor: Aldehyde dehydrogenase, mitochondrial, Mitochondrial import receptor subunit TOM20 homolog
Authors:Saitoh, T, Maita, Y, Kohda, D.
Deposit date:2011-03-28
Release date:2011-07-06
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystallographic snapshots of tom20-mitochondrial presequence interactions with disulfide-stabilized peptides.
Biochemistry, 50, 2011
3AX2
DownloadVisualize
BU of 3ax2 by Molmil
Crystal structure of rat TOM20-ALDH presequence complex: a disulfide-tethered complex with a non-optimized, long linker
Descriptor: Aldehyde dehydrogenase, mitochondrial, Mitochondrial import receptor subunit TOM20 homolog, ...
Authors:Saitoh, T, Maita, Y, Kohda, D.
Deposit date:2011-03-28
Release date:2011-07-06
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystallographic snapshots of tom20-mitochondrial presequence interactions with disulfide-stabilized peptides.
Biochemistry, 50, 2011
3AX5
DownloadVisualize
BU of 3ax5 by Molmil
Crystal structure of rat TOM20-ALDH presequence complex: A complex (form1) between Tom20 and a disulfide-bridged presequence peptide containing D-Cys and L-Cys at the i and i+3 positions.
Descriptor: Aldehyde dehydrogenase, mitochondrial, Mitochondrial import receptor subunit TOM20 homolog, ...
Authors:Saitoh, T, Maita, Y, Kohda, D.
Deposit date:2011-03-29
Release date:2011-07-06
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystallographic snapshots of tom20-mitochondrial presequence interactions with disulfide-stabilized peptides.
Biochemistry, 50, 2011
1IQG
DownloadVisualize
BU of 1iqg by Molmil
Human coagulation factor Xa in complex with M55159
Descriptor: 4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-1-[[4-HYDROXYIMINOMETHYL-1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]PIPERAZINONE, CALCIUM ION, coagulation Factor Xa
Authors:Shiromizu, I, Matsusue, T.
Deposit date:2001-07-23
Release date:2003-09-23
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa
To be Published
1IQN
DownloadVisualize
BU of 1iqn by Molmil
Human coagulation factor Xa in complex with M55192
Descriptor: 4-[[4-[(6-CHLORO-2-NAPHTHALENYL)SULFONYL]-6-OXO-1-[[1-(4-PYRIDINYL)-4-PIPERIDINYL]METHYL]-2-PIPERAZINYL]CARBONYL]MORPHOLINE, CALCIUM ION, coagulation Factor Xa
Authors:Shiromizu, I, Matsusue, T.
Deposit date:2001-07-23
Release date:2003-09-23
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Factor Xa Specific Inhibitor that Induces the Novel Binding Model in Complex with Human Fxa
To be Published

 

12>

218853

PDB entries from 2024-04-24

PDB statisticsPDBj update infoContact PDBjnumon