Author results

4WXH
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CARMINOMYCIN-4-O-METHYLTRANSFERASE (DNRK) VARIANT (298SER INSERT) IN COMPLEX WITH S-ADENOSYL-L-HOMOCYSTEINE (SAH) AND ACLACINOMYCIN T
Descriptor:Carminomycin 4-O-methyltransferase DnrK, S-ADENOSYL-L-HOMOCYSTEINE, methyl (1R,2R,4S)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy}-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate, ...
Authors:Metsa-Ketela, M., Niiranen, L.
Deposit date:2014-11-13
Release date:2015-07-29
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Divergent evolution of an atypical S-adenosyl-l-methionine-dependent monooxygenase involved in anthracycline biosynthesis.
Proc.Natl.Acad.Sci.USA, 112, 2015
4AMB
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CRYSTAL STRUCTURE OF THE GLYCOSYLTRANSFERASE SNOGD FROM STREPTOMYCES NOGALATER
Descriptor:SNOGD, DEOXYURIDINE-5'-DIPHOSPHATE
Authors:Claesson, M., Siitonen, V., Dobritzsch, D., Metsa-Ketela, M., Schneider, G.
Deposit date:2012-03-08
Release date:2012-09-05
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Crystal Structure of the Glycosyltransferase Snogd from the Biosynthetic Pathway of the Nogalamycin in Streptomyces Nogalater.
FEBS J., 279, 2012
4AMG
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CRYSTAL STRUCTURE OF THE GLYCOSYLTRANSFERASE SNOGD FROM STREPTOMYCES NOGALATER
Descriptor:SNOGD
Authors:Claesson, M., Siitonen, V., Dobritzsch, D., Metsa-Ketela, M., Schneider, G.
Deposit date:2012-03-09
Release date:2012-09-05
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Crystal Structure of the Glycosyltransferase Snogd from the Biosynthetic Pathway of the Nogalamycin in Streptomyces Nogalater.
FEBS J., 279, 2012
4AN4
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CRYSTAL STRUCTURE OF THE GLYCOSYLTRANSFERASE SNOGD FROM STREPTOMYCES NOGALATER
Descriptor:GLYCOSYL TRANSFERASE, DEOXYURIDINE-5'-DIPHOSPHATE
Authors:Claesson, M., Siitonen, V., Dobritzsch, D., Metsa-Ketela, M., Schneider, G.
Deposit date:2012-03-15
Release date:2012-09-05
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of the Glycosyltransferase Snogd from the Biosynthetic Pathway of the Nogalamycin in Streptomyces Nogalater.
FEBS J., 279, 2012
2QA1
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CRYSTAL STRUCTURE OF PGAE, AN AROMATIC HYDROXYLASE INVOLVED IN ANGUCYCLINE BIOSYNTHESIS
Descriptor:Polyketide oxygenase PgaE, ZINC ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Koskiniemi, H., Dobritzsch, D., Metsa-Ketela, M., Kallio, P., Niemi, J., Schneider, G.
Deposit date:2007-06-14
Release date:2007-08-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis
J.Mol.Biol., 372, 2007
2QA2
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CRYSTAL STRUCTURE OF CABE, AN AROMATIC HYDROXYLASE FROM ANGUCYCLINE BIOSYNTHESIS, DETERMINED TO 2.7 A RESOLUTION
Descriptor:Polyketide oxygenase CabE, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Koskiniemi, H., Dobritzsch, D., Metsa-Ketela, M., Kallio, P., Niemi, J., Schneider, G.
Deposit date:2007-06-14
Release date:2007-08-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis
J.Mol.Biol., 372, 2007
4EX6
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CRYSTAL STRUCTURE OF THE ALNUMYCIN P PHOSPHATASE ALNB
Descriptor:AlnB, MAGNESIUM ION, BORIC ACID
Authors:Oja, T., Niiranen, L., Sandalova, T., Klika, K.D., Niemi, J., Mantsala, P., Schneider, G., Metsa-Ketela, M.
Deposit date:2012-04-30
Release date:2013-01-16
Last modified:2013-02-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway.
Proc.Natl.Acad.Sci.USA, 110, 2013
4EX7
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CRYSTAL STRUCTURE OF THE ALNUMYCIN P PHOSPHATASE IN COMPLEX WITH FREE PHOSPHATE
Descriptor:AlnB, MAGNESIUM ION, BORIC ACID, ...
Authors:Oja, T., Niiranen, L., Sandalova, T., Klika, K.D., Niemi, J., Mantsala, P., Schneider, G., Metsa-Ketela, M.
Deposit date:2012-04-30
Release date:2013-01-16
Last modified:2013-02-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway.
Proc.Natl.Acad.Sci.USA, 110, 2013
4EX8
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CRYSTAL STRUCTURE OF THE PREALNUMYCIN C-GLYCOSYNTHASE ALNA
Descriptor:AlnA, CALCIUM ION, SULFATE ION, ...
Authors:Oja, T., Niiranen, L., Sandalova, T., Klika, K.D., Niemi, J., Mantsala, P., Schneider, G., Metsa-Ketela, M.
Deposit date:2012-04-30
Release date:2013-01-16
Last modified:2013-02-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway.
Proc.Natl.Acad.Sci.USA, 110, 2013
4EX9
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CRYSTAL STRUCTURE OF THE PREALNUMYCIN C-GLYCOSYNTHASE ALNA IN COMPLEX WITH RIBULOSE 5-PHOSPHATE
Descriptor:AlnA, CALCIUM ION, RIBULOSE-5-PHOSPHATE, ...
Authors:Oja, T., Niiranen, L., Sandalova, T., Klika, K.D., Niemi, J., Mantsala, P., Schneider, G., Metsa-Ketela, M.
Deposit date:2012-04-30
Release date:2013-01-16
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway.
Proc.Natl.Acad.Sci.USA, 110, 2013
4ICY
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TRACING THE EVOLUTION OF ANGUCYCLINONE MONOOXYGENASES: STRUCTURAL DETERMINANTS FOR C-12B HYDROXYLATION AND SUBSTRATE INHIBITION IN PGAE
Descriptor:Polyketide oxygenase PgaE, FLAVIN-ADENINE DINUCLEOTIDE, 1,2-ETHANEDIOL, ...
Authors:Kallio, P., Patrikainen, P., Belogurov, G., Mantsala, P., Yang, K., Niemi, J., Metsa-Ketela, M.
Deposit date:2012-12-11
Release date:2013-06-12
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Tracing the Evolution of Angucyclinone Monooxygenases: Structural Determinants for C-12b Hydroxylation and Substrate Inhibition in PgaE.
Biochemistry, 52, 2013
4KWH
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THE CRYSTAL STRUCTURE OF ANGUCYCLINE C-6 KETOREDUCTASE LANV WITH BOUND NADP
Descriptor:Reductase homolog, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ACETIC ACID, ...
Authors:Paananen, P., Patrikainen, P., Kallio, P., Mantsala, P., Niemi, J., Niiranen, L., Metsa-Ketela, M.
Deposit date:2013-05-24
Release date:2013-07-31
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and functional analysis of angucycline C-6 ketoreductase LanV involved in landomycin biosynthesis.
Biochemistry, 52, 2013
4KWI
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THE CRYSTAL STRUCTURE OF ANGUCYCLINE C-6 KETOREDUCTASE LANV WITH BOUND NADP AND 11-DEOXY-6-OXYLANDOMYCINONE
Descriptor:Reductase homolog, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 1,8-dihydroxy-3-methyltetraphene-6,7,12(5H)-trione, ...
Authors:Paananen, P., Patrikainen, P., Mantsala, P., Niemi, J., Niiranen, L., Metsa-Ketela, M.
Deposit date:2013-05-24
Release date:2013-07-31
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and functional analysis of angucycline C-6 ketoreductase LanV involved in landomycin biosynthesis.
Biochemistry, 52, 2013
4OSO
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THE CRYSTAL STRUCTURE OF LANDOMYCIN C-6 KETOREDUCTASE LANV WITH BOUND NADP AND RABELOMYCIN
Descriptor:Reductase homolog, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, rabelomycin, ...
Authors:Paananen, P., Niiranen, L., Patrikainen, P., Metsa-Ketela, M.
Deposit date:2014-02-13
Release date:2014-10-01
Last modified:2014-12-03
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-based engineering of angucyclinone 6-ketoreductases.
Chem.Biol., 21, 2014
4OSP
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THE CRYSTAL STRUCTURE OF URDAMYCIN C-6 KETOREDUCTASE DOMAIN URDMRED WITH BOUND NADP AND RABELOMYCIN
Descriptor:Oxygenase-reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, rabelomycin
Authors:Niiranen, L., Paananen, P., Patrikainen, P., Metsa-Ketela, M.
Deposit date:2014-02-13
Release date:2014-10-01
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure-based engineering of angucyclinone 6-ketoreductases.
Chem.Biol., 21, 2014
4X4J
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STRUCTURAL AND FUNCTIONAL STUDIES OF BEXE: INSIGHTS INTO OXIDATION DURING BE-7585A BIOSYNTHESIS
Descriptor:Putative oxygenase, SULFATE ION, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Tsai, S.-C., Jackson, D.R., Patel, A., Barajas, J.F., Rohr, J., Yu, X., Liu, H.-W., Sasaki, E., Calveras, J., Metsa-Ketela, M.
Deposit date:2014-12-02
Release date:2015-12-02
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural and Functional Studies of BexE: Insights into Oxidation During BE-7585A Biosynthesis
To Be Published
5EP9
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CRYSTAL STRUCTURE OF THE NON-HEME ALPHA KETOGLUTARATE DEPENDENT EPIMERASE SNON FROM NOGALAMYCIN BIOSYNTHESIS
Descriptor:SnoN,Epimerase SnoN, 2-OXOGLUTARIC ACID, FE (III) ION, ...
Authors:Selvaraj, B., Lindqvist, Y., Niiranen, L., Siitonen, V., Metsa-Ketela, M., Schneider, G.
Deposit date:2015-11-11
Release date:2016-05-11
Last modified:2016-05-18
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway.
Proc.Natl.Acad.Sci.USA, 113, 2016
5EPA
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CRYSTAL STRUCTURE OF NON-HEME ALPHA KETOGLUTARATE DEPENDENT CARBOCYCLASE SNOK FROM NOGALAMYCIN BIOSYNTHESIS
Descriptor:SnoK, FE (III) ION, 2-OXOGLUTARIC ACID, ...
Authors:Selvaraj, B., Lindqvist, Y., Siitonen, V., Niiranen, L., Metsa-Ketela, M., Schneider, G.
Deposit date:2015-11-11
Release date:2016-05-11
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway.
Proc.Natl.Acad.Sci.USA, 113, 2016
5EQU
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CRYSTAL STRUCTURE OF THE EPIMERASE SNON IN COMPLEX WITH FE3+, ALPHA KETOGLUTARATE AND NOGALAMYCIN RO
Descriptor:SnoN,SnoN, FE (III) ION, 2-OXOGLUTARIC ACID, ...
Authors:Selvaraj, B., Lindqvist, Y., Siitonen, V., Metsa-Ketela, M., Schneider, G.
Deposit date:2015-11-13
Release date:2016-05-11
Last modified:2016-05-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway.
Proc.Natl.Acad.Sci.USA, 113, 2016
5ERL
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CRYSTAL STRUCTURE OF THE EPIMERASE SNON IN COMPLEX WITH NI2+, SUCCINATE AND NOGALAMYCIN RO
Descriptor:SnoN,SnoN, NICKEL (II) ION, SUCCINIC ACID, ...
Authors:Selvaraj, B., Lindqvist, Y., Siitonen, V., Metsa-Ketela, M., Schneider, G.
Deposit date:2015-11-14
Release date:2016-05-11
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway.
Proc.Natl.Acad.Sci.USA, 113, 2016