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4WXH
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BU of 4wxh by Molmil
Carminomycin-4-O-methyltransferase (DnrK) variant (298Ser insert) in complex with S-adenosyl-L-homocysteine (SAH) and aclacinomycin T
Descriptor: (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, Carminomycin 4-O-methyltransferase DnrK, S-ADENOSYL-L-HOMOCYSTEINE, ...
Authors:Metsa-Ketela, M, Niiranen, L.
Deposit date:2014-11-13
Release date:2015-07-29
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Divergent evolution of an atypical S-adenosyl-l-methionine-dependent monooxygenase involved in anthracycline biosynthesis.
Proc.Natl.Acad.Sci.USA, 112, 2015
4X4J
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BU of 4x4j by Molmil
Structural and Functional Studies of BexE: Insights into Oxidation During BE-7585A Biosynthesis
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Putative oxygenase, SULFATE ION
Authors:Tsai, S.-C, Jackson, D.R, Patel, A, Barajas, J.F, Rohr, J, Yu, X, Liu, H.-W, Sasaki, E, Calveras, J, Metsa-Ketela, M.
Deposit date:2014-12-02
Release date:2015-12-02
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Structural and Functional Studies of BexE: Insights into Oxidation During BE-7585A Biosynthesis
To Be Published
2QA1
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BU of 2qa1 by Molmil
Crystal structure of PgaE, an aromatic hydroxylase involved in angucycline biosynthesis
Descriptor: 1,2-ETHANEDIOL, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ...
Authors:Koskiniemi, H, Dobritzsch, D, Metsa-Ketela, M, Kallio, P, Niemi, J, Schneider, G.
Deposit date:2007-06-14
Release date:2007-08-14
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis
J.Mol.Biol., 372, 2007
2QA2
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BU of 2qa2 by Molmil
Crystal structure of CabE, an aromatic hydroxylase from angucycline biosynthesis, determined to 2.7 A resolution
Descriptor: FLAVIN-ADENINE DINUCLEOTIDE, Polyketide oxygenase CabE
Authors:Koskiniemi, H, Dobritzsch, D, Metsa-Ketela, M, Kallio, P, Niemi, J, Schneider, G.
Deposit date:2007-06-14
Release date:2007-08-14
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis
J.Mol.Biol., 372, 2007
4EX8
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BU of 4ex8 by Molmil
Crystal structure of the prealnumycin C-glycosynthase AlnA
Descriptor: AlnA, CALCIUM ION, CHLORIDE ION, ...
Authors:Oja, T, Niiranen, L, Sandalova, T, Klika, K.D, Niemi, J, Mantsala, P, Schneider, G, Metsa-Ketela, M.
Deposit date:2012-04-30
Release date:2013-01-16
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway.
Proc.Natl.Acad.Sci.USA, 110, 2013
4EX9
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BU of 4ex9 by Molmil
Crystal structure of the prealnumycin C-glycosynthase AlnA in complex with ribulose 5-phosphate
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, AlnA, CALCIUM ION, ...
Authors:Oja, T, Niiranen, L, Sandalova, T, Klika, K.D, Niemi, J, Mantsala, P, Schneider, G, Metsa-Ketela, M.
Deposit date:2012-04-30
Release date:2013-01-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway.
Proc.Natl.Acad.Sci.USA, 110, 2013
4AMG
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BU of 4amg by Molmil
Crystal structure of the glycosyltransferase SnogD from Streptomyces nogalater
Descriptor: SNOGD
Authors:Claesson, M, Siitonen, V, Dobritzsch, D, Metsa-Ketela, M, Schneider, G.
Deposit date:2012-03-09
Release date:2012-09-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Crystal Structure of the Glycosyltransferase Snogd from the Biosynthetic Pathway of the Nogalamycin in Streptomyces Nogalater.
FEBS J., 279, 2012
4AMB
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BU of 4amb by Molmil
Crystal structure of the glycosyltransferase SnogD from Streptomyces nogalater
Descriptor: DEOXYURIDINE-5'-DIPHOSPHATE, SNOGD
Authors:Claesson, M, Siitonen, V, Dobritzsch, D, Metsa-Ketela, M, Schneider, G.
Deposit date:2012-03-08
Release date:2012-09-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Crystal Structure of the Glycosyltransferase Snogd from the Biosynthetic Pathway of the Nogalamycin in Streptomyces Nogalater.
FEBS J., 279, 2012
4AN4
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BU of 4an4 by Molmil
Crystal structure of the glycosyltransferase SnogD from Streptomyces nogalater
Descriptor: DEOXYURIDINE-5'-DIPHOSPHATE, GLYCOSYL TRANSFERASE
Authors:Claesson, M, Siitonen, V, Dobritzsch, D, Metsa-Ketela, M, Schneider, G.
Deposit date:2012-03-15
Release date:2012-09-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of the Glycosyltransferase Snogd from the Biosynthetic Pathway of the Nogalamycin in Streptomyces Nogalater.
FEBS J., 279, 2012
4ICY
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BU of 4icy by Molmil
Tracing the Evolution of Angucyclinone Monooxygenases: Structural Determinants for C-12b Hydroxylation and Substrate Inhibition in PgaE
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:Kallio, P, Patrikainen, P, Belogurov, G, Mantsala, P, Yang, K, Niemi, J, Metsa-Ketela, M.
Deposit date:2012-12-11
Release date:2013-06-12
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Tracing the Evolution of Angucyclinone Monooxygenases: Structural Determinants for C-12b Hydroxylation and Substrate Inhibition in PgaE.
Biochemistry, 52, 2013
4KWH
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BU of 4kwh by Molmil
The crystal structure of angucycline C-6 ketoreductase LanV with bound NADP
Descriptor: ACETIC ACID, DI(HYDROXYETHYL)ETHER, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Paananen, P, Patrikainen, P, Kallio, P, Mantsala, P, Niemi, J, Niiranen, L, Metsa-Ketela, M.
Deposit date:2013-05-24
Release date:2013-07-31
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and functional analysis of angucycline C-6 ketoreductase LanV involved in landomycin biosynthesis.
Biochemistry, 52, 2013
4KWI
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BU of 4kwi by Molmil
The crystal structure of angucycline C-6 ketoreductase LanV with bound NADP and 11-deoxy-6-oxylandomycinone
Descriptor: 1,8-dihydroxy-3-methyltetraphene-6,7,12(5H)-trione, DI(HYDROXYETHYL)ETHER, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Paananen, P, Patrikainen, P, Mantsala, P, Niemi, J, Niiranen, L, Metsa-Ketela, M.
Deposit date:2013-05-24
Release date:2013-07-31
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and functional analysis of angucycline C-6 ketoreductase LanV involved in landomycin biosynthesis.
Biochemistry, 52, 2013
4OSP
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BU of 4osp by Molmil
The crystal structure of urdamycin C-6 ketoreductase domain UrdMred with bound NADP and rabelomycin
Descriptor: NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Oxygenase-reductase, rabelomycin
Authors:Niiranen, L, Paananen, P, Patrikainen, P, Metsa-Ketela, M.
Deposit date:2014-02-13
Release date:2014-10-01
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure-based engineering of angucyclinone 6-ketoreductases.
Chem.Biol., 21, 2014
4OSO
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BU of 4oso by Molmil
The crystal structure of landomycin C-6 ketoreductase LanV with bound NADP and rabelomycin
Descriptor: DI(HYDROXYETHYL)ETHER, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Reductase homolog, ...
Authors:Paananen, P, Niiranen, L, Patrikainen, P, Metsa-Ketela, M.
Deposit date:2014-02-13
Release date:2014-10-01
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-based engineering of angucyclinone 6-ketoreductases.
Chem.Biol., 21, 2014
5EQU
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BU of 5equ by Molmil
Crystal structure of the epimerase SnoN in complex with Fe3+, alpha ketoglutarate and nogalamycin RO
Descriptor: 2-OXOGLUTARIC ACID, FE (III) ION, Nogalamycin RO, ...
Authors:Selvaraj, B, Lindqvist, Y, Siitonen, V, Metsa-Ketela, M, Schneider, G.
Deposit date:2015-11-13
Release date:2016-05-11
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway.
Proc.Natl.Acad.Sci.USA, 113, 2016
5EPA
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BU of 5epa by Molmil
Crystal structure of non-heme alpha ketoglutarate dependent carbocyclase SnoK from nogalamycin biosynthesis
Descriptor: 2-OXOGLUTARIC ACID, FE (III) ION, MAGNESIUM ION, ...
Authors:Selvaraj, B, Lindqvist, Y, Siitonen, V, Niiranen, L, Metsa-Ketela, M, Schneider, G.
Deposit date:2015-11-11
Release date:2016-05-11
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway.
Proc.Natl.Acad.Sci.USA, 113, 2016
5ERL
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BU of 5erl by Molmil
Crystal structure of the epimerase SnoN in complex with Ni2+, succinate and nogalamycin RO
Descriptor: NICKEL (II) ION, Nogalamycin RO, SUCCINIC ACID, ...
Authors:Selvaraj, B, Lindqvist, Y, Siitonen, V, Metsa-Ketela, M, Schneider, G.
Deposit date:2015-11-14
Release date:2016-05-11
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway.
Proc.Natl.Acad.Sci.USA, 113, 2016
5EP9
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BU of 5ep9 by Molmil
Crystal structure of the non-heme alpha ketoglutarate dependent epimerase SnoN from nogalamycin biosynthesis
Descriptor: 2-OXOGLUTARIC ACID, ACETATE ION, FE (III) ION, ...
Authors:Selvaraj, B, Lindqvist, Y, Niiranen, L, Siitonen, V, Metsa-Ketela, M, Schneider, G.
Deposit date:2015-11-11
Release date:2016-05-11
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.13 Å)
Cite:Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway.
Proc.Natl.Acad.Sci.USA, 113, 2016
4EX6
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BU of 4ex6 by Molmil
Crystal structure of the alnumycin P phosphatase AlnB
Descriptor: AlnB, BORIC ACID, MAGNESIUM ION
Authors:Oja, T, Niiranen, L, Sandalova, T, Klika, K.D, Niemi, J, Mantsala, P, Schneider, G, Metsa-Ketela, M.
Deposit date:2012-04-30
Release date:2013-01-16
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway.
Proc.Natl.Acad.Sci.USA, 110, 2013
4EX7
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BU of 4ex7 by Molmil
Crystal structure of the alnumycin P phosphatase in complex with free phosphate
Descriptor: AlnB, BORIC ACID, MAGNESIUM ION, ...
Authors:Oja, T, Niiranen, L, Sandalova, T, Klika, K.D, Niemi, J, Mantsala, P, Schneider, G, Metsa-Ketela, M.
Deposit date:2012-04-30
Release date:2013-01-16
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway.
Proc.Natl.Acad.Sci.USA, 110, 2013
7QZJ
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BU of 7qzj by Molmil
1.55 A X-ray crystallographic structure of SapH from Streptomyces sp. (HPH0547) involved in Pseudouridimycin biosynthesis
Descriptor: 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, Aspartate aminotransferase family protein, GLYCEROL, ...
Authors:Schnell, R, Schneider, G.
Deposit date:2022-01-31
Release date:2023-02-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Pseudouridine-Modifying Enzymes SapB and SapH Control Entry into the Pseudouridimycin Biosynthetic Pathway.
Acs Chem.Biol., 18, 2023
6P77
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BU of 6p77 by Molmil
2.5 Angstrom structure of Caci_6494 from Catenulispora Acidiphila
Descriptor: Aromatic-ring-hydroxylating dioxygenase beta subunit, GLYCEROL, TETRAETHYLENE GLYCOL, ...
Authors:Vuksanovic, N, Silvaggi, N.R.
Deposit date:2019-06-05
Release date:2020-06-17
Last modified:2020-09-02
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:Structural characterization of three noncanonical NTF2-like superfamily proteins: implications for polyketide biosynthesis.
Acta Crystallogr.,Sect.F, 76, 2020
6P7L
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BU of 6p7l by Molmil
1.8 Angstrom structure of Aln2 from Streptomyces sp. CM020
Descriptor: Aln2, GLYCEROL
Authors:Vuksanovic, N, Silvaggi, N.R.
Deposit date:2019-06-06
Release date:2020-06-17
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural characterization of three noncanonical NTF2-like superfamily proteins: implications for polyketide biosynthesis.
Acta Crystallogr.,Sect.F, 76, 2020
7OY1
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BU of 7oy1 by Molmil
DnrK mutant RTCR
Descriptor: Carminomycin 4-O-methyltransferase DnrK,Methyltransferase domain-containing protein,Aclacinomycin 10-hydroxylase RdmB, S-ADENOSYL-L-HOMOCYSTEINE, methyl (1R,2R,4S)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy}-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate
Authors:Dinis, P, MetsaKetela, M.
Deposit date:2021-06-23
Release date:2022-07-13
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Evolution-inspired engineering of anthracycline methyltransferases.
Pnas Nexus, 2, 2023
7OWB
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BU of 7owb by Molmil
Chimeric carminomycin-4-O-methyltransferase (DnrK) with a region from 10-hydroxylase CalMB
Descriptor: Carminomycin 4-O-methyltransferase DnrK,Methyltransferase domain-containing protein, S-ADENOSYL-L-HOMOCYSTEINE, methyl (1R,2R,4S)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-4-{[2,3,6-trideoxy-3-(dimethylamino)-alpha-L-lyxo-hexopyranosyl]oxy}-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate
Authors:Dinis, P, MetsaKetela, M.
Deposit date:2021-06-17
Release date:2022-07-13
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Evolution-inspired engineering of anthracycline methyltransferases.
Pnas Nexus, 2, 2023

 

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