Author results

4WG3
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CALCIUM-DEPENDENT PROTEIN KINASE 1 FROM TOXOPLASMA GONDII (TGCDPK1) IN COMPLEX WITH INHIBITOR UW1610
Descriptor:Calmodulin-domain protein kinase 1, 3-(7-ethoxynaphthalen-2-yl)-1-(2-methylpropyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Authors:Merritt, E.A.
Deposit date:2014-09-17
Release date:2014-10-15
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1610
to be published
4WG4
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CALCIUM-DEPENDENT PROTEIN KINASE 1 FROM TOXOPLASMA GONDII (TGCDPK1) IN COMPLEX WITH INHIBITOR UW1613
Descriptor:Calmodulin-domain protein kinase 1, 3-(7-ethoxynaphthalen-2-yl)-1-(piperidin-4-ylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Authors:Merritt, E.A.
Deposit date:2014-09-17
Release date:2014-10-15
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1613
to be published
4WG5
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CALCIUM-DEPENDENT PROTEIN KINASE 1 FROM TOXOPLASMA GONDII (TGCDPK1) IN COMPLEX WITH INHIBITOR UW1647
Descriptor:Calmodulin-domain protein kinase 1, 5-amino-3-[7-(cyclobutyloxy)quinolin-3-yl]-1-cyclohexyl-1H-pyrazole-4-carboxamide
Authors:Merritt, E.A.
Deposit date:2014-09-17
Release date:2014-10-15
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Calcium-Dependent Protein Kinase 1 from Toxoplasma gondii (TgCDPK1) in complex with inhibitor UW1647
to be published
3CHB
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CHOLERA TOXIN B-PENTAMER COMPLEXED WITH GM1 PENTASACCHARIDE
Descriptor:CHOLERA TOXIN, BETA-D-GALACTOSE, N-ACETYL-D-GALACTOSAMINE, ...
Authors:Merritt, E.A., Hol, W.G.J.
Deposit date:1998-03-24
Release date:1998-08-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:The 1.25 A resolution refinement of the cholera toxin B-pentamer: evidence of peptide backbone strain at the receptor-binding site.
J.Mol.Biol., 282, 1998
1CHP
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SURPRISING LEADS FOR A CHOLERA TOXIN RECEPTOR BINDING ANTAGONIST; CRYSTALLOGRAPHIC STUDIES OF CTB MUTANTS
Descriptor:CHOLERA TOXIN B PENTAMER, CHLORIDE ION
Authors:Merritt, E.A., Hol, W.G.J.
Deposit date:1995-02-15
Release date:1996-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Surprising leads for a cholera toxin receptor-binding antagonist: crystallographic studies of CTB mutants.
Structure, 3, 1995
1CHQ
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SURPRISING LEADS FOR A CHOLERA TOXIN RECEPTOR BINDING ANTAGONIST; CRYSTALLOGRAPHIC STUDIES OF CTB MUTANTS
Descriptor:CHOLERA TOXIN B PENTAMER
Authors:Merritt, E.A., Hol, W.G.J.
Deposit date:1995-02-15
Release date:1996-03-08
Last modified:2017-06-21
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Surprising leads for a cholera toxin receptor-binding antagonist: crystallographic studies of CTB mutants.
Structure, 3, 1995
1LT5
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HEAT-LABILE ENTEROTOXIN B-PENTAMER COMPLEXED WITH THIODIGALACTOSIDE
Descriptor:HEAT-LABILE ENTEROTOXIN, THIODIGALACTOSIDE
Authors:Merritt, E.A., Hol, W.G.J.
Deposit date:1997-09-30
Release date:1997-12-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural foundation for the design of receptor antagonists targeting Escherichia coli heat-labile enterotoxin.
Structure, 5, 1997
1LT6
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HEAT-LABILE ENTEROTOXIN B-PENTAMER COMPLEXED WITH METANITROPHENYLGALACTOSIDE
Descriptor:HEAT-LABILE ENTEROTOXIN, METANITROPHENYL-ALPHA-D-GALACTOSIDE
Authors:Merritt, E.A., Hol, W.G.J.
Deposit date:1997-10-01
Release date:1997-12-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural foundation for the design of receptor antagonists targeting Escherichia coli heat-labile enterotoxin.
Structure, 5, 1997
2CHB
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CHOLERA TOXIN B-PENTAMER COMPLEXED WITH GM1 PENTASACCHARIDE
Descriptor:CHOLERA TOXIN, BETA-D-GALACTOSE, N-ACETYL-D-GALACTOSAMINE, ...
Authors:Merritt, E.A., Hol, W.G.J.
Deposit date:1997-06-03
Release date:1997-12-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural studies of receptor binding by cholera toxin mutants.
Protein Sci., 6, 1997
4Y5Q
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ACTIVATED CALCIUM-DEPENDENT PROTEIN KINASE 1 FROM CRYPTOSPORIDIUM PARVUM (CPCDPK1) IN COMPLEX WITH AMP
Descriptor:Calmodulin-domain protein kinase 1, putative, CALCIUM ION, ...
Authors:Merritt, E.A., Larson, E.T., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2015-02-11
Release date:2015-02-25
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Activated Calcium-Dependent Protein Kinase 1 from Cryptosporidium parvum (CpCDPK1) in complex with AMP
To Be Published
1CT1
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CHOLERA TOXIN B-PENTAMER MUTANT G33R BOUND TO RECEPTOR PENTASACCHARIDE
Descriptor:CHOLERA TOXIN, BETA-D-GALACTOSE, N-ACETYL-D-GALACTOSAMINE, ...
Authors:Merritt, E.A., Hol, W.G.J.
Deposit date:1997-06-03
Release date:1997-10-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural studies of receptor binding by cholera toxin mutants.
Protein Sci., 6, 1997
1FER
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STRUCTURE AT PH 6.5 OF FERREDOXIN I FROM AZOTOBACTER VINELANDII AT 2.3 ANGSTROMS RESOLUTION
Descriptor:FERREDOXIN I, FE3-S4 CLUSTER, IRON/SULFUR CLUSTER
Authors:Merritt, E.A., Stout, G.H., Turley, S., Sieker, L.C., Jensen, L.H., Orme-Johnson, W.H.
Deposit date:1992-09-02
Release date:1993-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure at pH 6.5 of ferredoxin I from Azotobacter vinelandii at 2.3 A resolution.
Acta Crystallogr.,Sect.D, 49, 1993
1HTL
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MUTATION OF A BURIED RESIDUE CAUSES LACK OF ACTIVITY BUT NO CONFORMATIONAL CHANGE: CRYSTAL STRUCTURE OF E. COLI HEAT-LABILE ENTEROTOXIN MUTANT VAL 97--> LYS
Descriptor:HEAT-LABILE ENTEROTOXIN, SUBUNIT B, SUBUNIT A
Authors:Merritt, E.A., Hol, W.G.J.
Deposit date:1995-02-15
Release date:1995-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mutation of a buried residue causes loss of activity but no conformational change in the heat-labile enterotoxin of Escherichia coli.
Nat.Struct.Biol., 2, 1995
1LLR
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CHOLERA TOXIN B-PENTAMER WITH LIGAND BMSC-0012
Descriptor:CHOLERA TOXIN B SUBUNIT, 5-AMINOCARBONYL-3-NITROPHENYL-ALPHA-D-GALACTOPYRANOSE, 3-AMINO-4-{3-[2-(2-PROPOXY-ETHOXY)-ETHOXY]-PROPYLAMINO}-CYCLOBUT-3-ENE-1,2-DIONE
Authors:Merritt, E.A., Hol, W.G.J.
Deposit date:2002-04-30
Release date:2002-08-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Characterization and crystal structure of a high-affinity pentavalent receptor-binding inhibitor for cholera toxin and E. coli heat-labile enterotoxin.
J.Am.Chem.Soc., 124, 2002
1LTA
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2.2 ANGSTROMS CRYSTAL STRUCTURE OF E. COLI HEAT-LABILE ENTEROTOXIN (LT) WITH BOUND GALACTOSE
Descriptor:HEAT-LABILE ENTEROTOXIN, SUBUNIT B, SUBUNIT A, ...
Authors:Merritt, E.A., Sixma, T.K., Kalk, K.H., Van Zanten, B.A.M., Hol, W.G.J.
Deposit date:1993-09-15
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Galactose-binding site in Escherichia coli heat-labile enterotoxin (LT) and cholera toxin (CT).
Mol.Microbiol., 13, 1994
1LTB
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2.6 ANGSTROMS CRYSTAL STRUCTURE OF PARTIALLY-ACTIVATED E. COLI HEAT-LABILE ENTEROTOXIN (LT)
Descriptor:HEAT-LABILE ENTEROTOXIN, SUBUNIT B, SUBUNIT A
Authors:Merritt, E.A., Sixma, T.K., Hol, W.G.J.
Deposit date:1993-09-15
Release date:1994-01-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of partially-activated E. coli heat-labile enterotoxin (LT) at 2.6 A resolution.
FEBS Lett., 337, 1994
1LUQ
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FULL MATRIX ERROR ANALYSIS OF STREPTAVIDIN
Descriptor:Streptavidin, BIOTIN, GLYCEROL, ...
Authors:Merritt, E.A., Le Trong, I.
Deposit date:2002-05-23
Release date:2003-09-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (0.96 Å)
Cite:Full Matrix Error Analysis of Streptavidin
To be Published
1QB5
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ESCHERICHIA COLI HEAT LABILE ENTEROTOXIN TYPE IIB B-PENTAMER
Descriptor:PROTEIN (HEAT LABILE ENTEROTOXIN TYPE IIB B-PENTAMER)
Authors:Merritt, E.A., Hol, W.G.J.
Deposit date:1999-04-30
Release date:2003-06-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structures of the B-Pentamer from E. coli Enterotoxin LT-IIb
To be Published
1QCB
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ESCHERICHIA COLI HEAT LABILE ENTEROTOXIN TYPE IIB B-PENTAMER
Descriptor:PROTEIN (HEAT LABILE ENTEROTOXIN TYPE IIB B-PENTAMER)
Authors:Merritt, E.A., Hol, W.G.J.
Deposit date:1999-04-30
Release date:2003-06-10
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structures of the B-Pentamer from E. coli Enterotoxin LT-IIb
To be Published
2Q0X
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ALPHA/BETA HYDROLASE FOLD PROTEIN OF UNKNOWN FUNCTION
Descriptor:Uncharacterized protein, GLYCEROL
Authors:Merritt, E.A., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2007-05-22
Release date:2007-06-26
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of a Trypanosoma brucei alpha/beta-hydrolase fold protein with unknown function.
Acta Crystallogr.,Sect.F, 64, 2008
2QT8
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COPROPORPHYRINOGEN III OXIDASE FROM LEISHMANIA MAJOR
Descriptor:Coproporphyrinogen III oxidase, ACETATE ION
Authors:Merritt, E.A., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2007-08-01
Release date:2007-09-04
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Coproporphyrinogen III oxidase from Leishmania major.
To be Published
3BNW
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CRYSTAL STRUCTURE OF RIBOFLAVIN KINASE FROM TRYPANOSOMA BRUCEI
Descriptor:Riboflavin kinase, putative
Authors:Merritt, E.A., Holmes, M., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2007-12-14
Release date:2008-01-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Riboflavin kinase from Trypanosoma brucei.
To be Published
3LC0
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HISTIDYL-TRNA SYNTHETASE FROM TRYPANOSOMA CRUZI (HISTIDINE COMPLEX)
Descriptor:Histidyl-tRNA synthetase, HISTIDINE
Authors:Merritt, E.A., Larson, E.T., Medical Structural Genomics of Pathogenic Protozoa (MSGPP)
Deposit date:2010-01-08
Release date:2010-01-19
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structures of Trypanosomal Histidyl-tRNA Synthetase Illuminate Differences between Eukaryotic and Prokaryotic Homologs.
J.Mol.Biol., 397, 2010
3M3I
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HYPOTHETICAL PROTEIN FROM LEISHMANIA MAJOR
Descriptor:Putative uncharacterized protein
Authors:Merritt, E.A., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2010-03-09
Release date:2010-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Hypothetical protein from Leishmania major
To be Published
3S4O
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PROTEIN TYROSINE PHOSPHATASE (PUTATIVE) FROM LEISHMANIA MAJOR
Descriptor:Protein tyrosine phosphatase-like protein, THIOSULFATE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID
Authors:Merritt, E.A., Arakaki, T., Medical Structural Genomics of Pathogenic Protozoa (MSGPP), Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2011-05-19
Release date:2011-06-15
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Protein Tyrosine Phosphatase from Leishmania major
To be Published