Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
1YW2
DownloadVisualize
BU of 1yw2 by Molmil
Mutated Mus Musculus P38 Kinase (mP38)
Descriptor: 2-(ETHOXYMETHYL)-4-(4-FLUOROPHENYL)-3-[2-(2-HYDROXYPHENOXY)PYRIMIDIN-4-YL]ISOXAZOL-5(2H)-ONE, Mitogen-activated protein kinase 14
Authors:Laughlin, S.K, Clark, M.P, Djung, J.F, Golebiowski, A, Brugel, T.A, Sabat, M, Bookland, R.G, Laufersweiler, M.J, Vanrens, J.C, Townes, J.A, De, B, Hsieh, L.C, Xu, S.C, Walter, R.L, Mekel, M.J, Janusz, M.J.
Deposit date:2005-02-16
Release date:2005-05-10
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:The development of new isoxazolone based inhibitors of tumor necrosis factor-alpha (TNF-alpha) production.
Bioorg.Med.Chem.Lett., 15, 2005
1YWR
DownloadVisualize
BU of 1ywr by Molmil
Crystal Structure Analysis of inactive P38 kinase domain in complex with a Monocyclic Pyrazolone Inhibitor
Descriptor: 4-(4-FLUOROPHENYL)-1-METHYL-5-(2-{[(1S)-1-PHENYLETHYL]AMINO}PYRIMIDIN-4-YL)-2-PIPERIDIN-4-YL-1,2-DIHYDRO-3H-PYRAZOL-3-ONE, Mitogen-activated protein kinase 14
Authors:Golebiowski, A, Townes, J.A, Laufersweiler, M.J, Brugel, T.A, Clark, M.P, Clark, C.M, Djung, J.F, Laughlin, S.K, Sabat, M.P, Bookland, R.G, Vanrens, J.C, De, B, Hsieh, L.C, Janusz, M.J, Walter, R.L, Webster, M.E, Mekel, M.J.
Deposit date:2005-02-18
Release date:2005-05-10
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The development of monocyclic pyrazolone based cytokine synthesis inhibitors.
Bioorg.Med.Chem.Lett., 15, 2005
2GHL
DownloadVisualize
BU of 2ghl by Molmil
Mutant Mus Musculus P38 Kinase Domain in Complex with Inhibitor PG-874743
Descriptor: 3-(2-CHLOROPHENYL)-1-(2-{[(1S)-2-HYDROXY-1,2-DIMETHYLPROPYL]AMINO}PYRIMIDIN-4-YL)-1-(4-METHOXYPHENYL)UREA, Mitogen-activated protein kinase 14
Authors:Walter, R.L, Mekel, M.J, Evdokimov, A.G, Pokross, M.E, Brugel, T.A.
Deposit date:2006-03-27
Release date:2006-04-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Development of N-2,4-pyrimidine-N-phenyl-N'-phenyl ureas as inhibitors of tumor necrosis factor alpha (TNF-alpha) synthesis. Part 1.
Bioorg.Med.Chem.Lett., 16, 2006
2GHM
DownloadVisualize
BU of 2ghm by Molmil
Mutated MAP kinase P38 (Mus Musculus) in complex with Inhbitor PG-895449
Descriptor: 3-(2-CHLOROBENZYL)-1-(2-{[(1S)-2-HYDROXY-1,2-DIMETHYLPROPYL]AMINO}PYRIMIDIN-4-YL)-1-(4-METHOXYPHENYL)UREA, Mitogen-activated protein kinase 14
Authors:Walter, R.L, Mekel, M.J, Evdokimov, A.G, Pokross, M.E, Maier, J.A.
Deposit date:2006-03-27
Release date:2006-05-02
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Development of N-2,4-pyrimidine-N-phenyl-N'-phenyl ureas as inhibitors of tumor necrosis factor alpha (TNF-alpha) synthesis. Part 1.
Bioorg.Med.Chem.Lett., 16, 2006
2GTN
DownloadVisualize
BU of 2gtn by Molmil
Mutated MAP kinase P38 (Mus Musculus) in complex with Inhbitor PG-951717
Descriptor: 2-(2,6-DIFLUOROPHENOXY)-N-(2-FLUOROPHENYL)-9-ISOPROPYL-9H-PURIN-8-AMINE, Mitogen-activated protein kinase 14, SULFATE ION
Authors:Walter, R.L, Mekel, M.J, Evdokimov, A.G, Pokross, M.E, Sabat, M.
Deposit date:2006-04-28
Release date:2006-07-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The development of novel C-2, C-8, and N-9 trisubstituted purines as inhibitors of TNF-alpha production.
Bioorg.Med.Chem.Lett., 16, 2006
2GTM
DownloadVisualize
BU of 2gtm by Molmil
Mutated Mouse P38 MAP Kinase Domain in complex with Inhibitor PG-892579
Descriptor: 8-(2-CHLOROPHENYLAMINO)-2-(2,6-DIFLUOROPHENYLAMINO)-9-ETHYL-9H-PURINE-1,7-DIIUM, Mitogen-activated protein kinase 14
Authors:Walter, R.L, Mekel, M.J, Evdokimov, A.G, Pokross, M.E, Sabat, M.
Deposit date:2006-04-28
Release date:2006-05-23
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The development of novel C-2, C-8, and N-9 trisubstituted purines as inhibitors of TNF-alpha production.
Bioorg.Med.Chem.Lett., 16, 2006
2HK5
DownloadVisualize
BU of 2hk5 by Molmil
Hck Kinase in Complex with Lck targetted Inhibitor PG-1009247
Descriptor: 3-{[2-(1H-BENZIMIDAZOL-1-YL)-6-{[2-(DIETHYLAMINO)ETHYL]AMINO}PYRIMIDIN-4-YL]AMINO}-4-METHYLPHENOL, Tyrosine-protein kinase HCK
Authors:Walter, R.L, Mekel, M.J, Evdokimov, A.G, Pokross, M.E, Sabat, M.P.
Deposit date:2006-07-03
Release date:2006-09-05
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:The development of 2-benzimidazole substituted pyrimidine based inhibitors of lymphocyte specific kinase (Lck).
Bioorg.Med.Chem.Lett., 16, 2006
2GKO
DownloadVisualize
BU of 2gko by Molmil
S41 Psychrophilic Protease
Descriptor: CALCIUM ION, SODIUM ION, microbial serine proteinases; subtilisin, ...
Authors:Walter, R.L, Mekel, M.J, Grayling, R.A, Arnold, F.H, Wintrode, P.L, Almog, O.
Deposit date:2006-04-03
Release date:2007-05-01
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:The crystal structures of the psychrophilic subtilisin S41 and the mesophilic subtilisin Sph reveal the same calcium-loaded state.
Proteins, 74, 2009
3D43
DownloadVisualize
BU of 3d43 by Molmil
The crystal structure of Sph at 0.8A
Descriptor: CALCIUM ION, Sphericase
Authors:Almog, O.
Deposit date:2008-05-13
Release date:2009-04-28
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (0.8 Å)
Cite:The crystal structures of the psychrophilic subtilisin S41 and the mesophilic subtilisin Sph reveal the same calcium-loaded state.
Proteins, 74, 2009
2HFP
DownloadVisualize
BU of 2hfp by Molmil
Crystal Structure of PPAR Gamma with N-sulfonyl-2-indole carboxamide ligands
Descriptor: 3-(4-METHOXYPHENYL)-N-(PHENYLSULFONYL)-1-[3-(TRIFLUOROMETHYL)BENZYL]-1H-INDOLE-2-CARBOXAMIDE, Peroxisome proliferator-activated receptor gamma, SRC Peptide Fragment
Authors:Pokross, M.E, Evdokimov, A.G, Walter, R.L, Mekel, M.J, Hopkins, C.R.
Deposit date:2006-06-25
Release date:2006-09-19
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Design and synthesis of novel N-sulfonyl-2-indole carboxamides as potent PPAR-gamma binding agents with potential application to the treatment of osteoporosis.
Bioorg.Med.Chem.Lett., 16, 2006
2IXT
DownloadVisualize
BU of 2ixt by Molmil
SPHERICASE
Descriptor: 36KDA PROTEASE, CALCIUM ION
Authors:Almog, O, Gonzalez, A, Godin, N.
Deposit date:2006-07-11
Release date:2007-08-21
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (0.8 Å)
Cite:The Crystal Structures of the Psychrophilic Subtilisin S41 and the Mesophilic Subtilisin Sph Reveal the Same Calcium-Loaded State.
Proteins, 74, 2009

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon