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5ORL
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BU of 5orl by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, CHLORIDE ION, ...
Authors:McIntyre, P.J, Collins, P.M, Vrzal, L, Birchall, K, Arnold, L.H, Mpamhanga, C, Coombs, P.J, Burgess, S.G, Richards, M.W, Winter, A, Veverka, V, von Delft, F, Merritt, A, Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5ORO
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BU of 5oro by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: 3-(4-chlorophenyl)-5,6-dihydroimidazo[2,1-b][1,3]thiazole, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ...
Authors:McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2019-10-16
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5ORR
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BU of 5orr by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: 4-[4-(trifluoromethyl)phenyl]-1,2,3-thiadiazol-5-amine, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ...
Authors:McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5OS0
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BU of 5os0 by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: 2-[4-(3-chlorophenyl)piperazin-1-ium-1-yl]ethanenitrile, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ...
Authors:McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5ORN
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BU of 5orn by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: 3-thiophen-2-yl-4,5-dihydro-1~{H}-pyridazin-6-one, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ...
Authors:McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5ORT
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BU of 5ort by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, CHLORIDE ION, ...
Authors:McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.56 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5OS2
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BU of 5os2 by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, MAGNESIUM ION, ...
Authors:McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5ORZ
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BU of 5orz by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, CHLORIDE ION, ...
Authors:McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5OSE
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BU of 5ose by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, MAGNESIUM ION, ...
Authors:McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R.
Deposit date:2017-08-17
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5ORV
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BU of 5orv by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, CHLORIDE ION, ...
Authors:McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5OS3
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BU of 5os3 by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: (1~{R})-1-(4-ethoxyphenyl)ethanamine, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ...
Authors:McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5OS4
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BU of 5os4 by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: (3~{a}~{R},5~{S},7~{a}~{S})-5-phenyl-3~{a},4,5,6,7,7~{a}-hexahydroisoindole-1,3-dione, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ...
Authors:McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5ORP
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BU of 5orp by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: 1-[3-chloranyl-5-(trifluoromethyl)pyridin-2-yl]-1,4-diazepane, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ...
Authors:McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5OS1
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BU of 5os1 by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: 6-ethoxy-2-methyl-1,3-benzothiazole, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ...
Authors:McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5OSF
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BU of 5osf by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: 2-(4-ethylphenoxy)-1-piperidin-1-yl-ethanone, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ...
Authors:McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R.
Deposit date:2017-08-17
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5ORS
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BU of 5ors by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, MAGNESIUM ION, ...
Authors:McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5ORW
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BU of 5orw by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: 3-(4-fluoranylphenoxy)-1-thiomorpholin-4-yl-propan-1-one, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ...
Authors:McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5OS5
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BU of 5os5 by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: 4-(4-hydroxyphenyl)sulfanylphenol, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ...
Authors:McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5ORY
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BU of 5ory by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: 2,4-bis(fluoranyl)-6-(1~{H}-pyrazol-3-yl)phenol, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ...
Authors:McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5ORX
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BU of 5orx by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: 6-[2,6-bis(chloranyl)phenoxy]pyridin-3-amine, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ...
Authors:McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5OS6
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BU of 5os6 by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: (6-phenoxypyridin-3-yl)methanol, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ...
Authors:McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R.
Deposit date:2017-08-16
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5OSD
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BU of 5osd by Molmil
Crystal structure of Aurora-A kinase in complex with an allosterically binding fragment
Descriptor: 5-(4-chlorophenyl)furan-2-carbohydrazide, ADENOSINE-5'-DIPHOSPHATE, Aurora kinase A, ...
Authors:McIntyre, P.J, Collins, P.M, von Delft, F, Bayliss, R.
Deposit date:2017-08-17
Release date:2017-11-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Characterization of Three Druggable Hot-Spots in the Aurora-A/TPX2 Interaction Using Biochemical, Biophysical, and Fragment-Based Approaches.
ACS Chem. Biol., 12, 2017
5LXM
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BU of 5lxm by Molmil
Crystal structure of Aurora-A bound to a hydrocarbon-stapled proteomimetic of TPX2
Descriptor: 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ADENOSINE-5'-DIPHOSPHATE, ...
Authors:McIntyre, P.J, Bayliss, R.
Deposit date:2016-09-22
Release date:2016-11-02
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:A TPX2 Proteomimetic Has Enhanced Affinity for Aurora-A Due to Hydrocarbon Stapling of a Helix.
ACS Chem. Biol., 11, 2016
5AAG
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BU of 5aag by Molmil
Aurora A kinase bound to an imidazopyridine inhibitor (14b)
Descriptor: AURORA KINASE A, [3-[[4-[6-chloranyl-2-(1,3-dimethylpyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl]pyrazol-1-yl]methyl]phenyl]-(4-methylpiperazin-1-yl)methanone
Authors:McIntyre, P.J, Bayliss, R.
Deposit date:2015-07-24
Release date:2015-09-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:7-(Pyrazol-4-Yl)-3H-Imidazo[4,5-B]Pyridine-Based Derivatives for Kinase Inhibition: Co-Crystallisation Studies with Aurora-A Reveal Distinct Differences in the Orientation of the Pyrazole N1-Substituent.
Bioorg.Med.Chem.Lett., 25, 2015
5AAE
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BU of 5aae by Molmil
Aurora A kinase bound to an imidazopyridine inhibitor (14d)
Descriptor: 3-((4-(6-chloro-2-(1,3-dimethyl-1H-pyrazol-4-yl)-3H-imidazo[4,5-b]pyridin-7-yl)-1H-pyrazol-1-yl)methyl)-5-methylisoxazole, AURORA KINASE A
Authors:McIntyre, P.J, Bayliss, R.
Deposit date:2015-07-24
Release date:2015-09-02
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.11 Å)
Cite:7-(Pyrazol-4-Yl)-3H-Imidazo[4,5-B]Pyridine-Based Derivatives for Kinase Inhibition: Co-Crystallisation Studies with Aurora-A Reveal Distinct Differences in the Orientation of the Pyrazole N1-Substituent.
Bioorg.Med.Chem.Lett., 25, 2015

 

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