Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
5AD2
DownloadVisualize
BU of 5ad2 by Molmil
Bivalent binding to BET bromodomains
Descriptor: (3R)-4-(2-{4-[1-(3-chloro[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidinyl]phenoxy}ethyl)-1,3-dimethyl-2-piperazinone, BROMODOMAIN-CONTAINING PROTEIN 4
Authors:Waring, M.J, Chen, H, Rabow, A.A, Walker, G, Bobby, R, Boiko, S, Bradbury, R.H, Callis, R, Dale, I, Daniels, D, Flavell, L, Holdgate, G, Jowitt, T.A, Kikhney, A, McAlister, M, Ogg, D, Patel, J, Petteruti, P, Robb, G.R, Robers, M, Stratton, N, Svergun, D.I, Wang, W, Whittaker, D.
Deposit date:2015-08-19
Release date:2016-09-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Potent and Selective Bivalent Inhibitors of Bet Bromodomains
Nat.Chem.Biol., 12, 2016
5AD3
DownloadVisualize
BU of 5ad3 by Molmil
Bivalent binding to BET bromodomains
Descriptor: 3-methoxy-N-[2-[4-[1-(3-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-6-yl)-4-piperidyl]phenoxy]ethyl]-N-methyl-[1,2,4]triazolo[4,3-b]pyridazin-6-amine, BROMODOMAIN-CONTAINING PROTEIN 4
Authors:Waring, M.J, Chen, H, Rabow, A.A, Walker, G, Bobby, R, Boiko, S, Bradbury, R.H, Callis, R, Dale, I, Daniels, D, Flavell, L, Holdgate, G, Jowitt, T.A, Kikhney, A, McAlister, M, Ogg, D, Patel, J, Petteruti, P, Robb, G.R, Robers, M, Stratton, N, Svergun, D.I, Wang, W, Whittaker, D.
Deposit date:2015-08-19
Release date:2016-09-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Potent and Selective Bivalent Inhibitors of Bet Bromodomains
Nat.Chem.Biol., 12, 2016
4A0D
DownloadVisualize
BU of 4a0d by Molmil
Structure of unliganded human PARG catalytic domain
Descriptor: (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, GLYCEROL, POLY(ADP-RIBOSE) GLYCOHYDROLASE, ...
Authors:Brassington, C, Ellston, J, Hassall, G, Holdgate, G, McAlister, M, Overman, R, Smith, G, Tucker, J.A, Watson, M.
Deposit date:2011-09-08
Release date:2012-10-17
Last modified:2013-01-16
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structures of the Human Poly (Adp-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by Adp-Hpd Derivatives.
Plos One, 7, 2012
4B1J
DownloadVisualize
BU of 4b1j by Molmil
Structure of human PARG catalytic domain in complex with ADP-HPD
Descriptor: 5'-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]ADENOSINE, GLYCEROL, POLY(ADP-RIBOSE) GLYCOHYDROLASE, ...
Authors:Brassington, C, Ellston, J, Hassall, G, Holdgate, G, McAlister, M, Overman, R, Smith, G, Tucker, J.A, Watson, M.
Deposit date:2012-07-10
Release date:2012-12-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Structures of the Human Poly (Adp-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by Adp-Hpd Derivatives.
Plos One, 7, 2012
4B1I
DownloadVisualize
BU of 4b1i by Molmil
Structure of human PARG catalytic domain in complex with OA-ADP-HPD
Descriptor: (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 8-n-octylamino-adenosine diphosphate hydroxypyrrolidinediol, GLYCEROL, ...
Authors:Brassington, C, Ellston, J, Hassall, G, Holdgate, G, Johnson, T, McAlister, M, Smith, G, Tucker, J.A, Watson, M.
Deposit date:2012-07-10
Release date:2012-12-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Structures of the Human Poly (Adp-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by Adp-Hpd Derivatives.
Plos One, 7, 2012
4B1G
DownloadVisualize
BU of 4b1g by Molmil
Structure of unliganded human PARG catalytic domain
Descriptor: (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, POLY(ADP-RIBOSE) GLYCOHYDROLASE, SULFATE ION
Authors:Brassington, C, Ellston, J, Hassall, G, Holdgate, G, McAlister, M, Overman, R, Smith, G, Tucker, J.A, Watson, M.
Deposit date:2012-07-10
Release date:2012-12-19
Last modified:2013-01-16
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Structures of the Human Poly (Adp-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by Adp-Hpd Derivatives.
Plos One, 7, 2012
4B1H
DownloadVisualize
BU of 4b1h by Molmil
Structure of human PARG catalytic domain in complex with ADP-ribose
Descriptor: (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, BETA-MERCAPTOETHANOL, GLYCEROL, ...
Authors:Brassington, C, Ellston, J, Hassall, G, Holdgate, G, McAlister, M, Smith, G, Tucker, J.A, Watson, M.
Deposit date:2012-07-10
Release date:2012-12-19
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of the Human Poly (Adp-Ribose) Glycohydrolase Catalytic Domain Confirm Catalytic Mechanism and Explain Inhibition by Adp-Hpd Derivatives.
Plos One, 7, 2012
1H70
DownloadVisualize
BU of 1h70 by Molmil
DDAH FROM PSEUDOMONAS AERUGINOSA. C249S MUTANT COMPLEXED WITH CITRULLINE
Descriptor: CITRULLINE, NG, NG-DIMETHYLARGININE DIMETHYLAMINOHYDROLASE
Authors:Murray-Rust, J, Leiper, J, McAlister, M, Phelan, J, Tilley, S, Santamaria, J, Vallance, P, McDonald, N.
Deposit date:2001-06-30
Release date:2001-08-02
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural insights into the hydrolysis of cellular nitric oxide synthase inhibitors by dimethylarginine dimethylaminohydrolase.
Nat. Struct. Biol., 8, 2001
3ZFY
DownloadVisualize
BU of 3zfy by Molmil
Crystal structure of EphB3
Descriptor: EPHRIN TYPE-B RECEPTOR 3
Authors:Debreczeni, J.E, Overman, R, Truman, C, McAlister, M, Attwood, T.K.
Deposit date:2012-12-12
Release date:2014-01-08
Last modified:2014-05-07
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Completing the Structural Family Portrait of the Human Ephb Tyrosine Kinase Domains
Protein Sci., 23, 2014
3ZFM
DownloadVisualize
BU of 3zfm by Molmil
Crystal structure of EphB2
Descriptor: EPHRIN TYPE-B RECEPTOR 2
Authors:Debreczeni, J.E, Overman, R, Truman, C, McAlister, M, Attwood, T.K.
Deposit date:2012-12-12
Release date:2014-01-08
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Completing the Structural Family Portrait of the Human Ephb Tyrosine Kinase Domains
Protein Sci., 23, 2014
3ZEW
DownloadVisualize
BU of 3zew by Molmil
Crystal structure of EphB4 in complex with staurosporine
Descriptor: EPHRIN TYPE-B RECEPTOR 4, STAUROSPORINE, SULFATE ION
Authors:Debreczeni, J.E, Overman, R, Truman, C, McAlister, M, Attwood, T.K.
Deposit date:2012-12-07
Release date:2013-12-25
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Completing the Structural Family Portrait of the Human Ephb Tyrosine Kinase Domains
Protein Sci., 23, 2014
1GNU
DownloadVisualize
BU of 1gnu by Molmil
GABA(A) receptor associated protein GABARAP
Descriptor: GABARAP, NICKEL (II) ION
Authors:Knight, D, Harris, R, Moss, S, Driscoll, P.C, Keep, N.H.
Deposit date:2001-10-09
Release date:2001-12-03
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The X-Ray Crystal Structure and Putative Ligand-Derived Peptide Binding Properties of Gamma-Aminobutyric Acid Receptor Type a Receptor-Associated Protein
J.Biol.Chem., 277, 2002
3ZFX
DownloadVisualize
BU of 3zfx by Molmil
Crystal structure of EphB1
Descriptor: EPHRIN TYPE-B RECEPTOR 1, SULFATE ION
Authors:Debreczeni, J.E, Overman, R, Truman, C, McAlister, M, Attwood, T.K.
Deposit date:2012-12-12
Release date:2014-01-08
Last modified:2014-05-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Completing the Structural Family Portrait of the Human Ephb Tyrosine Kinase Domains
Protein Sci., 23, 2014
2VWU
DownloadVisualize
BU of 2vwu by Molmil
ephB4 kinase domain inhibitor complex
Descriptor: EPHRIN TYPE-B RECEPTOR 4, N-(5-chloro-1,3-benzodioxol-4-yl)-6-methoxy-7-(3-piperidin-1-ylpropoxy)quinazolin-4-amine
Authors:Read, J, Brassington, C.A, Green, I, McCall, E.J, Valentine, A.L, Barratt, D, Rowsell, S, Packer, M, McAlister, M.
Deposit date:2008-06-27
Release date:2008-07-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Inhibitors of the Tyrosine Kinase Ephb4. Part 1: Structure-Based Design and Optimization of a Series of 2,4-Bis-Anilinopyrimidines
Bioorg.Med.Chem.Lett., 18, 2008
4IWV
DownloadVisualize
BU of 4iwv by Molmil
Crystals structure of Human Glucokinase in complex with small molecule activator
Descriptor: (2S)-2-{[1-(2-chlorophenyl)-1H-pyrazolo[3,4-d]pyrimidin-4-yl]oxy}-N-(5-chloropyridin-2-yl)-3-(2-hydroxyethoxy)propanamide, Glucokinase isoform 3, SODIUM ION, ...
Authors:Ogg, D.J, Hargreaves, D, Gerhardt, S, Flavell, L, McAlister, M.
Deposit date:2013-01-24
Release date:2013-04-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Optimising pharmacokinetics of glucokinase activators with matched triplicate design sets the discovery of AZD3651 and AZD9485
To be Published

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon