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4IE1
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CRYSTAL STRUCTURE OF HUMAN ARGINASE-1 COMPLEXED WITH INHIBITOR 1H
Descriptor:Arginase-1, [(5R)-5-amino-5-carboxy-8-hydroxyoctyl](trihydroxy)borate(1-), MANGANESE (II) ION
Authors:Cousido-Siah, A., Mitschler, A., Ruiz, F.X., Beckett, P., Van Zandt, M.C., Ji, M.K., Whitehouse, D., Ryder, T., Jagdmann, E., Andreoli, M., Mazur, A., Padmanilayam, M., Schroeter, H., Golebiowski, A., Podjarny, A.
Deposit date:2012-12-13
Release date:2013-03-20
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.0006 Å)
Cite:2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors.
Bioorg.Med.Chem.Lett., 23, 2013
4IE2
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CRYSTAL STRUCTURE OF HUMAN ARGINASE-2 COMPLEXED WITH INHIBITOR 1H
Descriptor:Arginase-2, mitochondrial, MANGANESE (II) ION, ...
Authors:Cousido-Siah, A., Mitschler, A., Ruiz, F.X., Beckett, P., Van Zandt, M.C., Ji, M.K., Whitehouse, D., Ryder, T., Jagdmann, E., Andreoli, M., Mazur, A., Padmanilayam, M., Schroeter, H., Golebiowski, A., Podjarny, A.
Deposit date:2012-12-13
Release date:2013-03-20
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.2082 Å)
Cite:2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors.
Bioorg.Med.Chem.Lett., 23, 2013
4IE3
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CRYSTAL STRUCTURE OF HUMAN ARGINASE-2 COMPLEXED WITH INHBITOR 1O
Descriptor:Arginase-2, mitochondrial, MANGANESE (II) ION, ...
Authors:Cousido-Siah, A., Mitschler, A., Ruiz, F.X., Beckett, P., Van Zandt, M.C., Ji, M.K., Whitehouse, D., Ryder, T., Jagdmann, E., Andreoli, M., Mazur, A., Padmanilayam, M., Schroeter, H., Golebiowski, A., Podjarny, A.
Deposit date:2012-12-13
Release date:2013-03-20
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.3522 Å)
Cite:2-Substituted-2-amino-6-boronohexanoic acids as arginase inhibitors.
Bioorg.Med.Chem.Lett., 23, 2013
2N1F
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STRUCTURE AND ASSEMBLY OF THE MOUSE ASC FILAMENT BY COMBINED NMR SPECTROSCOPY AND CRYO-ELECTRON MICROSCOPY
Descriptor:Apoptosis-associated speck-like protein
Authors:Sborgi, L., Ravotti, F., Dandey, V., Dick, M., Mazur, A., Reckel, S., Chami, M., Scherer, S., Bockmann, A., Egelman, E., Stahlberg, H., Broz, P., Meier, B., Hiller, S.
Deposit date:2015-04-01
Release date:2015-10-14
Last modified:2018-07-18
Method:SOLID-STATE NMR (4 Å), ELECTRON MICROSCOPY
Cite:Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy.
Proc.Natl.Acad.Sci.USA, 112, 2015
4C4X
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CRYSTAL STRUCTURE OF HUMAN BIFUNCTIONAL EPOXIDE HYDROXYLASE 2 COMPLEXED WITH C9
Descriptor:BIFUNCTIONAL EPOXIDE HYDROLASE 2, 3-(3,4-dichlorophenyl)-1,1-dimethyl-urea
Authors:Pilger, J., Mazur, A., Monecke, P., Schreuder, H., Elshorst, B., Langer, T., Schiffer, A., Krimm, I., Wegstroth, M., Lee, D., Hessler, G., Wendt, K.-U., Becker, S., Griesinger, C.
Deposit date:2013-09-09
Release date:2014-10-01
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:A Combination of Spin Diffusion Methods for the Determination of Protein-Ligand Complex Structural Ensembles.
Angew.Chem.Int.Ed.Engl., 54, 2015
4C4Y
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CRYSTAL STRUCTURE OF HUMAN BIFUNCTIONAL EPOXIDE HYDROXYLASE 2 COMPLEXED WITH A4
Descriptor:BIFUNCTIONAL EPOXIDE HYDROLASE 2, 1-(3-chlorophenyl)-3-(2-methoxyethyl)urea
Authors:Pilger, J., Mazur, A., Monecke, P., Schreuder, H., Elshorst, B., Langer, T., Schiffer, A., Krimm, I., Wegstroth, M., Lee, D., Hessler, G., Wendt, K.-U., Becker, S., Griesinger, C.
Deposit date:2013-09-09
Release date:2014-10-01
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:A Combination of Spin Diffusion Methods for the Determination of Protein-Ligand Complex Structural Ensembles.
Angew.Chem.Int.Ed.Engl., 54, 2015
4C4Z
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CRYSTAL STRUCTURE OF HUMAN BIFUNCTIONAL EPOXIDE HYDROXYLASE 2 COMPLEXED WITH A8
Descriptor:BIFUNCTIONAL EPOXIDE HYDROLASE 2, 1-ethyl-3-naphthalen-1-ylurea
Authors:Pilger, J., Mazur, A., Monecke, P., Schreuder, H., Elshorst, B., Langer, T., Schiffer, A., Krimm, I., Wegstroth, M., Lee, D., Hessler, G., Wendt, K.-U., Becker, S., Griesinger, C.
Deposit date:2013-09-09
Release date:2014-10-01
Last modified:2015-06-10
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:A Combination of Spin Diffusion Methods for the Determination of Protein-Ligand Complex Structural Ensembles.
Angew.Chem.Int.Ed.Engl., 54, 2015
2MWH
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NMR SOLUTION STRUCTURE OF LIGAND-FREE OAA
Descriptor:Anti-HIV lectin OAA
Authors:Lee, D., Carneiro, M.G., Koharudin, L.M., Griesinger, C., Gronenborn, A.M., Ban, D., Sabo, T., Trigo-Mourino, P., Mazur, A.
Deposit date:2014-11-10
Release date:2015-04-22
Last modified:2015-06-10
Method:SOLUTION NMR
Cite:Sampling of Glycan-Bound Conformers by the Anti-HIV Lectin Oscillatoria agardhii agglutinin in the Absence of Sugar.
Angew.Chem.Int.Ed.Engl., 54, 2015
4QPF
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NEW LOWER BONE AFFINITY BISPHOSPHONATE DRUG DESIGN FOR EFFECTIVE USE IN DISEASES CHARACTERIZED BY ABNORMAL BONE RESORPTION
Descriptor:Farnesyl pyrophosphate synthase, [1-fluoro-2-(imidazo[1,2-a]pyridin-3-yl)ethane-1,1-diyl]bis(phosphonic acid), MAGNESIUM ION
Authors:Ebetino, F.H., Lundy, M., Kwaasi, A.A., Dunford, J.E., Duan, Z., Triffitt, J., Mazur, A., Jeans, G., Barnett, B.L., Russell, R.G.G.
Deposit date:2014-06-23
Release date:2015-06-24
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:New lower bone affinity bisphosphonate drug design for effective use in diseases characterized by abnormal bone resorption
To be Published
5OWI
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THE DYNAMIC DIMER STRUCTURE OF THE CHAPERONE TRIGGER FACTOR (CONFORMER 1)
Descriptor:Trigger factor
Authors:Morgado, L., Burmann, B.M., Sharpe, T., Mazur, A., Hiller, S.
Deposit date:2017-09-01
Release date:2017-11-29
Last modified:2017-12-20
Method:SOLUTION NMR
Cite:The dynamic dimer structure of the chaperone Trigger Factor.
Nat Commun, 8, 2017
5OWJ
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THE DYNAMIC DIMER STRUCTURE OF THE CHAPERONE TRIGGER FACTOR (CONFORMER 2)
Descriptor:Trigger factor
Authors:Morgado, L., Burmann, B.M., Sharpe, T., Mazur, A., Hiller, S.
Deposit date:2017-09-01
Release date:2017-11-29
Last modified:2017-12-20
Method:SOLUTION NMR
Cite:The dynamic dimer structure of the chaperone Trigger Factor.
Nat Commun, 8, 2017
4YXR
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CRYSTAL STRUCTURE OF PKA IN COMPLEX WITH INHIBITOR.
Descriptor:cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, 3-methyl-2H-indazole
Authors:Schiffer, A., Wendt, K.U.
Deposit date:2015-03-23
Release date:2015-05-27
Last modified:2015-06-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:A combination of spin diffusion methods for the determination of protein-ligand complex structural ensembles.
Angew.Chem.Int.Ed.Engl., 54, 2015
4YXS
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CAMP-DEPENDENT PROTEIN KINASE PKA CATALYTIC SUBUNIT WITH PKI-5-24
Descriptor:cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha, N-BENZYL-9H-PURIN-6-AMINE
Authors:Schiffer, A., Wendt, K.U.
Deposit date:2015-03-23
Release date:2015-05-20
Last modified:2015-06-03
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:A combination of spin diffusion methods for the determination of protein-ligand complex structural ensembles.
Angew.Chem.Int.Ed.Engl., 54, 2015
5CGL
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FIC PROTEIN FROM NEISSERIA MENINGITIDIS (NMFIC) MUTANT E102R IN DIMERIC FORM
Descriptor:Adenosine monophosphate-protein transferase NmFic, DI(HYDROXYETHYL)ETHER
Authors:Stanger, F.V., Schirmer, T.
Deposit date:2015-07-09
Release date:2016-01-27
Last modified:2016-02-10
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Intrinsic regulation of FIC-domain AMP-transferases by oligomerization and automodification.
Proc.Natl.Acad.Sci.USA, 113, 2016
5CKL
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FIC PROTEIN FROM NEISSERIA MENINGITIDIS (NMFIC) MUTANT E156R IN DIMERIC FORM
Descriptor:Adenosine monophosphate-protein transferase NmFic, GLYCEROL, CHLORIDE ION
Authors:Stanger, F.V., Schirmer, T.
Deposit date:2015-07-15
Release date:2016-01-27
Last modified:2016-02-10
Method:X-RAY DIFFRACTION (0.99 Å)
Cite:Intrinsic regulation of FIC-domain AMP-transferases by oligomerization and automodification.
Proc.Natl.Acad.Sci.USA, 113, 2016
5CMT
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FIC PROTEIN FROM NEISSERIA MENINGITIDIS (NMFIC) MUTANT E156R Y183F IN DIMERIC FORM
Descriptor:Adenosine monophosphate-protein transferase NmFic, GLYCEROL, CHLORIDE ION
Authors:Stanger, F.V., Schirmer, T.
Deposit date:2015-07-17
Release date:2016-01-27
Last modified:2016-02-10
Method:X-RAY DIFFRACTION (0.99 Å)
Cite:Intrinsic regulation of FIC-domain AMP-transferases by oligomerization and automodification.
Proc.Natl.Acad.Sci.USA, 113, 2016