1D66
 
 | | DNA RECOGNITION BY GAL4: STRUCTURE OF A PROTEIN/DNA COMPLEX | | Descriptor: | CADMIUM ION, DNA (5'-D(*CP*CP*GP*GP*AP*GP*GP*AP*CP*AP*GP*TP*CP*CP*TP*CP*C P*GP*G)-3'), DNA (5'-D(*CP*CP*GP*GP*AP*GP*GP*AP*CP*TP*GP*TP*CP*CP*TP*CP*C P*GP*G)-3'), ... | | Authors: | Marmorstein, R, Carey, M, Ptashne, M, Harrison, S.C. | | Deposit date: | 1992-03-06 | | Release date: | 1992-03-06 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | DNA recognition by GAL4: structure of a protein-DNA complex.
Nature, 356, 1992
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1PYI
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4ZBJ
 | | UBN1 peptide bound to H3.3/H4/Asf1 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, Histone H3, ... | | Authors: | Marmorstein, R, Ricketts, M.D, Tang, Y. | | Deposit date: | 2015-04-14 | | Release date: | 2015-07-15 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.248 Å) | | Cite: | Ubinuclein-1 confers histone H3.3-specific-binding by the HIRA histone chaperone complex.
Nat Commun, 6, 2015
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5T53
 | | MOLECULAR BASIS FOR COHESIN ACETYLATION BY ESTABLISHMENT OF SISTER CHROMATID COHESION N-ACETYLTRANSFERASE ESCO1 | | Descriptor: | ACETYL COENZYME *A, N-acetyltransferase ESCO1, ZINC ION | | Authors: | Marmorstein, R, Rivera-Colon, Y, Liszczak, G.P, Olia, A.S, Maguire, A. | | Deposit date: | 2016-08-30 | | Release date: | 2016-11-09 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.699 Å) | | Cite: | Molecular Basis for Cohesin Acetylation by Establishment of Sister Chromatid Cohesion N-Acetyltransferase ESCO1.
J. Biol. Chem., 291, 2016
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2I32
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2OD9
 | | Structural Basis for Nicotinamide Inhibition and Base Exchange in Sir2 Enzymes | | Descriptor: | 5'-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]ADENOSINE, H4 peptide, NAD-dependent deacetylase HST2, ... | | Authors: | Marmorstein, R, Sanders, B.D. | | Deposit date: | 2006-12-21 | | Release date: | 2007-02-27 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structural basis for nicotinamide inhibition and base exchange in sir2 enzymes.
Mol.Cell, 25, 2007
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2QQF
 | | Hst2 bound to ADP-HPD and Acetylated histone H4 | | Descriptor: | 5'-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]ADENOSINE, Histone H4, NAD-dependent deacetylase HST2, ... | | Authors: | Marmorstein, R, Sanders, B.D, Zhao, K, Slama, J. | | Deposit date: | 2007-07-26 | | Release date: | 2007-10-09 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural basis for nicotinamide inhibition and base exchange in sir2 enzymes.
Mol.Cell, 25, 2007
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2QQG
 | | Hst2 bound to ADP-HPD, acetyllated histone H4 and nicotinamide | | Descriptor: | 5'-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]ADENOSINE, Histone H4, NAD-dependent deacetylase HST2, ... | | Authors: | Marmorstein, R, Sanders, B, Zhao, K, Slama, J. | | Deposit date: | 2007-07-26 | | Release date: | 2007-10-09 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structural basis for nicotinamide inhibition and base exchange in sir2 enzymes.
Mol.Cell, 25, 2007
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1MX4
 | | Structure of p18INK4c (F82Q) | | Descriptor: | Cyclin-dependent kinase 6 inhibitor | | Authors: | Marmorstein, R, Venkataramani, R.N, MacLachlan, T.K, Chai, X, El-Deiry, W.S. | | Deposit date: | 2002-10-01 | | Release date: | 2002-10-16 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure-based design of p18INK4c proteins with increased thermodynamic stability and cell cycle inhibitory activity
J.Biol.Chem., 277, 2002
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1MX2
 | | Structure of F71N mutant of p18INK4c | | Descriptor: | Cyclin-dependent kinase 6 inhibitor | | Authors: | Marmorstein, R, Venkataramani, R.N, MacLachlan, T.K, Chai, X, El-Deiery, W.S. | | Deposit date: | 2002-10-01 | | Release date: | 2002-10-16 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Structure-based design of p18INK4c proteins with increased thermodynamic stability and cell cycle inhibitory activity
J.Biol.Chem., 277, 2002
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1MX6
 | | Structure of p18INK4c (F92N) | | Descriptor: | Cyclin-dependent kinase 6 inhibitor | | Authors: | Marmorstein, R, Venkataramani, R.N, MacLachlan, T.K, Chai, X, El-Deiry, W.S. | | Deposit date: | 2002-10-01 | | Release date: | 2002-10-16 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure-based design of p18INK4c proteins with increased thermodynamic stability and cell cycle inhibitory activity
J.Biol.Chem., 277, 2002
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2YAK
 | | Structure of death-associated protein Kinase 1 (dapk1) in complex with a ruthenium octasporine ligand (OSV) | | Descriptor: | DEATH-ASSOCIATED PROTEIN KINASE 1, RUTHENIUM OCTASPORINE 4 | | Authors: | Feng, L, Geisselbrecht, Y, Blanck, S, Wilbuer, A, Atilla-Gokcumen, G.E, Filippakopoulos, P, Kraeling, K, Celik, M.A, Harms, K, Maksimoska, J, Marmorstein, R, Frenking, G, Knapp, S, Essen, L.-O, Meggers, E. | | Deposit date: | 2011-02-23 | | Release date: | 2011-04-27 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structurally Sophisticated Octahedral Metal Complexes as Highly Selective Protein Kinase Inhibitors.
J.Am.Chem.Soc., 133, 2011
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1CM0
 | | CRYSTAL STRUCTURE OF THE PCAF/COENZYME-A COMPLEX | | Descriptor: | COENZYME A, P300/CBP ASSOCIATING FACTOR | | Authors: | Clements, A, Rojas, J.R, Trievel, R.C, Wang, L, Berger, S.L, Marmorstein, R. | | Deposit date: | 1999-05-12 | | Release date: | 1999-07-06 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal structure of the histone acetyltransferase domain of the human PCAF transcriptional regulator bound to coenzyme A.
EMBO J., 18, 1999
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1CS3
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7LJ9
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1TRO
 | | CRYSTAL STRUCTURE OF TRP REPRESSOR OPERATOR COMPLEX AT ATOMIC RESOLUTION | | Descriptor: | DNA (5'-D(*TP*GP*TP*AP*CP*TP*AP*GP*TP*TP*AP*AP*CP*TP*AP*GP*T P*AP*C)-3'), PROTEIN (TRP REPRESSOR), TRYPTOPHAN | | Authors: | Otwinowski, Z, Schevitz, R.W, Zhang, R.-G, Lawson, C.L, Joachimiak, A, Marmorstein, R, Luisi, B.F, Sigler, P.B. | | Deposit date: | 1992-08-30 | | Release date: | 1994-01-31 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of trp repressor/operator complex at atomic resolution.
Nature, 335, 1988
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3LBX
 | | Crystal Structure of the Erythrocyte Spectrin Tetramerization Domain Complex | | Descriptor: | Spectrin alpha chain, erythrocyte, Spectrin beta chain | | Authors: | Ipsaro, J.J, Harper, S.L, Messick, T.E, Marmorstein, R, Mondragon, A, Speicher, D.W. | | Deposit date: | 2010-01-08 | | Release date: | 2010-03-09 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Crystal structure and functional interpretation of the erythrocyte spectrin tetramerization domain complex.
Blood, 115, 2010
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1BC7
 | | SERUM RESPONSE FACTOR ACCESSORY PROTEIN 1A (SAP-1)/DNA COMPLEX | | Descriptor: | DNA (5'-D(*CP*AP*CP*AP*TP*CP*CP*TP*GP*TP*C)-3'), DNA (5'-D(*GP*AP*CP*AP*GP*GP*AP*TP*GP*TP*G)-3'), PROTEIN (ETS-DOMAIN PROTEIN) | | Authors: | Mo, Y, Vaessen, B, Johnston, K, Marmorstein, R. | | Deposit date: | 1998-05-05 | | Release date: | 1999-01-21 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: insights into DNA sequence discrimination by Ets proteins.
Mol.Cell, 2, 1998
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1BC8
 | | STRUCTURES OF SAP-1 BOUND TO DNA SEQUENCES FROM THE E74 AND C-FOS PROMOTERS PROVIDE INSIGHTS INTO HOW ETS PROTEINS DISCRIMINATE BETWEEN RELATED DNA TARGETS | | Descriptor: | DNA (5'-D(*AP*AP*CP*TP*TP*CP*CP*GP*GP*T)-3'), DNA (5'-D(*TP*AP*CP*CP*GP*GP*AP*AP*GP*T)-3'), PROTEIN (SAP-1 ETS DOMAIN), ... | | Authors: | Mo, Y, Vaessen, B, Johnston, K, Marmorstein, R. | | Deposit date: | 1998-05-05 | | Release date: | 1998-12-01 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: insights into DNA sequence discrimination by Ets proteins.
Mol.Cell, 2, 1998
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5DFP
 | | Crystal structure of PAK1 in complex with an inhibitor compound FRAX1036 | | Descriptor: | 6-[2-chloro-4-(6-methylpyrazin-2-yl)phenyl]-8-ethyl-2-{[2-(1-methylpiperidin-4-yl)ethyl]amino}pyrido[2,3-d]pyrimidin-7(8H)-one, DIMETHYL SULFOXIDE, Serine/threonine-protein kinase PAK 1 | | Authors: | Maksimoska, J, Marmorstein, R, Wang, W. | | Deposit date: | 2015-08-27 | | Release date: | 2016-01-27 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Design of Selective PAK1 Inhibitor G-5555: Improving Properties by Employing an Unorthodox Low-pK a Polar Moiety.
Acs Med.Chem.Lett., 6, 2015
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7LLA
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7LIW
 | | Local refinement of human ATP citrate lyase E599Q mutant ASH domain | | Descriptor: | (2S)-2-hydroxy-2-[2-oxo-2-(phosphonooxy)ethyl]butanedioic acid, ADENOSINE-5'-DIPHOSPHATE, ATP-citrate synthase, ... | | Authors: | Wei, X, Marmorstein, R. | | Deposit date: | 2021-01-28 | | Release date: | 2021-05-19 | | Last modified: | 2021-08-25 | | Method: | ELECTRON MICROSCOPY (2.85 Å) | | Cite: | Reply to: Acetyl-CoA is produced by the citrate synthase homology module of ATP-citrate lyase.
Nat.Struct.Mol.Biol., 28, 2021
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6POE
 | | Structure of ACLY in complex with CoA | | Descriptor: | ATP-citrate synthase, COENZYME A | | Authors: | Wei, X, Marmorstein, R. | | Deposit date: | 2019-07-03 | | Release date: | 2019-12-25 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Molecular basis for acetyl-CoA production by ATP-citrate lyase.
Nat.Struct.Mol.Biol., 27, 2020
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7KD7
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7KPU
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