Author results

5TEZ
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TCR F50 RECGONIZING M1-HLA-A2
Descriptor:GLY-ILE-LEU-GLY-PHE-VAL-PHE-THR-LEU, HLA class I histocompatibility antigen, A-2 alpha chain, ...
Authors:Yang, X., Mariuzza, R.A.
Deposit date:2016-09-23
Release date:2017-09-27
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural basis for clonal diversity of the human T-cell response to a dominant influenza virus epitope.
J. Biol. Chem., 292, 2017
5EUO
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PF6-M1-HLA-A2
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Yang, X.
Deposit date:2015-11-18
Release date:2016-11-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of PF6-M1-HLA-A2 complex
To Be Published
5D2L
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CRYSTAL STRUCTURE OF TCR C7 IN COMPLEX WITH HCMV NLV EPITOPE PRESENTED BY HLA-A2
Descriptor:HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, ...
Authors:Gao, M., Mariuzza, R.A.
Deposit date:2015-08-05
Release date:2015-10-07
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3.511 Å)
Cite:Crystal structure of TCR C7 in complex with HCMV NLV epitope presented by HLA-A2
J.Biol.Chem., 2015
5D2N
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CRYSTAL STRUCTURE OF C25-NLV-HLA-A2 COMPLEX
Descriptor:C25 alpha, C25 beta, HLA class I histocompatibility antigen, ...
Authors:Mariuzza, R.A., Yang, X.
Deposit date:2015-08-05
Release date:2015-10-07
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.099 Å)
Cite:Crystal structure of TCR C7 in complex with HCMV NLV epitope presented by HLA-A2
J.Biol.Chem., 2015
4ZXM
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CRYSTAL STRUCTURE OF PGRP DOMAIN FROM BRANCHIOSTOMA BELCHERI TSINGTAUENSE PEPTIDOGLYCAN RECOGNITION PROTEIN 3
Descriptor:PGRP domain of peptidoglycan recognition protein 3
Authors:Wang, W.J., Cheng, W., Jiang, Y.L., Yu, H.M., Luo, M.
Deposit date:2015-05-20
Release date:2015-10-14
Last modified:2015-11-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Activity Augmentation of Amphioxus Peptidoglycan Recognition Protein BbtPGRP3 via Fusion with a Chitin Binding Domain
Plos One, 10, 2015
4ZSO
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CRYSTAL STRUCTURE OF A COMPLEX BETWEEN B7-H6, A TUMOR CELL LIGAND FOR NATURAL CYTOTOXICITY RECEPTOR NKP30, AND AN INHIBITORY ANTIBODY
Descriptor:Antibody Light Chain, Antibody Heavy Chain, Natural cytotoxicity triggering receptor 3 ligand 1, ...
Authors:Xu, X., Li, Y., Mariuzza, R.A.
Deposit date:2015-05-13
Release date:2016-05-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of a complex between B7-H6, a tumor cell ligand for natural cytotoxicity receptor NKp30, and an inhibitory antibody
to be published
4Z8I
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CRYSTAL STRUCTURE OF BRANCHIOSTOMA BELCHERI TSINGTAUENSE PEPTIDOGLYCAN RECOGNITION PROTEIN 3
Descriptor:peptidoglycan recognition protein 3, ZINC ION
Authors:Wang, W.J., Cheng, W., Jiang, Y.L., Luo, M., Cao, D.D., Chi, C.B., Yang, H.B., Chen, Y., Zhou, C.Z.
Deposit date:2015-04-09
Release date:2015-10-14
Last modified:2015-11-04
Method:X-RAY DIFFRACTION (2.701 Å)
Cite:Activity Augmentation of Amphioxus Peptidoglycan Recognition Protein BbtPGRP3 via Fusion with a Chitin Binding Domain
Plos One, 10, 2015
4Z0X
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STRUCTURE OF HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 ANTIGENIC REGION 434-446 BOUND TO THE BROADLY NEUTRALIZING ANTIBODY HC26AM
Descriptor:Antibody HC26AM light chain variable domain, Antibody HC26AM heavy chain variable domain, HCV E2 Antigen (residues 432-446)
Authors:Rangarajan, S., Mariuzza, R.A.
Deposit date:2015-03-26
Release date:2016-07-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of Hepatitis C Virus Envelope glycoprotein E2 antigenic region 434-446 bound to the broadly neutralizing antibody HC26AM
To Be Published
4XVJ
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STRUCTURE OF THE HEPATITIS C VIRUS ENVELOPE GLYCOPROTEIN E2 ANTIGENIC 2 REGION 412-423 BOUND TO THE BROADLY NEUTRALIZING ANTIBODY HC33.1
Descriptor:HCV E2 antigen, antibody heavy chain variable domain, antibody light chain variable domain
Authors:Li, Y., Mariuzza, R.A.
Deposit date:2015-01-27
Release date:2015-03-11
Last modified:2016-12-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for penetration of the glycan shield of hepatitis C virus e2 glycoprotein by a broadly neutralizing human antibody.
J.Biol.Chem., 290, 2015
4PO4
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CRYSTAL STRUCTURE OF LAMPETRA PLANERI VLRC
Descriptor:Lampetra planeri VLRC
Authors:Gao, M.M., Mariuzza, R.
Deposit date:2014-02-24
Release date:2015-01-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Selection of the lamprey VLRC antigen receptor repertoire.
Proc.Natl.Acad.Sci.USA, 111, 2014
4K79
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RECOGNITION OF THE THOMSEN-FRIEDENREICH ANTIGEN BY A LAMPREY VARIABLE LYMPHOCYTE RECEPTOR
Descriptor:Variable lymphocyte receptor, BETA-D-GALACTOSE, N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE
Authors:Luo, M., Velikovsky, C.A., Yang, X.B., Mariuzza, R.A.
Deposit date:2013-04-16
Release date:2013-06-26
Last modified:2013-08-28
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Recognition of the thomsen-friedenreich pancarcinoma carbohydrate antigen by a lamprey variable lymphocyte receptor.
J.Biol.Chem., 288, 2013
4K5U
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RECOGNITION OF THE BG-H ANTIGEN BY A LAMPREY VARIABLE LYMPHOCYTE RECEPTOR
Descriptor:Variable lymphocyte receptor, BETA-D-GALACTOSE
Authors:Luo, M., Velikovsky, C.A., Yang, X.B., Mariuzza, R.A.
Deposit date:2013-04-15
Release date:2013-06-26
Last modified:2013-08-28
Method:X-RAY DIFFRACTION (1.698 Å)
Cite:Recognition of the thomsen-friedenreich pancarcinoma carbohydrate antigen by a lamprey variable lymphocyte receptor.
J.Biol.Chem., 288, 2013
4IS6
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CRYSTAL STRUCTURE OF HLA-DR4 BOUND TO GP100 PEPTIDE
Descriptor:HLA class II histocompatibility antigen, DR alpha chain, DRB1-4 beta chain, ...
Authors:Li, Y.
Deposit date:2013-01-16
Release date:2013-10-23
Last modified:2013-11-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure-Based Design of Altered MHC Class II-Restricted Peptide Ligands with Heterogeneous Immunogenicity.
J.Immunol., 191, 2013
4IOP
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CRYSTAL STRUCTURE OF NKP65 BOUND TO ITS LIGAND KACL
Descriptor:C-type lectin domain family 2 member A, Killer cell lectin-like receptor subfamily F member 2, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Li, Y.
Deposit date:2013-01-08
Release date:2013-07-17
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of NKp65 bound to its keratinocyte ligand reveals basis for genetically linked recognition in natural killer gene complex.
Proc.Natl.Acad.Sci.USA, 110, 2013
4E41
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STRUCTURAL BASIS FOR THE RECOGNITION OF MUTANT SELF BY A TUMOR-SPECIFIC, MHC CLASS II-RESTRICTED T CELL RECEPTOR G4
Descriptor:HLA class II histocompatibility antigen, DR alpha chain, DRB1-1 beta chain, ...
Authors:Deng, L., Langley, R.J., Wang, Q., Topalian, S.L., Mariuzza, R.A.
Deposit date:2012-03-11
Release date:2012-08-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4
Proc.Natl.Acad.Sci.USA, 2012
4E42
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STRUCTURAL BASIS FOR THE RECOGNITION OF MUTANT SELF BY A TUMOR-SPECIFIC, MHC CLASS II-RESTRICTED T CELL RECEPTOR G4
Descriptor:T cell receptor G4 alpha chain, T cell receptor G4 beta chain, CHLORIDE ION, ...
Authors:Deng, L., Langley, R.J., Wang, Q., Topalian, S.L., Mariuzza, R.A.
Deposit date:2012-03-11
Release date:2012-08-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor G4
Proc.Natl.Acad.Sci.USA, 2012
3T0E
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CRYSTAL STRUCTURE OF A COMPLETE TERNARY COMPLEX OF T CELL RECEPTOR, PEPTIDE-MHC AND CD4
Descriptor:HLA class II histocompatibility antigen, DR alpha chain, DRB1-4 beta chain, ...
Authors:Yin, Y., Mariuzza, R.A.
Deposit date:2011-07-20
Release date:2012-03-07
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (4 Å)
Cite:Crystal structure of a complete ternary complex of T-cell receptor, peptide-MHC, and CD4.
Proc.Natl.Acad.Sci.USA, 109, 2012
3S5L
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CRYSTAL STRUCTURE OF CD4 MUTANT BOUND TO HLA-DR1
Descriptor:HLA class II histocompatibility antigen, DR alpha chain, DRB1-1 beta chain, ...
Authors:Li, Y.
Deposit date:2011-05-23
Release date:2011-09-21
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex.
Proc.Natl.Acad.Sci.USA, 108, 2011
3S4S
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CRYSTAL STRUCTURE OF CD4 MUTANT BOUND TO HLA-DR1
Descriptor:HLA class II histocompatibility antigen, DR alpha chain, DRB1-1 beta chain, ...
Authors:Li, Y.
Deposit date:2011-05-20
Release date:2011-09-21
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Affinity maturation of human CD4 by yeast surface display and crystal structure of a CD4-HLA-DR1 complex.
Proc.Natl.Acad.Sci.USA, 108, 2011
3PV6
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CRYSTAL STRUCTURE OF NKP30 BOUND TO ITS LIGAND B7-H6
Descriptor:Ig-like domain-containing protein DKFZp686O24166/DKFZp686I21167, Natural cytotoxicity triggering receptor 3, N-ACETYL-D-GLUCOSAMINE
Authors:Li, Y.
Deposit date:2010-12-06
Release date:2011-03-16
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of the activating natural killer cell receptor NKp30 bound to its ligand B7-H6 reveals basis for tumor cell recognition in humans
to be published
3PV7
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CRYSTAL STRUCTURE OF NKP30 LIGAND B7-H6
Descriptor:Ig-like domain-containing protein DKFZp686O24166/DKFZp686I21167, N-ACETYL-D-GLUCOSAMINE
Authors:Li, Y.
Deposit date:2010-12-06
Release date:2011-03-16
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the activating natural killer cell receptor NKp30 bound to its ligand B7-H6 reveals basis for tumor cell recognition in humans
to be published
3OWE
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CRYSTAL STRUCTURE OF STAPHYLOCOCCAL ENTEROTOXIN G (SEG) IN COMPLEX WITH A HIGH AFFINITY MUTANT MOUSE T-CELL RECEPTOR CHAIN
Descriptor:Beta-chain, Enterotoxin SEG
Authors:Fernandez, M.M., Cho, S., Robinson, H., Mariuzza, R.A., Malchiodi, M.L.
Deposit date:2010-09-17
Release date:2010-11-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structure of staphylococcal enterotoxin G (SEG) in complex with a mouse T-cell receptor {beta} chain.
J.Biol.Chem., 286, 2011
3O6F
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CRYSTAL STRUCTURE OF A HUMAN AUTOIMMUNE TCR MS2-3C8 BOUND TO MHC CLASS II SELF-LIGAND MBP/HLA-DR4
Descriptor:HLA class II histocompatibility antigen, DR alpha chain, DRB1-4 beta chain, ...
Authors:Yin, Y., Li, Y., Martin, R., Mariuzza, R.A.
Deposit date:2010-07-29
Release date:2011-03-02
Last modified:2017-08-09
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of a TCR with high affinity for self-antigen reveals basis for escape from negative selection.
Embo J., 30, 2011
3MC0
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CRYSTAL STRUCTURE OF STAPHYLOCOCCAL ENTEROTOXIN G (SEG) IN COMPLEX WITH A MOUSE T-CELL RECEPTOR BETA CHAIN
Descriptor:variable beta 8.2 mouse T cell receptor, Enterotoxin SEG, ACETATE ION
Authors:Fernandez, M.M., Cho, S., Robinson, H., Mariuzza, R.A., Malchiodi, E.L.
Deposit date:2010-03-26
Release date:2010-10-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of staphylococcal enterotoxin G (SEG) in complex with a mouse T-cell receptor {beta} chain.
J.Biol.Chem., 286, 2011
3M18
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CRYSTAL STRUCTURE OF VARIABLE LYMPHOCYTE RECEPTOR VLRA.R2.1 IN COMPLEX WITH HEN EGG LYSOZYME
Descriptor:Variable lymphocyte receptor A diversity region, Lysozyme C, PHOSPHATE ION
Authors:Deng, L., Velikovsky, C.A., Mariuzza, R.A.
Deposit date:2010-03-04
Release date:2010-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A structural basis for antigen recognition by the T cell-like lymphocytes of sea lamprey.
Proc.Natl.Acad.Sci.USA, 107, 2010