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2QR7
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BU of 2qr7 by Molmil
2.0A X-ray structure of C-terminal kinase domain of p90 ribosomal S6 kinase 2: Se-Met derivative
Descriptor: Ribosomal protein S6 kinase alpha-3, SODIUM ION
Authors:Malakhova, M, Tereshko, V, Dong, Z.
Deposit date:2007-07-27
Release date:2007-12-11
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2.
Nat.Struct.Mol.Biol., 15, 2008
2QR8
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BU of 2qr8 by Molmil
2.0A X-ray structure of C-terminal kinase domain of p90 ribosomal S6 kinase 2 (RSK2)
Descriptor: Ribosomal protein S6 kinase alpha-3, SODIUM ION
Authors:Tereshko, V, Malakhova, M, Dong, Z.
Deposit date:2007-07-27
Release date:2007-12-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2.
Nat.Struct.Mol.Biol., 15, 2008
3KN6
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BU of 3kn6 by Molmil
Crystal structure of the C-terminal kinase domain of MSK1
Descriptor: Ribosomal protein S6 kinase alpha-5
Authors:D'Angelo, I, Malakhova, M, Dong, Z.
Deposit date:2009-11-12
Release date:2010-04-21
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of the active form of the C-terminal kinase domain of mitogen- and stress-activated protein kinase 1.
J.Mol.Biol., 399, 2010
3KN5
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BU of 3kn5 by Molmil
Crystal structure of the C-terminal kinase domain of msk1 in complex with AMP-PNP
Descriptor: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribosomal protein S6 kinase alpha-5
Authors:D'Angelo, I, Malakhova, M, Dong, Z.
Deposit date:2009-11-12
Release date:2010-04-21
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The crystal structure of the active form of the C-terminal kinase domain of mitogen- and stress-activated protein kinase 1.
J.Mol.Biol., 399, 2010
4N0S
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BU of 4n0s by Molmil
Complex of ERK2 with caffeic acid
Descriptor: CAFFEIC ACID, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ...
Authors:Kurinov, I, Malakhova, M.
Deposit date:2013-10-02
Release date:2014-08-27
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.7992 Å)
Cite:Caffeic Acid Directly Targets ERK1/2 to Attenuate Solar UV-Induced Skin Carcinogenesis.
Cancer Prev Res (Phila), 7, 2014
3SA0
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BU of 3sa0 by Molmil
Complex of ERK2 with norathyriol
Descriptor: Mitogen-activated protein kinase 1, SULFATE ION, norathyriol
Authors:Kurinov, I, Malakhova, M.
Deposit date:2011-06-02
Release date:2011-12-14
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.5947 Å)
Cite:Norathyriol Suppresses Skin Cancers Induced by Solar Ultraviolet Radiation by Targeting ERK Kinases.
Cancer Res., 72, 2012
4ZXT
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BU of 4zxt by Molmil
Complex of ERK2 with catechol
Descriptor: AMMONIUM ION, CATECHOL, Mitogen-activated protein kinase 1, ...
Authors:Kurinov, I, Malakhova, M.
Deposit date:2015-05-20
Release date:2016-05-25
Last modified:2016-10-05
Method:X-RAY DIFFRACTION (2 Å)
Cite:A natural small molecule, catechol, induces c-Myc degradation by directly targeting ERK2 in lung cancer.
Oncotarget, 7, 2016
5WP1
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BU of 5wp1 by Molmil
Complex of ERK2 with 5,7-dihydroxychromone
Descriptor: 5,7-dihydroxy-4H-1-benzopyran-4-one, BENZOIC ACID, Mitogen-activated protein kinase 1, ...
Authors:Kurinov, I, Malakhova, M.
Deposit date:2017-08-03
Release date:2018-08-08
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Multiple phytochemicals at low doses accumulatively inhibit one key protein in cancers
To Be Published
1SBX
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BU of 1sbx by Molmil
Crystal structure of the Dachshund-homology domain of human SKI
Descriptor: Ski oncogene
Authors:Wilson, J.J, Malakhova, M, Zhang, R, Joachimiak, A, Hegde, R.S.
Deposit date:2004-02-11
Release date:2004-05-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal Structure of the Dachshund Homology Domain of human SKI
Structure, 12, 2004
3G51
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BU of 3g51 by Molmil
Structural diversity of the active conformation of the N-terminal kinase domain of p90 ribosomal S6 kinase 2
Descriptor: PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ribosomal protein S6 kinase alpha-3
Authors:Kurinov, I.
Deposit date:2009-02-04
Release date:2009-12-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural diversity of the active N-terminal kinase domain of p90 ribosomal S6 kinase 2
Plos One, 4, 2009

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