Author results

1S5H
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POTASSIUM CHANNEL KCSA-FAB COMPLEX T75C MUTANT IN K+
Descriptor:ANTIBODY FAB FRAGMENT LIGHT CHAIN, ANTIBODY FAB FRAGMENT HEAVY CHAIN, Voltage-gated potassium channel, ...
Authors:Mackinnon, R., Zhou, M.
Deposit date:2004-01-20
Release date:2004-05-18
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A mutant KcsA K(+) channel with altered conduction properties and selectivity filter ion distribution.
J.Mol.Biol., 338, 2004
4JTA
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CRYSTAL STRUCTURE OF KV1.2-2.1 PADDLE CHIMERA CHANNEL IN COMPLEX WITH CHARYBDOTOXIN
Descriptor:Voltage-gated potassium channel subunit beta-2, Potassium voltage-gated channel subfamily A member 2, Potassium voltage-gated channel subfamily B member 1, ...
Authors:MacKinnon, R., Banerjee, A., Lee, A., Campbell, E.
Deposit date:2013-03-23
Release date:2013-06-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel.
Elife, 2, 2013
5TJ6
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CA2+ BOUND APLYSIA SLO1
Descriptor:High conductance calcium-activated potassium channel, POTASSIUM ION, MAGNESIUM ION, ...
Authors:MacKinnon, R., Tao, X., Hite, R.K.
Deposit date:2016-10-03
Release date:2016-12-14
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM structure of the open high-conductance Ca(2+)-activated K(+) channel.
Nature, 541, 2017
5TJI
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CA2+ BOUND APLYSIA SLO1
Descriptor:High conductance calcium-activated potassium channel, (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate
Authors:MacKinnon, R., Tao, X., Hite, R.K.
Deposit date:2016-10-04
Release date:2016-12-28
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural basis for gating the high-conductance Ca(2+)-activated K(+) channel.
Nature, 541, 2017
5VMS
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CRYOEM STRUCTURE OF XENOPUS KCNQ1 CHANNEL
Descriptor:Potassium voltage-gated channel subfamily KQT member 1, Calmodulin, CALCIUM ION
Authors:Mackinnon, R., Sun, J.
Deposit date:2017-04-28
Release date:2017-06-07
Last modified:2018-10-24
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Cryo-EM Structure of a KCNQ1/CaM Complex Reveals Insights into Congenital Long QT Syndrome.
Cell, 169, 2017
1LNQ
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CRYSTAL STRUCTURE OF MTHK AT 3.3 A
Descriptor:POTASSIUM CHANNEL RELATED PROTEIN, CALCIUM ION
Authors:Jiang, Y., Lee, A., Chen, J., Cadene, M., Chait, B.T., Mackinnon, R.
Deposit date:2002-05-03
Release date:2002-06-19
Last modified:2014-11-12
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:CRYSTAL STRUCTURE AND MECHANISM OF A CALCIUM-GATED POTASSIUM CHANNEL
Nature, 417, 2002
2A79
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MAMMALIAN SHAKER KV1.2 POTASSIUM CHANNEL- BETA SUBUNIT COMPLEX
Descriptor:Voltage-gated potassium channel beta-2 subunit, Potassium voltage-gated channel subfamily A member 2, poly-unknown chain, ...
Authors:Long, S.B., Campbell, E.B., MacKinnon, R.
Deposit date:2005-07-05
Release date:2005-07-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of a mammalian voltage-dependent Shaker family K+ channel.
Science, 309, 2005
2R9R
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SHAKER FAMILY VOLTAGE DEPENDENT POTASSIUM CHANNEL (KV1.2-KV2.1 PADDLE CHIMERA CHANNEL) IN ASSOCIATION WITH BETA SUBUNIT
Descriptor:Voltage-gated potassium channel subunit beta-2, Paddle chimera voltage gated potassium channel Kv1.2-Kv2.1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Long, S.B., Tao, X., Campbell, E.B., Mackinnon, R.
Deposit date:2007-09-13
Release date:2007-11-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment.
Nature, 450, 2007
1KPK
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CRYSTAL STRUCTURE OF THE CLC CHLORIDE CHANNEL FROM E. COLI
Descriptor:putative channel transporter
Authors:Dutzler, R., Campbell, E.B., Cadene, M., Chait, B.T., MacKinnon, R.
Deposit date:2001-12-31
Release date:2002-01-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity.
Nature, 415, 2002
1KPL
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CRYSTAL STRUCTURE OF THE CLC CHLORIDE CHANNEL FROM S. TYPHIMURIUM
Descriptor:putative ClC family, chlorine transport protein, CHLORIDE ION, ...
Authors:Dutzler, R., Campbell, E.B., Cadene, M., Chait, B.T., MacKinnon, R.
Deposit date:2001-12-31
Release date:2002-01-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity.
Nature, 415, 2002
1OTS
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STRUCTURE OF THE ESCHERICHIA COLI CLC CHLORIDE CHANNEL AND FAB COMPLEX
Descriptor:Voltage-gated ClC-type chloride channel eriC, Fab fragment (heavy chain), Fab fragment (light chain), ...
Authors:Dutzler, R., Campbell, E.B., MacKinnon, R.
Deposit date:2003-03-22
Release date:2003-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:Gating the Selectivity Filter in ClC Chloride Channels
Science, 300, 2003
1OTT
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STRUCTURE OF THE ESCHERICHIA COLI CLC CHLORIDE CHANNEL E148A MUTANT AND FAB COMPLEX
Descriptor:Voltage-gated ClC-type chloride channel eriC, Fab fragment (Heavy chain), Fab fragment (Light chain), ...
Authors:Dutzler, R., Campbell, E.B., MacKinnon, R.
Deposit date:2003-03-23
Release date:2003-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Gating the Selectivity Filter in ClC Chloride Channels
Science, 300, 2003
1OTU
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STRUCTURE OF THE ESCHERICHIA COLI CLC CHLORIDE CHANNEL E148Q MUTANT AND FAB COMPLEX
Descriptor:Voltage-gated ClC-type chloride channel eriC, Fab fragment (Heavy chain), Fab fragment (Light chain), ...
Authors:Dutzler, R., Campbell, E.B., MacKinnon, R.
Deposit date:2003-03-23
Release date:2003-04-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Gating the Selectivity Filter in ClC Chloride Channels
Science, 300, 2003
1AGT
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SOLUTION STRUCTURE OF THE POTASSIUM CHANNEL INHIBITOR AGITOXIN 2: CALIPER FOR PROBING CHANNEL GEOMETRY
Descriptor:AGITOXIN 2
Authors:Krezel, A.M., Kasibhatla, C., Hidalgo, P., Mackinnon, R., Wagner, G.
Deposit date:1995-04-14
Release date:1995-07-10
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Solution structure of the potassium channel inhibitor agitoxin 2: caliper for probing channel geometry.
Protein Sci., 4, 1995
1BE9
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THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95 IN COMPLEX WITH A C-TERMINAL PEPTIDE DERIVED FROM CRIPT.
Descriptor:PSD-95, CRIPT
Authors:Doyle, D.A., Lee, A., Lewis, J., Kim, E., Sheng, M., Mackinnon, R.
Deposit date:1998-05-20
Release date:1998-10-21
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ.
Cell(Cambridge,Mass.), 85, 1996
1BFE
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THE THIRD PDZ DOMAIN FROM THE SYNAPTIC PROTEIN PSD-95
Descriptor:PSD-95
Authors:Doyle, D.A., Lee, A., Lewis, J., Kim, E., Sheng, M., Mackinnon, R.
Deposit date:1998-05-20
Release date:1998-10-21
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ.
Cell(Cambridge,Mass.), 85, 1996
1BL8
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POTASSIUM CHANNEL (KCSA) FROM STREPTOMYCES LIVIDANS
Descriptor:PROTEIN (POTASSIUM CHANNEL PROTEIN), POTASSIUM ION
Authors:Doyle, D.A., Cabral, J.M., Pfuetzner, R.A., Kuo, A., Gulbis, J.M., Cohen, S.L., Chait, B.T., Mackinnon, R.
Deposit date:1998-07-23
Release date:1998-07-29
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The structure of the potassium channel: molecular basis of K+ conduction and selectivity.
Science, 280, 1998
1BYW
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STRUCTURE OF THE N-TERMINAL DOMAIN OF THE HUMAN-ERG POTASSIUM CHANNEL
Descriptor:PROTEIN (HUMAN ERG POTASSIUM CHANNEL)
Authors:Cabral, J.H.M., Lee, A., Mackinnon, R.
Deposit date:1998-10-15
Release date:1998-12-16
Last modified:2018-03-14
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure and Functional Analysis of the Herg Potassium Channel N-Terminus: A Eukaryotic Pas Domain
Cell(Cambridge,Mass.), 95, 1998
1EXB
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STRUCTURE OF THE CYTOPLASMIC BETA SUBUNIT-T1 ASSEMBLY OF VOLTAGE-DEPENDENT K CHANNELS
Descriptor:KV BETA2 PROTEIN, POTASSIUM CHANNEL KV1.1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Gulbis, J.M., Zhou, M., Mann, S., MacKinnon, R.
Deposit date:2000-05-02
Release date:2000-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels.
Science, 289, 2000
1ID1
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CRYSTAL STRUCTURE OF THE RCK DOMAIN FROM E.COLI POTASSIUM CHANNEL
Descriptor:PUTATIVE POTASSIUM CHANNEL PROTEIN
Authors:Jiang, Y., Pico, A., Cadene, M., Chait, B.T., MacKinnon, R.
Deposit date:2001-04-02
Release date:2001-04-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel.
Neuron, 29, 2001
1J95
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KCSA POTASSIUM CHANNEL WITH TBA (TETRABUTYLAMMONIUM) AND POTASSIUM
Descriptor:VOLTAGE-GATED POTASSIUM CHANNEL, POTASSIUM ION, TETRABUTYLAMMONIUM ION
Authors:Morais-Cabral, J.H., MacKinnon, R., Zhou, M.
Deposit date:2001-05-23
Release date:2001-06-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors
Nature, 411, 2001
1JVM
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KCSA POTASSIUM CHANNEL WITH TBA (TETRABUTYLAMMONIUM) AND RUBIDIUM
Descriptor:Voltage-gated potassium channel, RUBIDIUM ION, TETRABUTYLAMMONIUM ION
Authors:Morais-Cabral, J.H., Zhou, Y., MacKinnon, R.
Deposit date:2001-08-30
Release date:2001-12-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Energetic optimization of ion conduction rate by the K+ selectivity filter.
Nature, 414, 2001
1K4C
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POTASSIUM CHANNEL KCSA-FAB COMPLEX IN HIGH CONCENTRATION OF K+
Descriptor:antibody Fab fragment heavy chain, antibody Fab fragment light chain, potassium channel KcsA, ...
Authors:Zhou, Y., Morais-Cabral, J.H., Kaufman, A., MacKinnon, R.
Deposit date:2001-10-07
Release date:2001-11-14
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution.
Nature, 414, 2001
1K4D
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POTASSIUM CHANNEL KCSA-FAB COMPLEX IN LOW CONCENTRATION OF K+
Descriptor:antibody Fab fragment heavy chain, antibody Fab fragment light chain, potassium channel KcsA, ...
Authors:Zhou, Y., Morais-Cabral, J.H., Kaufman, A., MacKinnon, R.
Deposit date:2001-10-07
Release date:2001-11-14
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution.
Nature, 414, 2001
1N9P
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CRYSTAL STRUCTURE OF THE CYTOPLASMIC DOMAIN OF G-PROTEIN ACTIVATED INWARD RECTIFIER POTASSIUM CHANNEL 1
Descriptor:G protein-activated inward rectifier potassium channel 1
Authors:Nishida, M., MacKinnon, R.
Deposit date:2002-11-26
Release date:2003-01-07
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis of Inward Rectification: Cytoplasmic Pore of the G Protein-Gated Inward Rectifier GIRK1 at 1.8 A Resolution
Cell(Cambridge,Mass.), 111, 2002