Author results

2BGH
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CRYSTAL STRUCTURE OF VINORINE SYNTHASE
分子名称:VINORINE SYNTHASE
著者Ma, X., Koepke, J., Panjikar, S., Fritzsch, G., Stoeckigt, J.
登録日2004-12-22
公開日2005-01-24
最終更新日2015-04-15
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal Structure of Vinorine Synthase, the First Representative of the Bahd Superfamily.
J.Biol.Chem., 280, 2005
2O09
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CRYSTAL STRUCTURE OF THE H-NOX DOMAIN FROM NOSTOC SP. PCC 7120
分子名称:Alr2278 protein, PROTOPORPHYRIN IX CONTAINING FE
著者Ma, X., van den Akker, F.
登録日2006-11-27
公開日2007-01-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献NO and CO differentially activate soluble guanylyl cyclase via a heme pivot-bend mechanism.
Embo J., 26, 2007
2O0C
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CRYSTAL STRUCTURE OF THE H-NOX DOMAIN FROM NOSTOC SP. PCC 7120 COMPLEXED TO NO
分子名称:Alr2278 protein, PROTOPORPHYRIN IX CONTAINING FE, NITRIC OXIDE
著者Ma, X., van den Akker, F.
登録日2006-11-27
公開日2007-01-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献NO and CO differentially activate soluble guanylyl cyclase via a heme pivot-bend mechanism.
Embo J., 26, 2007
2O0G
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CRYSTAL STRUCTURE OF THE H-NOX DOMAIN FROM NOSTOC SP. PCC 7120 COMPLEXED TO CO
分子名称:Alr2278 protein, PROTOPORPHYRIN IX CONTAINING FE, CARBON MONOXIDE
著者Ma, X., van den Akker, F.
登録日2006-11-27
公開日2007-01-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献NO and CO differentially activate soluble guanylyl cyclase via a heme pivot-bend mechanism.
Embo J., 26, 2007
3HLS
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CRYSTAL STRUCTURE OF THE SIGNALING HELIX COILED-COIL DOIMAIN OF THE BETA-1 SUBUNIT OF THE SOLUBLE GUANYLYL CYCLASE
分子名称:Guanylate cyclase soluble subunit beta-1
著者Ma, X., van den Akker, F.
登録日2009-05-28
公開日2010-01-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Crystal structure of the signaling helix coiled-coil domain of the beta-1 subunit of the soluble guanylyl cyclase.
Bmc Struct.Biol., 10, 2010
3P9W
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CRYSTAL STRUCTURE OF AN ENGINEERED HUMAN AUTONOMOUS VH DOMAIN IN COMPLEX WITH VEGF
分子名称:Vascular endothelial growth factor A, human VEGF
著者Ma, X., Wiesmann, C.
登録日2010-10-18
公開日2012-04-18
最終更新日2013-06-19
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Design of Synthetic Autonomous VH Domain Libraries and Structural Analysis of a VH Domain Bound to Vascular Endothelial Growth Factor.
J.Mol.Biol., 425, 2013
4DKC
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CRYSTAL STRUCTURE OF HUMAN INTERLEUKIN-34
分子名称:Interleukin-34, N-ACETYL-D-GLUCOSAMINE, BETA-D-MANNOSE
著者Ma, X., Bazan, J.F., Starovasnik, M.A.
登録日2012-02-03
公開日2012-04-11
最終更新日2012-04-25
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R.
Structure, 20, 2012
4DKD
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CRYSTAL STRUCTURE OF HUMAN INTERLEUKIN-34 BOUND TO HUMAN CSF-1R
分子名称:Interleukin-34, Macrophage colony-stimulating factor 1 receptor, N-ACETYL-D-GLUCOSAMINE, ...
著者Ma, X., Bazan, J.F., Starovasnik, M.A.
登録日2012-02-03
公開日2012-04-11
最終更新日2012-04-25
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R.
Structure, 20, 2012
4DKE
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CRYSTAL STRUCTURE OF HUMAN INTERLEUKIN-34 BOUND TO FAB1.1
分子名称:Interleukin-34, FAb1.1 Heavy Chain, FAb1.1 Light Chain, ...
著者Ma, X., Chen, Y., Stawicki, S., Wu, Y., Bazan, J.F., Starovasnik, M.A.
登録日2012-02-03
公開日2012-04-11
最終更新日2012-04-25
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R.
Structure, 20, 2012
4DKF
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CRYSTAL STRUCTURE OF HUMAN INTERLEUKIN-34 BOUND TO FAB2
分子名称:Interleukin-34, FAb2 Heavy Chain, FAb2 Light Chain, ...
著者Ma, X., Chen, Y., Stawicki, S., Wu, Y., Bazan, J.F., Starovasnik, M.A.
登録日2012-02-03
公開日2012-04-11
最終更新日2012-04-25
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献Structural Basis for the Dual Recognition of Helical Cytokines IL-34 and CSF-1 by CSF-1R.
Structure, 20, 2012
4EUT
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STRUCTURE OF BX-795 COMPLEXED WITH UNPHOSPHORYLATED HUMAN TBK1 KINASE-ULD DOMAIN
分子名称:Serine/threonine-protein kinase TBK1, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, IODIDE ION, ...
著者Ma, X., Helgason, E., Phung, Q.T., Quan, C.L., Iyer, R.S., Lee, M.W., Bowman, K.K., Starovasnik, M.A., Dueber, E.C.
登録日2012-04-25
公開日2012-05-23
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation.
Proc.Natl.Acad.Sci.USA, 109, 2012
4EUU
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STRUCTURE OF BX-795 COMPLEXED WITH HUMAN TBK1 KINASE DOMAIN PHOSPHORYLATED ON SER172
分子名称:Serine/threonine-protein kinase TBK1, N-(3-{[5-iodo-4-({3-[(thiophen-2-ylcarbonyl)amino]propyl}amino)pyrimidin-2-yl]amino}phenyl)pyrrolidine-1-carboxamide, IODIDE ION, ...
著者Ma, X., Helgason, E., Phung, Q.T., Quan, C.L., Iyer, R.S., Lee, M.W., Bowman, K.K., Starovasnik, M.A., Dueber, E.C.
登録日2012-04-25
公開日2012-05-23
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Molecular basis of Tank-binding kinase 1 activation by transautophosphorylation.
Proc.Natl.Acad.Sci.USA, 109, 2012
5WL0
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CO-CRYSTAL STRUCTURE OF INFLUENZA A H3N2 PB2 (241-741) BOUND TO VX-787
分子名称:Polymerase basic protein 2, (2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, DI(HYDROXYETHYL)ETHER
著者Ma, X., Shia, S.
登録日2017-07-25
公開日2017-09-06
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis for therapeutic inhibition of influenza A polymerase PB2 subunit.
Sci Rep, 7, 2017
5Z55
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NMR SOLUTION STRUCTURE OF THE KRINGLE DOMAIN OF HUMAN RECEPTOR TYROSINE KINASE-LIKE ORPHAN RECEPTOR 1 (ROR1)
分子名称:Inactive tyrosine-protein kinase transmembrane receptor ROR1
著者Ma, X., Hu, K.F.
登録日2018-01-17
公開日2018-05-16
実験手法SOLUTION NMR
主引用文献Backbone and side-chain chemical shift assignments of the kringle domain of human receptor tyrosine kinase-like orphan receptor 1 (ROR1).
Biomol NMR Assign, 12, 2018
2P04
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2.1 ANG STRUCTURE OF THE DIMERIZED PAS DOMAIN OF SIGNAL TRANSDUCTION HISTIDINE KINASE FROM NOSTOC PUNCTIFORME PCC 73102 WITH HOMOLOGY TO THE H-NOXA/H-NOBA DOMAIN OF THE SOLUBLE GUANYLYL CYCLASE
分子名称:signal transduction histidine kinase
著者van den Akker, F., Ma, X.
登録日2007-02-28
公開日2007-11-13
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献PAS-mediated dimerization of soluble guanylyl cyclase revealed by signal transduction histidine kinase domain crystal structure.
J.Biol.Chem., 283, 2008
2P08
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STRUCTURE OF THE N-TERMINALLY TRUNCATED PAS DOMAIN OF SIGNAL TRANSDUCTION HISTIDINE KINASE FROM NOSTOC PUNCTIFORME PCC 73102 WITH HOMOLOGY TO THE H-NOXA/H-NOBA DOMAIN OF THE SOLUBLE GUANYLYL CYCLASE
分子名称:signal transduction histidine kinase, SULFATE ION
著者van den Akker, F., Ma, X.
登録日2007-02-28
公開日2007-11-13
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献PAS-mediated dimerization of soluble guanylyl cyclase revealed by signal transduction histidine kinase domain crystal structure.
J.Biol.Chem., 283, 2008
3TMP
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THE CATALYTIC DOMAIN OF HUMAN DEUBIQUITINASE DUBA IN COMPLEX WITH UBIQUITIN ALDEHYDE
分子名称:OTU domain-containing protein 5, Polyubiquitin-C
著者Ma, X., Yin, J., Hymowitz, S., Starovasnik, M., Cochran, A.
登録日2011-08-31
公開日2012-01-11
最終更新日2012-02-29
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Phosphorylation-dependent activity of the deubiquitinase DUBA.
Nat.Struct.Mol.Biol., 19, 2012
4K3J
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CRYSTAL STRUCTURE OF ONARTUZUMAB FAB IN COMPLEX WITH MET AND HGF-BETA
分子名称:Hepatocyte growth factor, Hepatocyte growth factor beta chain, Onartuzumab Fab heavy chain, ...
著者Ma, X., Starovasnik, M.A.
登録日2013-04-10
公開日2013-08-28
最終更新日2014-08-20
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Monovalent antibody design and mechanism of action of onartuzumab, a MET antagonist with anti-tumor activity as a therapeutic agent.
Proc.Natl.Acad.Sci.USA, 110, 2013
5BVD
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TETRAHYDROPYRROLO-DIAZEPENONES AS INHIBITORS OF ERK2 KINASE
分子名称:Mitogen-activated protein kinase 1, 2-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-7-[2-(tetrahydro-2H-pyran-4-ylamino)pyrimidin-4-yl]-3,4-dihydropyrrolo[1,2-a]pyrazin-1(2H)-one, SULFATE ION
著者Ma, X., Steven, S.
登録日2015-06-05
公開日2015-09-09
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Tetrahydropyrrolo-diazepenones as inhibitors of ERK2 kinase.
Bioorg.Med.Chem.Lett., 25, 2015
5BVE
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TETRAHYDROPYRROLO-DIAZEPENONES AS INHIBITORS OF ERK2 KINASE
分子名称:Mitogen-activated protein kinase 1, 2-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-8-[2-(tetrahydro-2H-pyran-4-ylamino)pyrimidin-4-yl]-2,3,4,5-tetrahydro-1H-pyrrolo[1,2-a][1,4]diazepin-1-one, SULFATE ION
著者Ma, X., Steven, S.
登録日2015-06-05
公開日2015-09-09
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Tetrahydropyrrolo-diazepenones as inhibitors of ERK2 kinase.
Bioorg.Med.Chem.Lett., 25, 2015
5BVF
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TETRAHYDROPYRROLO-DIAZEPENONES AS INHIBITORS OF ERK2 KINASE
分子名称:Mitogen-activated protein kinase 1, 2-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-8-(2-{[(1S,3R)-3-hydroxycyclopentyl]amino}pyrimidin-4-yl)-2,3,4,5-tetrahydro-1H-pyrrolo[1,2-a][1,4]diazepin-1-one, SULFATE ION
著者Ma, X., Steven, S.
登録日2015-06-05
公開日2015-09-09
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Tetrahydropyrrolo-diazepenones as inhibitors of ERK2 kinase.
Bioorg.Med.Chem.Lett., 25, 2015
5EF9
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STRUCTURE OF INFLUENZA B LEE PB2 CAP-BINDING DOMAIN
分子名称:Polymerase basic protein 2
著者Ma, X., Shia, S.
登録日2015-10-23
公開日2015-11-18
最終更新日2016-01-13
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Molecular Basis of mRNA Cap Recognition by Influenza B Polymerase PB2 Subunit.
J.Biol.Chem., 291, 2016
5EFA
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STRUCTURE OF INFLUENZA B LEE PB2 CAP-BINDING DOMAIN BOUND TO M7GTP
分子名称:Polymerase basic protein 2, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE
著者Ma, X., Shia, S.
登録日2015-10-23
公開日2015-11-18
最終更新日2016-01-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Molecular Basis of mRNA Cap Recognition by Influenza B Polymerase PB2 Subunit.
J.Biol.Chem., 291, 2016
5EFC
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STRUCTURE OF INFLUENZA B LEE PB2 CAP-BINDING DOMAIN BOUND TO GTP
分子名称:Polymerase basic protein 2, GUANOSINE-5'-TRIPHOSPHATE
著者Ma, X., Shia, S.
登録日2015-10-23
公開日2015-11-18
最終更新日2016-01-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Molecular Basis of mRNA Cap Recognition by Influenza B Polymerase PB2 Subunit.
J.Biol.Chem., 291, 2016
5Z9R
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NMNAT AS A SPECIFIC CHAPERONE ANTAGONIZING PATHOLOGICAL CONDENSATION OF PHOSPHORYLATED TAU
分子名称:Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3
著者Dou, S., Ma, X., Li, D., Liu, C.
登録日2018-02-05
公開日2019-02-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献NMNAT as a specific chaperone antagonizing pathological condensation of phosphorylated tau
To Be Published