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1X70
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HUMAN DIPEPTIDYL PEPTIDASE IV IN COMPLEX WITH A BETA AMINO ACID INHIBITOR
Descriptor:Dipeptidyl peptidase IV, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Kim, D., Wang, L., Beconi, M., Eiermann, G.J., Fisher, M.H., He, H., Hickey, G.J., Leiting, B., Lyons, K.
Deposit date:2004-08-12
Release date:2005-01-18
Last modified:2012-06-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:(2R)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin- 7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes
J.Med.Chem., 48, 2005
2FJP
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HUMAN DIPEPTIDYL PEPTIDASE IV/CD26 IN COMPLEX WITH AN INHIBITOR
Descriptor:Dipeptidyl peptidase 4, N-ACETYL-D-GLUCOSAMINE, 6-(4-{(1S,2S)-2-AMINO-1-[(DIMETHYLAMINO)CARBONYL]-3-[(3S)-3-FLUOROPYRROLIDIN-1-YL]-3-OXOPROPYL}PHENYL)-1H-[1,2,4]TRIAZOLO[1,5-A]PYRIDIN-4-IUM
Authors:Scapin, G., Patel, S.B., Becker, J.W.
Deposit date:2006-01-03
Release date:2006-07-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1,2,4]triazolo[1,5-a]- pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
J.Med.Chem., 49, 2006
2IIT
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HUMAN DIPEPTIDYL PEPTIDASE 4 IN COMPLEX WITH A DIAZEPAN-2-ONE INHIBITOR
Descriptor:Dipeptidyl peptidase 4 soluble form, N-ACETYL-D-GLUCOSAMINE, 2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE, ...
Authors:Scapin, G., Biftu, T., Weber, A.E.
Deposit date:2006-09-28
Release date:2006-11-28
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
Bioorg.Med.Chem.Lett., 17, 2007
2IIV
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HUMAN DIPEPTIDYL PEPTIDASE 4 IN COMPLEX WITH A DIAZEPAN-2-ONE INHIBITOR
Descriptor:Dipeptidyl peptidase 4 soluble form, N-ACETYL-D-GLUCOSAMINE, (3R)-4-[(3R)-3-AMINO-4-(2,4,5-TRIFLUOROPHENYL)BUTANOYL]-3-METHYL-1,4-DIAZEPAN-2-ONE
Authors:Scapin, G., Weber, A.E., Biftu, T.
Deposit date:2006-09-28
Release date:2006-11-28
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
Bioorg.Med.Chem.Lett., 17, 2007
2P8S
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HUMAN DIPEPTIDYL PEPTIDASE IV/CD26 IN COMPLEX WITH A CYCLOHEXALAMINE INHIBITOR
Descriptor:DIPEPTIDYL PEPTIDASE IV SOLUBLE FORM, N-ACETYL-D-GLUCOSAMINE, SODIUM ION, ...
Authors:Scapin, G., Biftu, T.
Deposit date:2007-03-23
Release date:2007-05-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin
Bioorg.Med.Chem.Lett., 17, 2007
4PNZ
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HUMAN DIPEPTIDYL PEPTIDASE IV/CD26 IN COMPLEX WITH THE LONG-ACTING INHIBITOR OMARIGLIPTIN (MK-3102)
Descriptor:Dipeptidyl peptidase 4, SODIUM ION, (2R,3S,5R)-5-[2-(methylsulfonyl)-2,6-dihydropyrrolo[3,4-c]pyrazol-5(4H)-yl]-2-(2,4,5-trifluorophenyl)tetrahydro-2H-pyran-3-amine, ...
Authors:Scapin, G., Yan, Y.
Deposit date:2014-02-22
Release date:2014-04-09
Last modified:2014-05-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Omarigliptin (MK-3102): A Novel Long-Acting DPP-4 Inhibitor for Once-Weekly Treatment of Type 2 Diabetes.
J.Med.Chem., 57, 2014