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1ZXT
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BU of 1zxt by Molmil
Crystal Structure of A Viral Chemokine
Descriptor: functional macrophage inflammatory protein 1-alpha homolog
Authors:Luz, J.G, Yu, M, Su, Y, Wu, Z, Zhou, Z, Sun, R, Wilson, I.A.
Deposit date:2005-06-08
Release date:2005-08-30
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structure of viral macrophage inflammatory protein I encoded by Kaposi's sarcoma-associated herpesvirus at 1.7A.
J.Mol.Biol., 352, 2005
6WT3
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BU of 6wt3 by Molmil
Structural basis for the binding of monoclonal antibody 5D2 to the tryptophan-rich lipid-binding loop in lipoprotein lipase
Descriptor: 5D2 FAB HEAVY CHAIN, 5D2 FAB LIGHT CHAIN
Authors:Luz, J.G, Birrane, G, Young, S.G, Meiyappan, M, Ploug, M.
Deposit date:2020-05-01
Release date:2020-07-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase.
J.Lipid Res., 61, 2020
6WN4
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BU of 6wn4 by Molmil
Structural basis for the binding of monoclonal antibody 5D2 to the tryptophan-rich lipid-binding loop in lipoprotein lipase
Descriptor: 5D2 FAB HEAVY CHAIN, 5D2 FAB LIGHT CHAIN, Lipoprotein lipase peptide
Authors:Luz, J.G, Birrane, G, Young, S.G, Meiyappan, M, Ploug, M.
Deposit date:2020-04-22
Release date:2020-07-29
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The structural basis for monoclonal antibody 5D2 binding to the tryptophan-rich loop of lipoprotein lipase.
J.Lipid Res., 61, 2020
1MWA
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BU of 1mwa by Molmil
2C/H-2KBM3/DEV8 ALLOGENEIC COMPLEX
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2C T CELL RECEPTOR ALPHA CHAIN, ...
Authors:Luz, J.G, Huang, M.D, Garcia, K.C, Rudolph, M.G, Teyton, L, Wilson, I.A.
Deposit date:2002-09-27
Release date:2002-11-27
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially increasing V(beta) Interactions.
J.EXP.MED., 195, 2002
4YK5
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BU of 4yk5 by Molmil
Crystal Structures of mPGES-1 Inhibitor Complexes
Descriptor: 2-(2-METHOXYETHOXY)ETHANOL, 3-[1-(4-chlorobenzyl)-5-(2-fluoro-2'-methylbiphenyl-4-yl)-3-methyl-1H-indol-2-yl]-2,2-dimethylpropanoic acid, GLUTATHIONE, ...
Authors:Luz, J.G, Antonysamy, S, Kuklish, S.L, Fisher, M.J.
Deposit date:2015-03-04
Release date:2015-07-15
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics.
J.Med.Chem., 58, 2015
4YL1
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BU of 4yl1 by Molmil
Crystal Structures of mPGES-1 Inhibitor Complexes
Descriptor: 5-(4-tert-butylphenyl)-1-[4-(propan-2-yloxy)phenyl]-1H-indole-2-carboxylic acid, DI(HYDROXYETHYL)ETHER, GLUTATHIONE, ...
Authors:Luz, J.G, Antonysamy, S, Kuklish, S.L, Fisher, M.J.
Deposit date:2015-03-04
Release date:2015-06-10
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics.
J.Med.Chem., 58, 2015
4YL3
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BU of 4yl3 by Molmil
Crystal Structures of mPGES-1 Inhibitor Complexes
Descriptor: 5-[4-bromo-2-(2-chloro-6-fluorophenyl)-1H-imidazol-5-yl]-2-{[4-(trifluoromethyl)phenyl]ethynyl}pyridine, GLUTATHIONE, Prostaglandin E synthase, ...
Authors:Luz, J.G, Antonysamy, S, Kuklish, S.L, Fisher, M.J.
Deposit date:2015-03-04
Release date:2015-07-08
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics.
J.Med.Chem., 58, 2015
4YL0
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BU of 4yl0 by Molmil
Crystal Structures of mPGES-1 Inhibitor Complexes
Descriptor: 2-(9-chloro-1H-phenanthro[9,10-d]imidazol-2-yl)benzene-1,3-dicarbonitrile, DI(HYDROXYETHYL)ETHER, GLUTATHIONE, ...
Authors:Luz, J.G, Antonysamy, S, Kuklish, S.L, Fisher, M.J.
Deposit date:2015-03-04
Release date:2015-06-10
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Crystal Structures of mPGES-1 Inhibitor Complexes Form a Basis for the Rational Design of Potent Analgesic and Anti-Inflammatory Therapeutics.
J.Med.Chem., 58, 2015
1LEK
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BU of 1lek by Molmil
Crystal Structure of H-2Kbm3 bound to dEV8
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, ...
Authors:Luz, J.G, Huang, M, Garcia, K.C, Rudolph, M.G, Apostolopoulos, V, Teyton, L, Wilson, I.A.
Deposit date:2002-04-09
Release date:2002-06-26
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially increasing V(beta) Interactions.
J.Exp.Med., 195, 2002
1LEG
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BU of 1leg by Molmil
Crystal Structure of H-2Kb bound to the dEV8 peptide
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, BETA-2-MICROGLOBULIN, ...
Authors:Luz, J.G, Huang, M, Garcia, K.C, Rudolph, M.G, Apostolopoulos, V, Teyton, L, Wilson, I.A.
Deposit date:2002-04-09
Release date:2002-06-19
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially increasing V(beta) Interactions.
J.Exp.Med., 195, 2002
1MG7
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BU of 1mg7 by Molmil
Crystal Structure of xol-1
Descriptor: early switch protein xol-1 2.2k splice form
Authors:Luz, J.G, Hassig, C.A, Godzik, A, Meyer, B.J, Wilson, I.A.
Deposit date:2002-08-14
Release date:2003-04-22
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators
Genes Dev., 17, 2003
5K0I
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BU of 5k0i by Molmil
mpges1 bound to an inhibitor
Descriptor: 1,5-anhydro-2,3,4-trideoxy-3-{[(4S)-3,3-dimethyl-1-(8-methylquinolin-2-yl)piperidine-4-carbonyl]amino}-D-erythro-hexitol, GLUTATHIONE, Prostaglandin E synthase, ...
Authors:Luz, J.G, Kuklish, S.L.
Deposit date:2016-05-17
Release date:2016-09-14
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Characterization of 3,3-dimethyl substituted N-aryl piperidines as potent microsomal prostaglandin E synthase-1 inhibitors.
Bioorg.Med.Chem.Lett., 26, 2016
4MDD
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BU of 4mdd by Molmil
Crystal Structure of the Glucocorticoid Receptor Bound to a Non-steroidal Antagonist Reveals Repositioning and Partial Disordering of Activation Function Helix 12
Descriptor: Glucocorticoid receptor, N-[2-{[benzyl(methyl)amino]methyl}-3-(4-fluoro-2-methoxyphenyl)-5-(propan-2-yl)-1H-indol-7-yl]methanesulfonamide, Nuclear receptor corepressor 1
Authors:Coghlan, M.J, Luz, J.G.
Deposit date:2013-08-22
Release date:2014-12-03
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of the Glucocorticoid Receptor Bound to a Non-steroidal Antagonist Reveals Repositioning and Partial Disordering of Activation Function Helix 12
To be Published
5T36
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BU of 5t36 by Molmil
Crystal structure of mPGES-1 bound to inhibitor
Descriptor: 4-chloro-2-[({(1S,2S)-2-[(2,2-dimethylpropanoyl)amino]cyclopentyl}methyl)amino]benzoic acid, GLUTATHIONE, Prostaglandin E synthase, ...
Authors:Luz, J.G, Antonysamy, S, Partridge, K, Fisher, M.
Deposit date:2016-08-24
Release date:2017-03-01
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1.
Bioorg. Med. Chem. Lett., 27, 2017
5T37
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BU of 5t37 by Molmil
crystal structure of mPGES-1 bound to inhibitor
Descriptor: 2-chloro-5-{[(2,2-dimethylpropanoyl)amino]methyl}-N-(1H-imidazol-2-yl)benzamide, GLUTATHIONE, Prostaglandin E synthase, ...
Authors:Luz, J.G, Antonysamy, S, Partridge, K, Fisher, M.
Deposit date:2016-08-24
Release date:2017-03-01
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.761 Å)
Cite:Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1.
Bioorg. Med. Chem. Lett., 27, 2017
5TL9
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BU of 5tl9 by Molmil
crystal structure of mPGES-1 bound to inhibitor
Descriptor: 2-{2-[(1S,2S)-2-{[1-(8-methylquinolin-2-yl)piperidine-4-carbonyl]amino}cyclopentyl]ethyl}benzoic acid, DI(HYDROXYETHYL)ETHER, GLUTATHIONE, ...
Authors:Luz, J.G, Antonysamy, S, Partridge, K, Fisher, M.
Deposit date:2016-10-10
Release date:2017-03-01
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Discovery and characterization of [(cyclopentyl)ethyl]benzoic acid inhibitors of microsomal prostaglandin E synthase-1.
Bioorg. Med. Chem. Lett., 27, 2017
5CJ6
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BU of 5cj6 by Molmil
Crystal Structure of a Selective Androgen Receptor Modulator Bound to the Ligand Binding Domain of the Human Androgen Receptor
Descriptor: 2-chloro-4-{[(1R,2R)-2-hydroxy-2-methylcyclopentyl]amino}-3-methylbenzonitrile, Androgen receptor, small peptide
Authors:Luz, J.G, Saeed, A, Wang, Y.
Deposit date:2015-07-14
Release date:2016-01-06
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:2-Chloro-4-[[(1R,2R)-2-hydroxy-2-methyl-cyclopentyl]amino]-3-methyl-benzonitrile: A Transdermal Selective Androgen Receptor Modulator (SARM) for Muscle Atrophy.
J.Med.Chem., 59, 2016
1LK2
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BU of 1lk2 by Molmil
1.35A crystal structure of H-2Kb complexed with the GNYSFYAL peptide
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Luz, J.G, Rudolph, M.G, Wilson, I.A, Eisen, H.
Deposit date:2002-04-23
Release date:2003-11-11
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:A peptide that antagonizes TCR-mediated reactions with both syngeneic and allogeneic agonists: functional and structural aspects.
J.Immunol., 172, 2004
4I5I
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BU of 4i5i by Molmil
Crystal structure of the SIRT1 catalytic domain bound to NAD and an EX527 analog
Descriptor: (6S)-2-chloro-5,6,7,8,9,10-hexahydrocyclohepta[b]indole-6-carboxamide, NAD-dependent protein deacetylase sirtuin-1, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Zhao, X, Allison, D, Condon, B, Zhang, F, Gheyi, T, Zhang, A, Ashok, S, Russell, M, Macewan, I, Qian, Y, Jamison, J.A, Luz, J.G.
Deposit date:2012-11-28
Release date:2013-01-23
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The 2.5 angstrom crystal structure of the SIRT1 catalytic domain bound to nicotinamide adenine dinucleotide (NAD+) and an indole (EX527 analogue) reveals a novel mechanism of histone deacetylase inhibition.
J.Med.Chem., 56, 2013
6PY1
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BU of 6py1 by Molmil
Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc
Descriptor: 2-acetamido-2-deoxy-alpha-D-galactopyranose, ACETATE ION, C-type lectin domain family 10 member A, ...
Authors:Birrane, G, Murphy, P.V, Gabba, A, Luz, J.G.
Deposit date:2019-07-28
Release date:2020-07-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.701 Å)
Cite:Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc and the Tumor-Associated Tn Antigen.
Biochemistry, 60, 2021
6PUV
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BU of 6puv by Molmil
Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin
Descriptor: C-type lectin domain family 10 member A, CALCIUM ION
Authors:Birrane, G, Murphy, P.V, Gabba, A, Luz, J.G.
Deposit date:2019-07-18
Release date:2020-07-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc and the Tumor-Associated Tn Antigen.
Biochemistry, 60, 2021
6W12
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BU of 6w12 by Molmil
Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to the Tumor-Associated Tn Antigen
Descriptor: 2-acetamido-2-deoxy-alpha-D-galactopyranose, C-type lectin domain family 10 member A, CALCIUM ION, ...
Authors:Birrane, G, Murphy, P.V, Gabba, A, Luz, J.G.
Deposit date:2020-03-03
Release date:2021-03-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc and the Tumor-Associated Tn Antigen.
Biochemistry, 60, 2021
6XIY
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BU of 6xiy by Molmil
Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to methyl 2-(acetylamino)-2-deoxy-1-thio-alpha-D-galactopyranose
Descriptor: C-type lectin domain family 10 member A, CALCIUM ION, CHLORIDE ION, ...
Authors:Birrane, G, Murphy, P.V, Gabba, A, Luz, J.G.
Deposit date:2020-06-22
Release date:2021-03-31
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.307 Å)
Cite:Crystal Structure of the Carbohydrate Recognition Domain of the Human Macrophage Galactose C-Type Lectin Bound to GalNAc and the Tumor-Associated Tn Antigen.
Biochemistry, 60, 2021
4LSJ
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BU of 4lsj by Molmil
Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Bound to a Dibenzoxapine Sulfonamide
Descriptor: D30 peptide, Glucocorticoid receptor, N-{3-[(1Z)-1-(10-methoxydibenzo[b,e]oxepin-11(6H)-ylidene)propyl]phenyl}methanesulfonamide
Authors:Carson, M, Luz, J.G, Clawson, D, Coghlan, M.
Deposit date:2013-07-22
Release date:2014-01-29
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Glucocorticoid receptor modulators informed by crystallography lead to a new rationale for receptor selectivity, function, and implications for structure-based design.
J.Med.Chem., 57, 2014
1P1X
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BU of 1p1x by Molmil
Comparison of class I aldolase binding site architecture based on the crystal structure of 2-deoxyribose-5-phosphate aldolase determined at 0.99 Angstrom resolution
Descriptor: Deoxyribose-phosphate aldolase
Authors:Heine, A, Luz, J.G, Wong, C.H, Wilson, I.A.
Deposit date:2003-04-14
Release date:2004-06-01
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (0.99 Å)
Cite:Analysis of the class I aldolase binding site architecture based on the crystal structure of 2-deoxyribose-5-phosphate aldolase at 0.99A resolution.
J.Mol.Biol., 343, 2004

 

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