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4ZUZ
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BU of 4zuz by Molmil
SidC 1-871
Descriptor: SidC
Authors:Luo, X, Wasilko, D.J, Liu, Y, Sun, J, Wu, X, Luo, Z.-Q, Mao, Y.
Deposit date:2015-05-18
Release date:2015-07-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Structure of the Legionella Virulence Factor, SidC Reveals a Unique PI(4)P-Specific Binding Domain Essential for Its Targeting to the Bacterial Phagosome.
Plos Pathog., 11, 2015
1S2H
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BU of 1s2h by Molmil
The Mad2 spindle checkpoint protein possesses two distinct natively folded states
Descriptor: Mitotic spindle assembly checkpoint protein MAD2A
Authors:Luo, X, Tang, Z, Xia, G, Wassmann, K, Matsumoto, T, Rizo, J, Yu, H.
Deposit date:2004-01-08
Release date:2004-03-30
Last modified:2021-10-27
Method:SOLUTION NMR
Cite:The Mad2 spindle checkpoint protein has two distinct natively folded states.
Nat.Struct.Mol.Biol., 11, 2004
1DUJ
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BU of 1duj by Molmil
SOLUTION STRUCTURE OF THE SPINDLE ASSEMBLY CHECKPOINT PROTEIN HUMAN MAD2
Descriptor: SPINDLE ASSEMBLY CHECKPOINT PROTEIN
Authors:Luo, X, Fang, G, Coldiron, M, Lin, Y, Yu, H.
Deposit date:2000-01-17
Release date:2000-03-08
Last modified:2022-12-21
Method:SOLUTION NMR
Cite:Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20.
Nat.Struct.Biol., 7, 2000
1KLQ
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BU of 1klq by Molmil
The Mad2 Spindle Checkpoint Protein Undergoes Similar Major Conformational Changes upon Binding to Either Mad1 or Cdc20
Descriptor: MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD2A, Mad2-binding peptide
Authors:Luo, X, Tang, Z, Rizo, J, Yu, H.
Deposit date:2001-12-12
Release date:2002-01-25
Last modified:2022-02-23
Method:SOLUTION NMR
Cite:The Mad2 spindle checkpoint protein undergoes similar major conformational changes upon binding to either Mad1 or Cdc20.
Mol.Cell, 9, 2002
1TBD
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BU of 1tbd by Molmil
SOLUTION STRUCTURE OF THE ORIGIN DNA BINDING DOMAIN OF SV40 T-ANTIGEN, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor: SV40 T-ANTIGEN
Authors:Luo, X, Sanford, D.G, Bullock, P.A, Bachovchin, W.W.
Deposit date:1996-11-04
Release date:1997-03-12
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Solution structure of the origin DNA-binding domain of SV40 T-antigen.
Nat.Struct.Biol., 3, 1996
3D3C
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BU of 3d3c by Molmil
Structural and functional analysis of the E. coli NusB-S10 transcription antitermination complex.
Descriptor: 30S ribosomal protein S10, N utilization substance protein B
Authors:Luo, X, Wahl, M.C.
Deposit date:2008-05-09
Release date:2009-01-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural and functional analysis of the E. coli NusB-S10 transcription antitermination complex.
Mol.Cell, 32, 2008
3D3B
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BU of 3d3b by Molmil
Structural and functional analysis of the E. coli NusB-S10 transcription antitermination complex.
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 30S ribosomal protein S10, N utilization substance protein B
Authors:Luo, X, Wahl, M.C.
Deposit date:2008-05-09
Release date:2009-01-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structural and functional analysis of the E. coli NusB-S10 transcription antitermination complex.
Mol.Cell, 32, 2008
2TBD
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BU of 2tbd by Molmil
SV40 T ANTIGEN DNA-BINDING DOMAIN, NMR, 30 STRUCTURES
Descriptor: SV40 T ANTIGEN
Authors:Luo, X, Sanford, D.G, Bullock, P.A, Bachovchin, W.W.
Deposit date:1997-01-09
Release date:1997-04-01
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Solution structure of the origin DNA-binding domain of SV40 T-antigen.
Nat.Struct.Biol., 3, 1996
5U36
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BU of 5u36 by Molmil
Crystal Structure Of A Mutant M. Jannashii Tyrosyl-tRNA Synthetase
Descriptor: Tyrosine--tRNA ligase
Authors:Luo, X, Fu, G, Zhu, X, Wilson, I.A, Wang, F.
Deposit date:2016-12-01
Release date:2017-06-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:Genetically encoding phosphotyrosine and its nonhydrolyzable analog in bacteria.
Nat. Chem. Biol., 13, 2017
6L1W
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BU of 6l1w by Molmil
Zinc-finger Antiviral Protein (ZAP) bound to RNA
Descriptor: RNA (5'-R(*CP*GP*UP*CP*GP*U)-3'), ZINC ION, Zinc finger CCCH-type antiviral protein 1
Authors:Luo, X, Wang, X, Gao, Y, Zhu, J, Liu, S, Gao, G, Gao, P.
Deposit date:2019-09-30
Release date:2020-01-01
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.194 Å)
Cite:Molecular Mechanism of RNA Recognition by Zinc-Finger Antiviral Protein.
Cell Rep, 30, 2020
4DZO
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BU of 4dzo by Molmil
Structure of Human Mad1 C-terminal Domain Reveals Its Involvement in Kinetochore Targeting
Descriptor: Mitotic spindle assembly checkpoint protein MAD1
Authors:Luo, X, Sun, H, Tomchick, D.R.
Deposit date:2012-03-01
Release date:2012-04-11
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.76 Å)
Cite:Structure of human Mad1 C-terminal domain reveals its involvement in kinetochore targeting.
Proc.Natl.Acad.Sci.USA, 109, 2012
5HGU
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BU of 5hgu by Molmil
Crystal structure of human transcription factor TEAD2 in complex with palmitate
Descriptor: PALMITIC ACID, Transcriptional enhancer factor TEF-4
Authors:Luo, X, Xiao, H.
Deposit date:2016-01-08
Release date:2016-02-17
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.046 Å)
Cite:Autopalmitoylation of TEAD proteins regulates transcriptional output of the Hippo pathway.
Nat.Chem.Biol., 12, 2016
3IMQ
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BU of 3imq by Molmil
Crystal structure of the NusB101-S10(delta loop) complex
Descriptor: 30S ribosomal protein S10, N utilization substance protein B, POTASSIUM ION
Authors:Luo, X, Wahl, M.C.
Deposit date:2009-08-11
Release date:2009-11-10
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Fine tuning of the E. coli NusB:NusE complex affinity to BoxA RNA is required for processive antitermination.
Nucleic Acids Res., 38, 2010
5BRM
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BU of 5brm by Molmil
Structural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in Hippo signaling
Descriptor: MOB kinase activator 1A, Serine/threonine-protein kinase 3, ZINC ION
Authors:Luo, X, Ni, L.
Deposit date:2015-05-31
Release date:2015-07-08
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.651 Å)
Cite:Structural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in Hippo signaling.
Genes Dev., 29, 2015
4N14
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BU of 4n14 by Molmil
Crystal structure of Cdc20 and apcin complex
Descriptor: 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl [(1R)-2,2,2-trichloro-1-(pyrimidin-2-ylamino)ethyl]carbamate, Cell division cycle protein 20 homolog
Authors:Luo, X, Tian, W, Yu, H.
Deposit date:2013-10-03
Release date:2014-08-20
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C.
Nature, 514, 2014
4GGD
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BU of 4ggd by Molmil
Structural analysis of human Cdc20 supports multisite degron recognition by APC/C.
Descriptor: Cell division cycle protein 20 homolog, Mitotic checkpoint serine/threonine-protein kinase BUB1 beta
Authors:Luo, X, Tian, W, Tomchick, D.R.
Deposit date:2012-08-06
Release date:2012-11-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.435 Å)
Cite:Structural analysis of human Cdc20 supports multisite degron recognition by APC/C.
Proc.Natl.Acad.Sci.USA, 109, 2012
4GGA
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BU of 4gga by Molmil
Structural Analysis of Human Cdc20 Supports Multi-site Degron Recognition by APC/C
Descriptor: Cell division cycle protein 20 homolog
Authors:Luo, X, Tian, W, Tomchick, D.R.
Deposit date:2012-08-06
Release date:2012-11-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.044 Å)
Cite:Structural analysis of human Cdc20 supports multisite degron recognition by APC/C.
Proc.Natl.Acad.Sci.USA, 109, 2012
4GGC
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BU of 4ggc by Molmil
Structural Analysis of Human Cdc20 Supports Multi-site Degron Recognition by APC/C
Descriptor: (4R)-2-METHYLPENTANE-2,4-DIOL, Cell division cycle protein 20 homolog
Authors:Luo, X, Tian, W, Tomchick, D.R.
Deposit date:2012-08-06
Release date:2012-11-07
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structural analysis of human Cdc20 supports multisite degron recognition by APC/C.
Proc.Natl.Acad.Sci.USA, 109, 2012
4LGD
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BU of 4lgd by Molmil
Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Ras association domain family member 5, ...
Authors:Luo, X, Ni, L, Tomchick, D.R.
Deposit date:2013-06-27
Release date:2013-09-18
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5.
Structure, 21, 2013
4LG4
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BU of 4lg4 by Molmil
Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5
Descriptor: GLYCEROL, Serine/threonine-protein kinase 3
Authors:Luo, X, Ni, L, Tomchick, D.R.
Deposit date:2013-06-27
Release date:2013-09-18
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5.
Structure, 21, 2013
5XPI
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BU of 5xpi by Molmil
Structure of UHRF1 TTD in complex with NV01
Descriptor: E3 ubiquitin-protein ligase UHRF1, N-[3-(diethylamino)propyl]-2-(12-methyl-9-oxidanylidene-5-thia-1,10,11-triazatricyclo[6.4.0.0^2,6]dodeca-2(6),3,7,11-tetraen-10-yl)ethanamide
Authors:Luo, X, Zhao, K.
Deposit date:2017-06-02
Release date:2018-04-25
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of Small-Molecule Antagonists of the H3K9me3 Binding to UHRF1 Tandem Tudor Domain
SLAS Discov, 23, 2018
4TRG
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BU of 4trg by Molmil
the SNL domain of SidC
Descriptor: MERCURY (II) ION, SidC
Authors:Hsu, F.S, Luo, X, Qiu, J, Teng, Y, Jin, J, Smolka, M.B, Luo, Z.Q, Mao, Y.
Deposit date:2014-06-16
Release date:2014-07-02
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:The Legionella effector SidC defines a unique family of ubiquitin ligases important for bacterial phagosomal remodeling.
Proc.Natl.Acad.Sci.USA, 111, 2014
4TRH
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BU of 4trh by Molmil
The Legionella effector SidC defines a unique family of ubiquitin ligases important for bacterial phagosomal remodeling
Descriptor: SidC
Authors:Hsu, F.S, Luo, X, Qiu, J, Teng, Y, Jin, J, Smolka, M.B, Luo, Z.Q, Mao, Y.
Deposit date:2014-06-16
Release date:2014-07-02
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:The Legionella effector SidC defines a unique family of ubiquitin ligases important for bacterial phagosomal remodeling.
Proc.Natl.Acad.Sci.USA, 111, 2014
4RYL
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BU of 4ryl by Molmil
Human Protein Arginine Methyltransferase 3 in complex with 1-isoquinolin-6-yl-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl]urea
Descriptor: 1-isoquinolin-6-yl-3-[2-oxo-2-(pyrrolidin-1-yl)ethyl]urea, PRMT3 protein, UNKNOWN ATOM OR ION
Authors:Dong, A, Dobrovetsky, E, Kaniskan, H.U, Szewczyk, M, Yu, Z, Eram, M.S, Yang, X, Schmidt, K, Luo, X, Dai, M, He, F, Zang, I, Lin, Y, Kennedy, S, Li, F, Tempel, W, Smil, D, Min, S.J, Landon, M, Lin-Jones, J, Huang, X.P, Roth, B.L, Schapira, M, Atadja, P, Barsyte-Lovejoy, D, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Brown, P.J, Zhao, K, Jin, J, Vedadi, M, Structural Genomics Consortium (SGC)
Deposit date:2014-12-15
Release date:2015-02-25
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A Potent, Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3).
Angew.Chem.Int.Ed.Engl., 54, 2015
7QK4
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BU of 7qk4 by Molmil
EED in complex with PRC2 allosteric inhibitor compound 22 (MAK683)
Descriptor: CHLORIDE ION, Histone-lysine N-methyltransferase EZH2, N-[(5-fluoranyl-2,3-dihydro-1-benzofuran-4-yl)methyl]-8-(2-methylpyridin-3-yl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine, ...
Authors:Zhao, K, Zhao, M, Luo, X, Zhang, H, Scheufler, C.
Deposit date:2021-12-17
Release date:2022-04-13
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.602 Å)
Cite:Discovery of the Clinical Candidate MAK683: An EED-Directed, Allosteric, and Selective PRC2 Inhibitor for the Treatment of Advanced Malignancies.
J.Med.Chem., 65, 2022

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