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5VGZ
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CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE
Descriptor:26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, 26S proteasome regulatory subunit 8, ...
Authors:Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y.
Deposit date:2017-04-12
Release date:2017-08-23
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
5VHF
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CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE
Descriptor:26S proteasome non-ATPase regulatory subunit 10, 26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, ...
Authors:Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y.
Deposit date:2017-04-13
Release date:2017-08-23
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (5.7 Å)
Cite:Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
5VHH
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CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE
Descriptor:26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, 26S proteasome regulatory subunit 8, ...
Authors:Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y.
Deposit date:2017-04-13
Release date:2017-08-23
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (6.1 Å)
Cite:Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
5VHI
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CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE
Descriptor:26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, 26S proteasome regulatory subunit 8, ...
Authors:Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y.
Deposit date:2017-04-13
Release date:2017-08-23
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (6.8 Å)
Cite:Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
5VHJ
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CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE
Descriptor:26S proteasome non-ATPase regulatory subunit 10, 26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, ...
Authors:Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y.
Deposit date:2017-04-13
Release date:2017-08-23
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (8.5 Å)
Cite:Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
5VHM
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CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE
Descriptor:26S proteasome non-ATPase regulatory subunit 10, 26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, ...
Authors:Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y.
Deposit date:2017-04-13
Release date:2017-08-23
Last modified:2018-09-12
Method:ELECTRON MICROSCOPY (8.3 Å)
Cite:Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
5VHN
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CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE
Descriptor:26S proteasome non-ATPase regulatory subunit 10, 26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, ...
Authors:Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y.
Deposit date:2017-04-13
Release date:2017-08-23
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (7.3 Å)
Cite:Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
5VHO
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CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE
Descriptor:26S proteasome non-ATPase regulatory subunit 10, 26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, ...
Authors:Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y.
Deposit date:2017-04-13
Release date:2017-08-23
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (8.3 Å)
Cite:Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
5VHP
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CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE
Descriptor:26S proteasome non-ATPase regulatory subunit 10, 26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, ...
Authors:Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y.
Deposit date:2017-04-13
Release date:2017-08-23
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (7.9 Å)
Cite:Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
5VHQ
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CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE
Descriptor:26S proteasome non-ATPase regulatory subunit 10, 26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, ...
Authors:Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y.
Deposit date:2017-04-13
Release date:2017-08-23
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (8.9 Å)
Cite:Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
5VHR
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CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE
Descriptor:26S proteasome non-ATPase regulatory subunit 10, 26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, ...
Authors:Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y.
Deposit date:2017-04-13
Release date:2017-08-23
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (7.7 Å)
Cite:Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
5VHS
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CONFORMATIONAL LANDSCAPE OF THE P28-BOUND HUMAN PROTEASOME REGULATORY PARTICLE
Descriptor:26S proteasome regulatory subunit 7, 26S proteasome regulatory subunit 4, 26S proteasome regulatory subunit 8, ...
Authors:Lu, Y., Wu, J., Dong, Y., Chen, S., Sun, S., Ma, Y.B., Ouyang, Q., Finley, D., Kirschner, M.W., Mao, Y.
Deposit date:2017-04-13
Release date:2017-08-23
Last modified:2018-08-22
Method:ELECTRON MICROSCOPY (8.8 Å)
Cite:Conformational Landscape of the p28-Bound Human Proteasome Regulatory Particle.
Mol. Cell, 67, 2017
5WZX
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STRUCTURAL BASIS FOR A PENTACYCLIC OLEANANE-TYPE TRITERPENOID AS A LIGAND OF FXR
Descriptor:Bile acid receptor, SRC2-3 peptide from Nuclear receptor coactivator 2, (4aR,6aR,6aS,6bS,8aS,9R,12aR,14bR)-2,2,6a,6b,9,12a-hexamethyl-10-oxidanylidene-1,3,4,5,6,6a,7,8,8a,9,11,12,13,14b-tetradecahydropicene-4a-carboxylic acid, ...
Authors:Lu, Y., Li, Y.
Deposit date:2017-01-19
Release date:2018-01-03
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Identification of an Oleanane-Type Triterpene Hedragonic Acid as a Novel Farnesoid X Receptor Ligand with Liver Protective Effects and Anti-inflammatory Activity
Mol. Pharmacol., 93, 2018
5Y1J
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CRYSTAL STRUCTURE OF HUMAN FXR IN COMPLEX WITH A FUNCTIONAL DRUG LIGAND
Descriptor:Bile acid receptor, Peptide from Nuclear receptor coactivator 2, 2-[[2-fluoranyl-4-(3-methoxyphenyl)phenyl]carbamoyl]cyclopentene-1-carboxylic acid
Authors:Lu, Y., Li, Y.
Deposit date:2017-07-20
Release date:2018-10-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of human FXR in complex with a functional drug liagnd
To Be Published
5Y44
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A NOVEL MODERATOR XD4 FOR BILE ACID RECEPTOR
Descriptor:Bile acid receptor, Peptide from Nuclear receptor coactivator 1, [(1R,2R,4R)-1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl] 4-azanyl-3-methyl-benzoate, ...
Authors:Lu, Y., Li, Y.
Deposit date:2017-08-01
Release date:2019-02-20
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:A novel moderator XD4 for bile acid receptor
To Be Published
5Y49
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A MODERATOR XD22 BINDING TO BILE ACID RECEPTOR
Descriptor:Bile acid receptor, Peptide from Nuclear receptor coactivator 2, [(1R,2S,4S)-2-bicyclo[2.2.1]heptanyl] 4-azanylbenzoate
Authors:Lu, Y., Li, Y.
Deposit date:2017-08-02
Release date:2019-02-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A moderator XD22 binding to bile acid receptor
To Be Published
3K3P
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CRYSTAL STRUCTURE OF THE APO FORM OF D-ALANINE:D-ALANINE LIGASE (DDL) FROM STREPTOCOCCUS MUTANS
Descriptor:D-alanine--D-alanine ligase
Authors:Lu, Y.
Deposit date:2009-10-03
Release date:2010-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Crystal structure of the Apo form of D-Alanine:D-Alanine ligase (DDl) from Streptococcus mutans
Protein Pept.Lett., 17, 2010
5XQ5
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NMR STRUCTURE OF THE DOMAIN 5 OF THE E. COLI RIBOSOMAL PROTEIN S1
Descriptor:30S ribosomal protein S1
Authors:Lu, Y., Lim, L.Z., Song, J.
Deposit date:2017-06-06
Release date:2018-06-06
Method:SOLUTION NMR
Cite:NMR structure of the domain 5 of the E. coli ribosomal protein S1
To Be Published
5IAW
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NOVEL NATURAL FXR MODULATOR WITH A UNIQUE BINDING MODE
Descriptor:Bile acid receptor, Peptide from Nuclear receptor coactivator 2, (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl 4-hydroxybenzoate
Authors:Lu, Y., Li, Y.
Deposit date:2016-02-22
Release date:2017-03-08
Last modified:2017-05-03
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:A Novel Class of Natural FXR Modulators with a Unique Mode of Selective Co-regulator Assembly
Chembiochem, 18, 2017
5ICK
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A UNIQUE BINDING MODEL OF FXR LBD WITH FEROLINE
Descriptor:Bile acid receptor, Nuclear receptor coactivator 2, (1S,2S,3Z,5S,8Z)-5-hydroxy-5,9-dimethyl-2-(propan-2-yl)cyclodeca-3,8-dien-1-yl 4-hydroxybenzoate
Authors:Lu, Y., Li, Y.
Deposit date:2016-02-23
Release date:2017-03-08
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:A Novel Class of Natural FXR Modulators with a Unique Mode of Selective Co-regulator Assembly
Chembiochem, 18, 2017
5Z12
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A STRUCTURE OF FXR/RXR
Descriptor:Bile acid receptor, Retinoic acid receptor RXR-alpha, Peptide from Nuclear receptor coactivator 2, ...
Authors:Lu, Y., Li, Y.
Deposit date:2017-12-23
Release date:2018-07-04
Last modified:2018-08-22
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structural insights into the heterodimeric complex of the nuclear receptors FXR and RXR
J. Biol. Chem., 293, 2018
4FQ5
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CRYSTAL STRUCTURE OF THE MALEATE ISOMERASE ISO(C200A) FROM PSEUDOMONAS PUTIDA S16 WITH MALEATE
Descriptor:Maleate cis-trans isomerase, MALEIC ACID
Authors:Lu, Y., Chen, D., Zhang, Z., Li, Q., Wu, G., Xu, P.
Deposit date:2012-06-25
Release date:2013-07-24
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and computational studies of the maleate isomerase from Pseudomonas putida S16 reveal a breathing motion wrapping the substrate inside.
Mol.Microbiol., 87, 2013
4FQ7
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CRYSTAL STRUCTURE OF THE MALEATE ISOMERASE ISO FROM PSEUDOMONAS PUTIDA S16
Descriptor:Maleate cis-trans isomerase
Authors:Lu, Y., Chen, D., Zhang, Z., Li, Q., Wu, G., Xu, P.
Deposit date:2012-06-25
Release date:2013-07-24
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structural and computational studies of the maleate isomerase from Pseudomonas putida S16 reveal a breathing motion wrapping the substrate inside.
Mol.Microbiol., 87, 2013
2FDP
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CRYSTAL STRUCTURE OF BETA-SECRETASE COMPLEXED WITH AN AMINO-ETHYLENE INHIBITOR
Descriptor:Beta-secretase 1, N1-((2S,3S,5R)-3-AMINO-6-(4-FLUOROPHENYLAMINO)-5-METHYL-6-OXO-1-PHENYLHEXAN-2-YL)-N3,N3-DIPROPYLISOPHTHALAMIDE
Authors:Yang, W., Lu, W., Lu, Y., Zhong, M., Sun, J., Thomas, A.E., Wilkinson, J.M., Fucini, R.V., Lam, M., Randal, M., Shi, X.P., Jacobs, J.W., McDowell, R.S., Gordon, E.M., Ballinger, M.D.
Deposit date:2005-12-14
Release date:2006-01-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Aminoethylenes: a tetrahedral intermediate isostere yielding potent inhibitors of the aspartyl protease BACE-1.
J.Med.Chem., 49, 2006
5VFO
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NUCLEOTIDE-DRIVEN TRIPLE-STATE REMODELING OF THE AAA-ATPASE CHANNEL IN THE ACTIVATED HUMAN 26S PROTEASOME
Descriptor:Proteasome subunit alpha type-6, Proteasome subunit alpha type-2, Proteasome subunit alpha type-4, ...
Authors:Zhu, Y., Wang, W.L., Yu, D., Ouyang, Q., Lu, Y., Mao, Y.
Deposit date:2017-04-08
Release date:2018-07-18
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural mechanism for nucleotide-driven remodeling of the AAA-ATPase unfoldase in the activated human 26S proteasome.
Nat Commun, 9, 2018